CN114008210B - 基于肽的非蛋白质负荷递送 - Google Patents

基于肽的非蛋白质负荷递送

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Publication number
CN114008210B
CN114008210B CN202080044034.4A CN202080044034A CN114008210B CN 114008210 B CN114008210 B CN 114008210B CN 202080044034 A CN202080044034 A CN 202080044034A CN 114008210 B CN114008210 B CN 114008210B
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China
Prior art keywords
ext
protein
synthetic peptide
peptide
agent
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Application number
CN202080044034.4A
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English (en)
Chinese (zh)
Other versions
CN114008210A (zh
Inventor
D·盖伊
T·德尔吉迪斯
J-P·巴比欧莱皮蒂-斯托菲丝
X·巴比欧
N·梅西耶
S·哈利
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Feldan Bio Inc
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Feldan Bio Inc
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Priority to CN202511579767.9A priority Critical patent/CN121652233A/zh
Publication of CN114008210A publication Critical patent/CN114008210A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
CN202080044034.4A 2019-04-18 2020-04-17 基于肽的非蛋白质负荷递送 Active CN114008210B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511579767.9A CN121652233A (zh) 2019-04-18 2020-04-17 基于肽的非蛋白质负荷递送

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA3040645A CA3040645A1 (en) 2019-04-18 2019-04-18 Peptide-based non-proteinaceous cargo delivery
CA3,040,645 2019-04-18
PCT/CA2020/050517 WO2020210916A1 (en) 2019-04-18 2020-04-17 Peptide-based non-proteinaceous cargo delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202511579767.9A Division CN121652233A (zh) 2019-04-18 2020-04-17 基于肽的非蛋白质负荷递送

Publications (2)

Publication Number Publication Date
CN114008210A CN114008210A (zh) 2022-02-01
CN114008210B true CN114008210B (zh) 2025-11-18

Family

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CN202080044034.4A Active CN114008210B (zh) 2019-04-18 2020-04-17 基于肽的非蛋白质负荷递送
CN202511579767.9A Pending CN121652233A (zh) 2019-04-18 2020-04-17 基于肽的非蛋白质负荷递送

Family Applications After (1)

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Country Status (10)

Country Link
US (1) US12428447B2 (https=)
EP (1) EP3956348A4 (https=)
JP (1) JP2022529651A (https=)
KR (1) KR20220031545A (https=)
CN (2) CN114008210B (https=)
AU (1) AU2020260283A1 (https=)
CA (2) CA3040645A1 (https=)
IL (1) IL287271A (https=)
SG (1) SG11202111461XA (https=)
WO (1) WO2020210916A1 (https=)

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CA2981716C (en) 2015-04-10 2022-04-12 Feldan Bio Inc. Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same
CN110291100B (zh) 2016-10-12 2024-06-11 费尔丹生物公司 用于将多肽负荷从细胞外空间递送至靶真核细胞的胞质溶胶和/或细胞核的合理设计的合成肽穿梭剂，其用途、与其相关的方法和试剂盒
CA3040645A1 (en) 2019-04-18 2020-10-18 Feldan Bio Inc. Peptide-based non-proteinaceous cargo delivery
AU2021366976A1 (en) * 2020-10-22 2023-06-08 Feldan Bio Inc. Shuttle agent peptides of minimal length and variants thereof adapted for transduction of cas9-rnp and other nucleoprotein cargos
US20230416334A1 (en) * 2020-11-10 2023-12-28 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Cell-penetrating peptides
CN116997656A (zh) * 2021-02-15 2023-11-03 生物马林药物股份有限公司 富含组氨酸的肽作为用于rAAV和rBV生产的转染试剂的用途
MX2023009816A (es) * 2021-02-24 2024-03-25 Univ Jagiellonski Una jaula de proteínas artificial que comprende una carga de huésped encapsulada en la misma.
JP2024511537A (ja) * 2021-03-29 2024-03-13 フェルダン・バイオ・インコーポレーテッド 細胞内カーゴ送達のための合成ペプチドシャトル媒介物バイオコンジュゲート
WO2023092733A1 (zh) * 2021-11-25 2023-06-01 苏州慧疗生物医药科技有限公司 一种用于有效递送核酸的环状多肽载体及其变化形式
GB202209228D0 (en) 2022-06-23 2022-08-10 Univ Strathclyde Modified amino acids and uses thereof

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Also Published As

Publication number Publication date
EP3956348A4 (en) 2023-07-19
CN114008210A (zh) 2022-02-01
CN121652233A (zh) 2026-03-13
SG11202111461XA (en) 2021-11-29
US20220204561A1 (en) 2022-06-30
CA3133525A1 (en) 2020-10-22
IL287271A (en) 2021-12-01
EP3956348A1 (en) 2022-02-23
CA3040645A1 (en) 2020-10-18
WO2020210916A1 (en) 2020-10-22
KR20220031545A (ko) 2022-03-11
JP2022529651A (ja) 2022-06-23
AU2020260283A1 (en) 2021-11-11
US12428447B2 (en) 2025-09-30

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