CN113874376A - 作为磷酸肌醇3-激酶抑制剂的异色烯衍生物 - Google Patents
作为磷酸肌醇3-激酶抑制剂的异色烯衍生物 Download PDFInfo
- Publication number
- CN113874376A CN113874376A CN202080034539.2A CN202080034539A CN113874376A CN 113874376 A CN113874376 A CN 113874376A CN 202080034539 A CN202080034539 A CN 202080034539A CN 113874376 A CN113874376 A CN 113874376A
- Authority
- CN
- China
- Prior art keywords
- isochromen
- phenyl
- ethyl
- methyl
- pyrazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19167245.0 | 2019-04-04 | ||
| EP19167245 | 2019-04-04 | ||
| PCT/EP2020/058168 WO2020200918A1 (en) | 2019-04-04 | 2020-03-24 | Isochromene derivatives as phosphoinositide 3-kinases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113874376A true CN113874376A (zh) | 2021-12-31 |
Family
ID=66092138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080034539.2A Pending CN113874376A (zh) | 2019-04-04 | 2020-03-24 | 作为磷酸肌醇3-激酶抑制剂的异色烯衍生物 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US12527797B2 (enExample) |
| EP (1) | EP3947384B1 (enExample) |
| JP (1) | JP2022526973A (enExample) |
| KR (1) | KR20210149077A (enExample) |
| CN (1) | CN113874376A (enExample) |
| AR (1) | AR118588A1 (enExample) |
| AU (1) | AU2020252904A1 (enExample) |
| BR (1) | BR112021019589A2 (enExample) |
| CA (1) | CA3135309A1 (enExample) |
| DK (1) | DK3947384T3 (enExample) |
| ES (1) | ES2970530T3 (enExample) |
| FI (1) | FI3947384T3 (enExample) |
| HR (1) | HRP20240130T1 (enExample) |
| HU (1) | HUE065052T2 (enExample) |
| IL (1) | IL286937A (enExample) |
| MA (1) | MA55479A (enExample) |
| MX (1) | MX2021011979A (enExample) |
| MY (1) | MY206575A (enExample) |
| PH (1) | PH12021552402A1 (enExample) |
| PL (1) | PL3947384T3 (enExample) |
| PT (1) | PT3947384T (enExample) |
| SG (1) | SG11202110801XA (enExample) |
| SI (1) | SI3947384T1 (enExample) |
| TW (1) | TW202102504A (enExample) |
| WO (1) | WO2020200918A1 (enExample) |
| ZA (1) | ZA202107710B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024180207A1 (en) | 2023-03-02 | 2024-09-06 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150166549A1 (en) * | 2013-12-18 | 2015-06-18 | Chiesi Farmaceutici S.P.A. | Isochromene derivatives as phoshoinositide 3-kinases inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| PT1158958E (pt) | 1999-03-05 | 2007-08-13 | Chiesi Farma Spa | ''composições farmacêuticas em pó, melhoradas, para inalação'' |
| LT2496567T (lt) | 2009-11-05 | 2017-11-27 | Rhizen Pharmaceuticals S.A. | Nauji benzopirano kinazės moduliatoriai |
| ES2750791T3 (es) | 2014-06-17 | 2020-03-27 | Chiesi Farm Spa | Derivados de indolizina como inhibidores de fosfoinositido 3-quinasas |
| US9745308B2 (en) | 2014-09-12 | 2017-08-29 | Chiesi Farmaceutici S.P.A. | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors |
| US9968604B2 (en) | 2015-04-16 | 2018-05-15 | Chiesi Farmaceutici S.P.A. | Chromene derivatives as phoshoinositide 3-kinases inhibitors |
| WO2017134053A1 (en) | 2016-02-04 | 2017-08-10 | Chiesi Farmaceutici S.P.A. | Pyrazole derivatives as phosphoinositide 3-kinases inhibitors |
-
2020
- 2020-03-24 EP EP20711985.0A patent/EP3947384B1/en active Active
- 2020-03-24 MA MA055479A patent/MA55479A/fr unknown
- 2020-03-24 US US17/600,676 patent/US12527797B2/en active Active
- 2020-03-24 FI FIEP20711985.0T patent/FI3947384T3/fi active
- 2020-03-24 MX MX2021011979A patent/MX2021011979A/es unknown
- 2020-03-24 DK DK20711985.0T patent/DK3947384T3/da active
- 2020-03-24 HR HRP20240130TT patent/HRP20240130T1/hr unknown
- 2020-03-24 MY MYPI2021005864A patent/MY206575A/en unknown
- 2020-03-24 HU HUE20711985A patent/HUE065052T2/hu unknown
- 2020-03-24 CA CA3135309A patent/CA3135309A1/en active Pending
- 2020-03-24 WO PCT/EP2020/058168 patent/WO2020200918A1/en not_active Ceased
- 2020-03-24 PT PT207119850T patent/PT3947384T/pt unknown
- 2020-03-24 JP JP2021558911A patent/JP2022526973A/ja active Pending
- 2020-03-24 ES ES20711985T patent/ES2970530T3/es active Active
- 2020-03-24 PH PH1/2021/552402A patent/PH12021552402A1/en unknown
- 2020-03-24 SI SI202030355T patent/SI3947384T1/sl unknown
- 2020-03-24 PL PL20711985.0T patent/PL3947384T3/pl unknown
- 2020-03-24 SG SG11202110801XA patent/SG11202110801XA/en unknown
- 2020-03-24 KR KR1020217033595A patent/KR20210149077A/ko not_active Withdrawn
- 2020-03-24 BR BR112021019589A patent/BR112021019589A2/pt not_active Application Discontinuation
- 2020-03-24 AU AU2020252904A patent/AU2020252904A1/en not_active Abandoned
- 2020-03-24 CN CN202080034539.2A patent/CN113874376A/zh active Pending
- 2020-03-27 TW TW109110464A patent/TW202102504A/zh unknown
- 2020-04-03 AR ARP200100946A patent/AR118588A1/es not_active Application Discontinuation
-
2021
- 2021-10-03 IL IL286937A patent/IL286937A/en unknown
- 2021-10-12 ZA ZA2021/07710A patent/ZA202107710B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150166549A1 (en) * | 2013-12-18 | 2015-06-18 | Chiesi Farmaceutici S.P.A. | Isochromene derivatives as phoshoinositide 3-kinases inhibitors |
| CN105829308A (zh) * | 2013-12-18 | 2016-08-03 | 奇斯药制品公司 | 作为磷酸肌醇酯3-激酶抑制剂的异色烯衍生物 |
Non-Patent Citations (1)
| Title |
|---|
| TIMOTHY D. CUSHING ET AL.: "PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases", 《J. MED. CHEM.》, vol. 55, 27 August 2012 (2012-08-27), pages 8559 - 8581, XP055110817, DOI: 10.1021/jm300847w * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2970530T3 (es) | 2024-05-29 |
| CA3135309A1 (en) | 2020-10-08 |
| MX2021011979A (es) | 2021-11-03 |
| HRP20240130T1 (hr) | 2024-04-12 |
| AU2020252904A1 (en) | 2021-11-18 |
| SG11202110801XA (en) | 2021-10-28 |
| AR118588A1 (es) | 2021-10-20 |
| ZA202107710B (en) | 2025-03-26 |
| JP2022526973A (ja) | 2022-05-27 |
| HUE065052T2 (hu) | 2024-04-28 |
| PH12021552402A1 (en) | 2022-06-20 |
| DK3947384T3 (da) | 2024-01-08 |
| EP3947384A1 (en) | 2022-02-09 |
| MY206575A (en) | 2024-12-24 |
| EP3947384B1 (en) | 2023-11-01 |
| WO2020200918A1 (en) | 2020-10-08 |
| FI3947384T3 (fi) | 2024-01-30 |
| US20220175784A1 (en) | 2022-06-09 |
| US12527797B2 (en) | 2026-01-20 |
| BR112021019589A2 (pt) | 2021-12-07 |
| MA55479A (fr) | 2022-02-09 |
| PT3947384T (pt) | 2024-01-29 |
| IL286937A (en) | 2021-10-31 |
| SI3947384T1 (sl) | 2024-03-29 |
| KR20210149077A (ko) | 2021-12-08 |
| PL3947384T3 (pl) | 2024-03-25 |
| TW202102504A (zh) | 2021-01-16 |
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Legal Events
| Date | Code | Title | Description |
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| PB01 | Publication | ||
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| REG | Reference to a national code |
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