JP2022529651A5 - - Google Patents
Info
- Publication number
- JP2022529651A5 JP2022529651A5 JP2021561766A JP2021561766A JP2022529651A5 JP 2022529651 A5 JP2022529651 A5 JP 2022529651A5 JP 2021561766 A JP2021561766 A JP 2021561766A JP 2021561766 A JP2021561766 A JP 2021561766A JP 2022529651 A5 JP2022529651 A5 JP 2022529651A5
- Authority
- JP
- Japan
- Prior art keywords
- synthetic peptide
- shuttle
- shuttle agent
- cargo
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3040645A CA3040645A1 (en) | 2019-04-18 | 2019-04-18 | Peptide-based non-proteinaceous cargo delivery |
| CA3,040,645 | 2019-04-18 | ||
| PCT/CA2020/050517 WO2020210916A1 (en) | 2019-04-18 | 2020-04-17 | Peptide-based non-proteinaceous cargo delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022529651A JP2022529651A (ja) | 2022-06-23 |
| JP2022529651A5 true JP2022529651A5 (https=) | 2023-07-04 |
Family
ID=72836884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021561766A Pending JP2022529651A (ja) | 2019-04-18 | 2020-04-17 | ペプチドに基づく非タンパク質カーゴ送達 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12428447B2 (https=) |
| EP (1) | EP3956348A4 (https=) |
| JP (1) | JP2022529651A (https=) |
| KR (1) | KR20220031545A (https=) |
| CN (2) | CN114008210B (https=) |
| AU (1) | AU2020260283A1 (https=) |
| CA (2) | CA3040645A1 (https=) |
| IL (1) | IL287271A (https=) |
| SG (1) | SG11202111461XA (https=) |
| WO (1) | WO2020210916A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2981716C (en) | 2015-04-10 | 2022-04-12 | Feldan Bio Inc. | Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same |
| CN110291100B (zh) | 2016-10-12 | 2024-06-11 | 费尔丹生物公司 | 用于将多肽负荷从细胞外空间递送至靶真核细胞的胞质溶胶和/或细胞核的合理设计的合成肽穿梭剂，其用途、与其相关的方法和试剂盒 |
| CA3040645A1 (en) | 2019-04-18 | 2020-10-18 | Feldan Bio Inc. | Peptide-based non-proteinaceous cargo delivery |
| AU2021366976A1 (en) * | 2020-10-22 | 2023-06-08 | Feldan Bio Inc. | Shuttle agent peptides of minimal length and variants thereof adapted for transduction of cas9-rnp and other nucleoprotein cargos |
| US20230416334A1 (en) * | 2020-11-10 | 2023-12-28 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Cell-penetrating peptides |
| CN116997656A (zh) * | 2021-02-15 | 2023-11-03 | 生物马林药物股份有限公司 | 富含组氨酸的肽作为用于rAAV和rBV生产的转染试剂的用途 |
| MX2023009816A (es) * | 2021-02-24 | 2024-03-25 | Univ Jagiellonski | Una jaula de proteínas artificial que comprende una carga de huésped encapsulada en la misma. |
| JP2024511537A (ja) * | 2021-03-29 | 2024-03-13 | フェルダン・バイオ・インコーポレーテッド | 細胞内カーゴ送達のための合成ペプチドシャトル媒介物バイオコンジュゲート |
| WO2023092733A1 (zh) * | 2021-11-25 | 2023-06-01 | 苏州慧疗生物医药科技有限公司 | 一种用于有效递送核酸的环状多肽载体及其变化形式 |
| GB202209228D0 (en) | 2022-06-23 | 2022-08-10 | Univ Strathclyde | Modified amino acids and uses thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030104622A1 (en) | 1999-09-01 | 2003-06-05 | Robbins Paul D. | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses |
| FR2849603B1 (fr) | 2003-01-07 | 2006-09-08 | Centre Nat Rech Scient | Composition pour le transport intracellulaire de macromolecules ou particules biologiques |
| US7084248B2 (en) | 2004-07-14 | 2006-08-01 | Gene Tools, Llc | Peptide composition and method for delivering substances into the cytosol of cells |
| US7579318B2 (en) | 2005-12-06 | 2009-08-25 | Centre De La Recherche De La Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| EP1969000A2 (en) | 2005-12-06 | 2008-09-17 | Centre National de la Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| KR101095841B1 (ko) * | 2009-02-19 | 2011-12-21 | 주식회사 나이벡 | 표적 선택적 세포／조직 투과기능 활성을 가지는 펩타이드 및 그 용도 |
| US8895526B2 (en) | 2009-03-27 | 2014-11-25 | Cold Spring Harbor Laboratory | Identification of RNAI targets and use of RNAI for rational therapy of chemotherapy-resistant leukemia and other cancers |
| EP2470201A4 (en) * | 2009-08-28 | 2013-01-30 | Bayer Healthcare Llc | COFACTORS ENABLING THE THROMBINIC ACTIVATION OF FACTOR VII AND THEIR USES |
| US20110165143A1 (en) | 2010-01-06 | 2011-07-07 | The Regents Of The University Of Colorado, A Body Corporate | Modulation of caspases and therapeutical applications |
| US8993532B2 (en) | 2010-04-23 | 2015-03-31 | Cold Spring Harbor Laboratory | Structurally designed shRNAs |
| WO2013055397A1 (en) | 2011-10-14 | 2013-04-18 | Children's Medical Center Corporation | Inhibition and enhancement of reprogramming by chromatin modifying enzymes |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| ES2794599T3 (es) | 2013-09-10 | 2020-11-18 | Texas A & M Univ Sys | Composiciones y métodos para la distribución de moléculas en células vivas |
| JP7103750B2 (ja) | 2013-12-12 | 2022-07-20 | ザ・ブロード・インスティテュート・インコーポレイテッド | ゲノム編集のためのＣＲＩＳＰＲ－Ｃａｓ系及び組成物の送達、使用及び治療適用 |
| WO2016052442A1 (ja) | 2014-09-29 | 2016-04-07 | 国立大学法人京都大学 | 細胞質送達ペプチド |
| CA2981716C (en) | 2015-04-10 | 2022-04-12 | Feldan Bio Inc. | Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same |
| WO2017049407A1 (en) | 2015-09-23 | 2017-03-30 | UNIVERSITé LAVAL | Modification of the dystrophin gene and uses thereof |
| EP3184638A1 (en) | 2015-12-24 | 2017-06-28 | ETH Zurich | Programmable differentiation control network |
| WO2017175072A1 (en) * | 2016-04-08 | 2017-10-12 | Feldan Bio Inc. | Peptide shuttle based gene disruption |
| CA3037635A1 (en) | 2016-09-23 | 2018-03-29 | Universite Laval | Methods of modifying the dystrophin gene and restoring dystrophin expression and uses thereof |
| US11629170B2 (en) | 2016-10-12 | 2023-04-18 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| CN110291100B (zh) * | 2016-10-12 | 2024-06-11 | 费尔丹生物公司 | 用于将多肽负荷从细胞外空间递送至靶真核细胞的胞质溶胶和/或细胞核的合理设计的合成肽穿梭剂，其用途、与其相关的方法和试剂盒 |
| US9982267B2 (en) * | 2016-10-12 | 2018-05-29 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| EP3597223A1 (en) | 2018-07-17 | 2020-01-22 | Centre National De La Recherche Scientifique | Peptides for use as cell-penetrating peptides |
| KR20210121092A (ko) | 2019-01-29 | 2021-10-07 | 유니버시티 오브 워싱턴 | 유전자 편집 방법 |
| CA3040645A1 (en) | 2019-04-18 | 2020-10-18 | Feldan Bio Inc. | Peptide-based non-proteinaceous cargo delivery |
| JP2023545546A (ja) | 2020-10-18 | 2023-10-30 | フェルダン・バイオ・インコーポレーテッド | 遺伝子発現調節のための非アニオン性ポリヌクレオチド類似体のペプチドに基づく導入 |
| AU2021366976A1 (en) | 2020-10-22 | 2023-06-08 | Feldan Bio Inc. | Shuttle agent peptides of minimal length and variants thereof adapted for transduction of cas9-rnp and other nucleoprotein cargos |
| US20220259673A1 (en) | 2021-02-09 | 2022-08-18 | Memorial Sloan-Kettering Cancer Center | Methods for identifying and treating high-plasticity cell state driving tumor progression in lung cancer |
| JP2024511537A (ja) | 2021-03-29 | 2024-03-13 | フェルダン・バイオ・インコーポレーテッド | 細胞内カーゴ送達のための合成ペプチドシャトル媒介物バイオコンジュゲート |
| US20260033466A1 (en) | 2022-08-30 | 2026-02-05 | Feldan Bio Inc. | Method and animal model for inducing bcc tumors |
-
2019
- 2019-04-18 CA CA3040645A patent/CA3040645A1/en active Pending
-
2020
- 2020-04-17 AU AU2020260283A patent/AU2020260283A1/en active Pending
- 2020-04-17 CN CN202080044034.4A patent/CN114008210B/zh active Active
- 2020-04-17 KR KR1020217037483A patent/KR20220031545A/ko active Pending
- 2020-04-17 CA CA3133525A patent/CA3133525A1/en active Pending
- 2020-04-17 WO PCT/CA2020/050517 patent/WO2020210916A1/en not_active Ceased
- 2020-04-17 EP EP20791483.9A patent/EP3956348A4/en active Pending
- 2020-04-17 JP JP2021561766A patent/JP2022529651A/ja active Pending
- 2020-04-17 CN CN202511579767.9A patent/CN121652233A/zh active Pending
- 2020-04-17 US US17/604,328 patent/US12428447B2/en active Active
- 2020-04-17 SG SG11202111461XA patent/SG11202111461XA/en unknown
-
2021
- 2021-10-14 IL IL287271A patent/IL287271A/en unknown
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