JP2022526659A5 - - Google Patents

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Publication number
JP2022526659A5
JP2022526659A5 JP2021559890A JP2021559890A JP2022526659A5 JP 2022526659 A5 JP2022526659 A5 JP 2022526659A5 JP 2021559890 A JP2021559890 A JP 2021559890A JP 2021559890 A JP2021559890 A JP 2021559890A JP 2022526659 A5 JP2022526659 A5 JP 2022526659A5
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JP
Japan
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compound
formula
acid
reacted
obtain compound
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JP2021559890A
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English (en)
Japanese (ja)
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JP2022526659A (ja
JP7631218B2 (ja
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Priority claimed from PCT/US2020/027655 external-priority patent/WO2020210613A1/en
Publication of JP2022526659A publication Critical patent/JP2022526659A/ja
Publication of JP2022526659A5 publication Critical patent/JP2022526659A5/ja
Priority to JP2025017468A priority Critical patent/JP2025084766A/ja
Application granted granted Critical
Publication of JP7631218B2 publication Critical patent/JP7631218B2/ja
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JP2021559890A 2019-04-11 2020-04-10 （６ｒ，１０ｓ）－１０－｛４－［５－クロロ－２－（４－クロロ－１ｈ－１，２，３－トリアゾール－１－イル）フェニル］－６－オキソ－１（６ｈ）－ピリミジニル｝－１－（ジフルオロメチル）－６－メチル－１，４，７，８，９，１０－ヘキサヒドロ－１１，１５－（メタノ）ピラゾロ［４，３－ｂ］［１，７］ジアザシクロテトラデシン－５（６ｈ）－オンの製造における新規合成法 Active JP7631218B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025017468A JP2025084766A (ja) 2019-04-11 2025-02-05 （６ｒ，１０ｓ）－１０－｛４－［５－クロロ－２－（４－クロロ－１ｈ－１，２，３－トリアゾール－１－イル）フェニル］－６－オキソ－１（６ｈ）－ピリミジニル｝－１－（ジフルオロメチル）－６－メチル－１，４，７，８，９，１０－ヘキサヒドロ－１１，１５－（メタノ）ピラゾロ［４，３－ｂ］［１，７］ジアザシクロテトラデシン－５（６ｈ）－オンの製造における新規合成法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962832614P 2019-04-11 2019-04-11
US62/832,614 2019-04-11
PCT/US2020/027655 WO2020210613A1 (en) 2019-04-11 2020-04-10 Novel synthetic options towards the manufacture of (6r,10s)-10- {4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6h)- pyrimidinyl}- 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15 -(metheno)pyrazolo [4,3-b] [1,7] diazacyclotetradecin-5(6h)-one

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025017468A Division JP2025084766A (ja) 2019-04-11 2025-02-05 （６ｒ，１０ｓ）－１０－｛４－［５－クロロ－２－（４－クロロ－１ｈ－１，２，３－トリアゾール－１－イル）フェニル］－６－オキソ－１（６ｈ）－ピリミジニル｝－１－（ジフルオロメチル）－６－メチル－１，４，７，８，９，１０－ヘキサヒドロ－１１，１５－（メタノ）ピラゾロ［４，３－ｂ］［１，７］ジアザシクロテトラデシン－５（６ｈ）－オンの製造における新規合成法

Publications (3)

Publication Number Publication Date
JP2022526659A JP2022526659A (ja) 2022-05-25
JP2022526659A5 true JP2022526659A5 (https=) 2023-04-12
JP7631218B2 JP7631218B2 (ja) 2025-02-18

Family

ID=70457148

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021559890A Active JP7631218B2 (ja) 2019-04-11 2020-04-10 （６ｒ，１０ｓ）－１０－｛４－［５－クロロ－２－（４－クロロ－１ｈ－１，２，３－トリアゾール－１－イル）フェニル］－６－オキソ－１（６ｈ）－ピリミジニル｝－１－（ジフルオロメチル）－６－メチル－１，４，７，８，９，１０－ヘキサヒドロ－１１，１５－（メタノ）ピラゾロ［４，３－ｂ］［１，７］ジアザシクロテトラデシン－５（６ｈ）－オンの製造における新規合成法
JP2025017468A Pending JP2025084766A (ja) 2019-04-11 2025-02-05 （６ｒ，１０ｓ）－１０－｛４－［５－クロロ－２－（４－クロロ－１ｈ－１，２，３－トリアゾール－１－イル）フェニル］－６－オキソ－１（６ｈ）－ピリミジニル｝－１－（ジフルオロメチル）－６－メチル－１，４，７，８，９，１０－ヘキサヒドロ－１１，１５－（メタノ）ピラゾロ［４，３－ｂ］［１，７］ジアザシクロテトラデシン－５（６ｈ）－オンの製造における新規合成法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025017468A Pending JP2025084766A (ja) 2019-04-11 2025-02-05 （６ｒ，１０ｓ）－１０－｛４－［５－クロロ－２－（４－クロロ－１ｈ－１，２，３－トリアゾール－１－イル）フェニル］－６－オキソ－１（６ｈ）－ピリミジニル｝－１－（ジフルオロメチル）－６－メチル－１，４，７，８，９，１０－ヘキサヒドロ－１１，１５－（メタノ）ピラゾロ［４，３－ｂ］［１，７］ジアザシクロテトラデシン－５（６ｈ）－オンの製造における新規合成法

Country Status (16)

Country Link
US (2) US12378246B2 (https=)
EP (2) EP4234555A3 (https=)
JP (2) JP7631218B2 (https=)
KR (2) KR20260047658A (https=)
CN (2) CN114375290B (https=)
AR (1) AR118649A1 (https=)
AU (2) AU2020272973B2 (https=)
BR (1) BR112021020368A2 (https=)
CA (1) CA3132365A1 (https=)
EA (1) EA202192807A1 (https=)
ES (1) ES2969253T3 (https=)
IL (1) IL287102B2 (https=)
MX (2) MX2021012286A (https=)
SG (1) SG11202111132WA (https=)
TW (1) TWI880924B (https=)
WO (1) WO2020210613A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4133064A4 (en) 2020-04-10 2024-07-24 Codexis, Inc. Engineered transaminase polypeptides
TW202229280A (zh) * 2020-10-12 2022-08-01 美商必治妥美雅史谷比公司 （６ｒ，１０ｓ）－１０－｛４－［５－氯－２－（４－氯－１ｈ－１，２，３－三唑－１－基）苯基］－６－側氧基－１（６ｈ）－嘧啶基｝－１－（二氟甲基）－６－甲基－１，４，７，８，９，１０－六氫－１１，１５－（亞甲橋基）吡唑并［４，３－ｂ］［１，７］二氮雜環十四炔－５（６ｈ）－酮之製備方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012125797A1 (en) 2011-03-15 2012-09-20 Abbott Laboratories Nuclear hormone receptor modulators
SG10201908467RA (en) 2014-01-31 2019-10-30 Bristol Myers Squibb Co Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
NO2721243T3 (https=) 2014-10-01 2018-10-20
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
CN105294496A (zh) * 2015-09-28 2016-02-03 中山大学 一种西酞普兰中间体的制备方法
CN110062757B (zh) 2017-01-18 2022-03-04 广东东阳光药业有限公司 凝血因子XIa抑制剂及其用途
WO2020211781A1 (zh) * 2019-04-16 2020-10-22 南京明德新药研发有限公司 作为XIa因子抑制剂的大环衍生物
CN114008047B (zh) * 2019-07-23 2023-03-21 南京明德新药研发有限公司 作为XIa因子抑制剂的大环衍生物
JP7747337B2 (ja) * 2020-04-10 2025-10-01 コデクシス， インコーポレイテッド 速度論的光学分割のためのカルボキシエステラーゼポリペプチド

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