JP7260606B2 - 固体形態のｃｄｋ４阻害薬 - Google Patents
固体形態のｃｄｋ４阻害薬 Download PDFInfo
- Publication number
- JP7260606B2 JP7260606B2 JP2021148619A JP2021148619A JP7260606B2 JP 7260606 B2 JP7260606 B2 JP 7260606B2 JP 2021148619 A JP2021148619 A JP 2021148619A JP 2021148619 A JP2021148619 A JP 2021148619A JP 7260606 B2 JP7260606 B2 JP 7260606B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fats And Perfumes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022172594A JP7291839B2 (ja) | 2020-09-15 | 2022-10-27 | 固体形態のｃｄｋ４阻害薬 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063078636P | 2020-09-15 | 2020-09-15 | |
| US63/078636 | 2020-09-15 | ||
| US202163240268P | 2021-09-02 | 2021-09-02 | |
| US63/240268 | 2021-09-02 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022172594A Division JP7291839B2 (ja) | 2020-09-15 | 2022-10-27 | 固体形態のｃｄｋ４阻害薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022049005A JP2022049005A (ja) | 2022-03-28 |
| JP2022049005A5 JP2022049005A5 (https=) | 2022-05-10 |
| JP7260606B2 true JP7260606B2 (ja) | 2023-04-18 |
Family
ID=78000744
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021148619A Active JP7260606B2 (ja) | 2020-09-15 | 2021-09-13 | 固体形態のｃｄｋ４阻害薬 |
| JP2022172594A Active JP7291839B2 (ja) | 2020-09-15 | 2022-10-27 | 固体形態のｃｄｋ４阻害薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022172594A Active JP7291839B2 (ja) | 2020-09-15 | 2022-10-27 | 固体形態のｃｄｋ４阻害薬 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US12570641B2 (https=) |
| EP (2) | EP4578450A3 (https=) |
| JP (2) | JP7260606B2 (https=) |
| KR (1) | KR20230069983A (https=) |
| CN (1) | CN116507620B (https=) |
| AU (1) | AU2021345531B2 (https=) |
| DK (1) | DK4214202T3 (https=) |
| ES (1) | ES3022913T3 (https=) |
| FI (1) | FI4214202T3 (https=) |
| HU (1) | HUE070846T2 (https=) |
| MX (1) | MX2023003054A (https=) |
| PL (1) | PL4214202T3 (https=) |
| PT (1) | PT4214202T (https=) |
| SI (1) | SI4214202T1 (https=) |
| TW (2) | TW202334125A (https=) |
| WO (1) | WO2022058871A1 (https=) |
| ZA (1) | ZA202303655B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL320609A (en) | 2019-08-26 | 2025-07-01 | Arvinas Operations Inc | Methods for treating breast cancer with a history of tetrahydronaphthalene as estrogen receptor-disrupting agents |
| SI4214202T1 (sl) | 2020-09-15 | 2025-05-30 | Pfizer Inc. | Trdne oblike inhibitorja cdk4 |
| IL312650A (en) * | 2021-12-02 | 2024-07-01 | Pfizer | CDK4 inhibitor for cancer treatment |
| WO2024023703A1 (en) | 2022-07-29 | 2024-02-01 | Pfizer Inc. | Dosing regimens comprising a kat6 inhibitor for the treatment of cancer |
| CN117645604A (zh) * | 2022-09-05 | 2024-03-05 | 浙江同源康医药股份有限公司 | 用作cdk4激酶抑制剂的化合物及其应用 |
| WO2024201340A1 (en) | 2023-03-30 | 2024-10-03 | Pfizer Inc. | Kat6a as a predictive biomarker for treatment of breast cancer with a cdk4 inhibitor and an antiestrogen and methods of treatment thereof |
| EP4689660A1 (en) | 2023-03-30 | 2026-02-11 | Pfizer Inc. | Kat6a as a predictive biomarker for treatment with a kat6a inhibitor and methods of treatment thereof |
| EP4719405A1 (en) | 2023-06-02 | 2026-04-08 | Pfizer Inc. | Methods and modified dosing regimens comprising a cdk4 inhibitor for the treatment of cancer |
| CN121368483A (zh) | 2023-06-02 | 2026-01-20 | 辉瑞公司 | 雌激素受体降解剂与cdk4抑制剂的组合 |
| WO2025024388A1 (en) | 2023-07-21 | 2025-01-30 | Accutar Biotechnology Inc. | Aminopyrimidine derivatives as cyclin-dependent kinase inhibitors |
| WO2025104624A1 (en) | 2023-11-14 | 2025-05-22 | Pfizer Inc. | Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol |
| WO2025202900A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Cdk4 inhibitors for use in the treatment of mantle cell lymphoma |
| WO2025202871A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Methods for identifying biomarkers of treatment response and use thereof with a cdk4 inhibitor |
| WO2025202854A1 (en) | 2024-03-27 | 2025-10-02 | Pfizer Inc. | Cdk4 inhibitors and combinations with cdk2 inhibitors or further agents for use in the treatment of cancer |
| WO2026025013A2 (en) | 2024-07-26 | 2026-01-29 | Pfizer Inc. | Combination therapy using cdk4 inhibitors for cancer treatments |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019207463A1 (en) | 2018-04-26 | 2019-10-31 | Pfizer Inc. | 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| TW201105669A (en) | 2009-07-30 | 2011-02-16 | Irm Llc | Compounds and compositions as Syk kinase inhibitors |
| TW201444820A (zh) | 2013-03-13 | 2014-12-01 | Abbvie Inc | 吡啶ｃｄｋ９激酶抑制劑 |
| CN105111191B (zh) | 2015-07-21 | 2018-06-08 | 上海皓元生物医药科技有限公司 | 一种用于合成cdk9抑制剂的关键中间体及其制备方法和用途 |
| SG11201900328WA (en) | 2016-07-13 | 2019-02-27 | Jason Marineau | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| CN109803968A (zh) | 2016-08-15 | 2019-05-24 | 辉瑞公司 | 吡啶并嘧啶酮cdk2/4/6抑制剂 |
| SI4214202T1 (sl) | 2020-09-15 | 2025-05-30 | Pfizer Inc. | Trdne oblike inhibitorja cdk4 |
-
2021
- 2021-09-13 SI SI202130288T patent/SI4214202T1/sl unknown
- 2021-09-13 US US18/245,039 patent/US12570641B2/en active Active
- 2021-09-13 WO PCT/IB2021/058320 patent/WO2022058871A1/en not_active Ceased
- 2021-09-13 FI FIEP21783049.6T patent/FI4214202T3/fi active
- 2021-09-13 PL PL21783049.6T patent/PL4214202T3/pl unknown
- 2021-09-13 PT PT217830496T patent/PT4214202T/pt unknown
- 2021-09-13 AU AU2021345531A patent/AU2021345531B2/en active Active
- 2021-09-13 EP EP25153633.0A patent/EP4578450A3/en active Pending
- 2021-09-13 KR KR1020237012766A patent/KR20230069983A/ko not_active Ceased
- 2021-09-13 ES ES21783049T patent/ES3022913T3/es active Active
- 2021-09-13 DK DK21783049.6T patent/DK4214202T3/da active
- 2021-09-13 JP JP2021148619A patent/JP7260606B2/ja active Active
- 2021-09-13 MX MX2023003054A patent/MX2023003054A/es unknown
- 2021-09-13 HU HUE21783049A patent/HUE070846T2/hu unknown
- 2021-09-13 CN CN202180071477.7A patent/CN116507620B/zh active Active
- 2021-09-13 EP EP21783049.6A patent/EP4214202B1/en active Active
- 2021-09-14 TW TW112102545A patent/TW202334125A/zh unknown
- 2021-09-14 TW TW110134168A patent/TWI809503B/zh active
-
2022
- 2022-10-27 JP JP2022172594A patent/JP7291839B2/ja active Active
-
2023
- 2023-03-16 ZA ZA2023/03655A patent/ZA202303655B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019207463A1 (en) | 2018-04-26 | 2019-10-31 | Pfizer Inc. | 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
Non-Patent Citations (3)
| Title |
|---|
| 杉本 功 外１名、粉体工学会誌、１９８５年、Ｖｏｌ．２２、Ｎｏ．２、ｐ．８５～９７ |
| 芦澤 一英編著、医薬品の多形現象と晶析の科学、丸善プラネット株式会社、２００２年９月２０日、ｐ．２７３、２７８、３０５～３１７ |
| 高田 則幸、ＰＨＡＲＭ ＳＴＡＧＥ、２００７年１月１５日、Ｖｏｌ．６、Ｎｏ．１０、ｐ．２０～２５ |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021345531B2 (en) | 2024-02-29 |
| EP4578450A2 (en) | 2025-07-02 |
| ES3022913T3 (en) | 2025-05-29 |
| AU2021345531A1 (en) | 2023-04-20 |
| JP2022186995A (ja) | 2022-12-15 |
| DK4214202T3 (da) | 2025-03-31 |
| BR112023004713A2 (pt) | 2023-04-18 |
| TW202334125A (zh) | 2023-09-01 |
| PL4214202T3 (pl) | 2025-05-19 |
| TW202216698A (zh) | 2022-05-01 |
| EP4214202A1 (en) | 2023-07-26 |
| JP7291839B2 (ja) | 2023-06-15 |
| EP4214202B1 (en) | 2025-02-26 |
| CN116507620A (zh) | 2023-07-28 |
| EP4578450A3 (en) | 2025-07-16 |
| PT4214202T (pt) | 2025-04-11 |
| MX2023003054A (es) | 2023-04-05 |
| WO2022058871A1 (en) | 2022-03-24 |
| KR20230069983A (ko) | 2023-05-19 |
| CA3195063A1 (en) | 2022-03-24 |
| HUE070846T2 (hu) | 2025-07-28 |
| CN116507620B (zh) | 2025-11-18 |
| US20230357211A1 (en) | 2023-11-09 |
| US12570641B2 (en) | 2026-03-10 |
| TWI809503B (zh) | 2023-07-21 |
| JP2022049005A (ja) | 2022-03-28 |
| SI4214202T1 (sl) | 2025-05-30 |
| ZA202303655B (en) | 2024-09-25 |
| FI4214202T3 (fi) | 2025-04-25 |
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