JP2022533432A5 - - Google Patents

Info

Publication number
JP2022533432A5
JP2022533432A5 JP2021569353A JP2021569353A JP2022533432A5 JP 2022533432 A5 JP2022533432 A5 JP 2022533432A5 JP 2021569353 A JP2021569353 A JP 2021569353A JP 2021569353 A JP2021569353 A JP 2021569353A JP 2022533432 A5 JP2022533432 A5 JP 2022533432A5
Authority
JP
Japan
Prior art keywords
seq
sequence
tdp
amino acid
chain variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021569353A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022533432A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2020/064335 external-priority patent/WO2020234473A1/en
Publication of JP2022533432A publication Critical patent/JP2022533432A/ja
Publication of JP2022533432A5 publication Critical patent/JP2022533432A5/ja
Priority to JP2025050500A priority Critical patent/JP2025094219A/ja
Pending legal-status Critical Current

Links

JP2021569353A 2019-05-23 2020-05-22 抗tdp-43結合分子およびその使用 Pending JP2022533432A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025050500A JP2025094219A (ja) 2019-05-23 2025-03-25 抗tdp-43結合分子およびその使用

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP19176314 2019-05-23
EP19176314.3 2019-05-23
EP19195916 2019-09-06
EP19195916.2 2019-09-06
EP19207839.2 2019-11-07
EP19207839 2019-11-07
EP20161060 2020-03-04
EP20161060.7 2020-03-04
PCT/EP2020/064335 WO2020234473A1 (en) 2019-05-23 2020-05-22 Anti-tdp-43 binding molecules and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025050500A Division JP2025094219A (ja) 2019-05-23 2025-03-25 抗tdp-43結合分子およびその使用

Publications (2)

Publication Number Publication Date
JP2022533432A JP2022533432A (ja) 2022-07-22
JP2022533432A5 true JP2022533432A5 (https=) 2023-05-24

Family

ID=70779783

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021569353A Pending JP2022533432A (ja) 2019-05-23 2020-05-22 抗tdp-43結合分子およびその使用
JP2025050500A Pending JP2025094219A (ja) 2019-05-23 2025-03-25 抗tdp-43結合分子およびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025050500A Pending JP2025094219A (ja) 2019-05-23 2025-03-25 抗tdp-43結合分子およびその使用

Country Status (15)

Country Link
US (1) US12600766B2 (https=)
EP (1) EP3972692A1 (https=)
JP (2) JP2022533432A (https=)
KR (1) KR20220012270A (https=)
CN (2) CN120943956A (https=)
AU (1) AU2020278907A1 (https=)
BR (1) BR112021023487A2 (https=)
CA (1) CA3137882A1 (https=)
CL (2) CL2021003027A1 (https=)
IL (1) IL288314A (https=)
MX (1) MX2021014274A (https=)
PH (1) PH12021552938A1 (https=)
SG (1) SG11202112453TA (https=)
TW (1) TW202110879A (https=)
WO (1) WO2020234473A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112920264B (zh) * 2021-02-08 2022-07-05 武汉大学 Tdp-43蛋白的o-糖基化突变体及其应用
WO2022174036A2 (en) * 2021-02-11 2022-08-18 Mayo Foundation For Medical Education And Research Methods and materials for treating tdp-43 proteinopathies
US20230107901A1 (en) * 2021-10-01 2023-04-06 University Of Utah Research Foundation Pathologic tdp-43 as a biomarker for the diagnosis of tdp-43 proteinopathy
CA3243689A1 (en) 2022-02-16 2023-08-24 Ac Immune Sa Humanized Anti-TDP-43 Bonding Molecules and Their Uses
US20260043816A1 (en) 2022-04-08 2026-02-12 Ac Immune Sa Anti-TDP-43 Binding Molecules
EP4389215A1 (en) * 2022-12-20 2024-06-26 Consejo Superior De Investigaciones Científicas Chemically modified tdp-43 derived polypeptides and uses thereof
EP4676596A1 (en) 2023-03-08 2026-01-14 AC Immune SA Anti-tdp-43 binding molecules and uses thereof
KR102859015B1 (ko) * 2023-07-20 2025-09-12 충북대학교 산학협력단 c­Abl에 의한 TDP­43의 특이적 인산화 분석을 통한 신경퇴행성 질환을 진단하는 방법 및 이를 이용한 신경퇴행성 질환의 치료제 스크리닝 방법
CN117126269B (zh) * 2023-10-25 2024-02-13 首都儿科研究所 一种1型人博卡病毒型别特异性抗体及其应用
WO2025134068A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Antibody drug conjugates targeting proteinopathies, and uses thereof
WO2025186332A1 (en) 2024-03-05 2025-09-12 Ac Immune Sa Vectorized anti-tdp-43 antibodies
WO2026013218A1 (en) * 2024-07-10 2026-01-15 Ac Immune Sa Anti-tdp-43 vectors, binding molecules and uses thereof

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
US7018809B1 (en) 1991-09-19 2006-03-28 Genentech, Inc. Expression of functional antibody fragments
US5688511A (en) 1991-11-05 1997-11-18 Board Of Regents, The University Of Texas System Cellular protein TDP-43 and regulation of HIV-1 gene expression
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
FR2707189B1 (fr) 1993-07-09 1995-10-13 Gradient Ass Procédé de traitement de résidus de combustion et installation de mise en Óoeuvre dudit procédé.
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
ES2244066T3 (es) 1997-06-24 2005-12-01 Genentech, Inc. Procedimiento y composiciones de glicoproteinas galactosiladas.
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
AU759779B2 (en) 1997-10-31 2003-05-01 Genentech Inc. Methods and compositions comprising glycoprotein glycoforms
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
ATE375365T1 (de) 1998-04-02 2007-10-15 Genentech Inc Antikörper varianten und fragmente davon
DK1071700T3 (da) 1998-04-20 2010-06-07 Glycart Biotechnology Ag Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
PL209392B1 (pl) 1999-01-15 2011-08-31 Genentech Inc Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
CA2704600C (en) 1999-04-09 2016-10-25 Kyowa Kirin Co., Ltd. A method for producing antibodies with increased adcc activity
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
ES2248127T3 (es) 1999-10-04 2006-03-16 Medicago Inc. Metodo para regular la transcripcion de genes foraneos en presencia de nigtrogeno.
EP1229125A4 (en) 1999-10-19 2005-06-01 Kyowa Hakko Kogyo Kk PROCESS FOR PREPARING A POLYPEPTIDE
EA013564B1 (ru) 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
EP1332209B1 (en) 2000-09-08 2009-11-11 Universität Zürich Collections of repeat proteins comprising repeat modules
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
CA2953239A1 (en) 2000-10-06 2002-04-18 Kyowa Hakko Kirin Co., Ltd. Antibody composition-producing cell
US7064191B2 (en) 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
EP2141243A3 (en) 2000-10-16 2010-01-27 Brystol-Myers Squibb Company Protein scaffolds for antibody mimics and other binding proteins
US20030157561A1 (en) 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
NZ571596A (en) 2001-08-03 2010-11-26 Glycart Biotechnology Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
CA2463879C (en) 2001-10-25 2012-12-04 Genentech, Inc. Glycoprotein compositions
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
AU2003210060B2 (en) 2002-03-22 2010-02-25 Aprogen, Inc. Humanized antibody and process for preparing same
BR0309145A (pt) 2002-04-09 2005-02-01 Kyowa Hakko Kogyo Kk Células das quais o genoma é modificado
CA2481658A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Method of enhancing of binding activity of antibody composition to fcy receptor iiia
EP1500400A4 (en) 2002-04-09 2006-10-11 Kyowa Hakko Kogyo Kk MEDICAMENT WITH ANTIBODY COMPOSITION
EP1498490A4 (en) 2002-04-09 2006-11-29 Kyowa Hakko Kogyo Kk PROCESS FOR PREPARING ANTIBODY COMPOSITION
ATE503829T1 (de) 2002-04-09 2011-04-15 Kyowa Hakko Kirin Co Ltd Zelle mit erniedrigter oder deletierter aktivität eines am gdp-fucosetransport beteiligten proteins
CA2481925A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Therapeutic agent for patients having human fc.gamma.riiia
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
TWI335821B (en) 2002-12-16 2011-01-11 Genentech Inc Immunoglobulin variants and uses thereof
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
JPWO2005035586A1 (ja) 2003-10-08 2007-11-22 協和醗酵工業株式会社 融合蛋白質組成物
JPWO2005035778A1 (ja) 2003-10-09 2006-12-21 協和醗酵工業株式会社 α1,6−フコシルトランスフェラーゼの機能を抑制するRNAを用いた抗体組成物の製造法
US20050164301A1 (en) 2003-10-24 2005-07-28 Avidia Research Institute LDL receptor class A and EGF domain monomers and multimers
US9296820B2 (en) 2003-11-05 2016-03-29 Roche Glycart Ag Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function
WO2005053742A1 (ja) 2003-12-04 2005-06-16 Kyowa Hakko Kogyo Co., Ltd. 抗体組成物を含有する医薬
PT1737891E (pt) 2004-04-13 2013-04-16 Hoffmann La Roche Anticorpos anti p-selectina
TWI380996B (zh) 2004-09-17 2013-01-01 Hoffmann La Roche 抗ox40l抗體
DK1791565T3 (en) 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
WO2008151055A1 (en) 2007-06-01 2008-12-11 Mayo Foundation For Medical Education And Research Diagnosing neurodegenerative diseases
WO2012020124A1 (en) 2010-08-12 2012-02-16 Ac Immune S.A. Vaccine engineering
JP6027011B2 (ja) 2010-10-26 2016-11-16 エーシー イミューン ソシエテ アノニム 疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物
US9587014B2 (en) 2011-10-28 2017-03-07 Biogen International Neuroscience Gmbh TDP-43 specific binding molecules
JP6325463B2 (ja) 2012-03-16 2018-05-16 コヴァジェン アクチェン ゲゼルシャフト 抗腫瘍活性を有する新規結合分子
WO2017027691A1 (en) 2015-08-13 2017-02-16 New York University Antibody-based molecules selective for the {p}ser404 epitope of tau and their uses in the diagnosis and treatment of tauopathy
WO2018218352A1 (en) * 2017-05-30 2018-12-06 The University Of British Columbia Epitopes in the rna recognition motif 1 (rrm1) of tdp-43 and misfolding-selective antibodies thereto

Similar Documents

Publication Publication Date Title
JP2022533432A5 (https=)
JP7626416B2 (ja) 神経変性疾患または神経炎症性疾患におけるグリア細胞活性化の早期検出方法
CN114008073B (zh) 抗tdp-43结合分子及其用途
US9512224B2 (en) Use of semaphorin-4D binding molecules for treatment of atherosclerosis
AU2018271353A1 (en) Antibodies recognizing alpha-synuclein
JP7499228B2 (ja) 神経成長因子に対するモノクローナル抗体、並びにそれをコードする遺伝子及びその使用
KR102105436B1 (ko) 뇌졸중 후 신경발생을 촉진시키는 세마포린-4d 결합 분자의 용도
JP2023537761A5 (https=)
EP3854875B1 (en) Human monoclonal antibody binding specifically to human hmgb1, and pharmaceutical composition for treating or preventing alzheimer's disease containing said human monoclonal antibody
JP2025507569A5 (https=)
WO2018204895A1 (en) Human anti-semaphorin 4d antibody
JP2022033757A (ja) タウオパチーを治療するための組成物及び方法
JP2023018038A (ja) シヌクレイン病の治療のための投与レジメン
JP2025513799A5 (https=)
CN112533635A (zh) 末梢神经病变或者伴随确认到末梢神经病变或星形胶质细胞病变的疾病的疼痛的预防或治疗方法
JP2022547993A5 (https=)
JP2024544997A5 (https=)
JP7610767B2 (ja) レット症候群の処置のためのセマフォリン4d結合分子の使用
TW201840583A (zh) 對β-類澱粉肽的初原纖維形式具有特異性的抗體之神經細胞保護作用
JP2023552919A5 (https=)
EP4537842A1 (en) Preventative agent or therapeutic agent for amyotrophic lateral sclerosis, parkinson's disease, huntington's disease, spinocerebellar ataxia, aging-related degenerative or neurological disease, brain aging, or diseases associated with brain aging
JP2024535403A (ja) 神経変性障害を処置するための抗セマフォリン4d結合分子の使用に関する予測アウトカムプロファイリング
RU2575629C2 (ru) Гуманизированные антитела, которые распознают альфа-синуклеин
González-Artero et al. Passive immunotherapy for Parkinson’s disease in 2025: Status and perspective
AU2024342582A1 (en) Anti-tdp-43 antibodies and uses thereof