JP2022516646A - 生体内誘電分光装置 - Google Patents
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
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- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/0507—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
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- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0538—Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
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Abstract
Description
本願は、2019年1月4日に出願された米国特許仮出願第62/788,197号の優先権主張出願であり、この米国仮出願を参照により引用し、その記載内容全体を本明細書の一部とする。
Claims (20)
- 生体の電気透過率の生体内検出のためのマイクロストリップ導波路構造体であって、前記生体の前記電気透過率は、既知の透過率成分および未知の透過率成分を含み、前記マイクロストリップ導波路構造体は、
第1の側部および前記第1の側部と反対側の第2の側部を備えた誘電複合体を有し、前記誘電複合体は、直線状に整然と並べられた3つの誘電領域、すなわち、第1の誘電領域、第2の誘電領域、および第3の誘電領域を有し、前記第2の誘電領域は、前記第1の誘電領域および前記第2の誘電領域の電気透過率とは異なる異方性電気透過率を有し、前記第2の誘電領域の前記異方性電気透過率は、前記生体の前記電気透過率の前記既知の透過率成分に実質的に等しいよう選択され、
前記誘電複合体の前記第1の側部上に形成されたマイクロストリップ送信線を有し、前記マイクロストリップ送信線は、前記第1の誘電領域上に形成された入力区分、前記第2の誘電領域上に形成されたラジエータ部分、および前記第3の誘電領域上に形成された出力部分を有し、
前記誘電複合体の前記第2の側部上に形成されたグラウンドプレーンを有する、マイクロストリップ導波路構造体。 - 前記第1の誘電領域の前記電気透過率は、前記第3の誘電領域の前記電気透過率と同等である、請求項1記載のマイクロストリップ導波路構造体。
- 前記マイクロストリップ送信線の前記ラジエータ部分は、平面巻線として形成されている、請求項1記載のマイクロストリップ導波路構造体。
- 前記平面巻線は、交互曲折体として形成されている、請求項3記載のマイクロストリップ導波路構造体。
- 前記平面巻線は、平面螺旋体として形成されている、請求項3記載のマイクロストリップ導波路構造体。
- 前記誘電複合体は、湾曲している、請求項1記載のマイクロストリップ導波路構造体。
- 前記第2の誘電領域の誘電率は、25~55である、請求項1記載のマイクロストリップ導波路構造体。
- 前記第2の誘電領域の誘電率は、2~3である、請求項1記載のマイクロストリップ導波路構造体。
- 前記第2の誘電領域の誘電率は、偏差±10%の400である、請求項1記載のマイクロストリップ導波路構造体。
- 前記誘電複合体の厚さは、前記生体の高さの半分未満である、請求項1記載のマイクロストリップ導波路構造体。
- 前記第2の誘電領域の前記誘電率は、100kHz~220MHzの周波数範囲において、前記生体の前記電気透過率の前記既知の透過率成分に実質的に等しいよう選択されている、請求項1記載のマイクロストリップ導波路構造体。
- 前記第1および前記第3の誘電領域のうちの少なくとも一方は、異方性誘電率を有する、請求項1記載のマイクロストリップ導波路構造体。
- 生体の成分の生体内測定のための誘電分光システムであって、前記生体は、第1の誘電率を有する第1の組をなす成分、および測定されるべき誘電率を備えた第2の組をなす成分を有し、前記システムは、
センサを有し、前記センサは、
第1の側部および前記第1の側部と反対側の第2の側部を備えた誘電複合体を有し、前記誘電複合体は、直線状に整然と並べられた3つの誘電領域、すなわち、第1の誘電領域、第2の誘電領域、および第3の誘電領域を有し、前記第2の誘電領域は、前記第1の誘電領域および前記第2の誘電領域の電気透過率とは異なる異方性電気透過率を有し、前記第2の誘電領域の前記異方性電気透過率は、前記生体の前記電気透過率の前記既知の透過率成分に実質的に等しいよう選択され、
前記誘電複合体の前記第1の側部上に形成されたマイクロストリップ送信線を有し、前記マイクロストリップ送信線は、前記第1の誘電領域上に形成された入力区分、前記第2の誘電領域上に形成されたラジエータ部分、および前記第3の誘電領域上に形成された出力部分を有し、
前記誘電複合体の前記第2の側部上に形成されたグラウンドプレーンを有し、
前記入力区分に結合されていて、複数の互いに異なる周波数で信号を提供するよう構成された信号発生器を有し、
前記入力区分に結合されていて、前記センサからの反射信号を検出するカップラを有し、
送信信号を受信するよう前記センサの前記出力区分に結合された受信器を有する、誘電分光システム。 - 前記第1の誘電領域の前記電気透過率は、前記第3の誘電領域の前記電気透過率と同等である、請求項13記載の誘電分光システム。
- 前記マイクロストリップ送信線の前記ラジエータ部分は、平面巻線として形成されている、請求項13記載の誘電分光システム。
- 生体の生体内検出のための誘電分光センサであって、
第1の側部および前記第1の側部と反対側の第2の側部を備えた誘電複合体を有し、前記誘電複合体は、直線状に整然と並べられた3つの誘電領域、すなわち、第1の誘電領域、第2の誘電領域、および第3の誘電領域を有し、前記第2の誘電領域は、前記第1の誘電領域と前記第3の誘電領域との間に位置し、かつ前記第1の誘電領域および前記第2の誘電領域の電気透過率とは異なる異方性電気透過率を有し、
前記誘電複合体の前記第1の側部上に形成されたマイクロストリップ送信線を有し、前記マイクロストリップ送信線は、前記第1の誘電領域上に形成された入力区分、前記第2の誘電領域上に形成されたラジエータ部分、および前記第3の誘電領域上に形成された出力部分を有し、
前記誘電複合体の前記第2の側部上に形成されたグラウンドプレーンを有し、
前記第2の誘電領域の前記異方性電気透過率は、所与の周波数範囲において、前記ラジエータ部分が前記生体中に電気的に埋め込まれているように見えるよう選択されている、誘電分光センサ。 - 前記第1の誘電領域の前記電気透過率は、前記第3の誘電領域の前記電気透過率と同等である、請求項16記載の誘電分光センサ。
- 前記マイクロストリップ送信線の前記ラジエータ部分は、平面巻線として形成されている、請求項16記載の誘電分光センサ。
- 前記平面巻線は、交互曲折体として形成されている、請求項18記載の誘電分光センサ。
- 前記平面巻線は、平面螺旋体として形成されている、請求項18記載の誘電分光センサ。
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PCT/US2020/012356 WO2020142766A1 (en) | 2019-01-04 | 2020-01-06 | Apparatus for in vivo dielectric spectroscopy |
US16/734,534 US10921274B2 (en) | 2019-01-04 | 2020-01-06 | Apparatus for in vivo dielectric spectroscopy |
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PL226423B1 (pl) | 2012-12-21 | 2017-07-31 | Bumar Elektronika Spółka Akcyjna | Układ pomiarowy sondy |
DE102014109549A1 (de) | 2014-07-08 | 2016-01-14 | Infineon Technologies Ag | 300 mhz bis 3 thz elektromagnetischer wellensensor zum bestimmen eines interstitiellen flüssigkeitsparameters in vivo |
CN104330642B (zh) * | 2014-11-12 | 2017-03-22 | 中国人民解放军国防科学技术大学 | 测量生物组织各向异性介电谱特性的探头及其测算方法 |
AR104766A1 (es) | 2015-07-21 | 2017-08-16 | Consejo Nac De Investig Científicas Y Técnicas (Conicet) | Traductor para medición de glucosa en sangre de forma no invasiva |
DE102015119180A1 (de) * | 2015-11-06 | 2017-05-11 | Infineon Technologies Ag | Elektromagnetischer Wellensensor, um einen Hydrationsstatus eines Körpergewebes in vivo zu bestimmen |
EA030390B1 (ru) | 2016-03-25 | 2018-07-31 | Учреждение Образования "Белорусский Государственный Университет Информатики И Радиоэлектроники" | Способ и устройство определения индивидуальной характеристической частоты биологического объекта |
FI128912B (fi) * | 2016-11-01 | 2021-03-15 | Elcoflex Oy | Menetelmä fysikaalisten suureitten mittaamiseksi ja menetelmässä hyödynnettävä mittausjärjestely |
WO2018092146A1 (en) | 2016-11-21 | 2018-05-24 | ContinUse Biometrics Ltd. | System and method for monitoring of objects with increased sensitivity |
CN111565639B (zh) | 2017-11-15 | 2023-06-06 | 新加坡科技设计大学 | 非侵入式监测血糖的装置和方法 |
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