JP2022513199A - 操作されたチロシンアンモニアリアーゼ - Google Patents

操作されたチロシンアンモニアリアーゼ Download PDF

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Publication number
JP2022513199A
JP2022513199A JP2021533201A JP2021533201A JP2022513199A JP 2022513199 A JP2022513199 A JP 2022513199A JP 2021533201 A JP2021533201 A JP 2021533201A JP 2021533201 A JP2021533201 A JP 2021533201A JP 2022513199 A JP2022513199 A JP 2022513199A
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JP
Japan
Prior art keywords
lyase
seq
recombinant
tal
tyrosine ammonia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021533201A
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English (en)
Japanese (ja)
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JP2022513199A5 (enExample
Inventor
ジョイス リウ，
ニッキ デラス，
スティーブン ジェンヌ，
Original Assignee
コデクシス， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by コデクシス， インコーポレイテッド filed Critical コデクシス， インコーポレイテッド
Publication of JP2022513199A publication Critical patent/JP2022513199A/ja
Publication of JP2022513199A5 publication Critical patent/JP2022513199A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/225—Tyrosine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01023—Tyrosine ammonia-lyase (4.3.1.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021533201A 2018-12-14 2019-12-06 操作されたチロシンアンモニアリアーゼ Pending JP2022513199A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862779647P 2018-12-14 2018-12-14
US62/779,647 2018-12-14
PCT/US2019/064891 WO2020123286A1 (en) 2018-12-14 2019-12-06 Engineered tyrosine ammonia lyase

Publications (2)

Publication Number Publication Date
JP2022513199A true JP2022513199A (ja) 2022-02-07
JP2022513199A5 JP2022513199A5 (enExample) 2022-10-20

Family

ID=71073423

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021533201A Pending JP2022513199A (ja) 2018-12-14 2019-12-06 操作されたチロシンアンモニアリアーゼ

Country Status (8)

Country Link
US (3) US11473077B2 (enExample)
EP (1) EP3893860A4 (enExample)
JP (1) JP2022513199A (enExample)
AU (1) AU2019397401A1 (enExample)
CA (1) CA3122524A1 (enExample)
IL (1) IL283894A (enExample)
SG (1) SG11202105668PA (enExample)
WO (1) WO2020123286A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019397401A1 (en) * 2018-12-14 2021-06-17 Codexis, Inc. Engineered tyrosine ammonia lyase
GB202009250D0 (en) 2020-06-17 2020-07-29 Nicoventures Trading Ltd Non-combustible aerosol delivery system
GB202009251D0 (en) 2020-06-17 2020-07-29 Nicoventures Trading Ltd Non-combustible aerosol delivery system
GB202009252D0 (en) 2020-06-17 2020-07-29 Nicoventures Trading Ltd Non-combustible aerosol delivery system, filter unit and assmebly
CN113735394A (zh) * 2021-09-18 2021-12-03 江苏省农业科学院 一种蓝藻泥氨基酸的制备方法及其产品和应用
WO2025226636A1 (en) * 2024-04-26 2025-10-30 Merck Sharp & Dohme Llc Engineered phenylalanine ammonia lyase polypeptides and methods of making and using the same
WO2026125585A2 (en) 2024-12-11 2026-06-18 Bgene Genetics Enzymes with tyrosine ammonia lyase capability and uses thereof

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JP2016516428A (ja) * 2013-04-18 2016-06-09 コデクシス， インコーポレイテッド 操作されたフェニルアラニンアンモニアリアーゼポリペプチド
US20170159038A1 (en) * 2014-04-16 2017-06-08 Codexis, Inc. Engineered tyrosine ammonia lyase

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Also Published As

Publication number Publication date
SG11202105668PA (en) 2021-06-29
WO2020123286A1 (en) 2020-06-18
US11473077B2 (en) 2022-10-18
IL283894A (en) 2021-07-29
EP3893860A4 (en) 2023-03-29
EP3893860A1 (en) 2021-10-20
AU2019397401A1 (en) 2021-06-17
CA3122524A1 (en) 2020-06-18
US20230020928A1 (en) 2023-01-19
US20230002752A1 (en) 2023-01-05
US20200190499A1 (en) 2020-06-18

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