JP2022518504A - 閉端ｄｎａ（ｃｅｄｎａ）ならびに遺伝子療法または核酸療法に関連する免疫応答を低減させる方法における使用 - Google Patents

閉端ｄｎａ（ｃｅｄｎａ）ならびに遺伝子療法または核酸療法に関連する免疫応答を低減させる方法における使用 Download PDF

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JP2022518504A
JP2022518504A JP2021542384A JP2021542384A JP2022518504A JP 2022518504 A JP2022518504 A JP 2022518504A JP 2021542384 A JP2021542384 A JP 2021542384A JP 2021542384 A JP2021542384 A JP 2021542384A JP 2022518504 A JP2022518504 A JP 2022518504A
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inhibitor
cedna
itr
itrs
immune response
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JP2022518504A5 (https=
JPWO2020154645A5 (https=
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ダグラス アンソニー カー，
フィリップ サマヨア，
ロバート エム． コーティン，
マシュー ジー． スタントン，
オザン アルカン，
マシュー チオッコ，
ラジ ラジェンドラン，
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ジェネレーション バイオ カンパニー
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JP2021542384A 2019-01-24 2020-01-24 閉端ｄｎａ（ｃｅｄｎａ）ならびに遺伝子療法または核酸療法に関連する免疫応答を低減させる方法における使用 Pending JP2022518504A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201962796417P 2019-01-24 2019-01-24
US201962796450P 2019-01-24 2019-01-24
US62/796,417 2019-01-24
US62/796,450 2019-01-24
US201962800303P 2019-02-01 2019-02-01
US201962800285P 2019-02-01 2019-02-01
US62/800,285 2019-02-01
US62/800,303 2019-02-01
US201962814414P 2019-03-06 2019-03-06
US201962814424P 2019-03-06 2019-03-06
US62/814,414 2019-03-06
US62/814,424 2019-03-06
US201962857542P 2019-06-05 2019-06-05
US62/857,542 2019-06-05
PCT/US2020/015026 WO2020154645A1 (en) 2019-01-24 2020-01-24 Close-ended dna (cedna) and use in methods of reducing gene or nucleic acid therapy related immune response

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JP2022518504A true JP2022518504A (ja) 2022-03-15
JP2022518504A5 JP2022518504A5 (https=) 2023-02-02
JPWO2020154645A5 JPWO2020154645A5 (https=) 2023-02-02

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JP2021542384A Pending JP2022518504A (ja) 2019-01-24 2020-01-24 閉端ｄｎａ（ｃｅｄｎａ）ならびに遺伝子療法または核酸療法に関連する免疫応答を低減させる方法における使用

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US (1) US20220119840A1 (https=)
EP (1) EP3914717A4 (https=)
JP (1) JP2022518504A (https=)
KR (1) KR20210119416A (https=)
CN (1) CN113412331A (https=)
AU (1) AU2020211457A1 (https=)
CA (1) CA3127799A1 (https=)
MA (1) MA54826A (https=)
MX (1) MX2021008874A (https=)
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TW202545984A (zh) 2017-08-09 2025-12-01 美商生物化學醫療公司 核酸分子及其用途
SG11202005271TA (en) * 2018-01-19 2020-07-29 Generation Bio Co Closed-ended dna vectors obtainable from cell-free synthesis and process for obtaining cedna vectors
CN108920903B (zh) * 2018-07-09 2022-04-01 湘潭大学 基于朴素贝叶斯的LncRNA与疾病的关联关系预测方法及系统
WO2020033863A1 (en) 2018-08-09 2020-02-13 Bioverativ Therapeutics Inc. Nucleic acid molecules and uses thereof for non-viral gene therapy
EP3956448A4 (en) * 2019-04-18 2022-10-19 University of Massachusetts AIM2 INHIBITORS AND USES THEREOF
US20210371465A1 (en) * 2020-03-26 2021-12-02 Yale University Method of using a tlr9 antagonist as an anti-inflammatory and anti-fibrotic agent
CN116234917A (zh) 2020-07-27 2023-06-06 安杰瑞姆生物科学公司 Dna分子组合物及其制备方法和使用方法
US20220090130A1 (en) * 2020-08-23 2022-03-24 Bioverativ Therapeutics Inc. MODIFIED BACULOVIRUS SYSTEM FOR IMPROVED PRODUCTION OF CLOSED-ENDED DNA (ceDNA)
CN112138164B (zh) * 2020-09-25 2022-06-03 徐州医科大学 Aim2在制备降低car-t治疗毒副作用的药物中的应用
EP4297728A1 (en) 2021-02-23 2024-01-03 Poseida Therapeutics, Inc. Compositions and methods for delivery of nucleic acids
CA3230386A1 (en) * 2021-07-23 2023-01-26 Spark Therapeutics, Inc. Methods and composition for non-viral dna delivery
AU2022211795A1 (en) * 2021-08-06 2023-02-23 Syte.Bio Inc. Hairpin loop ended self-complementary double-stranded covalently closed linear dna vector, manufacturing system and process, and uses of said resulting dna vector
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