JP2022501327A - イミダゾキノリン化合物およびその使用 - Google Patents

イミダゾキノリン化合物およびその使用 Download PDF

Info

Publication number
JP2022501327A
JP2022501327A JP2021512742A JP2021512742A JP2022501327A JP 2022501327 A JP2022501327 A JP 2022501327A JP 2021512742 A JP2021512742 A JP 2021512742A JP 2021512742 A JP2021512742 A JP 2021512742A JP 2022501327 A JP2022501327 A JP 2022501327A
Authority
JP
Japan
Prior art keywords
compound
compound according
pharmaceutically acceptable
acceptable salt
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021512742A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020051356A5 (https=
JP2022501327A5 (https=
Inventor
ヤン、リフ
Original Assignee
バーディー バイオファーマシューティカルズ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バーディー バイオファーマシューティカルズ インコーポレイテッド filed Critical バーディー バイオファーマシューティカルズ インコーポレイテッド
Publication of JP2022501327A publication Critical patent/JP2022501327A/ja
Publication of JPWO2020051356A5 publication Critical patent/JPWO2020051356A5/ja
Publication of JP2022501327A5 publication Critical patent/JP2022501327A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021512742A 2018-09-07 2019-09-05 イミダゾキノリン化合物およびその使用 Pending JP2022501327A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862728556P 2018-09-07 2018-09-07
US62/728,556 2018-09-07
PCT/US2019/049784 WO2020051356A1 (en) 2018-09-07 2019-09-05 Imidazoquinoline compounds and uses thereof

Publications (3)

Publication Number Publication Date
JP2022501327A true JP2022501327A (ja) 2022-01-06
JPWO2020051356A5 JPWO2020051356A5 (https=) 2022-07-04
JP2022501327A5 JP2022501327A5 (https=) 2022-07-04

Family

ID=69722888

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021512742A Pending JP2022501327A (ja) 2018-09-07 2019-09-05 イミダゾキノリン化合物およびその使用

Country Status (9)

Country Link
US (1) US20210214354A1 (https=)
EP (2) EP4306523A3 (https=)
JP (1) JP2022501327A (https=)
KR (1) KR20210074290A (https=)
CN (1) CN113164460A (https=)
AU (1) AU2019335366A1 (https=)
CA (1) CA3111786A1 (https=)
ES (1) ES2963112T3 (https=)
WO (1) WO2020051356A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105899539B (zh) 2014-01-10 2021-11-09 博笛生物科技有限公司 用于免疫疗法的化合物和组合物
EP3166976B2 (en) 2014-07-09 2026-04-08 Birdie Biopharmaceuticals Inc. Anti-pd-l1 combinations for treating tumors
CN112587672A (zh) 2014-09-01 2021-04-02 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
CN115252792A (zh) 2016-01-07 2022-11-01 博笛生物科技有限公司 用于治疗肿瘤的抗-egfr组合
CN115350279A (zh) 2016-01-07 2022-11-18 博笛生物科技有限公司 用于治疗肿瘤的抗-her2组合
CN106943596A (zh) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 用于治疗肿瘤的抗-cd20组合
KR102726248B1 (ko) 2016-07-07 2024-11-05 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 항체-애쥬번트 접합체
CN118515666A (zh) 2017-04-27 2024-08-20 博笛生物科技有限公司 2-氨基-喹啉衍生物
IL312120B2 (en) 2017-06-23 2025-06-01 Birdie Biopharmaceuticals Inc Pharmaceutical compositions
AU2020241686A1 (en) 2019-03-15 2021-11-04 Bolt Biotherapeutics, Inc. Immunoconjugates targeting HER2
CN115916342A (zh) * 2020-07-08 2023-04-04 普渡研究基金会 用于治疗纤维化疾病和癌症的化合物、组合物和方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504232A (ja) * 2003-09-05 2007-03-01 アナディス ファーマシューティカルズ インク Ｃ型肝炎ウイルス感染治療用のｔｌｒ７リガンド及びそのプロドラッグの投与
JP2008514548A (ja) * 2004-09-14 2008-05-08 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド イミダゾキノリン化合物
JP2017513883A (ja) * 2014-04-22 2017-06-01 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ４−アミノ−イミダゾキノリン化合物
WO2017118405A1 (en) * 2016-01-07 2017-07-13 Birdie Biopharmaceuticals, Inc. Anti-her2 combinations for treating tumors
JP2017521420A (ja) * 2014-07-09 2017-08-03 シャンハイ バーディー バイオテック インコーポレイテッド 腫瘍を治療するための抗ｐｄ−ｌ１組み合わせ
JP2017521421A (ja) * 2014-07-09 2017-08-03 シャンハイ バーディー バイオテック インコーポレイテッド 癌を治療するための併用療法組成物及び方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US689338A (en) * 1901-03-29 1901-12-17 Nat Faucet Company Tapping-bung.
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US8728486B2 (en) * 2011-05-18 2014-05-20 University Of Kansas Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
WO2013033345A1 (en) * 2011-08-30 2013-03-07 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
CN105732635A (zh) * 2014-12-29 2016-07-06 南京明德新药研发股份有限公司 一类Toll样受体7激动剂

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504232A (ja) * 2003-09-05 2007-03-01 アナディス ファーマシューティカルズ インク Ｃ型肝炎ウイルス感染治療用のｔｌｒ７リガンド及びそのプロドラッグの投与
JP2008514548A (ja) * 2004-09-14 2008-05-08 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド イミダゾキノリン化合物
JP2017513883A (ja) * 2014-04-22 2017-06-01 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ４−アミノ−イミダゾキノリン化合物
JP2017521420A (ja) * 2014-07-09 2017-08-03 シャンハイ バーディー バイオテック インコーポレイテッド 腫瘍を治療するための抗ｐｄ−ｌ１組み合わせ
JP2017521421A (ja) * 2014-07-09 2017-08-03 シャンハイ バーディー バイオテック インコーポレイテッド 癌を治療するための併用療法組成物及び方法
WO2017118405A1 (en) * 2016-01-07 2017-07-13 Birdie Biopharmaceuticals, Inc. Anti-her2 combinations for treating tumors
JP2019501197A (ja) * 2016-01-07 2019-01-17 バーディー バイオファーマシューティカルズ インコーポレイテッド 腫瘍を処置するための抗ｈｅｒ２合剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CE SHI ET AL.: "Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction", ACS MEDICINAL CHEMISTRY LETTERS, vol. 3(6), JPN6023027685, 2012, pages 501 - 504, ISSN: 0005275288 *

Also Published As

Publication number Publication date
EP3846807B1 (en) 2023-08-02
KR20210074290A (ko) 2021-06-21
CN113164460A (zh) 2021-07-23
EP4306523A3 (en) 2024-01-24
EP3846807A4 (en) 2022-05-18
CA3111786A1 (en) 2020-03-12
US20210214354A1 (en) 2021-07-15
EP3846807A1 (en) 2021-07-14
EP4306523A2 (en) 2024-01-17
ES2963112T3 (es) 2024-03-25
AU2019335366A1 (en) 2021-03-25
WO2020051356A1 (en) 2020-03-12

Similar Documents

Publication Publication Date Title
JP2022501327A (ja) イミダゾキノリン化合物およびその使用
US10280180B2 (en) Macrocyclic purines for the treatment of viral infections
KR102164443B1 (ko) Ｉｄｏ 억제제로서 유용한 융합된 이미다졸 유도체
US10875872B2 (en) Heteroaryl amide compounds as sting activators
WO2019227007A1 (en) Tricyclic heterocyclic compounds as sting activators
JP2019505541A (ja) Ｒｓｋ阻害剤として有用なカルボキサミド誘導体
JP2021513996A (ja) Ｐｄ−ｌ１アンタゴニストとしてのインダン−アミン
JP2017528510A (ja) 自己免疫疾患の処置に有用な置換ピリミジン誘導体
WO2025093059A1 (zh) 3-(氨基)亚甲基吲哚啉类衍生物及其制备方法和应用
FI91156C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
CN1269801A (zh) 作为抗病毒剂的嘌呤非环核苷
WO2025093058A1 (zh) 2-氧代吲哚啉类衍生物及其制备方法和应用
KR102606167B1 (ko) 불소 함유 치환 벤조티오펜 화합물, 그의 약학적 조성물 및 응용
WO2019184919A1 (zh) 一种含有金刚烷的化合物及其在治疗癌症中的用途
JP2009537551A (ja) ホルモン受容体を調節するためのピリミジン低分子量リガンド
HK40101420A (en) Imidazoquinoline compounds and uses thereof
CN118541173A (zh) 缀合物、其组合物及其相关方法
HK40057163B (en) Imidazoquinoline compounds and uses thereof
HK40057163A (en) Imidazoquinoline compounds and uses thereof
CN116120254B (zh) 13,14-双一氧化氮供体-β-榄香烯衍生物及其制备和应用
CN112759583B (zh) 包含呋喃基的喹啉类衍生物及其制备方法和用途
CA3152757C (en) 4-amino-imidazoquinoline compounds and use thereof
CN112625025B (zh) 吡啶基取代的喹啉类衍生物及其制备方法和用途
JPWO2018194172A1 (ja) 化合物又はその塩、抗ウイルス剤、医薬組成物
CN103910718B (zh) 双环取代的吡唑酮偶氮类化合物、其制备方法和用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220624

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220624

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230622

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230704

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231004

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231201

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231225

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240305

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240604

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20241001