JP2022518282A - 抗ｃｄ３８結合ドメイン - Google Patents

抗ｃｄ３８結合ドメイン Download PDF

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Publication number
JP2022518282A
JP2022518282A JP2021543170A JP2021543170A JP2022518282A JP 2022518282 A JP2022518282 A JP 2022518282A JP 2021543170 A JP2021543170 A JP 2021543170A JP 2021543170 A JP2021543170 A JP 2021543170A JP 2022518282 A JP2022518282 A JP 2022518282A
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Japan
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seq
sequence
domain
composition
binding
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JP2021543170A
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English (en)
Japanese (ja)
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JP2022518282A5 (enExample
Inventor
キャスリーン アン イライアス，
グレゴリー ランデス，
シュウェタ シン，
ウーター コーバー，
アンドリュー ウォリング ドレイク，
メアリー ハーク－フレンドショー，
ヴィナイ バスカー，
エリン ウィレルト，
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of JP2022518282A publication Critical patent/JP2022518282A/ja
Publication of JP2022518282A5 publication Critical patent/JP2022518282A5/ja
Priority to JP2024229904A priority Critical patent/JP2025060876A/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Gas Separation By Absorption (AREA)
JP2021543170A 2019-01-23 2020-01-23 抗ｃｄ３８結合ドメイン Withdrawn JP2022518282A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024229904A JP2025060876A (ja) 2019-01-23 2024-12-26 抗ｃｄ３８結合ドメイン

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962795855P 2019-01-23 2019-01-23
US62/795,855 2019-01-23
PCT/US2020/014845 WO2020154540A1 (en) 2019-01-23 2020-01-23 Anti-cd38 antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024229904A Division JP2025060876A (ja) 2019-01-23 2024-12-26 抗ｃｄ３８結合ドメイン

Publications (2)

Publication Number Publication Date
JP2022518282A true JP2022518282A (ja) 2022-03-14
JP2022518282A5 JP2022518282A5 (enExample) 2023-02-01

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JP2021543170A Withdrawn JP2022518282A (ja) 2019-01-23 2020-01-23 抗ｃｄ３８結合ドメイン
JP2024229904A Pending JP2025060876A (ja) 2019-01-23 2024-12-26 抗ｃｄ３８結合ドメイン

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Country Status (9)

Country Link
US (2) US11414496B2 (enExample)
EP (1) EP3914358A1 (enExample)
JP (2) JP2022518282A (enExample)
CN (1) CN113710324B (enExample)
AR (1) AR119677A1 (enExample)
AU (1) AU2020211407A1 (enExample)
CA (1) CA3127624A1 (enExample)
TW (1) TWI863959B (enExample)
WO (1) WO2020154540A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7418756B2 (ja) 2019-01-23 2024-01-22 ミレニアム ファーマシューティカルズ， インコーポレイテッド 脱免疫化志賀毒素ａサブユニットエフェクターを含むｃｄ３８結合性タンパク質
AU2020211407A1 (en) 2019-01-23 2021-08-12 Millennium Pharmaceuticals, Inc. Anti-CD38 antibodies
CA3180690A1 (en) * 2020-06-17 2021-12-23 Ahmed Mahiuddin Cd38 antibodies for treatment of human diseases
EP4490168A1 (en) * 2022-03-08 2025-01-15 Molecular Templates, Inc. Ctla-4 binding molecules comprising shiga toxin a subunit scaffolds and uses thereof

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JP2014509187A (ja) * 2010-12-30 2014-04-17 武田薬品工業株式会社 結合抗ｃｄ３８抗体
JP2016522816A (ja) * 2013-04-29 2016-08-04 テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド 抗ｃｄ３８抗体及び弱毒化インターフェロンアルファ−２ｂとの融合物
WO2018083126A1 (en) * 2016-11-01 2018-05-11 Genmab B.V. Polypeptide variants and uses thereof

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WO1998048032A2 (en) 1997-04-21 1998-10-29 Donlar Corporation POLY-(α-L-ASPARTIC ACID), POLY-(α-L-GLUTAMIC ACID) AND COPOLYMERS OF L-ASP AND L-GLU, METHOD FOR THEIR PRODUCTION AND THEIR USE
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JP6935195B2 (ja) 2014-03-11 2021-09-15 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 結合領域、志賀毒素ａサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質
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JP2014509187A (ja) * 2010-12-30 2014-04-17 武田薬品工業株式会社 結合抗ｃｄ３８抗体
JP2016522816A (ja) * 2013-04-29 2016-08-04 テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド 抗ｃｄ３８抗体及び弱毒化インターフェロンアルファ−２ｂとの融合物
WO2018083126A1 (en) * 2016-11-01 2018-05-11 Genmab B.V. Polypeptide variants and uses thereof

Also Published As

Publication number Publication date
TW202043281A (zh) 2020-12-01
CN113710324A (zh) 2021-11-26
US20230203186A1 (en) 2023-06-29
AR119677A1 (es) 2022-01-05
EP3914358A1 (en) 2021-12-01
WO2020154540A1 (en) 2020-07-30
US12312411B2 (en) 2025-05-27
CA3127624A1 (en) 2020-07-30
US11414496B2 (en) 2022-08-16
AU2020211407A1 (en) 2021-08-12
TWI863959B (zh) 2024-12-01
US20200231696A1 (en) 2020-07-23
CN113710324B (zh) 2025-02-14
JP2025060876A (ja) 2025-04-10

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