JP2022526367A - リポカリンムテインの吸入投与 - Google Patents
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- JP2022526367A JP2022526367A JP2021557778A JP2021557778A JP2022526367A JP 2022526367 A JP2022526367 A JP 2022526367A JP 2021557778 A JP2021557778 A JP 2021557778A JP 2021557778 A JP2021557778 A JP 2021557778A JP 2022526367 A JP2022526367 A JP 2022526367A
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- lipocalin
- lipocalin mutane
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| TW202241490A (zh) * | 2020-12-18 | 2022-11-01 | 瑞典商阿斯特捷利康公司 | 用於治療氣喘之脂質運載蛋白突變蛋白乾粉配製物 |
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| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
| US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
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| WO2005019255A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of tear lipocalin |
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| SG173332A1 (en) * | 2006-08-01 | 2011-08-29 | Pieris Ag | Muteins of tear lipocalin and methods for obtaining the same |
| CN106986926A (zh) | 2008-01-30 | 2017-07-28 | 皮里斯股份公司 | 具有对人c‑met受体酪氨酸激酶的亲和性的泪脂质运载蛋白的突变蛋白及其获得方法 |
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| AU2011263786B2 (en) * | 2010-06-08 | 2014-11-13 | Astrazeneca Ab | Tear lipocalin muteins binding IL-4 R alpha |
| CN103154023B (zh) | 2010-08-16 | 2017-04-05 | 皮里斯制药有限公司 | 铁调素的结合蛋白 |
| US9260492B2 (en) * | 2010-11-15 | 2016-02-16 | Pieris Ag | Muteins of human lipocalin 2 with affinity for glypican-3 (GPC-3) |
| EP2646552B1 (en) | 2010-12-02 | 2017-07-05 | Pieris Pharmaceuticals GmbH | Muteins of human lipocalin 2 with affinity for ctla-4 |
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| EP2802341B1 (en) * | 2012-01-09 | 2019-03-06 | Pieris Pharmaceuticals GmbH | Methods for preventing, treating or diagnosing disorders |
| US9522940B2 (en) * | 2012-05-23 | 2016-12-20 | Pieris Pharmaceuticals Gmbh | Lipocalin muteins with binding-affinity for glypican-3 (GPC-3) and use of lipocalin muteins for target-specific delivery to cells expressing GPC-3 |
| US10526384B2 (en) * | 2012-11-19 | 2020-01-07 | Pieris Pharmaceuticals Gmbh | Interleukin-17A-specific and interleukin-23-specific binding polypeptides and uses thereof |
| SG11201505856TA (en) | 2013-03-14 | 2015-08-28 | Daiichi Sankyo Co Ltd | Novel binding proteins for pcsk9 |
| US10927154B2 (en) * | 2014-01-13 | 2021-02-23 | Pieris Pharmaceuticals Gmbh | Multi-specific polypeptide useful for localized tumor immunomodulation |
| CA2949405C (en) * | 2014-05-22 | 2023-08-01 | Pieris Pharmaceuticals Gmbh | Novel specific-binding polypeptides and uses thereof |
| RU2720688C2 (ru) | 2015-01-28 | 2020-05-12 | ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ | Новые белки, специфические в отношении ангиогенеза |
| AU2016221816B2 (en) | 2015-02-18 | 2020-07-02 | Pieris Pharmaceuticals Gmbh | Novel proteins specific for pyoverdine and pyochelin |
| AU2016258977C1 (en) * | 2015-05-04 | 2022-07-14 | Pieris Pharmaceuticals Gmbh | Anti-cancer fusion polypeptide |
| AU2016258952C1 (en) * | 2015-05-04 | 2020-12-24 | Pieris Pharmaceuticals Gmbh | Proteins specific for CD137 |
| RU2754466C2 (ru) * | 2015-05-18 | 2021-09-02 | ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ | Слитый полипептид с противораковой активностью |
| US10273275B2 (en) | 2015-05-18 | 2019-04-30 | Pieris Pharmaceuticals Gmbh | Muteins of human lipocalin 2 with affinity for glypican-3 (GPC3) and methods of use thereof |
| EP3115371A1 (en) * | 2015-07-07 | 2017-01-11 | Sanofi | Fusion molecules |
| CA2988831A1 (en) * | 2015-07-15 | 2017-01-19 | Pieris Pharmaceuticals Gmbh | Novel proteins specific for lag-3 |
| TW201725212A (zh) | 2015-12-10 | 2017-07-16 | 第一三共股份有限公司 | 特異性於降鈣素基因相關胜肽的新穎蛋白 |
| WO2018087108A1 (en) | 2016-11-09 | 2018-05-17 | Pieris Pharmaceuticals Gmbh | Proteins specific for cd137 |
| RU2019122482A (ru) | 2017-01-18 | 2021-02-19 | Пирис Фармасьютикалс Гмбх | Мутеины липокалина с аффинностью связывания в отношении lag-3 |
| LT3830120T (lt) * | 2018-07-31 | 2023-07-10 | Pieris Pharmaceuticals Gmbh | Naujas sulietas baltymas specifinis cd137 ir pd-l1 atžvilgiu |
| AU2019328632A1 (en) * | 2018-08-27 | 2021-03-25 | Pieris Pharmaceuticals Gmbh | Combination therapies comprising CD137/HER2 bispecific agents and PD-1 axis inhibitors and uses thereof |
| IL284687B2 (en) * | 2019-02-26 | 2025-11-01 | Pieris Pharmaceuticals Gmbh | Novel fusion proteins specific for cd137 and gpc3 |
| CA3133422A1 (en) * | 2019-03-29 | 2020-10-08 | Astrazeneca Ab | Lipocalin mutein for treatment of asthma |
| CN116249709A (zh) * | 2020-06-05 | 2023-06-09 | 皮里斯制药有限公司 | 靶向4-1bb的多聚体免疫调节剂 |
| WO2022058505A1 (en) * | 2020-09-18 | 2022-03-24 | Pieris Pharmaceuticals Gmbh | Biomarker methods and uses |
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| AU2020253034A1 (en) | 2021-08-19 |
| CN113939307A (zh) | 2022-01-14 |
| EP3946417A1 (en) | 2022-02-09 |
| KR20210146999A (ko) | 2021-12-06 |
| US20220168387A1 (en) | 2022-06-02 |
| CA3127973A1 (en) | 2020-10-08 |
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