JP2022105062A5 - - Google Patents
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- JP2022105062A5 JP2022105062A5 JP2022070030A JP2022070030A JP2022105062A5 JP 2022105062 A5 JP2022105062 A5 JP 2022105062A5 JP 2022070030 A JP2022070030 A JP 2022070030A JP 2022070030 A JP2022070030 A JP 2022070030A JP 2022105062 A5 JP2022105062 A5 JP 2022105062A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- dna
- oligonucleotide
- sample
- ligation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 70
- 239000000523 sample Substances 0.000 claims 54
- 108020004414 DNA Proteins 0.000 claims 50
- 239000002773 nucleotide Substances 0.000 claims 20
- 125000003729 nucleotide group Chemical group 0.000 claims 20
- 239000012634 fragment Substances 0.000 claims 16
- 102000003960 Ligases Human genes 0.000 claims 13
- 108090000364 Ligases Proteins 0.000 claims 13
- 102000053602 DNA Human genes 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 102000012410 DNA Ligases Human genes 0.000 claims 4
- 108010061982 DNA Ligases Proteins 0.000 claims 4
- 238000001712 DNA sequencing Methods 0.000 claims 4
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 4
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 4
- 239000012530 fluid Substances 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 210000003097 mucus Anatomy 0.000 claims 3
- 210000000582 semen Anatomy 0.000 claims 3
- 108020004635 Complementary DNA Proteins 0.000 claims 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 238000010804 cDNA synthesis Methods 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 208000035657 Abasia Diseases 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 206010003445 Ascites Diseases 0.000 claims 1
- 241000238557 Decapoda Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 108091093078 Pyrimidine dimer Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- ASJWEHCPLGMOJE-LJMGSBPFSA-N ac1l3rvh Chemical compound N1C(=O)NC(=O)[C@@]2(C)[C@@]3(C)C(=O)NC(=O)N[C@H]3[C@H]21 ASJWEHCPLGMOJE-LJMGSBPFSA-N 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000002533 bulbourethral gland Anatomy 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 230000002550 fecal effect Effects 0.000 claims 1
- 238000012252 genetic analysis Methods 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 231100000640 hair analysis Toxicity 0.000 claims 1
- 210000003780 hair follicle Anatomy 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 210000004880 lymph fluid Anatomy 0.000 claims 1
- 230000001926 lymphatic effect Effects 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 210000004908 prostatic fluid Anatomy 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023099273A JP2023113960A (ja) | 2015-11-11 | 2023-06-16 | Ｄｎａライブラリーの高効率構築 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562254110P | 2015-11-11 | 2015-11-11 | |
| US62/254,110 | 2015-11-11 | ||
| JP2021010196A JP7223788B2 (ja) | 2015-11-11 | 2021-01-26 | Ｄｎａライブラリーの高効率構築 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021010196A Division JP7223788B2 (ja) | 2015-11-11 | 2021-01-26 | Ｄｎａライブラリーの高効率構築 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023099273A Division JP2023113960A (ja) | 2015-11-11 | 2023-06-16 | Ｄｎａライブラリーの高効率構築 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022105062A JP2022105062A (ja) | 2022-07-12 |
| JP2022105062A5 true JP2022105062A5 (https=) | 2023-02-24 |
| JP7318054B2 JP7318054B2 (ja) | 2023-07-31 |
Family
ID=58695623
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524250A Active JP6913089B2 (ja) | 2015-11-11 | 2016-11-10 | Ｄｎａライブラリーの高効率構築 |
| JP2021010196A Active JP7223788B2 (ja) | 2015-11-11 | 2021-01-26 | Ｄｎａライブラリーの高効率構築 |
| JP2022070030A Active JP7318054B2 (ja) | 2015-11-11 | 2022-04-21 | Ｄｎａライブラリーの高効率構築 |
| JP2023099273A Pending JP2023113960A (ja) | 2015-11-11 | 2023-06-16 | Ｄｎａライブラリーの高効率構築 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524250A Active JP6913089B2 (ja) | 2015-11-11 | 2016-11-10 | Ｄｎａライブラリーの高効率構築 |
| JP2021010196A Active JP7223788B2 (ja) | 2015-11-11 | 2021-01-26 | Ｄｎａライブラリーの高効率構築 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023099273A Pending JP2023113960A (ja) | 2015-11-11 | 2023-06-16 | Ｄｎａライブラリーの高効率構築 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11339391B2 (https=) |
| EP (2) | EP3374525B1 (https=) |
| JP (4) | JP6913089B2 (https=) |
| KR (1) | KR102788327B1 (https=) |
| CN (2) | CN115044645A (https=) |
| AU (1) | AU2016353133B2 (https=) |
| CA (1) | CA3004435A1 (https=) |
| DK (1) | DK3374525T3 (https=) |
| ES (1) | ES2856598T3 (https=) |
| IL (2) | IL285202B2 (https=) |
| MX (2) | MX2018005858A (https=) |
| RU (1) | RU2018121254A (https=) |
| WO (1) | WO2017083562A1 (https=) |
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| JP6913089B2 (ja) | 2015-11-11 | 2021-08-04 | レゾリューション バイオサイエンス， インコーポレイテッド | Ｄｎａライブラリーの高効率構築 |
| US11319594B2 (en) * | 2016-08-25 | 2022-05-03 | Resolution Bioscience, Inc. | Methods for the detection of genomic copy changes in DNA samples |
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| AU2018328324B2 (en) | 2017-09-11 | 2024-12-12 | Ludwig Institute For Cancer Research Ltd | Selective labeling of 5-methylcytosine in circulating cell-free DNA |
| CN111526793A (zh) | 2017-10-27 | 2020-08-11 | 朱诺诊断学公司 | 用于超低体积液体活检的设备、系统和方法 |
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