JP2022513412A - 癌を治療するための物質及び方法 - Google Patents

癌を治療するための物質及び方法 Download PDF

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JP2022513412A
JP2022513412A JP2021548569A JP2021548569A JP2022513412A JP 2022513412 A JP2022513412 A JP 2022513412A JP 2021548569 A JP2021548569 A JP 2021548569A JP 2021548569 A JP2021548569 A JP 2021548569A JP 2022513412 A JP2022513412 A JP 2022513412A
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cells
csf
car
cell
subject
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JP2022513412A5 (https=
Inventor
デュラント、キャメロン
チャペル、デール
ケンデリアン、サアド・ジェイ
スターナー、ロザリー・エム
コックス、ミシェル・ジェイ
玲央奈 酒村
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Mayo Clinic in Florida
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Mayo Clinic in Florida
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JP2021548569A 2018-10-31 2019-10-31 癌を治療するための物質及び方法 Pending JP2022513412A (ja)

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Application Number Priority Date Filing Date Title
US201862753485P 2018-10-31 2018-10-31
US62/753,485 2018-10-31
PCT/US2019/059275 WO2020092850A1 (en) 2018-10-31 2019-10-31 Materials and methods for treating cancer

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JP2022513412A true JP2022513412A (ja) 2022-02-07
JP2022513412A5 JP2022513412A5 (https=) 2022-11-04

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US (2) US20220040229A1 (https=)
EP (1) EP3873205B1 (https=)
JP (1) JP2022513412A (https=)
KR (1) KR20210105344A (https=)
CN (1) CN113194715B (https=)
AU (1) AU2019374102A1 (https=)
BR (1) BR112021008263A2 (https=)
CA (1) CA3116412A1 (https=)
IL (1) IL282478A (https=)
MX (1) MX2021004993A (https=)
SG (1) SG11202103589XA (https=)
WO (1) WO2020092850A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4314037A4 (en) * 2018-10-31 2025-06-04 Mayo Foundation For Medical Education And Research Materials and methods for treating cancer
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
EP4370676A2 (en) * 2021-06-18 2024-05-22 Artisan Development Labs, Inc. Compositions and methods for targeting, editing or modifying human genes
WO2023081252A1 (en) * 2021-11-03 2023-05-11 Mayo Foundation For Medical Education And Research Methods and materials for improving t cell therapies
CN114606237B (zh) * 2022-05-11 2025-10-28 上海优替济生生物医药有限公司 Gm-csf抑制剂及其用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010538676A (ja) * 2007-09-18 2010-12-16 アムジェン インコーポレイテッド ヒトgm−csf抗原結合性タンパク質
US20140127814A1 (en) * 2010-08-10 2014-05-08 Srinivasan Chandrasegaran Generation and use of pluripotent stem cells
WO2015066262A1 (en) * 2013-11-04 2015-05-07 Trustees Of Dartmouth College Methods for preventing toxicity of adoptive cell therapy
JP2015134742A (ja) * 2013-12-19 2015-07-27 国立研究開発法人国立精神・神経医療研究センター GM−CSF産生T細胞制御剤、及びTh1/Th2免疫バランス調節剤
JP2015522081A (ja) * 2012-07-13 2015-08-03 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Carの抗腫瘍活性のための毒性管理
JP2016538861A (ja) * 2013-11-22 2016-12-15 セレクティス 免疫療法のための化学療法薬耐性t細胞を工学的に作製する方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US674A (en) 1838-04-05 Draft-box eob steam-engines
US9017A (en) 1852-06-15 Cast-iron cab-wheel
US7741450B2 (en) * 2006-02-08 2010-06-22 Morphotek Inc. Antibodies to GM-CSF
US20100055116A1 (en) * 2006-04-13 2010-03-04 Liou Hsiou-Chi Methods and Compositions for Targeting c-Rel
CN101165070B (zh) * 2006-10-20 2010-12-08 余波 一系列双重生物活性的融合蛋白及其医疗应用
EP2101780B1 (en) * 2006-11-21 2013-10-09 Kalobios Pharmaceuticals, Inc. Methods of treating chronic inflammatory diseases using a gm-csf antagonist
WO2009134805A2 (en) 2008-04-28 2009-11-05 Kalobios Pharmaceuticals, Inc. Antibodies to granulocyte-macrophage colony-stimulating factor
CN103827143A (zh) * 2011-07-06 2014-05-28 莫弗系统股份公司 抗cd20抗体和抗gm-csf抗体的治疗性组合产品及其用途
CN113684185A (zh) * 2013-02-26 2021-11-23 纪念斯隆-凯特琳癌症中心 用于免疫疗法的组合物和方法
US20160186208A1 (en) * 2013-04-16 2016-06-30 Whitehead Institute For Biomedical Research Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal
WO2015121454A1 (en) * 2014-02-14 2015-08-20 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
AU2015244039B2 (en) * 2014-04-07 2021-10-21 Novartis Ag Treatment of cancer using anti-CD19 chimeric antigen receptor
RU2696312C2 (ru) * 2014-07-16 2019-08-01 Трансген Са Онколитический вирус для экспрессии модуляторов иммунологических контрольных точек
MX392487B (es) * 2014-10-20 2025-03-21 Juno Therapeutics Inc Métodos y composiciones para dosificación en terapia celular adoptiva.
WO2016073381A1 (en) * 2014-11-03 2016-05-12 Cerus Corporation Compositions and methods for improved car-t cell therapies
CN105884828A (zh) * 2015-02-16 2016-08-24 上海迪诺医药科技有限公司 多环化合物、其药物组合物及应用
WO2017040930A2 (en) * 2015-09-03 2017-03-09 The Trustees Of The University Of Pennsylvania Biomarkers predictive of cytokine release syndrome
EP3353296B1 (en) * 2015-09-24 2020-11-04 Editas Medicine, Inc. Use of exonucleases to improve crispr/cas-mediated genome editing
WO2017079400A1 (en) * 2015-11-04 2017-05-11 The Trustees Of The University Of Pennsylvania Methods and compositions for gene editing in hematopoietic stem cells
US11815514B2 (en) * 2015-12-04 2023-11-14 Juno Therapeutics, Inc. Methods and compositions related to toxicity associated with cell therapy
CN109069539A (zh) * 2016-02-18 2018-12-21 恩立夫克治疗有限责任公司 用于癌症治疗的联合免疫疗法和细胞因子控制疗法
CN106399375A (zh) * 2016-08-31 2017-02-15 南京凯地生物科技有限公司 利用CRISPR/Cas9敲除人PD‑1基因构建靶向CD19CAR‑T细胞的方法
JP2020507339A (ja) * 2017-02-07 2020-03-12 エムイー セラピューティクス インコーポレーテッド 抗g−csf抗体及びその使用
CN107271675B (zh) * 2017-03-24 2020-06-02 郑猛 抗人adrb3单克隆抗体及其在疾病诊断和治疗中的应用
AU2018345751A1 (en) * 2017-10-02 2020-05-07 Humanigen, Inc. Methods of treating immunotherapy-related toxicity using a GM-CSF antagonist
JP7411578B2 (ja) * 2018-06-01 2024-01-11 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ 癌を治療するための物質及び方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010538676A (ja) * 2007-09-18 2010-12-16 アムジェン インコーポレイテッド ヒトgm−csf抗原結合性タンパク質
US20140127814A1 (en) * 2010-08-10 2014-05-08 Srinivasan Chandrasegaran Generation and use of pluripotent stem cells
JP2015522081A (ja) * 2012-07-13 2015-08-03 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Carの抗腫瘍活性のための毒性管理
WO2015066262A1 (en) * 2013-11-04 2015-05-07 Trustees Of Dartmouth College Methods for preventing toxicity of adoptive cell therapy
JP2016538861A (ja) * 2013-11-22 2016-12-15 セレクティス 免疫療法のための化学療法薬耐性t細胞を工学的に作製する方法
JP2015134742A (ja) * 2013-12-19 2015-07-27 国立研究開発法人国立精神・神経医療研究センター GM−CSF産生T細胞制御剤、及びTh1/Th2免疫バランス調節剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PROC. NATL. ACAD. SCI. USA, vol. 94, JPN6023039532, 1997, pages 12557 - 12561, ISSN: 0005304900 *

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