JP2022526973A - ホスホイノシチド３－キナーゼ阻害剤としてのイソクロメン誘導体 - Google Patents

ホスホイノシチド３－キナーゼ阻害剤としてのイソクロメン誘導体 Download PDF

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Publication number
JP2022526973A
JP2022526973A JP2021558911A JP2021558911A JP2022526973A JP 2022526973 A JP2022526973 A JP 2022526973A JP 2021558911 A JP2021558911 A JP 2021558911A JP 2021558911 A JP2021558911 A JP 2021558911A JP 2022526973 A JP2022526973 A JP 2022526973A
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JP
Japan
Prior art keywords
isochromen
phenyl
ethyl
amino
methyl
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Pending
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JP2021558911A
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English (en)
Japanese (ja)
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JP2022526973A5 (enExample
Inventor
ビアジェッティ，マッテオ
ロンキ，パウロ
フィオレッリ，クラウディオ
ブルーノ，パオロ
Original Assignee
キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ
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Publication of JP2022526973A publication Critical patent/JP2022526973A/ja
Publication of JP2022526973A5 publication Critical patent/JP2022526973A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
JP2021558911A 2019-04-04 2020-03-24 ホスホイノシチド３－キナーゼ阻害剤としてのイソクロメン誘導体 Pending JP2022526973A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19167245.0 2019-04-04
EP19167245 2019-04-04
PCT/EP2020/058168 WO2020200918A1 (en) 2019-04-04 2020-03-24 Isochromene derivatives as phosphoinositide 3-kinases inhibitors

Publications (2)

Publication Number Publication Date
JP2022526973A true JP2022526973A (ja) 2022-05-27
JP2022526973A5 JP2022526973A5 (enExample) 2023-03-30

Family

ID=66092138

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021558911A Pending JP2022526973A (ja) 2019-04-04 2020-03-24 ホスホイノシチド３－キナーゼ阻害剤としてのイソクロメン誘導体

Country Status (26)

Country Link
US (1) US12527797B2 (enExample)
EP (1) EP3947384B1 (enExample)
JP (1) JP2022526973A (enExample)
KR (1) KR20210149077A (enExample)
CN (1) CN113874376A (enExample)
AR (1) AR118588A1 (enExample)
AU (1) AU2020252904A1 (enExample)
BR (1) BR112021019589A2 (enExample)
CA (1) CA3135309A1 (enExample)
DK (1) DK3947384T3 (enExample)
ES (1) ES2970530T3 (enExample)
FI (1) FI3947384T3 (enExample)
HR (1) HRP20240130T1 (enExample)
HU (1) HUE065052T2 (enExample)
IL (1) IL286937A (enExample)
MA (1) MA55479A (enExample)
MX (1) MX2021011979A (enExample)
MY (1) MY206575A (enExample)
PH (1) PH12021552402A1 (enExample)
PL (1) PL3947384T3 (enExample)
PT (1) PT3947384T (enExample)
SG (1) SG11202110801XA (enExample)
SI (1) SI3947384T1 (enExample)
TW (1) TW202102504A (enExample)
WO (1) WO2020200918A1 (enExample)
ZA (1) ZA202107710B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024180207A1 (en) 2023-03-02 2024-09-06 Chiesi Farmaceutici S.P.A. Pyridazinyl amino derivatives as alk5 inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016166239A1 (en) * 2015-04-16 2016-10-20 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
JP2017501146A (ja) * 2013-12-18 2017-01-12 チエシ ファルマスティスィ エス．ピー．エー． ホスホイノシチド３−キナーゼ阻害剤としてのイソクロメン誘導体
JP2017518326A (ja) * 2014-06-17 2017-07-06 キエージ・フアルマチエウテイチ・エツセ・ピ・ア ホスホイノシチド３−キナーゼ阻害剤としてのインドリジン誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
PT1158958E (pt) 1999-03-05 2007-08-13 Chiesi Farma Spa ''composições farmacêuticas em pó, melhoradas, para inalação''
LT2496567T (lt) 2009-11-05 2017-11-27 Rhizen Pharmaceuticals S.A. Nauji benzopirano kinazės moduliatoriai
US9745308B2 (en) 2014-09-12 2017-08-29 Chiesi Farmaceutici S.P.A. Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors
WO2017134053A1 (en) 2016-02-04 2017-08-10 Chiesi Farmaceutici S.P.A. Pyrazole derivatives as phosphoinositide 3-kinases inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017501146A (ja) * 2013-12-18 2017-01-12 チエシ ファルマスティスィ エス．ピー．エー． ホスホイノシチド３−キナーゼ阻害剤としてのイソクロメン誘導体
JP2017518326A (ja) * 2014-06-17 2017-07-06 キエージ・フアルマチエウテイチ・エツセ・ピ・ア ホスホイノシチド３−キナーゼ阻害剤としてのインドリジン誘導体
WO2016166239A1 (en) * 2015-04-16 2016-10-20 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors

Also Published As

Publication number Publication date
ES2970530T3 (es) 2024-05-29
CA3135309A1 (en) 2020-10-08
MX2021011979A (es) 2021-11-03
HRP20240130T1 (hr) 2024-04-12
AU2020252904A1 (en) 2021-11-18
SG11202110801XA (en) 2021-10-28
AR118588A1 (es) 2021-10-20
ZA202107710B (en) 2025-03-26
HUE065052T2 (hu) 2024-04-28
PH12021552402A1 (en) 2022-06-20
DK3947384T3 (da) 2024-01-08
EP3947384A1 (en) 2022-02-09
MY206575A (en) 2024-12-24
CN113874376A (zh) 2021-12-31
EP3947384B1 (en) 2023-11-01
WO2020200918A1 (en) 2020-10-08
FI3947384T3 (fi) 2024-01-30
US20220175784A1 (en) 2022-06-09
US12527797B2 (en) 2026-01-20
BR112021019589A2 (pt) 2021-12-07
MA55479A (fr) 2022-02-09
PT3947384T (pt) 2024-01-29
IL286937A (en) 2021-10-31
SI3947384T1 (sl) 2024-03-29
KR20210149077A (ko) 2021-12-08
PL3947384T3 (pl) 2024-03-25
TW202102504A (zh) 2021-01-16

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