JP2022534303A5 - - Google Patents

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Publication number
JP2022534303A5
JP2022534303A5 JP2021570930A JP2021570930A JP2022534303A5 JP 2022534303 A5 JP2022534303 A5 JP 2022534303A5 JP 2021570930 A JP2021570930 A JP 2021570930A JP 2021570930 A JP2021570930 A JP 2021570930A JP 2022534303 A5 JP2022534303 A5 JP 2022534303A5
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JP
Japan
Prior art keywords
amine
quinazoline
methyl
fluorophenyl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021570930A
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English (en)
Japanese (ja)
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JP2022534303A (ja
JP7644029B2 (ja
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Priority claimed from PCT/EP2020/064913 external-priority patent/WO2020239951A1/en
Publication of JP2022534303A publication Critical patent/JP2022534303A/ja
Publication of JP2022534303A5 publication Critical patent/JP2022534303A5/ja
Priority to JP2025029719A priority Critical patent/JP2025098014A/ja
Application granted granted Critical
Publication of JP7644029B2 publication Critical patent/JP7644029B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2021570930A 2019-05-31 2020-05-28 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体 Active JP7644029B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025029719A JP2025098014A (ja) 2019-05-31 2025-02-27 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19177604 2019-05-31
EP19177604.6 2019-05-31
EP19201168 2019-10-02
EP19201168.2 2019-10-02
PCT/EP2020/064913 WO2020239951A1 (en) 2019-05-31 2020-05-28 Amino quinazoline derivatives as p2x3 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025029719A Division JP2025098014A (ja) 2019-05-31 2025-02-27 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体

Publications (3)

Publication Number Publication Date
JP2022534303A JP2022534303A (ja) 2022-07-28
JP2022534303A5 true JP2022534303A5 (https=) 2023-06-05
JP7644029B2 JP7644029B2 (ja) 2025-03-11

Family

ID=70861506

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021570931A Active JP7641917B2 (ja) 2019-05-31 2020-05-28 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体
JP2021570930A Active JP7644029B2 (ja) 2019-05-31 2020-05-28 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体
JP2025029719A Pending JP2025098014A (ja) 2019-05-31 2025-02-27 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2021570931A Active JP7641917B2 (ja) 2019-05-31 2020-05-28 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025029719A Pending JP2025098014A (ja) 2019-05-31 2025-02-27 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体

Country Status (20)

Country Link
US (2) US20230092892A1 (https=)
EP (2) EP3976179A1 (https=)
JP (3) JP7641917B2 (https=)
KR (2) KR102921972B1 (https=)
CN (3) CN114269432B (https=)
AU (2) AU2020281923B2 (https=)
BR (2) BR112021021738A2 (https=)
CA (2) CA3139018A1 (https=)
CL (1) CL2021003165A1 (https=)
CO (1) CO2021017031A2 (https=)
GE (2) GEP20257823B (https=)
IL (1) IL288405A (https=)
MA (2) MA56021A (https=)
MX (2) MX2021014113A (https=)
PE (1) PE20220934A1 (https=)
PH (1) PH12021552881A1 (https=)
SA (1) SA521430920B1 (https=)
SG (1) SG11202112187YA (https=)
WO (2) WO2020239952A1 (https=)
ZA (1) ZA202108273B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3142351A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
JP7797204B2 (ja) * 2019-05-31 2026-01-13 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ｐ２ｘ３阻害剤としてのピリドピリミジン誘導体
CA3139018A1 (en) * 2019-05-31 2020-12-03 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
UA130430C2 (uk) 2019-05-31 2026-02-18 Янссен Фармацевтика Нв НИЗЬКОМОЛЕКУЛЯРНІ ІНГІБІТОРИ КІНАЗИ, ЩО ІНДУКУЄ NF-kB
CA3141826A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2022063205A1 (zh) * 2020-09-24 2022-03-31 中国医药研究开发中心有限公司 芳基甲酰胺类化合物及其制备方法和医药用途
WO2022083657A1 (zh) * 2020-10-20 2022-04-28 苏州泽璟生物制药股份有限公司 取代苯并或吡啶并嘧啶胺类抑制剂及其制备方法和应用
JP2023550830A (ja) * 2020-11-27 2023-12-05 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ｐ２ｘ３阻害剤としての（アザ）キノリン４－アミン誘導体
WO2022112490A1 (en) * 2020-11-27 2022-06-02 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
CN112661803A (zh) * 2020-12-17 2021-04-16 上海药明康德新药开发有限公司 DNA编码化合物库构建中On-DNA 4-胺基喹唑啉化合物的合成方法
US20240239764A1 (en) 2020-12-22 2024-07-18 Mekanistic Therapeutics Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors
WO2022171118A1 (zh) * 2021-02-10 2022-08-18 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
CN115677601B (zh) * 2021-07-29 2025-06-03 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
WO2024235225A1 (zh) * 2023-05-15 2024-11-21 苏州泽璟生物制药股份有限公司 取代嘧啶并环类抑制剂及其制备方法和应用
AU2024275670A1 (en) 2023-05-22 2026-01-15 Chiesi Farmaceutici S.P.A. Salts of amino quinazoline derivatives
AR132737A1 (es) 2023-05-22 2025-07-23 Chiesi Farm Spa Proceso e intermedios para la preparación de un inhibidor p2x3
WO2025101598A1 (en) * 2023-11-07 2025-05-15 Zeno Management, Inc. Bi-cyclic pyrimidine compounds, methods and uses thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH31122A (en) * 1993-03-31 1998-02-23 Eisai Co Ltd Nitrogen-containing fused-heterocycle compounds.
JPH0710843A (ja) * 1993-03-31 1995-01-13 Eisai Co Ltd 含窒素縮合複素環化合物
JP4342007B2 (ja) 1998-08-10 2009-10-14 大日本住友製薬株式会社 キナゾリン誘導体
GB0126433D0 (en) * 2001-11-03 2002-01-02 Astrazeneca Ab Compounds
CA2557372C (en) * 2004-03-05 2013-01-08 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 antagonists
MX2008002014A (es) * 2005-08-15 2008-03-27 Hoffmann La Roche Derivados de piperidina y piperazina como antagonistas de p2x3.
CN101300012B (zh) 2005-09-01 2011-09-14 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物在制备治疗呼吸系统疾病的药物中的应用
EP2038264B1 (en) 2006-06-29 2016-10-26 F.Hoffmann-La Roche Ag Tetrazole-substituted arylamides
EP2136639B1 (en) 2007-04-02 2016-03-09 Evotec AG Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof
PT2139334E (pt) 2007-04-17 2013-10-02 Evotec Ag Compostos heterocíclicos fusionados de 2-cianofenilo, e composições e utilizações dos mesmos
CA2715835C (en) 2008-02-29 2017-03-21 Renovis, Inc. Amide compounds, compositions and uses thereof
JP5608655B2 (ja) 2008-09-18 2014-10-15 エヴォテック アーゲー Ｐ２ｘ３受容体活性のモジュレーター
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
KR101685862B1 (ko) * 2012-12-27 2016-12-20 에프. 호프만-라 로슈 아게 Comt 억제제
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
WO2016053794A1 (en) * 2014-09-30 2016-04-07 Bristol-Myers Squibb Company Quinazoline-based kinase inhibitors
JPWO2016084922A1 (ja) 2014-11-28 2017-09-07 塩野義製薬株式会社 １，２，４−トリアジン誘導体およびその医薬組成物
WO2016088838A1 (ja) 2014-12-04 2016-06-09 塩野義製薬株式会社 プリン誘導体およびその医薬組成物
EP3230281B1 (en) 2014-12-09 2021-05-26 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
WO2017011729A1 (en) 2015-07-16 2017-01-19 Patara Pharma, LLC Combination therapies for the treatment of lung diseases
DK3355889T3 (da) * 2015-09-29 2023-05-15 Afferent Pharmaceuticals Inc Diaminopyrimidin-p2x3- og p2x2/3-receptormodulatorer til anvendelse i behandling af hoste
JP6882289B2 (ja) * 2015-11-25 2021-06-02 コンバージーン・リミテッド・ライアビリティ・カンパニーＣｏｎｖｅｒｇｅｎｅ Ｌｌｃ 二環式ｂｅｔブロモドメイン阻害剤及びその使用
CA3029457A1 (en) * 2016-06-30 2018-01-04 Gilead Sciences, Inc. 4,6-diaminoquinazolines as cot modulators and methods of use thereof
WO2018035061A1 (en) 2016-08-15 2018-02-22 Neupharma, Inc. Certain chemical entities, compositions, and methods
EP3558979B1 (en) * 2016-12-22 2021-02-17 Boehringer Ingelheim International GmbH Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors
GB201700814D0 (en) 2017-01-17 2017-03-01 Liverpool School Tropical Medicine Compounds
WO2018172250A1 (en) * 2017-03-21 2018-09-27 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
US11000491B2 (en) * 2017-05-05 2021-05-11 Hepanova, Inc. Amino-aryl-benzamide compounds and methods of use thereof
CA3139018A1 (en) 2019-05-31 2020-12-03 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
JP7797204B2 (ja) 2019-05-31 2026-01-13 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ｐ２ｘ３阻害剤としてのピリドピリミジン誘導体

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