JP2022502366A5 - - Google Patents
Info
- Publication number
- JP2022502366A5 JP2022502366A5 JP2021516369A JP2021516369A JP2022502366A5 JP 2022502366 A5 JP2022502366 A5 JP 2022502366A5 JP 2021516369 A JP2021516369 A JP 2021516369A JP 2021516369 A JP2021516369 A JP 2021516369A JP 2022502366 A5 JP2022502366 A5 JP 2022502366A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- fluorophenyl
- methoxy
- triazole
- naphthyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP1800333 | 2018-09-28 | ||
| HU1800333A HU231223B1 (hu) | 2018-09-28 | 2018-09-28 | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| PCT/IB2019/058208 WO2020065597A1 (en) | 2018-09-28 | 2019-09-27 | Bicyclic derivatives as gabaa α5 receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022502366A JP2022502366A (ja) | 2022-01-11 |
| JP2022502366A5 true JP2022502366A5 (https=) | 2022-09-21 |
| JP7480128B2 JP7480128B2 (ja) | 2024-05-09 |
Family
ID=89992765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021516369A Active JP7480128B2 (ja) | 2018-09-28 | 2019-09-27 | Ｇａｂａａ ａ５受容体モジュレーターとしての二環式誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US12370182B2 (https=) |
| EP (1) | EP3856342B1 (https=) |
| JP (1) | JP7480128B2 (https=) |
| KR (1) | KR20210086631A (https=) |
| CN (1) | CN112805063B (https=) |
| AR (1) | AR116549A1 (https=) |
| AU (1) | AU2019346147B2 (https=) |
| BR (1) | BR112021005837A2 (https=) |
| CA (1) | CA3113072A1 (https=) |
| EA (1) | EA202190857A1 (https=) |
| HU (1) | HU231223B1 (https=) |
| MX (1) | MX2021003670A (https=) |
| TW (1) | TWI868079B (https=) |
| UA (1) | UA130217C2 (https=) |
| WO (1) | WO2020065597A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4126858B1 (en) * | 2020-03-26 | 2026-03-18 | Richter Gedeon Nyrt. | Dihydro-2-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
| TWI901650B (zh) * | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
| HU231691B1 (hu) * | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1237793B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
| CA2288789C (en) | 1997-05-08 | 2009-07-21 | Merck Sharp & Dohme Limited | Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands |
| GB9813576D0 (en) | 1998-06-24 | 1998-08-19 | Merck Sharp & Dohme | Therapeutic agents |
| GB0017518D0 (en) | 2000-07-17 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| JP4148672B2 (ja) * | 2000-11-17 | 2008-09-10 | 武田薬品工業株式会社 | イソオキサゾール誘導体 |
| JP2003261545A (ja) * | 2001-12-28 | 2003-09-19 | Takeda Chem Ind Ltd | 神経栄養因子産生・分泌促進剤 |
| US7595395B2 (en) | 2005-05-16 | 2009-09-29 | Wisys Technology Foundation | Gabaergic agents to treat memory deficits |
| US7790745B2 (en) | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
| US8106077B2 (en) | 2006-05-24 | 2012-01-31 | Eli Lilly And Company | Compounds and methods for modulating FXR |
| WO2008157270A1 (en) | 2007-06-13 | 2008-12-24 | Smithkline Beecham Corporation | Farnesoid x receptor agonists |
| UA100132C2 (en) | 2007-12-04 | 2012-11-26 | Ф. Хоффманн-Ля Рош Аг | Isoxazolo-pyridine derivatives |
| US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| WO2009071464A1 (en) * | 2007-12-04 | 2009-06-11 | F. Hoffmann-La Roche Ag | Isoxazolo-pyrazine derivatives |
| US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| AU2010244552A1 (en) * | 2009-05-05 | 2011-09-29 | F. Hoffmann-La Roche Ag | Isoxazole-pyrazole derivatives |
| MX2011011484A (es) | 2009-05-07 | 2011-11-18 | Hoffmann La Roche | Derivados de isoxazol-piridina como moduladores del acido gamma-aminobutirico. |
| GB2474120B (en) * | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| GB201016088D0 (en) * | 2010-09-24 | 2010-11-10 | Phase Focus Ltd | Improvements in imaging |
| MX341471B (es) | 2010-11-05 | 2016-08-22 | Hoffmann La Roche | Uso de compuestos farmaceuticos activos para el tratamiento de estados patologicos del sistema nervioso central. |
| US8742097B2 (en) * | 2010-11-09 | 2014-06-03 | Hoffmann-La Roche Inc. | Triazole compounds I |
| EP2638035B1 (en) | 2010-11-09 | 2014-12-17 | F.Hoffmann-La Roche Ag | Triazole derivatives as ligands for Gaba receptors |
| AU2011329233A1 (en) * | 2010-11-15 | 2013-05-23 | Abbvie Deutschland Gmbh & Co Kg | NAMPT and ROCK inhibitors |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| US8604062B2 (en) | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
| AR088989A1 (es) | 2011-11-30 | 2014-07-23 | Hoffmann La Roche | Derivados biciclicos de dihidroisoquinolin-1-ona |
| WO2014001278A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| CA2876778A1 (en) | 2012-06-26 | 2014-01-03 | Saniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| CN107108610B (zh) | 2014-12-30 | 2019-06-04 | 豪夫迈·罗氏有限公司 | 用于治疗和预防肝炎b病毒感染的新的四氢吡啶并嘧啶和四氢吡啶并吡啶化合物 |
| WO2017133521A1 (zh) | 2016-02-01 | 2017-08-10 | 山东轩竹医药科技有限公司 | Fxr受体激动剂 |
| ES2910110T3 (es) * | 2016-12-08 | 2022-05-11 | Hoffmann La Roche | Nuevos derivados de isoxazolil-éter como PAM de alfa 5 GABA A |
-
2018
- 2018-09-28 HU HU1800333A patent/HU231223B1/hu unknown
-
2019
- 2019-09-27 WO PCT/IB2019/058208 patent/WO2020065597A1/en not_active Ceased
- 2019-09-27 CA CA3113072A patent/CA3113072A1/en active Pending
- 2019-09-27 BR BR112021005837-0A patent/BR112021005837A2/pt unknown
- 2019-09-27 AU AU2019346147A patent/AU2019346147B2/en active Active
- 2019-09-27 EA EA202190857A patent/EA202190857A1/ru unknown
- 2019-09-27 MX MX2021003670A patent/MX2021003670A/es unknown
- 2019-09-27 EP EP19779613.9A patent/EP3856342B1/en active Active
- 2019-09-27 TW TW108135172A patent/TWI868079B/zh active
- 2019-09-27 KR KR1020217012783A patent/KR20210086631A/ko not_active Ceased
- 2019-09-27 US US17/279,654 patent/US12370182B2/en active Active
- 2019-09-27 CN CN201980063431.3A patent/CN112805063B/zh active Active
- 2019-09-27 JP JP2021516369A patent/JP7480128B2/ja active Active
- 2019-09-27 UA UAA202102250A patent/UA130217C2/uk unknown
- 2019-09-27 AR ARP190102762A patent/AR116549A1/es unknown
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