JP2022517767A5 - - Google Patents
Info
- Publication number
- JP2022517767A5 JP2022517767A5 JP2021539640A JP2021539640A JP2022517767A5 JP 2022517767 A5 JP2022517767 A5 JP 2022517767A5 JP 2021539640 A JP2021539640 A JP 2021539640A JP 2021539640 A JP2021539640 A JP 2021539640A JP 2022517767 A5 JP2022517767 A5 JP 2022517767A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- hydrogen
- compound according
- heteroalkylene
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024232794A JP2025069133A (ja) | 2019-01-08 | 2024-12-27 | 無痕跡型リンカー及びそのタンパク質－コンジュゲート |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16/243,020 | 2019-01-08 | ||
| US16/243,020 US12070506B2 (en) | 2018-01-08 | 2019-01-08 | Steroids and antibody-conjugates thereof |
| USPCT/US2019/012786 | 2019-01-08 | ||
| PCT/US2019/012786 WO2019136487A2 (en) | 2018-01-08 | 2019-01-08 | Steroids and antibody-conjugates thereof |
| US201962872229P | 2019-07-09 | 2019-07-09 | |
| US62/872,229 | 2019-07-09 | ||
| US201962937721P | 2019-11-19 | 2019-11-19 | |
| US62/937,721 | 2019-11-19 | ||
| PCT/US2020/012798 WO2020146541A2 (en) | 2019-01-08 | 2020-01-08 | Traceless linkers and protein-conjugates thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024232794A Division JP2025069133A (ja) | 2019-01-08 | 2024-12-27 | 無痕跡型リンカー及びそのタンパク質－コンジュゲート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022517767A JP2022517767A (ja) | 2022-03-10 |
| JP2022517767A5 true JP2022517767A5 (enExample) | 2023-01-23 |
Family
ID=71521936
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021539640A Pending JP2022517767A (ja) | 2019-01-08 | 2020-01-08 | 無痕跡型リンカー及びそのタンパク質－コンジュゲート |
| JP2024232794A Pending JP2025069133A (ja) | 2019-01-08 | 2024-12-27 | 無痕跡型リンカー及びそのタンパク質－コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024232794A Pending JP2025069133A (ja) | 2019-01-08 | 2024-12-27 | 無痕跡型リンカー及びそのタンパク質－コンジュゲート |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP3908323A2 (enExample) |
| JP (2) | JP2022517767A (enExample) |
| KR (2) | KR20250156850A (enExample) |
| CN (2) | CN119264215A (enExample) |
| AU (1) | AU2020205662A1 (enExample) |
| BR (1) | BR112021013464A2 (enExample) |
| CA (1) | CA3125998A1 (enExample) |
| CL (3) | CL2021001790A1 (enExample) |
| CO (1) | CO2021010315A2 (enExample) |
| IL (1) | IL284673A (enExample) |
| MA (2) | MA59295B1 (enExample) |
| MX (1) | MX2021008114A (enExample) |
| PH (1) | PH12021551629A1 (enExample) |
| SG (1) | SG11202107212QA (enExample) |
| WO (1) | WO2020146541A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250114431A (ko) | 2016-11-08 | 2025-07-29 | 리제너론 파마슈티칼스 인코포레이티드 | 스테로이드 및 이의 단백질-접합체 |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| IL313068A (en) | 2017-11-07 | 2024-07-01 | Regeneron Pharma | Hydrophilic linkers for antibody drug conjugates |
| IL275757B2 (en) | 2018-01-08 | 2025-08-01 | Regeneron Pharma | Steroids and antibody-conjugates thereof |
| MX2020011546A (es) | 2018-05-09 | 2021-01-29 | Regeneron Pharma | Anticuerpos anti-msr1 y metodos de uso de los mismos. |
| JP7624255B2 (ja) * | 2021-03-31 | 2025-01-30 | 日本マイクロバイオファーマ株式会社 | 抗体薬物複合体の製造方法及びそれに用いる酵素 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| US12545716B2 (en) | 2021-07-19 | 2026-02-10 | Immunome, Inc. | Immunoconjugates and methods |
| US20250057962A1 (en) * | 2021-11-03 | 2025-02-20 | Ripple Therapeutics Corporation | Processable compositions and use for the same |
| CN118829449A (zh) | 2022-01-12 | 2024-10-22 | 瑞泽恩制药公司 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
| JP2025508665A (ja) * | 2022-01-29 | 2025-04-10 | 上海盛迪医薬有限公司 | グルココルチコイドの薬物複合体 |
| CN120659785A (zh) | 2022-11-30 | 2025-09-16 | 里珍纳龙药品有限公司 | Tlr7激动剂及其抗体-药物缀合物 |
| CN118236514B (zh) * | 2022-12-24 | 2025-10-31 | 津药生物科技（天津）有限公司 | 抗体-糖皮质激素偶联物及其用途 |
| EP4661914A1 (en) * | 2023-02-09 | 2025-12-17 | Regeneron Pharmaceuticals, Inc. | Antibody-drug conjugates via inverse electron demand diels-alder reactions |
| AU2024315507A1 (en) * | 2023-07-28 | 2026-02-26 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition containing antibody-drug conjugate of glucocorticoid |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
| TW200539855A (en) | 2004-03-15 | 2005-12-16 | Wyeth Corp | Calicheamicin conjugates |
| MXPA06014065A (es) | 2004-06-01 | 2007-01-31 | Genentech Inc | Conjugados de droga-anticuerpo y metodos. |
| AU2005316844A1 (en) | 2004-11-29 | 2006-06-22 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| WO2008122039A2 (en) | 2007-04-02 | 2008-10-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selenocysteine mediated hybrid antibody molecules |
| ES2731432T3 (es) | 2007-05-23 | 2019-11-15 | Ventana Med Syst Inc | Transportadores poliméricos para inmunohistoquímica e hibridación in situ |
| RU2487877C2 (ru) | 2008-04-30 | 2013-07-20 | Иммьюноджен, Инк. | Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры) |
| KR101000067B1 (ko) | 2008-12-30 | 2010-12-10 | 엘지전자 주식회사 | 고효율 태양전지용 레이저 소성장치 및 고효율 태양전지 제조방법 |
| WO2011130598A1 (en) | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines and conjugates thereof |
| WO2012005982A2 (en) | 2010-07-06 | 2012-01-12 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Reporter for rna polymerase ii termination |
| EP2714685B1 (en) | 2011-05-27 | 2016-10-19 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| MX358757B (es) | 2011-10-14 | 2018-09-03 | Seattle Genetics Inc | Pirrolobenzodiazepinas y conjugados dirigidos. |
| SG11201401021TA (en) | 2011-10-14 | 2014-08-28 | Spirogen Sarl | Pyrrolobenzodiazepines |
| US9102704B2 (en) | 2011-10-14 | 2015-08-11 | Spirogen Sarl | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines |
| US9526798B2 (en) | 2011-10-14 | 2016-12-27 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| WO2013068874A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Antibody-drug conjugates |
| ES2659270T5 (en) | 2012-10-23 | 2026-02-11 | Synaffix Bv | Modified antibody, antibody-conjugate and process for the preparation thereof |
| JP6744212B2 (ja) * | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | ポリペプチドの酵素的結合 |
| TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗－ｐｒｌｒ抗體及其用途 |
| CN111228511B (zh) * | 2014-04-10 | 2024-06-18 | 第一三共株式会社 | 抗her3抗体-药物偶联物 |
| EP3407916B1 (en) | 2016-01-29 | 2023-12-20 | Merck Sharp & Dohme LLC | Phosphonate linkers and their use to facilitate cellular retention of compounds |
| PE20190622A1 (es) * | 2016-06-02 | 2019-04-26 | Abbvie Inc | Agonista del receptor de glucocorticoides e inmunoconjugados del mismo |
| MA46417A (fr) | 2016-09-23 | 2019-07-31 | Regeneron Pharma | Anticorps anti-steap2, conjugués anticorps-médicament, et molécules bispécifiques de liaison à l'antigène qui se lient à steap2 et cd3, et leurs utilisations |
| KR20250114431A (ko) * | 2016-11-08 | 2025-07-29 | 리제너론 파마슈티칼스 인코포레이티드 | 스테로이드 및 이의 단백질-접합체 |
| KR20200007905A (ko) * | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| AU2018269568B2 (en) * | 2017-05-18 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Bis-octahydrophenanthrene carboxamides and protein conjugates thereof |
| WO2019034176A1 (zh) * | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | 一种喜树碱-抗体偶联物 |
| CN108853514B (zh) * | 2017-08-18 | 2022-07-22 | 四川百利药业有限责任公司 | 具有两种不同药物的抗体药物偶联物 |
| IL275757B2 (en) * | 2018-01-08 | 2025-08-01 | Regeneron Pharma | Steroids and antibody-conjugates thereof |
| US20190343221A1 (en) | 2018-05-08 | 2019-11-14 | Nike, Inc. | Bonding to polyolefin plates and articles of footwear formed therefrom |
| MX2020011546A (es) | 2018-05-09 | 2021-01-29 | Regeneron Pharma | Anticuerpos anti-msr1 y metodos de uso de los mismos. |
-
2020
- 2020-01-08 WO PCT/US2020/012798 patent/WO2020146541A2/en not_active Ceased
- 2020-01-08 CN CN202411172153.4A patent/CN119264215A/zh active Pending
- 2020-01-08 MX MX2021008114A patent/MX2021008114A/es unknown
- 2020-01-08 MA MA59295A patent/MA59295B1/fr unknown
- 2020-01-08 CA CA3125998A patent/CA3125998A1/en active Pending
- 2020-01-08 JP JP2021539640A patent/JP2022517767A/ja active Pending
- 2020-01-08 KR KR1020257035503A patent/KR20250156850A/ko active Pending
- 2020-01-08 CN CN202080019317.3A patent/CN113905767A/zh active Pending
- 2020-01-08 AU AU2020205662A patent/AU2020205662A1/en active Pending
- 2020-01-08 EP EP20702563.6A patent/EP3908323A2/en active Pending
- 2020-01-08 BR BR112021013464-6A patent/BR112021013464A2/pt unknown
- 2020-01-08 SG SG11202107212QA patent/SG11202107212QA/en unknown
- 2020-01-08 PH PH1/2021/551629A patent/PH12021551629A1/en unknown
- 2020-01-08 KR KR1020217024347A patent/KR102877468B1/ko active Active
- 2020-01-08 MA MA53772A patent/MA53772B1/fr unknown
-
2021
- 2021-07-06 CL CL2021001790A patent/CL2021001790A1/es unknown
- 2021-07-07 IL IL284673A patent/IL284673A/en unknown
- 2021-08-04 CO CONC2021/0010315A patent/CO2021010315A2/es unknown
-
2024
- 2024-05-23 CL CL2024001547A patent/CL2024001547A1/es unknown
- 2024-05-23 CL CL2024001546A patent/CL2024001546A1/es unknown
- 2024-12-27 JP JP2024232794A patent/JP2025069133A/ja active Pending
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