JP2022186995A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2022186995A5 JP2022186995A5 JP2022172594A JP2022172594A JP2022186995A5 JP 2022186995 A5 JP2022186995 A5 JP 2022186995A5 JP 2022172594 A JP2022172594 A JP 2022172594A JP 2022172594 A JP2022172594 A JP 2022172594A JP 2022186995 A5 JP2022186995 A5 JP 2022186995A5
- Authority
- JP
- Japan
- Prior art keywords
- ppm
- cancer
- values
- theta
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 238000001228 spectrum Methods 0.000 claims 12
- 238000004922 13C solid-state nuclear magnetic resonance spectroscopy Methods 0.000 claims 5
- 238000004319 19F solid-state nuclear magnetic resonance spectroscopy Methods 0.000 claims 5
- 238000001144 powder X-ray diffraction data Methods 0.000 claims 5
- 150000004682 monohydrates Chemical class 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 238000001237 Raman spectrum Methods 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 238000000371 solid-state nuclear magnetic resonance spectroscopy Methods 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010007953 Central nervous system lymphoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 201000008211 brain sarcoma Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000002628 peritoneum cancer Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063078636P | 2020-09-15 | 2020-09-15 | |
| US63/078636 | 2020-09-15 | ||
| US202163240268P | 2021-09-02 | 2021-09-02 | |
| US63/240268 | 2021-09-02 | ||
| JP2021148619A JP7260606B2 (ja) | 2020-09-15 | 2021-09-13 | 固体形態のｃｄｋ４阻害薬 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021148619A Division JP7260606B2 (ja) | 2020-09-15 | 2021-09-13 | 固体形態のｃｄｋ４阻害薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022186995A JP2022186995A (ja) | 2022-12-15 |
| JP2022186995A5 true JP2022186995A5 (https=) | 2023-02-08 |
| JP7291839B2 JP7291839B2 (ja) | 2023-06-15 |
Family
ID=78000744
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021148619A Active JP7260606B2 (ja) | 2020-09-15 | 2021-09-13 | 固体形態のｃｄｋ４阻害薬 |
| JP2022172594A Active JP7291839B2 (ja) | 2020-09-15 | 2022-10-27 | 固体形態のｃｄｋ４阻害薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021148619A Active JP7260606B2 (ja) | 2020-09-15 | 2021-09-13 | 固体形態のｃｄｋ４阻害薬 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US12570641B2 (https=) |
| EP (2) | EP4578450A3 (https=) |
| JP (2) | JP7260606B2 (https=) |
| KR (1) | KR20230069983A (https=) |
| CN (1) | CN116507620B (https=) |
| AU (1) | AU2021345531B2 (https=) |
| DK (1) | DK4214202T3 (https=) |
| ES (1) | ES3022913T3 (https=) |
| FI (1) | FI4214202T3 (https=) |
| HU (1) | HUE070846T2 (https=) |
| MX (1) | MX2023003054A (https=) |
| PL (1) | PL4214202T3 (https=) |
| PT (1) | PT4214202T (https=) |
| SI (1) | SI4214202T1 (https=) |
| TW (2) | TW202334125A (https=) |
| WO (1) | WO2022058871A1 (https=) |
| ZA (1) | ZA202303655B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL320609A (en) | 2019-08-26 | 2025-07-01 | Arvinas Operations Inc | Methods for treating breast cancer with a history of tetrahydronaphthalene as estrogen receptor-disrupting agents |
| SI4214202T1 (sl) | 2020-09-15 | 2025-05-30 | Pfizer Inc. | Trdne oblike inhibitorja cdk4 |
| IL312650A (en) * | 2021-12-02 | 2024-07-01 | Pfizer | CDK4 inhibitor for cancer treatment |
| WO2024023703A1 (en) | 2022-07-29 | 2024-02-01 | Pfizer Inc. | Dosing regimens comprising a kat6 inhibitor for the treatment of cancer |
| CN117645604A (zh) * | 2022-09-05 | 2024-03-05 | 浙江同源康医药股份有限公司 | 用作cdk4激酶抑制剂的化合物及其应用 |
| WO2024201340A1 (en) | 2023-03-30 | 2024-10-03 | Pfizer Inc. | Kat6a as a predictive biomarker for treatment of breast cancer with a cdk4 inhibitor and an antiestrogen and methods of treatment thereof |
| EP4689660A1 (en) | 2023-03-30 | 2026-02-11 | Pfizer Inc. | Kat6a as a predictive biomarker for treatment with a kat6a inhibitor and methods of treatment thereof |
| EP4719405A1 (en) | 2023-06-02 | 2026-04-08 | Pfizer Inc. | Methods and modified dosing regimens comprising a cdk4 inhibitor for the treatment of cancer |
| CN121368483A (zh) | 2023-06-02 | 2026-01-20 | 辉瑞公司 | 雌激素受体降解剂与cdk4抑制剂的组合 |
| WO2025024388A1 (en) | 2023-07-21 | 2025-01-30 | Accutar Biotechnology Inc. | Aminopyrimidine derivatives as cyclin-dependent kinase inhibitors |
| WO2025104624A1 (en) | 2023-11-14 | 2025-05-22 | Pfizer Inc. | Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol |
| WO2025202900A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Cdk4 inhibitors for use in the treatment of mantle cell lymphoma |
| WO2025202871A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Methods for identifying biomarkers of treatment response and use thereof with a cdk4 inhibitor |
| WO2025202854A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Cdk4 inhibitors and combinations with cdk2 inhibitors or further agents for use in the treatment of cancer |
| WO2026025013A2 (en) | 2024-07-26 | 2026-01-29 | Pfizer Inc. | Combination therapy using cdk4 inhibitors for cancer treatments |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| TW201105669A (en) | 2009-07-30 | 2011-02-16 | Irm Llc | Compounds and compositions as Syk kinase inhibitors |
| TW201444820A (zh) | 2013-03-13 | 2014-12-01 | Abbvie Inc | 吡啶ｃｄｋ９激酶抑制劑 |
| CN105111191B (zh) | 2015-07-21 | 2018-06-08 | 上海皓元生物医药科技有限公司 | 一种用于合成cdk9抑制剂的关键中间体及其制备方法和用途 |
| SG11201900328WA (en) | 2016-07-13 | 2019-02-27 | Jason Marineau | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| CN109803968A (zh) | 2016-08-15 | 2019-05-24 | 辉瑞公司 | 吡啶并嘧啶酮cdk2/4/6抑制剂 |
| MD3784664T2 (ro) * | 2018-04-26 | 2025-06-30 | Pfizer | Derivați de 2-amino-piridină sau de 2-amino-pirimidină utilizați ca inhibitori de kinaze dependente de cicline |
| SI4214202T1 (sl) | 2020-09-15 | 2025-05-30 | Pfizer Inc. | Trdne oblike inhibitorja cdk4 |
-
2021
- 2021-09-13 SI SI202130288T patent/SI4214202T1/sl unknown
- 2021-09-13 US US18/245,039 patent/US12570641B2/en active Active
- 2021-09-13 WO PCT/IB2021/058320 patent/WO2022058871A1/en not_active Ceased
- 2021-09-13 FI FIEP21783049.6T patent/FI4214202T3/fi active
- 2021-09-13 PL PL21783049.6T patent/PL4214202T3/pl unknown
- 2021-09-13 PT PT217830496T patent/PT4214202T/pt unknown
- 2021-09-13 AU AU2021345531A patent/AU2021345531B2/en active Active
- 2021-09-13 EP EP25153633.0A patent/EP4578450A3/en active Pending
- 2021-09-13 KR KR1020237012766A patent/KR20230069983A/ko not_active Ceased
- 2021-09-13 ES ES21783049T patent/ES3022913T3/es active Active
- 2021-09-13 DK DK21783049.6T patent/DK4214202T3/da active
- 2021-09-13 JP JP2021148619A patent/JP7260606B2/ja active Active
- 2021-09-13 MX MX2023003054A patent/MX2023003054A/es unknown
- 2021-09-13 HU HUE21783049A patent/HUE070846T2/hu unknown
- 2021-09-13 CN CN202180071477.7A patent/CN116507620B/zh active Active
- 2021-09-13 EP EP21783049.6A patent/EP4214202B1/en active Active
- 2021-09-14 TW TW112102545A patent/TW202334125A/zh unknown
- 2021-09-14 TW TW110134168A patent/TWI809503B/zh active
-
2022
- 2022-10-27 JP JP2022172594A patent/JP7291839B2/ja active Active
-
2023
- 2023-03-16 ZA ZA2023/03655A patent/ZA202303655B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022186995A5 (https=) | ||
| JP2022049005A5 (https=) | ||
| FI4214202T3 (fi) | Cdk4-estäjän kiinteät muodot | |
| JP2021119136A5 (https=) | ||
| CN110573500A (zh) | N-(氮杂芳基)环内酰胺-1-甲酰胺衍生物及其制备方法和应用 | |
| JP2016528179A5 (https=) | ||
| RU2697521C2 (ru) | Кристаллы азабициклического соединения | |
| JP6190079B2 (ja) | ３，５−二置換ベンゼンアルキニル化合物の結晶 | |
| JP2018115191A5 (https=) | ||
| JP2020517616A5 (https=) | ||
| CA3019450A1 (en) | Indoleamine 2,3-dioxygenase inhibitor, preparation method therefor, and application | |
| JP2014527042A5 (https=) | ||
| HRP20100166T1 (hr) | Postupak za pripremu 2-aminotiazol-5-aromatičnih karboksamida kao inhibitora kinaze | |
| JP2013545812A5 (https=) | ||
| JP2020033359A5 (https=) | ||
| JP2022071077A5 (https=) | ||
| JP2020536893A5 (https=) | ||
| RU2012136148A (ru) | Новая кристаллическая форма производного циклопропилбензамида | |
| CN114026068A (zh) | Ep2拮抗剂 | |
| JP2010514725A5 (https=) | ||
| JP2020508337A (ja) | バルベナジン塩の結晶形態 | |
| CN103965174A (zh) | 含有锌结合基的喹唑啉基egfr酪氨酸激酶抑制剂 | |
| JPWO2020210669A5 (https=) | ||
| JPWO2022137106A5 (https=) | ||
| JP2020512975A5 (https=) |