JP2022163194A5 - - Google Patents
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- Publication number
- JP2022163194A5 JP2022163194A5 JP2022129624A JP2022129624A JP2022163194A5 JP 2022163194 A5 JP2022163194 A5 JP 2022163194A5 JP 2022129624 A JP2022129624 A JP 2022129624A JP 2022129624 A JP2022129624 A JP 2022129624A JP 2022163194 A5 JP2022163194 A5 JP 2022163194A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- daltons
- seq
- ethylene glycol
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 poly(ethylene glycol) Polymers 0.000 claims 10
- 102000000704 Interleukin-7 Human genes 0.000 claims 7
- 108010002586 Interleukin-7 Proteins 0.000 claims 7
- 229940100994 interleukin-7 Drugs 0.000 claims 7
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000002262 Schiff base Substances 0.000 claims 2
- 150000004753 Schiff bases Chemical class 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131634P | 2015-03-11 | 2015-03-11 | |
| US62/131,634 | 2015-03-11 | ||
| PCT/US2016/022146 WO2016145388A1 (en) | 2015-03-11 | 2016-03-11 | Conjugates of an il-7 moiety and an polymer |
| JP2017547157A JP2018510863A (ja) | 2015-03-11 | 2016-03-11 | Ｉｌ−７部分とポリマーとのコンジュゲート |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547157A Division JP2018510863A (ja) | 2015-03-11 | 2016-03-11 | Ｉｌ−７部分とポリマーとのコンジュゲート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022163194A JP2022163194A (ja) | 2022-10-25 |
| JP2022163194A5 true JP2022163194A5 (enExample) | 2023-01-04 |
Family
ID=56878892
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547157A Withdrawn JP2018510863A (ja) | 2015-03-11 | 2016-03-11 | Ｉｌ−７部分とポリマーとのコンジュゲート |
| JP2021031726A Pending JP2021091708A (ja) | 2015-03-11 | 2021-03-01 | Ｉｌ−７部分とポリマーとのコンジュゲート |
| JP2022129624A Pending JP2022163194A (ja) | 2015-03-11 | 2022-08-16 | Ｉｌ－７部分とポリマーとのコンジュゲート |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547157A Withdrawn JP2018510863A (ja) | 2015-03-11 | 2016-03-11 | Ｉｌ−７部分とポリマーとのコンジュゲート |
| JP2021031726A Pending JP2021091708A (ja) | 2015-03-11 | 2021-03-01 | Ｉｌ−７部分とポリマーとのコンジュゲート |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20190290733A1 (enExample) |
| EP (1) | EP3285799A4 (enExample) |
| JP (3) | JP2018510863A (enExample) |
| KR (2) | KR20170125839A (enExample) |
| CN (1) | CN107405384A (enExample) |
| AU (1) | AU2016228555B2 (enExample) |
| CA (1) | CA2978330C (enExample) |
| IL (1) | IL254389B2 (enExample) |
| MA (1) | MA41957A (enExample) |
| MX (1) | MX391071B (enExample) |
| WO (1) | WO2016145388A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2367891T3 (es) | 2000-09-29 | 2011-11-10 | Schering Corporation | Interleucina-10 pegilada. |
| US20080081031A1 (en) | 2006-09-28 | 2008-04-03 | Schering Corporation | Use of Pegylated IL-10 to Treat Cancer |
| CA2908198A1 (en) | 2013-04-18 | 2014-10-23 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| EP3434277A1 (en) | 2013-06-17 | 2019-01-30 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| RU2016122957A (ru) | 2013-11-11 | 2017-12-19 | Армо Байосайенсиз, Инк. | Способы применения интерлейкина-10 для лечения заболеваний и расстройств |
| CN106573072A (zh) | 2014-06-02 | 2017-04-19 | 阿尔莫生物科技股份有限公司 | 降低血清胆固醇的方法 |
| CN107106655A (zh) | 2014-10-22 | 2017-08-29 | 阿尔莫生物科技股份有限公司 | 使用白细胞介素‑10治疗疾病和病症的方法 |
| WO2016126615A1 (en) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| KR20180020141A (ko) | 2015-05-28 | 2018-02-27 | 아르모 바이오사이언시스 인코포레이티드 | 암 치료에 사용되는 peg화된 인터류킨-10 |
| KR20180038553A (ko) | 2015-08-25 | 2018-04-16 | 아르모 바이오사이언시스 인코포레이티드 | 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법 |
| US11702446B2 (en) | 2018-12-12 | 2023-07-18 | Levim Biotech Llp | Acylation process for preparation of N-substituted peptide |
| WO2022020637A1 (en) * | 2020-07-22 | 2022-01-27 | Nektar Therapeutics | Il-7 receptor agonist composition and related methods and uses |
| EP4463135A2 (en) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666400B2 (en) * | 2005-04-06 | 2010-02-23 | Ibc Pharmaceuticals, Inc. | PEGylation by the dock and lock (DNL) technique |
| WO2002085300A2 (en) * | 2001-04-23 | 2002-10-31 | The Regents Of The University Of California | Methods of using interleukin-7 to modulate physiological processes in mammalian pulmonary fibroblasts |
| JP2005525302A (ja) * | 2001-11-20 | 2005-08-25 | ファルマシア・コーポレーション | 化学的に修飾されたヒト成長ホルモンコンジュゲート |
| EP1391513A1 (en) * | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
| JP2006519170A (ja) * | 2002-12-26 | 2006-08-24 | マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド | サイトカイン、ケモカイン、増殖因子、ポリペプチドホルモン、およびレセプター結合活性が保存されたそのアンタゴニストのポリマー結合体 |
| CN101072793B (zh) * | 2004-12-09 | 2012-06-20 | 默克专利有限公司 | 具有降低的免疫原性的il-7变体 |
| EP2242505A4 (en) * | 2008-01-08 | 2012-03-07 | Biogenerix Ag | GLYCOCONJUGATION OF POLYPEPTIDES USING OLIGOSACCHARYLTRANSFERASES |
| RS61854B1 (sr) * | 2010-11-12 | 2021-06-30 | Nektar Therapeutics | Konjugati il-2 dela i polimera |
| CN102145178B (zh) * | 2011-04-15 | 2012-09-26 | 北京凯因科技股份有限公司 | Peg化白介素15 |
| WO2013020079A2 (en) * | 2011-08-04 | 2013-02-07 | Nektar Therapeutics | Conjugates of an il-11 moiety and a polymer |
| EP2780361B1 (en) * | 2011-11-14 | 2018-01-17 | Emory University | Conjugates of gm-csf and il-7, compositions and methods related thereto |
-
2016
- 2016-03-11 IL IL254389A patent/IL254389B2/en unknown
- 2016-03-11 JP JP2017547157A patent/JP2018510863A/ja not_active Withdrawn
- 2016-03-11 EP EP16762659.7A patent/EP3285799A4/en active Pending
- 2016-03-11 KR KR1020177024937A patent/KR20170125839A/ko not_active Ceased
- 2016-03-11 US US15/556,996 patent/US20190290733A1/en active Pending
- 2016-03-11 AU AU2016228555A patent/AU2016228555B2/en active Active
- 2016-03-11 CN CN201680014816.7A patent/CN107405384A/zh active Pending
- 2016-03-11 KR KR1020257010980A patent/KR20250052471A/ko active Pending
- 2016-03-11 MX MX2017011562A patent/MX391071B/es unknown
- 2016-03-11 CA CA2978330A patent/CA2978330C/en active Active
- 2016-03-11 MA MA041957A patent/MA41957A/fr unknown
- 2016-03-11 WO PCT/US2016/022146 patent/WO2016145388A1/en not_active Ceased
-
2021
- 2021-03-01 JP JP2021031726A patent/JP2021091708A/ja active Pending
-
2022
- 2022-08-16 JP JP2022129624A patent/JP2022163194A/ja active Pending
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