JP2022508768A - ツボクサ抽出物を含む網膜疾患の予防又は治療用組成物 - Google Patents
ツボクサ抽出物を含む網膜疾患の予防又は治療用組成物 Download PDFInfo
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- JP2022508768A JP2022508768A JP2021545658A JP2021545658A JP2022508768A JP 2022508768 A JP2022508768 A JP 2022508768A JP 2021545658 A JP2021545658 A JP 2021545658A JP 2021545658 A JP2021545658 A JP 2021545658A JP 2022508768 A JP2022508768 A JP 2022508768A
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- centella asiatica
- extract
- retinal
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- asiatica extract
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Abstract
Description
以下、具体的な実施例を挙げて本発明をより具体的に説明する。下記実施例は、本発明の理解を助けるための例示に過ぎず、本発明の範囲がこれに限定されるものではない。
Claims (16)
- ツボクサ(Centella asiatica)抽出物を有効成分として含む、酸化的ストレスから網膜神経細胞を保護するための網膜神経細胞保護用食品組成物。
- 前記ツボクサ(Centella asiatica)抽出物が糖利用性増大により網膜神経細胞の生存率又は網膜色素上皮細胞の生存率を改善する、請求項1に記載の食品組成物。
- 前記ツボクサ(Centella asiatica)抽出物が網膜神経細胞のアポトーシス(apoptosis)を抑制する、請求項1に記載の食品組成物。
- 前記ツボクサ(Centella asiatica)抽出物がA2Eによる酸化的ストレスから網膜神経細胞の死滅を防止する、請求項1に記載の食品組成物。
- 前記食品組成物が酸化的ストレスによる網膜神経細胞損傷疾患を予防又は改善する、請求項1に記載の食品組成物。
- ツボクサ(Centella asiatica)抽出物を有効成分として含む、酸化的ストレスによる網膜神経細胞損傷疾患を予防、改善又は治療するための薬学組成物。
- 前記ツボクサ(Centella asiatica)抽出物が糖利用性増大により網膜神経細胞の生存率又は網膜色素上皮細胞の生存率を改善する、請求項6に記載の薬学組成物。
- 前記ツボクサ(Centella asiatica)抽出物が網膜神経細胞のアポトーシス(apoptosis)を抑制する、請求項6に記載の薬学組成物。
- 前記ツボクサ(Centella asiatica)抽出物がA2Eによる酸化的ストレスから網膜神経細胞の死滅を防止する、請求項6に記載の薬学組成物。
- 前記疾患が黄斑変性又は緑内障である、請求項6に記載の薬学組成物。
- 前記ツボクサ(Centella asiatica)抽出物が、水、C1-6の低級アルコール、又はそれらの混合溶媒で抽出した抽出物である、請求項1~10のいずれかに記載の組成物。
- 前記ツボクサ(Centella asiatica)抽出物が30%~90%のエタノール水溶液抽出物である、請求項1~10のいずれかに記載の組成物。
- 前記ツボクサ(Centella asiatica)抽出物が0.01mg/kg/日~10g/kg/日の投与量で投与される、請求項1~10のいずれかに記載の組成物。
- 局所投与用製剤である、請求項6~10のいずれかに記載の組成物。
- 眼科製剤である、請求項14に記載の組成物。
- 前記ツボクサ(Centella asiatica)抽出物が組成物全重量を基準に5~500μg/mlの濃度で組成物に含まれた、請求項1~10のいずれかに記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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KR10-2018-0122947 | 2018-10-16 | ||
KR1020180122947A KR20200042618A (ko) | 2018-10-16 | 2018-10-16 | 병풀 추출물을 포함하는 망막 질환의 예방 또는 치료용 조성물 |
PCT/KR2019/011310 WO2020080673A1 (ko) | 2018-10-16 | 2019-09-03 | 병풀 추출물을 포함하는 망막 질환의 예방 또는 치료용 조성물 |
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JP2022508768A true JP2022508768A (ja) | 2022-01-19 |
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JP2021545658A Pending JP2022508768A (ja) | 2018-10-16 | 2019-09-03 | ツボクサ抽出物を含む網膜疾患の予防又は治療用組成物 |
Country Status (6)
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US (1) | US20220047664A1 (ja) |
EP (1) | EP3868218B1 (ja) |
JP (1) | JP2022508768A (ja) |
KR (1) | KR20200042618A (ja) |
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WO2024095279A1 (en) * | 2022-10-31 | 2024-05-10 | Laila Nutraceuticals | Synergistic herbal composition with nootropic activity for improving cognitive function and gaming performance |
KR102576779B1 (ko) * | 2023-03-29 | 2023-09-11 | 록야 주식회사 | 아시아티코사이드 함량이 증대된 병풀 추출물 및 이의 용도 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005008590A (ja) * | 2003-06-20 | 2005-01-13 | Pola Chem Ind Inc | 経皮吸収促進化粧料 |
JP2005247826A (ja) * | 2004-02-04 | 2005-09-15 | Kose Corp | デコリン産生促進剤及びそれを含有する皮膚外用剤 |
US20100303934A1 (en) * | 2004-06-29 | 2010-12-02 | Oregon Health & Science University | Methods and compositions for nerve regeneration |
WO2017130130A1 (en) * | 2016-01-28 | 2017-08-03 | Roberto Pinelli | Nutritional supplement for maintaining the state of health of the eye |
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KR101426356B1 (ko) * | 2012-05-29 | 2014-08-14 | 한국과학기술연구원 | 감나무 추출물을 포함하는 망막질환 예방 또는 치료용 조성물 |
US9211298B2 (en) * | 2012-11-16 | 2015-12-15 | Song Gao | Compositions containing enriched natural crocin and/or crocetin, and their therapeutic or nutraceutical uses |
FR3027228B1 (fr) * | 2014-10-20 | 2016-12-09 | Valbiotis | Composition comprenant un melange d'extraits vegetaux et utilisation pour agir sur le metabolisme glucidique et/ou lipidique |
CN104689079A (zh) * | 2015-04-01 | 2015-06-10 | 青岛云天生物技术有限公司 | 一种治疗糖尿病视网膜病变的中药组合物及其制备方法 |
KR20170036352A (ko) * | 2015-09-24 | 2017-04-03 | 동아에스티 주식회사 | 들쭉 추출물을 유효성분으로 함유하는 황반변성증 치료용 조성물 |
CN105267632A (zh) * | 2015-10-13 | 2016-01-27 | 青岛辰达生物科技有限公司 | 一种治疗糖尿病性视网膜病变合并黄斑水肿的中药组合物 |
KR101700903B1 (ko) | 2016-06-03 | 2017-02-01 | 신형석 | 병풀 추출물, 티모사포닌, 히아루론산 및 콜라겐을 포함하는 주름 개선용 화장료 조성물 |
KR101957774B1 (ko) | 2017-01-04 | 2019-07-04 | 유씨엘 주식회사 | 병풀 추출물을 포함하는 산화성 염모제 조성물 |
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- 2019-09-03 US US17/274,876 patent/US20220047664A1/en active Pending
- 2019-09-03 JP JP2021545658A patent/JP2022508768A/ja active Pending
- 2019-09-03 EP EP19873759.5A patent/EP3868218B1/en active Active
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005008590A (ja) * | 2003-06-20 | 2005-01-13 | Pola Chem Ind Inc | 経皮吸収促進化粧料 |
JP2005247826A (ja) * | 2004-02-04 | 2005-09-15 | Kose Corp | デコリン産生促進剤及びそれを含有する皮膚外用剤 |
US20100303934A1 (en) * | 2004-06-29 | 2010-12-02 | Oregon Health & Science University | Methods and compositions for nerve regeneration |
WO2017130130A1 (en) * | 2016-01-28 | 2017-08-03 | Roberto Pinelli | Nutritional supplement for maintaining the state of health of the eye |
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KR20200042618A (ko) | 2020-04-24 |
US20220047664A1 (en) | 2022-02-17 |
EP3868218B1 (en) | 2023-07-05 |
EP3868218A1 (en) | 2021-08-25 |
WO2020080673A1 (ko) | 2020-04-23 |
CN112788952A (zh) | 2021-05-11 |
EP3868218A4 (en) | 2022-06-15 |
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