JP2022116008A5 - - Google Patents
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- JP2022116008A5 JP2022116008A5 JP2022077425A JP2022077425A JP2022116008A5 JP 2022116008 A5 JP2022116008 A5 JP 2022116008A5 JP 2022077425 A JP2022077425 A JP 2022077425A JP 2022077425 A JP2022077425 A JP 2022077425A JP 2022116008 A5 JP2022116008 A5 JP 2022116008A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- subject
- pharmaceutically acceptable
- cardiomyopathy
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000031229 Cardiomyopathies Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 201000005943 Barth syndrome Diseases 0.000 claims 3
- 101000835595 Homo sapiens Tafazzin Proteins 0.000 claims 3
- 102100026508 Tafazzin Human genes 0.000 claims 3
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000002327 cardiovascular agent Substances 0.000 claims 2
- 229940125692 cardiovascular agent Drugs 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 229940123413 Angiotensin II antagonist Drugs 0.000 claims 1
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 241000208011 Digitalis Species 0.000 claims 1
- 102000003938 Thromboxane Receptors Human genes 0.000 claims 1
- 108090000300 Thromboxane Receptors Proteins 0.000 claims 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 239000004004 anti-anginal agent Substances 0.000 claims 1
- 229940124345 antianginal agent Drugs 0.000 claims 1
- 239000003416 antiarrhythmic agent Substances 0.000 claims 1
- 239000003524 antilipemic agent Substances 0.000 claims 1
- 229940127218 antiplatelet drug Drugs 0.000 claims 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 239000002368 cardiac glycoside Substances 0.000 claims 1
- 229940097217 cardiac glycoside Drugs 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000001882 diuretic effect Effects 0.000 claims 1
- 239000003527 fibrinolytic agent Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000002516 radical scavenger Substances 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 239000000932 sedative agent Substances 0.000 claims 1
- 230000001624 sedative effect Effects 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 229930002534 steroid glycoside Natural products 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000002889 sympathetic effect Effects 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 claims 1
- 229960000103 thrombolytic agent Drugs 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229940124549 vasodilator Drugs 0.000 claims 1
- 239000003071 vasodilator agent Substances 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361771642P | 2013-03-01 | 2013-03-01 | |
| US201361771534P | 2013-03-01 | 2013-03-01 | |
| US61/771,534 | 2013-03-01 | ||
| US61/771,642 | 2013-03-01 | ||
| US201361839753P | 2013-06-26 | 2013-06-26 | |
| US61/839,753 | 2013-06-26 | ||
| JP2019080101A JP6918046B2 (ja) | 2013-03-01 | 2019-04-19 | バース症候群の予防または治療のための方法及び組成物 |
| JP2021019903A JP7072692B2 (ja) | 2013-03-01 | 2021-02-10 | バース症候群の予防または治療のための方法及び組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021019903A Division JP7072692B2 (ja) | 2013-03-01 | 2021-02-10 | バース症候群の予防または治療のための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022116008A JP2022116008A (ja) | 2022-08-09 |
| JP2022116008A5 true JP2022116008A5 (https=) | 2023-03-03 |
| JP7381652B2 JP7381652B2 (ja) | 2023-11-15 |
Family
ID=51428869
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560377A Active JP6518197B2 (ja) | 2013-03-01 | 2014-02-28 | バース症候群の予防または治療のための方法及び組成物 |
| JP2019080101A Active JP6918046B2 (ja) | 2013-03-01 | 2019-04-19 | バース症候群の予防または治療のための方法及び組成物 |
| JP2021019903A Active JP7072692B2 (ja) | 2013-03-01 | 2021-02-10 | バース症候群の予防または治療のための方法及び組成物 |
| JP2022077425A Active JP7381652B2 (ja) | 2013-03-01 | 2022-05-10 | バース症候群の予防または治療のための方法及び組成物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560377A Active JP6518197B2 (ja) | 2013-03-01 | 2014-02-28 | バース症候群の予防または治療のための方法及び組成物 |
| JP2019080101A Active JP6918046B2 (ja) | 2013-03-01 | 2019-04-19 | バース症候群の予防または治療のための方法及び組成物 |
| JP2021019903A Active JP7072692B2 (ja) | 2013-03-01 | 2021-02-10 | バース症候群の予防または治療のための方法及び組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US9687519B2 (https=) |
| EP (2) | EP3626252A1 (https=) |
| JP (4) | JP6518197B2 (https=) |
| CN (3) | CN105407906A (https=) |
| CA (1) | CA2916880C (https=) |
| DK (1) | DK2961420T3 (https=) |
| ES (1) | ES2750258T3 (https=) |
| HU (1) | HUE046924T2 (https=) |
| WO (1) | WO2014134554A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3009141A1 (en) * | 2011-12-09 | 2016-04-20 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| EP3626252A1 (en) * | 2013-03-01 | 2020-03-25 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention or treatment of barth syndrome |
| CN110339339A (zh) | 2013-03-01 | 2019-10-18 | 康德生物医疗技术公司 | 治疗线粒体疾病的方法 |
| US10047395B2 (en) * | 2013-06-26 | 2018-08-14 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| US9550981B2 (en) | 2014-01-22 | 2017-01-24 | University Of Washington | Modified tafazzin proteins and methods of making and using the same |
| WO2016094791A1 (en) * | 2014-12-12 | 2016-06-16 | University Of Washington | Methods for treating and preventing cardiomyopathy |
| WO2018104172A1 (en) | 2016-12-06 | 2018-06-14 | Centre National De La Recherche Scientifique (Cnrs) | Compounds for treating barth syndrome |
| CN110914287A (zh) | 2017-04-05 | 2020-03-24 | 隐形生物治疗公司 | Boc-d-arg-dmt-lys-(boc)-phe-nh2的结晶盐形式 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| EP3898653A4 (en) | 2018-12-18 | 2022-08-24 | Stealth BioTherapeutics Inc. | ANALOGS TARGETING MITOCHONDRIAL DISEASES |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| US7713733B2 (en) | 2001-08-06 | 2010-05-11 | Vanderbilt University | Device and methods for detecting the response of a plurality of cells to at least one analyte of interest |
| BRPI0105509B8 (pt) | 2001-11-05 | 2021-05-25 | Univ Minas Gerais | formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga |
| SI2656854T1 (sl) | 2003-02-04 | 2015-09-30 | Cornell Research Foundation, Inc. | Uporabe aromatsko-kationskega peptida |
| CN101440124B (zh) | 2003-02-04 | 2012-07-18 | 科内尔研究基金会 | 用于防止线粒体通透性改变的方法 |
| AU2004210013A1 (en) * | 2003-02-10 | 2004-08-19 | Autogen Research Pty Ltd | Therapeutic molecules |
| WO2005023274A1 (en) | 2003-09-05 | 2005-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium |
| CA2851972C (en) | 2004-01-23 | 2015-06-23 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| US8500720B2 (en) | 2005-05-09 | 2013-08-06 | Medtronic, Inc | Method and apparatus for treatment of cardiac disorders |
| US20070265216A1 (en) * | 2005-10-05 | 2007-11-15 | Gross Richard W | Enhanced medical treatment in diabetic cardiomyopathy |
| US20090298848A1 (en) | 2006-04-18 | 2009-12-03 | Cortendo Invest Ab, | Methods and Compositions for Treating Barth Syndrome, Cardiomyopathy, Mitochondrial Diseases and Other Conditions |
| EP2150117A4 (en) | 2007-05-02 | 2011-10-05 | Mclean Hospital Corp | METHODS AND COMPOSITIONS FOR MITOCHONDRIA REPLACEMENT THERAPY |
| US20080318909A1 (en) | 2007-06-14 | 2008-12-25 | Sparagna Genevieve C | Use Of Linoleic Compounds Against Heart Failure |
| US20090143279A1 (en) | 2007-06-15 | 2009-06-04 | Vamsi Krishna Mootha | Methods and compositions for treating metabolic disorders |
| DK2262520T3 (en) | 2008-02-26 | 2017-08-07 | Univ Cornell | COMPOSITIONS FOR PREVENTION AND TREATMENT OF Kidney Injury |
| WO2009149307A2 (en) | 2008-06-04 | 2009-12-10 | San Diego State University Research Foundation | Compositions and methods for restoring mitochondrial electron transfer function |
| AU2009280021B2 (en) | 2008-08-07 | 2012-10-04 | Ipsen Pharma S.A.S. | Analogues of glucose-dependent insulinotropic polypeptide (GIP) modified at N-terminal |
| EP3563862B1 (en) | 2009-03-20 | 2021-05-05 | The General Hospital Corporation d/b/a Massachusetts General Hospital | D-arg-2'6'-dimethyltyrosine-lys-phe-nh2 for use in the prevention of secondary complications of burn injuries |
| EP2419513A2 (en) | 2009-04-17 | 2012-02-22 | The Salk Institute For Biological Studies | Regulation of aging by modulation of mitochondrial function |
| WO2010132347A2 (en) | 2009-05-11 | 2010-11-18 | University Of Maryland, Baltimore | Docosahexaenoic acid for the treatment of heart failure |
| CN105031605A (zh) | 2009-08-12 | 2015-11-11 | 康奈尔大学 | 预防或治疗代谢综合症的方法 |
| PL2470191T3 (pl) * | 2009-08-24 | 2014-09-30 | Stealth Peptides Int Inc | Sposoby i kompozycje do profilaktyki lub leczenia stanów okulistycznych |
| EP2485749A4 (en) | 2009-10-05 | 2013-07-24 | Univ Cornell | METHOD FOR THE PREVENTION AND TREATMENT OF HEART FAILURE |
| CN103751763A (zh) | 2009-12-31 | 2014-04-30 | 康肽德生物医药技术有限公司 | 用于预防或治疗血管阻塞损伤的方法 |
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| JP4643749B1 (ja) | 2010-02-03 | 2011-03-02 | 昭和電工株式会社 | 表面被覆サーメット部材の耐酸化膜形成用の処理液 |
| EP3332795A1 (en) | 2010-02-26 | 2018-06-13 | Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| EP3375449A1 (en) * | 2010-03-15 | 2018-09-19 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| JP2013532124A (ja) | 2010-05-03 | 2013-08-15 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 芳香族系陽イオンペプチド及びその使用 |
| WO2012009171A2 (en) | 2010-07-15 | 2012-01-19 | The Schepens Eye Research Institute, Inc. | Compositions and methods of treatment of corneal endothelium disorders |
| EP2601168A4 (en) | 2010-08-06 | 2013-12-04 | Ampere Life Sciences Inc | TREATMENT OF MITOCHONDRIAL DISEASES BY VITAMIN K |
| EA201300215A1 (ru) | 2010-08-06 | 2013-07-30 | Эдисон Фармасьютикалз, Инк. | Лечение митохондриальных болезней нафтохинонами |
| US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| CA2831151A1 (en) * | 2011-03-24 | 2012-09-27 | Cornell University | Aromatic-cationic peptides and uses of same |
| AU2012315586B2 (en) | 2011-09-29 | 2017-07-20 | Mayo Foundation For Medical Education And Research | Aromatic-cationic peptides and methods for using same |
| WO2013059071A1 (en) | 2011-10-17 | 2013-04-25 | Cornell University | Aromatic-cationic peptides and uses of same |
| CN104094119A (zh) * | 2011-10-21 | 2014-10-08 | 斯特姆詹尼克斯公司 | 用于胞内传递生物活性分子的官能化纳米粒子 |
| HK1204988A1 (en) | 2012-02-22 | 2015-12-11 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating ophthalmic conditions |
| CA2865409C (en) * | 2012-02-23 | 2020-07-21 | Cornell University | Aromatic-cationic peptides and uses of same |
| AU2013329312A1 (en) | 2012-10-09 | 2015-05-28 | Massachusetts Institute Of Technology | Treatment of age-related and mitochondrial diseases by inhibition of HIF-1 alpha function |
| AU2013334788A1 (en) * | 2012-10-22 | 2015-06-04 | Henry Ford Health Systems | Methods for reducing risks associated with heart failure and factors associated therewith |
| CN110339339A (zh) | 2013-03-01 | 2019-10-18 | 康德生物医疗技术公司 | 治疗线粒体疾病的方法 |
| EP3626252A1 (en) * | 2013-03-01 | 2020-03-25 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention or treatment of barth syndrome |
| US10047395B2 (en) * | 2013-06-26 | 2018-08-14 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
-
2014
- 2014-02-28 EP EP19190165.1A patent/EP3626252A1/en not_active Withdrawn
- 2014-02-28 JP JP2015560377A patent/JP6518197B2/ja active Active
- 2014-02-28 CN CN201480022767.2A patent/CN105407906A/zh active Pending
- 2014-02-28 CA CA2916880A patent/CA2916880C/en active Active
- 2014-02-28 WO PCT/US2014/019622 patent/WO2014134554A1/en not_active Ceased
- 2014-02-28 US US14/771,408 patent/US9687519B2/en active Active
- 2014-02-28 CN CN202211635437.3A patent/CN115990242A/zh active Pending
- 2014-02-28 EP EP14756991.7A patent/EP2961420B1/en active Active
- 2014-02-28 CN CN202211634590.4A patent/CN115990241A/zh active Pending
- 2014-02-28 DK DK14756991.7T patent/DK2961420T3/da active
- 2014-02-28 ES ES14756991T patent/ES2750258T3/es active Active
- 2014-02-28 HU HUE14756991A patent/HUE046924T2/hu unknown
-
2017
- 2017-06-19 US US15/626,255 patent/US11083771B2/en active Active
-
2019
- 2019-04-19 JP JP2019080101A patent/JP6918046B2/ja active Active
-
2020
- 2020-07-15 US US16/929,370 patent/US11083772B2/en active Active
-
2021
- 2021-02-10 JP JP2021019903A patent/JP7072692B2/ja active Active
- 2021-07-09 US US17/371,475 patent/US11771734B2/en active Active
-
2022
- 2022-05-10 JP JP2022077425A patent/JP7381652B2/ja active Active
-
2023
- 2023-08-23 US US18/454,319 patent/US12268724B2/en active Active
-
2025
- 2025-03-10 US US19/074,720 patent/US20260061023A1/en active Pending
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