JP2022082618A - Medical liquid injection device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To easily set up an appropriate amount of contrast medium, while retaining properties of bolus, even in a case where a type of the contrast media is changed.

SOLUTION: A medical liquid injection device includes an injection head, and an injection control part. In the injection control part, a plurality of parameters as a base for setting up injection protocol are registered, the parameters including mix injection for injecting a contrast medium and physiological saline at a prescribed mixing ratio. When a concentration of the contrast-enhancing agent of the contrast medium out of the parameters is changed, the injection control part changes the mixing ratio according to the changed concentration and applies a changed mixing ratio to the injection protocol.

SELECTED DRAWING: Figure 10

COPYRIGHT: (C)2022,JPO&INPIT

Description

The present invention relates to a drug solution injection device that injects a contrast medium into a subject in order to obtain a good contrast effect when a fluoroscopic image of the subject is imaged by an image diagnostic device.

Medical diagnostic imaging devices include CT devices, MRI devices, PET devices, angio devices, MRA devices, ultrasonic diagnostic imaging devices, and the like. When using these devices, a chemical solution such as a contrast medium or physiological saline is often injected into the subject in order to enhance the contrast effect. The contrast agent contains a contrast enhancer.

Usually, these chemicals are filled in a container such as a syringe or a bottle and used, and a chemical injection device is generally used to inject the chemicals filled in the container. The chemical injection device has a holding mechanism for holding the container and a driving mechanism for operating the chemical liquid to be discharged from the container. By operating the drive mechanism while the container is held by the holding mechanism, the drug solution filled in the container can be injected into the subject.

When injecting the drug solution, the conditions for injecting the drug solution are set so that a fluoroscopic image optimal for diagnostic imaging can be obtained. For example, in the imaging of a CT image, the injection amount of the contrast medium is set so that the CT value proportional to the concentration of the contrast medium in the blood is maintained at a certain value or more at least during the imaging period.

On the other hand, for example, in a CT device, there is a proportional relationship between the CT value and the injection amount of the contrast medium, and between the CT value and the injection rate of the contrast medium. Further, the CT value has a correlation with the irradiation intensity of the electromagnetic wave from the fluoroscopic imaging device, specifically, the tube voltage which is the voltage applied to the X-ray tube of the CT device, and the lower the tube voltage, the more. , The obtained CT value is high. Therefore, by lowering the set value of the tube voltage, the optimum CT value can be obtained with a smaller amount of contrast medium. Utilizing this relationship, in Patent Document 1, the tube voltage of the CT device is taken into consideration in calculating the injection amount of the contrast medium, and the tube voltage is stepped according to the purpose of imaging and the symptoms of the subject. It is stated that it can be changed.

Japanese Patent No. 5416761

As described above, imaging a fluoroscopic image with a lower tube voltage enables imaging with a smaller amount of contrast medium, and as a result, can reduce the physical burden on the subject. However, since a noisy image can be obtained when a fluoroscopic image is imaged with a low tube voltage, imaging with a low tube voltage has not been performed so much in the past. However, noise has been reduced due to improvements in image processing technology in recent years, and as a result, images with less noise can be obtained even when images are taken with a lower tube voltage.

Here, when the tube voltage is set to a low value and the injection amount of the contrast medium is reduced, a new problem arises. Even when the injection amount of the contrast medium is reduced, the injection time is usually not changed because the injection time is often determined according to the imaging time. Therefore, reducing the injection amount of the contrast medium results in a decrease in the injection rate. If the injection amount and injection speed are too low, the contrast medium will not maintain the bolus property of the contrast medium until it reaches the target site, and will diffuse into the blood, resulting in sufficient injection. Sometimes the CT value could not be obtained.

Such a phenomenon can occur, for example, in the following situations. When taking a CT image of the heart, the contrast medium is injected, for example, from the basilic vein of the arm and flows into the superior vena cava. The superior vena cava joins the inferior vena cava shortly before reaching the right ventricle of the heart. At this time, if the injection amount of the contrast agent is too small or the injection speed is too low, the blood flow from the inferior vena cava or the superior vena cava itself becomes difficult to flow, and the contrast agent enters the blood. It spreads and the bolus property cannot be maintained.

In order to maintain good bolus even with a small amount of contrast medium, it is conceivable to dilute the contrast medium with physiological saline. However, there are several types of contrast media with different concentrations of contrast enhancer (eg, iodine) that affect the contrast effect. Therefore, in order to obtain a good contrast effect regardless of the type of contrast medium, the dilution rate of the contrast medium is newly obtained according to the type of contrast medium, particularly the concentration of the contrast medium, and a new dilution rate is used. It will be necessary to configure the injection protocol based on this.

One of the objects of the present invention is to make it possible to easily set an appropriate amount of contrast medium while maintaining bolus even when the type of contrast medium is changed.

According to one aspect of the present invention, when a medical image of a subject is imaged using a fluoroscopic imaging device having an electromagnetic wave irradiator, a contrast medium and a physiological saline solution are injected into the subject prior to the imaging of the medical image. It is a chemical injection device that
A first driving mechanism that operates to drain the contrast medium from the first container filled with the contrast medium, and a second driving mechanism filled with the saline solution to drain the saline solution. With a second drive mechanism that operates in, and an injection head,
At least one data entry interface that accepts data entry,
The injection protocol of the contrast medium and the saline solution is set using the data input via the data input interface, and the operation of the first drive mechanism and the second drive mechanism according to the set injection protocol. With an injection control unit configured to control
Have,
The injection control unit is registered with the injection protocol including mixed injection in which a contrast medium and physiological saline are injected at a predetermined mixing ratio, which are set using a plurality of parameters.
When the concentration of the contrast enhancer of the contrast medium is changed among the plurality of parameters used to set the registered injection protocol, the injection control unit may perform the injection control unit according to the changed concentration. Provided is a drug solution infusion apparatus configured to change the admixture ratio and apply the modified admixture ratio to the infusion protocol.

The present invention also provides a fluoroscopic imaging system.
A fluoroscopic imager with an electromagnetic wave irradiator and
A plurality of containers including a first container for contrast medium and a second container for saline solution.
Injection including a first driving mechanism that operates to discharge the contrast medium from the first container and a second driving mechanism that operates to discharge the physiological saline solution from the second container. With the head
At least one data entry interface that accepts data entry,
The injection protocol of the contrast medium and the saline solution is set using the data input via the data input interface, and the operation of the first drive mechanism and the second drive mechanism according to the set injection protocol. With an injection control unit configured to control
Have,
The injection control unit is registered with the injection protocol including mixed injection in which a contrast medium and physiological saline are injected at a predetermined mixing ratio, which are set using a plurality of parameters.
When the concentration of the contrast enhancer of the contrast medium is changed among the plurality of parameters used to set the registered injection protocol, the injection control unit may perform the injection control unit according to the changed concentration. It is configured to change the mixing ratio and apply the changed mixing ratio to the injection protocol.

According to still another aspect of the present invention, a first driving mechanism that operates to drain the contrast medium from a first container filled with the contrast medium and a second driven mechanism filled with saline. A second drive mechanism that operates to drain the saline solution from the container, and an injection protocol of the contrast medium and the saline solution are set, and the first drive mechanism and the first drive mechanism and the above are set according to the set injection protocol. The injection control unit for controlling the operation of the second drive mechanism, and the mixture injection including the mixture injection in which the contrast medium and the physiological saline solution are injected at a predetermined mixing ratio, which is set by using a plurality of parameters. It is a control method of the drug solution injection device for which the injection protocol is set.
When the concentration of the contrast enhancer of the contrast medium is changed among the plurality of parameters used by the injection control unit to set the registered injection protocol, the mixture is made according to the changed concentration. Steps to change the ratio and
A step in which the injection control unit applies the modified miscibility to the injection protocol.
A method for controlling a drug solution injection device is provided.

According to still another aspect of the present invention, there is a calculation method of an injection protocol including mixed injection in which a contrast medium and physiological saline are injected at a predetermined mixing ratio in a drug solution injection device having an injection control unit.
A step of obtaining a reference injection amount, which is an injection amount when the injection control unit injects only the contrast medium in the mixed injection, and a step.
A step in which the injection control unit obtains an actual miscibility ratio, which is an actual miscibility ratio, from a preset reference miscibility ratio and the concentration of the contrast enhancer of the contrast medium.
A step in which the injection control unit obtains the injection amount of the contrast medium and the injection amount of the physiological saline using the obtained reference injection amount and the actual miscibility ratio.
A method of calculating an injection protocol with is provided.

In the present invention, the "injection protocol" indicates what kind of drug solution is to be injected under what conditions (amount, rate, time, etc.). In addition, when injecting a plurality of drug solutions, for example, a contrast medium and a saline solution, the injection sequence thereof and the injection conditions for each are also included in the injection protocol.

In the present invention, the "perspective image pickup device" refers to a device such as a CT device, an angio device, and an MRI device that captures a fluoroscopic image by using the irradiation of electromagnetic waves, and the "perspective image pickup device" refers to a "transparent image pickup device" that irradiates electromagnetic waves. It has an "electromagnetic wave irradiator". The CT device and the angio device have an X-ray tube as an "electromagnetic wave irradiator", and the MRI device has a high frequency pulse transmitter for irradiating a high frequency pulse as an "electromagnetic wave irradiator".

In the present invention, the "contrast agent" is administered to a subject in order to give contrast to the image or emphasize a specific tissue when the fluoroscopic image of the subject is imaged by using a fluoroscopic imaging device. It refers to a chemical solution and contains a "contrast enhancer". "Contrast enhancer" includes iodine (used when imaging images using CT and angio equipment), gadolinium (used when imaging images using MRI equipment), barium, carbon dioxide. Examples include gas.

In the present invention, the "mixture ratio" means the amount of contrast medium with respect to the total amount of contrast medium to be injected and the amount of physiological saline solution, which is represented by (amount of contrast medium) / (amount of contrast medium + amount of physiological saline). ..

According to the present invention, even when the type of contrast medium used is changed, the mixing ratio of the contrast medium and the physiological saline is changed according to the concentration of the contrast medium-enhancing agent of the changed contrast medium. Therefore, it is possible to set an appropriate amount of contrast medium extremely easily while maintaining the bolus property.

It is a layout drawing of the fluoroscopic imaging system by one Embodiment of this invention. It is a front view of the console shown in FIG. It is a perspective view of the injection head shown in FIG. It is a figure explaining the procedure of attaching a syringe to the injection head shown in FIG. 1. It is a figure explaining the procedure of attaching a syringe to the injection head shown in FIG. 1. It is a block diagram which shows the main function of the control system in the fluoroscopic imaging system shown in FIG. It is sectional drawing which shows the positional relationship between the RFID tag and the antenna of an RFID module in a state where a cylinder is normally attached to a cylinder holding mechanism. It is a figure which shows one form of the extension tube connected to a syringe. It is a figure which shows an example of the injection condition call screen displayed on the display unit in one Embodiment of this invention. It is a figure which shows the next step of the injection condition call screen shown in FIG. It is a figure which shows an example of the protocol screen displayed on the display unit in one Embodiment of this invention. It is a figure which shows an example of the screen for injection pattern selection among the protocol setting screens displayed on the display unit in one Embodiment of this invention. It is a figure which shows an example of the screen for inputting some of the items necessary for setting the injection protocol among the protocol setting screens displayed on the display unit in one Embodiment of this invention. It is a perspective view which shows one form of the structure of the syringe which can be used in this invention. It is a perspective view which shows the other form of the structure of the syringe which can be used in this invention. It is a figure which shows the other form of the extension tube connected to a syringe schematically. It is a perspective view of the mixing device provided in the extension tube shown in FIG. 13A. It is sectional drawing of the mixing tube provided in the extension tube shown in FIG. 14A. It is a perspective view which shows an example of the arrangement of the 2nd display unit which can be provided in the fluoroscopic imaging system of this invention. It is a perspective view which shows the other example of the arrangement of the 2nd display unit which the fluoroscopic imaging system of this invention can have. It is a block diagram of the fluoroscopic imaging system by another embodiment of this invention.

Referring to FIG. 1, a fluoroscopic imaging system according to an embodiment of the present invention, which includes a fluoroscopic imaging device 200 and a chemical solution injection device 100, is shown. The fluoroscopic imaging device 200 and the chemical solution injection device 100 can be connected to each other so that data can be transmitted and received between them. The connection between the fluoroscopic image pickup device 200 and the chemical solution injection device 100 may be a wired connection or a wireless connection.

The fluoroscopic imaging device 200 includes a scanner 201 that executes an imaging operation and an imaging control unit (not shown) that controls the operation of the scanner 201, and is a medical image of a subject in which the drug solution is injected by the drug solution injection device 100. Can be obtained. The scanner 201 has an electromagnetic wave irradiator 153 (see FIG. 6) that irradiates an electromagnetic wave, and the electromagnetic wave irradiator 153 can change the setting of the electromagnetic wave irradiation intensity. The image pickup control unit can include a display device such as a liquid crystal display capable of displaying an image pickup condition and an acquired tomographic image, and an input device such as a keyboard and / or a mouse for inputting an image pickup condition and the like. The display device may have a touch screen that also serves as an input device.

The chemical injection device 100 includes, for example, an injection head 110 rotatably attached to the upper part of the stand 121 via a swivel arm 122 in the vertical direction, and various functions for controlling the operation of the entire chemical injection device 100. It also has a console 101. The injection head 110 and the console 101 may be configured in one housing, but in the present embodiment, the injection head 110 and the console 101 are configured as separate units. In this case, the injection head 110 can be arranged in the examination room together with the scanner 201, and the console 101 can be arranged in the operation room together with the image pickup control unit of the fluoroscopic image pickup device 200. The stand 121 can be a stand with casters to facilitate the movement of the injection head 110.

The console 101 has a built-in AC / DC converter, and power converted from alternating current to direct current is supplied to the console 101. As shown in FIG. 2, the console 101 includes a button group 102 including a stop button 102a for forcibly stopping the injection, a home button 102b for displaying the home screen, and a power button 102c for power on / off. It has a touch panel 103 that also serves as an input unit and a display unit.

As shown in FIGS. 3 to 5, the injection head 110 can be detachably attached with two syringes 800, which are containers filled with chemicals. The syringe 800 can be, for example, one for a contrast medium and the other for a saline solution. The syringe 800 has a cylinder that houses a chemical solution and has a conduit formed at the tip thereof, and a piston that is inserted into the cylinder so as to be able to move forward and backward. The injection head 110 operates the cylinder holding mechanism 111 for holding the cylinder and the piston of the syringe 800 whose cylinder is held by the cylinder holding mechanism 111 (for example, pushing into the cylinder) in the axial direction of the syringe 800. It has two linear motion units to be moved.

The linear motion unit includes a rod 113 that is moved back and forth by an appropriate rotary motion conversion mechanism such as a lead screw mechanism or a rack and pinion mechanism that converts the rotary motion of the motor into a linear motion, and a presser 112 fixed to the tip of the rod 113. And have. A mechanism having these motors, a rotational motion conversion mechanism, and a linear motion unit (a unit that linearly motions including a rod 113 and a presser 112) for moving the piston forward and backward is referred to as a piston drive mechanism here. In this embodiment, the injection head 110 includes two piston drive mechanisms.

In the present specification, the cylinder holding mechanism and the piston driving mechanism for the syringe for the contrast agent are referred to as the first holding mechanism and the first driving mechanism, respectively, and the cylinder holding mechanism and the piston driving for the physiological saline solution are referred to, respectively. The mechanism may be referred to as a second holding mechanism and a second driving mechanism, respectively. Further, in the illustrated example, one cylinder holding mechanism and one piston driving mechanism for the contrast medium are arranged, but the number may be plural. Similarly, there may be a plurality of cylinder holding mechanisms and piston driving mechanisms for physiological saline.

As a motor as a drive source of the piston drive mechanism, a DC motor can be used, and among them, a DC brushless motor can be particularly preferably used. Since the brushless motor does not have a brush, it is excellent in quietness and durability. In addition, since the brushless motor can rotate at a higher speed, if the external gear ratio is increased and the torque applied to the motor is reduced, the current required to inject the chemical solution at the desired injection pressure is compared with that of the brush motor. Can be made smaller. Alternatively, an ultrasonic motor can be used as a drive source for the piston drive mechanism.

The injection head 110 is entirely covered with a synthetic resin housing 115 except for a part of the piston drive mechanism (for example, the presser 112). On the upper surface of the housing 115, some operation buttons 116 are arranged so that the piston drive mechanism can be operated by the user's operation.

For example, in the present embodiment, the injection head 110 has an operation button 116, a check button 116a operated to enable injection, a start button 116b operated when starting injection, and a presser 112 at an arbitrary distance. The forward button 116c, which is operated only when moving forward (eg, at a speed of 1.5 ml / sec), adds an additional 8 ml / sec to the current speed when accelerating the movement speed of the presser 112 (eg, forward and backward). Both are possible.) The acceleration button 116d operated to retract the presser 112 by an arbitrary distance (for example, at a speed of 1.5 ml / sec), the retract button 116e operated to retract the presser 112 to the initialization position. The auto-return button 116f operated when the operation is stopped, the stop buttons 116g, 116h operated when the operation is manually stopped or interrupted, and the operation when the presser is moved forward / backward at a low speed (for example, 0.7 ml / sec). The root switch 116h and the like can be included. In this embodiment, two forward buttons 116c, two acceleration buttons 116d, two backward buttons 116e, and two auto-return buttons 116f are provided so that each piston drive mechanism can be operated independently.

The initialization position, which is the retracting end retracted by the operation of the auto return button 116f, is the size of the syringe 800 when the cylinder holding mechanism 111 is configured so that the syringe 800 of various sizes can be mounted as described below. It may be set at a different position for each and / or for each type of chemical solution to be filled. Further, when the syringe 800 is configured to be attached via the adapter 600, the initialization position may be set for each type of the adapter 600. The initialization position may be arbitrarily set by the operator according to the type of the syringe 800 and / or the type of the adapter 600, or may be automatically set by the fluoroscopic imaging system.

If the initialization position can be set by the fluoroscopic imaging system, for example, as will be described in detail later, if the type of the syringe 800 can be specified by using RFID technology, the initialization position can be specified based on the result. Can be set. Further, if the injection head has an appropriate adapter sensor (not shown) capable of detecting the type of the adapter 600, the initialization position can be set based on the detection result by the adapter sensor.

Similar to the initialization position, the most advanced position of the presser 112 may be set to a different position for each size of the syringe 800 and / or for each type of chemical solution to be filled, and for each type of adapter 600. The setting of the most forward position of the presser 112 may be set arbitrarily by the operator as in the case of the initialized position, and the syringe 800 mounted may be set by using RFID technology or an appropriate detection sensor. And / or the type of the adapter 600 and the like can be specified, and the fluoroscopic imaging system can be automatically set according to the type and / or the type of the specified syringe 800 / and / or the adapter 600.

The cylinder holding mechanism 111 is configured so that the syringe 800 is mounted via the adapter 600. The syringe 800 has various sizes depending on the volume of the chemical solution that can be filled. Adapter 600 is provided for each size of syringe 800 and is configured to hold the cylinder flange 801 formed at the end of the cylinder of each matching syringe 800, as shown in FIG. It is detachably attached to the cylinder holding mechanism 111 of the head 110. In this embodiment, the syringe 800 is mounted via the adapter 600, but the syringe 800 may be mounted directly on the injection head 110 without the adapter 600.

The syringe 800 can be attached to the injection head 110, for example, by attaching the adapter 600 to the cylinder holding mechanism 111 of the injection head 110, and then holding the cylinder flange 801 of the syringe 800 to the adapter 600. The adapter 600 has a groove for receiving the cylinder flange 801, and the syringe 800 is held by the adapter 600 by inserting the cylinder flange 801 into the groove. Further, after the cylinder flange 801 is inserted into the groove of the adapter 600, it may have a locking mechanism for locking the cylinder by rotating the syringe 800 around its axis by a predetermined angle (for example, 90 degrees). As described above, by preparing the adapter 600 according to the size of the syringe 800, the syringe 800 of various sizes can be attached to the injection head 110.

The syringe 800 may be a prefilled type syringe provided by the pharmaceutical manufacturer in a state of being filled with the drug solution, or may be a field-filled type syringe filled with the drug solution at the medical site.

In the above-described configuration, the scanner 201 and the injection head 110 are installed in the examination room, and the imaging control unit of the fluoroscopic imaging device 200 and the console 101 of the drug solution injection device 100 are in the examination room when injecting the drug solution into the subject and capturing an image. Is installed in the operation room separated by a wall. Therefore, when signals and data are transmitted and received between the console 101 and the injection head 110 by wire communication, a cable passage is formed on the wall separating the inspection room and the operation room, and the cable is passed through this passage. Be routed. Signals and data can also be transmitted and received between the console 101 and the injection head 110 by wireless communication, in which case there is no need to form a cable passage in the wall. For wireless communication, for example, the console 101 and the injection head 110 may each be equipped with a wireless communication unit (not shown).

Hereinafter, the flow of data and the like in the fluoroscopic imaging system described above will be described with reference to the block diagram shown in FIG. Note that FIG. 6 shows only the main functions of the control system in the fluoroscopic imaging system of the present embodiment, and the present invention is not limited thereto.

The image pickup control unit 152 can be incorporated into the image pickup control unit of the fluoroscopic image pickup device 200, for example, and is configured to generally control the operation of the fluoroscopic image pickup device 200 such as the scanner 201 and the display device of the image pickup control unit. .. The image pickup control unit 152 can be configured as a so-called microcomputer, and can have an interface with a CPU, ROM, RAM, and other devices. A computer program for controlling the fluoroscopic image pickup device 200 is mounted on the ROM. The CPU controls the operation of each part of the fluoroscopic imaging apparatus 200 by executing various functions corresponding to this computer program. Further, the imaging control unit 152 can receive data and signals from the injection control unit 150, and the data and signals received from the injection control unit 150 are used to control the operation of each unit of the fluoroscopic imaging device 200. You can also.

The electromagnetic wave irradiator 153 is a device provided in the fluoroscopic image pickup device 200 (see FIG. 1), and is configured to irradiate electromagnetic waves with an intensity corresponding to the applied voltage value when a voltage is applied. ing. A fluoroscopic image of the subject can be captured by performing a predetermined process on the signal obtained by irradiating the subject with electromagnetic waves.

The injection control unit 150 can be incorporated in, for example, the console 101, and is configured to generally control the operation of the console 101 and the injection head 110. More specifically, the injection control unit 150 controls the screen and data to be displayed on the display unit 154 in response to the input of data and information from the input unit 156 and the input of data and information from the RFID module 166. Alternatively, the injection protocol including the injection amount and injection speed of the drug solution can be determined using the data input from the input unit 156, and the operation of the piston drive mechanism 140 can be controlled according to the determined injection conditions.

The injection control unit 150 can be configured as a so-called microcomputer and can have an interface with a CPU, ROM, RAM, and other devices. A computer program for controlling the chemical injection device 100 is mounted on the ROM. The CPU controls the operation of each part of the chemical solution injection device 100 by executing various functions corresponding to this computer program. Further, the injection control unit 150 has a timekeeping function using a clock possessed by the CPU, and can count, for example, the current time and the elapsed time from the start of injection. The injection control unit 150 can also receive data and signals from the image pickup control unit 152, and the data and signals received from the image pickup control unit 152 can also be used to control the operation of each part of the chemical solution injection device 100. can.

The display unit 154 can be the touch panel 103 of the console 101. The input unit 156 is a data input interface in the data input interface of the present invention configured to accept a data input operation by an operator. The input unit 156 can include a touch panel 103, a button group 102 of the console 101, and a button group 116 of the injection head 110. The touch panel 103 is a modularized version of a display that normally functions as a display unit 154, a touch screen that functions as an input unit, and control circuits thereof.

As the display, any display including a liquid crystal display, an organic EL display, and the like can be used. As the touch screen, any touch screen such as a capacitance type and a pressure sensitive type can be used. The control circuit of the touch panel 103 displays a predetermined screen and data based on the signal transmitted from the injection control unit 150 on the display, and a signal generated from the touch screen when an operator or the like touches the touch screen. The input information based on the above is transmitted to the injection control unit 150.

The RFID module 166 has an RFID control circuit 164 and an antenna 165. In this embodiment, the syringe 800 has an RFID tag 802, which is a data carrier, attached to the outer peripheral surface of the cylinder (see FIG. 4), and the RFID module 166 uses an antenna 165 to transfer information recorded on the RFID tag 802 to the RFID tag. It is read from 802, and the read information is transmitted to the injection control unit 150. The RFID module 166 may further have a function of writing the information transmitted from the injection control unit 150 to the RFID tag 802. The RFID control circuit 164 controls the transmission / reception operation of information by the RFID module 166. That is, the RFID module 166 functions as a reader that reads information from the RFID tag 802, or further, a reader / writer that writes information to the RFID tag 802.

The fluoroscopic imaging system may further include a memory card reader / writer 158 connected to the injection control unit 150 so as to be able to send and receive data. The memory card reader / writer 158 can be built in, for example, the console 101 shown in FIG. 2, in which case, as shown in FIG. 2, the housing of the console 101 is provided with a memory card slot 104. Of course, the fluoroscopic imaging system may include a memory card reader / writer 158 as an independent unit.

The memory card reader / writer 158 writes data to a memory card (not shown) and reads data recorded on the memory card. For example, the injection protocol can be recorded as data on a memory card, and the recorded injection protocol can be read out via the memory card reader / writer 158 and transmitted to the injection control unit 150, and vice versa. The injection protocol set in the injection control unit 150 can also be written to the memory card via the memory card reader / writer 158. By doing so, for example, the injection protocol set in one chemical injection device can be transmitted to another chemical injection device via the memory card.

In this way, when data is transmitted via a memory card, it is preferable to prevent unauthorized transmission / reception of data by setting a password or the like. Further, the control program of the chemical injection device is recorded in the memory card, and the control program is installed in the injection control unit 150 via the memory card reader / writer 158, or the installed control program is updated. You can also.

The memory card may be any memory card such as a CF memory card or an SD memory card, and the memory card reader / writer 158 can use any device suitable for reading and writing the memory card. Although it has been described here that both the data writing and the data reading are performed for the data exchange between the memory card and the injection control unit 150, either the data writing or the data reading is performed. A memory card reader or memory card writer that performs only one of them may be connected to the injection control unit 150.

As described above, the RFID module 166 receives data input from the RFID tag 802, and in that sense, the RFID module 166 together with the input unit 156 constitutes the data input interface in the present invention.

The information recorded on the RFID tag 802 includes information on the chemical solution filled in the syringe 800, for example, the manufacturer, the type of the chemical solution, the product name, the product number, and the contained components (particularly, when the chemical solution is a contrast medium, contrast medium). The agent contains iodine, which is a contrast enhancer, and information about the syringe, such as iodine concentration per unit amount of contrast agent), filling amount, lot number, expiration date, etc. Unique identification numbers such as manufacturer, product name, and product number, allowable pressure value, syringe capacity, piston stroke, required dimensions of each part, lot number, etc. can be mentioned. At least a part of this information can be transmitted to the fluoroscopic imaging apparatus 200.

Although the RFID control circuit 164 can be installed at any position, it is desirable that the antenna 165 be installed at a position facing the RFID tag 802 while the syringe 800 is normally held by the cylinder holding mechanism 111. ..

In particular, in this embodiment, as shown in FIG. 4, the RFID tag 802 has a shape having a longitudinal direction, and the RFID tag 802 is attached so that the longitudinal direction thereof coincides with the circumferential direction of the syringe 800. The syringe 800 is normally held by being inserted into the cylinder holding mechanism 111, or after being inserted, the syringe 800 is normally held and held normally by rotating the syringe 800 in a specific orientation. The RFID tag 802 is designed to face downward in the open state.

The antenna 165 of the RFID module 166 has an FPC (flexible printed circuit board) in which a predetermined pattern (for example, one or a plurality of loop-shaped patterns) composed of conductors is formed, and as shown in FIG. 7, a cylinder. The cylinder is normally held by the holding mechanism at a position facing the RFID tag 802 of the syringe 800, and is bent and arranged in an arc shape so as to be concentric with the syringe 800. As a result, the detection range of the RFID tag 802 attached on the curved surface is expanded.

Further, in the present embodiment, the antenna 165 has a larger area than the RFID tag 802 so that the RFID tag 802 can surely face the antenna 165 even if the attachment position of the RFID tag 802 varies. ing. Therefore, it is preferable that the size of the antenna 165 is designed in consideration of the variation in the attachment position of the RFID tag 802 to the syringe 800.

On the other hand, by bending the antenna 165 into an arc shape, the smaller the radius of curvature of the antenna 165 and the longer the length of the antenna 165 in the circumferential direction, the more easily the radio waves for communication interfere with each other, and the communication sensitivity decreases. Tend to do. Therefore, in order to suppress radio wave interference, it is preferable that the antenna 165 has a ferrite sheet 165a on a surface opposite to the surface facing the RFID tag 802 of the FPC.

The output of the RFID module 166 can be, for example, 200 mW. With such a weak output, data can be satisfactorily read from the RFID tag 802 with the syringe 800 mounted in the normal position where the RFID tag 802 faces the antenna 165, and the syringe 800 is normal. It can be prevented from being read if it is not mounted in the position. As a result, if the data is not read from the RFID tag 802, the injection control unit 150 warns the operator by displaying on the display unit 154 that the syringe 800 may not be normally attached. Can be prompted.

Next, regarding the operation of the fluoroscopic imaging system described above, the operation of the chemical solution injection device 100 will be described in more detail by taking as an example the case where the fluoroscopic imaging device 200 is an X-ray CT device. The following description is shown only as an example, and the present invention is not limited to the examples described below.

First, the power is turned on to the chemical injection device 100 and the fluoroscopic image pickup device 200, and the chemical solution injection device 100 and the fluoroscopic image pickup device 200 are started. When the chemical injection device 100 is activated, the injection control unit 150 causes the display unit 154 (for example, the touch panel 103) to display the injection condition calling screen 300 as shown in FIG. The operator can call a preset injection condition by using the injection condition calling screen 300.

On the injection condition calling screen 300, an imaging site icon 301 imitating a human body is displayed. The imaging site icon 301 is represented by an image in which the human body is divided into a plurality of categories such as the head, chest, abdomen, and legs. When the operator taps one of these plurality of categories, the tapped category is selected. When the category is selected, the injection condition call screen 300 is further displayed with a plurality of site detail icons 302 registered in advance corresponding to the selected category, for example, as shown in FIG. 9A. A part is selected by the operator by tapping one part from these plurality of part detail icons 302. The display of the selected divisions and parts is changed, such as being displayed in a different color from the other divisions and parts so that they can be visually distinguished from the other divisions and parts. 9 and 9A show a state in which the abdomen is selected as the division and the liver is selected as the site.

When the site is selected as described above, the injection control unit 150 calls the parameters registered in advance corresponding to the selected site, sets the injection protocol by calculation or the like using the called parameters, and sets the injection protocol. The set injection protocol is displayed on the display unit 154 as a protocol screen.

FIG. 10 shows an example of the protocol screen. The protocol screen 310 shown in FIG. 10 displays various data / information including the imaging site icon 301 and the injection graph thumbnail 311. The indications of "A" and "B" on the protocol screen 310 mean a contrast medium and a physiological saline solution, respectively.

The imaging site icon 301 is the same as the imaging site icon 301 displayed on the injection condition calling screen 300 described above, and the injection protocol displayed is the injection protocol of which imaging site.

In the illustrated example, the image pickup site icon 301 is an image showing a state in which a supine person is viewed from the side, but may be an image showing a state in which a supine person is viewed from above. Further, the orientation of the human body image on the screen may be portrait orientation or landscape orientation. Further, the imaging site icon 301 does not have to be an image imitating a human body, and may be arbitrary, such as an image representing an organ and representing an imaging site, a character-only image representing an imaging site, or a combination thereof. May be. This also applies to the image pickup site icon 301 on other screens.

The weight icon 312 is used to display and input the subject's weight. For example, when the operator taps the weight icon 312, the numeric keypad is displayed in the vicinity of the weight icon 312, and when the displayed numeric keypad is tapped or the weight icon 312 is tapped, the numeric keypad is displayed on the weight icon 312. The weight of the subject can be input by displaying the increase / decrease icon for increasing / decreasing the numerical value one by one and tapping the increase / decrease icon.

The injection time icon 313 is used to display and input the injection time of the contrast medium, and the reference iodine amount icon 314 is used to display and input the required iodine amount per subject's body weight. The injection time is often the same as the imaging time by the fluoroscopic imaging device. The operation for inputting the injection time and the iodine amount can be the same as in the case of the body weight icon 312. A predetermined value of the subject's body weight, injection time, and reference iodine amount is stored in the memory of the injection control unit 150, and this value may be displayed on each icon by default. .. Alternatively, at least one of these data may be transmitted from an external unit of the chemical injection device 100 to the injection control unit 150, and the transmitted data may be displayed with corresponding icons. Examples of the external unit include a fluoroscopic imaging device 200, RIS, PACS, HIS, etc., which will be described later.

The pressure limit icon 315 is used to display and input the pressure limit value of the syringe 800 used. When the data of the pressure limit value is recorded on the RFID tag 802, the data read by the RFID module 166 is displayed on the pressure limit icon 309. The pressure limit icon 309 allows the operator to input numerical values in the same manner as the weight icon 305, and if these data are not recorded on the RFID tag 802, or the syringe does not have the RFID tag 802. When is attached, the operator can input each numerical value in the same manner as in the case of the weight icon 305. The syringe capacity icon 316 displays the remaining volume of the drug solution in the syringe 800 calculated by the injection control unit 150 corresponding to the position of the presser 112.

The iodine concentration of the contrast medium is displayed on the actual iodine concentration icon 317. There are several types of contrast media with different iodine concentrations. The actual iodine concentration icon 317 displays the iodine concentration that is the basis for setting the injection protocol shown in the injection graph thumbnail 311. The value of the iodine concentration displayed on the actual iodine concentration icon 317 can be changed if it is different from the iodine concentration of the contrast medium actually used. For example, when the iodine concentration data is recorded on the RFID tag 802, the change of the iodine concentration value is changed to the read value after the data is read by the RFID module 166. Alternatively, like the weight icon 312, it can be changed by the operation of the operator.

The timing icon 318 is an icon for causing the drug solution injection device to perform a test injection. The test injection is an injection of a contrast medium performed to determine the timing of starting imaging of a medical image by the fluoroscopic imaging apparatus 200. When the operator taps the timing icon 318, the injection control unit 150 causes the display unit 154 to display a screen for test injection setting. The operator makes a predetermined setting for the test injection according to the displayed screen, and after the setting, performs a predetermined operation for starting the test injection, so that the injection control unit 150 operates the chemical solution injection device according to the setting. Controls, which results in a test injection.

The root icon 319 is an icon operated when the chemical injection device is made to execute a root test. The root test is a test for confirming whether or not the injection circuit from the syringe 800 to the subject is normally secured. Generally, in a root test, while injecting a saline solution into a subject, the pressure acting on a syringe filled with the saline solution is detected, and the detected pressure is within a predetermined range set in advance. If it is, it is judged that the injection circuit is normally secured. On the other hand, if the pressure is lower than the predetermined range, liquid leakage in the injection circuit may be considered, and conversely, if the pressure is high, the injection circuit may be clogged.

The injection graph thumbnail 311 represents the injection protocol in a graph format over time. Explaining the injection protocol shown in the injection graph thumbnail 311 of FIG. 10, this injection protocol consists of a first phase in which a contrast medium and a saline solution are mixed and injected, and a second phase in which only the saline solution is injected. It consists of two phases. Such an injection protocol is a typical injection protocol when imaging an image with a tube voltage lower than usual, and if only the contrast medium that is supposed to be used is injected, the amount of iodine will be too large. In the first phase, the contrast medium is diluted with physiological saline to reduce the amount of iodine to be injected, while ensuring a sufficient injection amount and injection rate as a whole. In the second phase, the injection is performed in the first phase. Boost the iodine with physiological saline.

As an example, in the injection protocol shown in FIG. 10, specifically, the ratio of the contrast medium to the saline solution in the first phase, that is, the contrast medium: saline solution is the time-lapse graph of the injection graph thumbnail 311. It is 60:40, as shown by the horizontal band graph. Further, in the first phase, the total injection rate and injection amount of the contrast medium and the physiological saline solution are 4.0 mL / sec and 100 mL, respectively. The injection time in the first phase is 25 seconds. In the second phase, 20 mL of saline is infused at an infusion rate of 4.0 mL / sec. The injection time in the second phase is 5 seconds.

The actual iodine amount icon 320 may be displayed on the protocol screen 310 shown in FIG. What is displayed on the actual iodine amount icon 320 is the amount of iodine injected when the contrast medium is injected by the injection protocol displayed on the injection graph thumbnail 311.

The operator confirms the protocol screen 310, taps the check icon 321 if the displayed content is acceptable, or operates the check button 116a of the injection head 110. As a result, data necessary for setting the injection protocol, such as the displayed injection amount and injection rate, is temporarily stored in the memory in the injection control unit 150, and the injection protocol is determined.

Next, the operator attaches the syringe 800 filled with the chemical solution to the injection head 110 according to a predetermined procedure. When the syringe 800 is attached, the RFID module 166 reads out the data / information recorded on the RFID tag 802. Here, it is assumed that two syringes 800, specifically, a syringe for a contrast medium filled with a contrast medium and a syringe for a physiological saline solution filled with a saline solution are attached to the injection head 110. .. In the present specification, when distinguishing the syringe code by the type of the filled drug solution, the syringe filled with the contrast medium is referred to as syringe 800C with a subscript C, and is filled with physiological saline. The syringe may be referred to as a syringe 800P with a subscript P.

After the attachment of the syringe 800C filled with the contrast medium and the syringe 800P filled with the saline solution to the injection head 110 is completed, the operator attaches the extension tube 400 as shown in FIG. 8 to each syringe as an example. Connect to 800C and 800P. The extension tube 400 has three tubes connected via a T-connector. Connection connectors 401 and 402 are attached to the ends of the tubes connected to the syringes 800C and 800P, and another form of connection connector 403 is attached to the ends of the tubes facing the subject side. Each of the connection connectors 401 and 402 may have a cylindrical portion having a threaded portion formed at the tip thereof, and may be connected to a conduit portion provided at the tip of the syringes 800C and 800P by a luer lock method. Further, among these connection connectors 401 and 402, at least the connection connector 402 connected to the syringe 800P for physiological saline has a function as a one-sided valve, for example, as described in International Publication No. WO2012 / 060365. It may be anything. An indwelling needle or catheter (not shown) is connected to the connector 403. By using such an extension tube 400, the contrast agent and saline can be injected into the subject simultaneously or separately.

When the syringe 800 for the contrast medium is attached, at least the iodine content data per unit amount of the contrast medium is read out from the RFID tag 802 and temporarily stored in the memory in the injection control unit 150. The injection control unit 150 displays at least a part of the data / information read from the RFID tag 802 on the display unit 154, or moves the presser 112 to the standby position. The standby position is an arbitrary position between the position where the presser 112 abuts on the end of the piston of the syringe 800 and the position at the end. To move to the standby position, the injection control unit 150 obtains the end position of the piston based on the information read from the RFID tag 802, and the distance from the initial position, which is the end position of the movable range of the presser 112, to the piston end position. This can be done by operating the piston drive mechanism 140 so that the presser 112 advances by the distance and an arbitrary offset value predetermined. As a result, the presser 112 is moved to the standby position of the piston.

This completes the preparation for injection. After the injection preparation is completed, when the operator operates the start button 116b of the injection head 110, a corresponding signal is sent to the injection control unit 150, and the injection control unit 150 is stored in the memory using this signal as a trigger. Various data are read out, and the operation of the piston drive mechanism 140 is controlled so that the piston drive mechanism 140 operates according to the determined injection protocol. As a result, the drug solution filled in the syringe 800 can be injected into the subject.

By the way, the injection protocol displayed on the protocol screen 310 shown in FIG. 10 is obtained according to the parameters registered in advance. The registration of the parameters required for setting this injection protocol will be described.

It is preferable that the parameter input for setting the injection protocol is performed in a menu different from the series of flows described so far, for example, the series of flows using the protocol screen 310. By doing so, it is possible to prevent the registered parameters from being deleted or changed due to an erroneous operation at the injection preparation stage due to an erroneous operation or the like at the injection preparation stage.

For example, the procedure for setting the protocol can be called from the home screen for parameter registration. The home screen is displayed by operating the home button 102b of the console 101. When the procedure for protocol setting is called from the home screen, for example, the home screen contains the protocol setting icon, and the operator selects the protocol setting by tapping the protocol setting icon, etc., and the injection control is performed. The unit 150 can call the protocol setting procedure. From the home screen to calling the protocol setting procedure, several steps may be taken, for example, after the protocol setting is selected, the user who performs the protocol setting is selected.

In the protocol setting procedure, the site is first selected. The site selection may be, for example, similar to the procedure for invoking the infusion conditions described above. That is, the injection control unit 150 displays the imaging site icon 301 and the site detail icon 302 as shown in FIGS. 9 and 9A on the display unit 154, and sets the injection protocol by a predetermined operation by the operator. Can be decided.

After the site for setting the injection protocol is determined, the injection control unit 150 causes the display unit 154 to display the injection protocol setting screen. Before displaying the injection protocol setting screen, a name may be given to the injection protocol set here. As the name, the operator can arbitrarily give a name that can be easily identified when the operator later edits or deletes the registered injection protocol.

11A and 11B show an example of the protocol setting screen. As shown in FIGS. 11A and 11B, the protocol setting screen 350 includes a menu display area including a plurality of menu tabs such as detail name tab 351 and injection pattern tab 352, first item tab 353 and second item tab 354. , A main display area 355 and the like. In the main display area 355, the contents corresponding to the selected menu tab are displayed. Alternatively, the "Next" icon 358 and the return icon 357 may be displayed in the main display area 355, and the menu tabs may be switched in order by tapping them. Further, the protocol setting screen 350 can have a deletion icon 356. By tapping the delete icon 356, the displayed injection protocol is deleted.

When the detail name tab 351 is selected, the main display area 355 displays a list of names of injection protocols already registered. The operator can switch to the display of the injection protocol with the selected name by selecting one from this list, and the operator can edit or delete the displayed injection protocol.

When the injection pattern tab 352 is selected, some injection patterns are displayed in the main display area 355, as shown in FIG. 11A. In the illustrated example, the injection pattern is represented by an icon which is a schematic diagram of an injection graph in which the horizontal axis is the elapsed time and the vertical axis is the injection rate. Further, what is displayed in the upper row is an injection pattern when only the contrast medium is injected, and what is displayed in the lower row is an injection pattern when the contrast medium and the physiological saline are injected. The operator can select an injection pattern by tapping one of the displayed plurality of injection pattern icons.

Further, in the main display area 355, in addition to the icon indicating the injection pattern, an icon indicating whether the target site is a vascular system or a parenchymal system, an icon indicating whether the injection is a mixed injection, and the like, etc. May also be displayed. These icons are displayed differently from other icons so that the selection can be visually identified. In the example shown in FIG. 11A, since the liver is selected as the site in advance, it is automatically selected to be a parenchymal system, and as an injection pattern, a contrast medium and a physiological saline solution are injected at the same time. A mixed injection consisting of one phase and a second phase in which only physiological saline is injected is selected.

The target site is divided into a vascular system and a parenchymal system because the contrast effect differs depending on which of these is used. In general, the contrast effect of the vasculature is determined by the amount of iodine injected per unit time, so multiplying the injection rate by the injection time determines the total amount of iodine to be used. On the other hand, in the real system, the total amount of iodine injected is important, and the injection rate and the like are determined based on the total amount of iodine used.

After the injection pattern is determined, the operator taps the "Next" icon 358 to display the parameter input icon corresponding to the first item tab 353 in the main display area 355. Although not shown, here, the body weight of the subject, which is the basis for calculating the injection amount and injection rate of the drug solution, is displayed as one of the parameter input icons. The operator inputs an appropriate numerical value in the parameter input icon displayed in the main display area 355. The input numerical value is temporarily stored in the memory of the injection control unit 150. The main display area 355 includes the same "Next" icon 358 as shown in FIG. 11A, and when the input to the parameter input icon displayed in the main display area 355 is completed, the operator can perform this. Tap the "Next" icon 358.

As a result, as shown in FIG. 11B, the parameter input icon corresponding to the second item tab 354 is displayed in the main display area 355. The operator inputs appropriate numerical values and conditions in each parameter input icon displayed in the main display area 355. The input numerical values and conditions are temporarily stored in the memory of the injection control unit 150.

In the example shown in FIG. 11B, specifically, the following parameters are input as the second item.
First phase (mixed injection of contrast medium and saline)
Reference injection time: 25 [sec]
Reference miscibility ratio: 0.7 (contrast agent amount: physiological saline amount = 70:30)
Standard iodine amount: 500 [mgI / kg]
Reference iodine concentration: 300 [mgI / mL]
Second phase (injection of saline only)
Injection speed: A follow-up (* 1)
Injection amount: 20 [mL]
Injection time: Automatic setting Other pressure limit: 10.0 [kg / cm ² ]
(* 1) Injection at the same injection rate as the overall injection rate in the first phase.

In this embodiment, the first item tab 353 and the second item tab 354 are configured to input all the parameters necessary for the calculation of the injection protocol. After inputting the numerical value and the condition to each parameter input icon of the first item tab 353 and the second item tab 354, when the operator taps the "Next" icon 358, the injection control unit 150 is temporarily saved in the memory. The parameters are read out and as detailed below, the injection protocol, specifically the injection amount and infusion rate of the contrast agent and saline in the first phase, and the infusion amount and saline in the second phase. Calculate the injection rate.

First, the injection amount L [mL] and the injection rate S [mL / sec] are calculated assuming that the injection in the first phase is not a mixed injection but all the contrast medium is injected. The injection amount L [mL] of the contrast medium is W [kg] for the weight of the subject, I [mgI / kg] for the reference iodine amount required per unit weight of the subject, and the reference iodine concentration per unit amount of the contrast medium. Is C [mgI / mL], and the injection time of the contrast medium is T [sec].

で求められ、造影剤の注入速度Ｓ［ｍＬ／ｓｅｃ］は、
Ｓ［mL/sec］＝Ｌ［mL］／Ｔ［sec］ ・・・式（２）
で求められる。

The injection rate S [mL / sec] of the contrast medium is determined by
S [mL / sec] = L [mL] / T [sec] ・ ・ ・ Equation (2)
Is sought after.

For example, assuming that W = 60 [kg], I = 500 [mgI / kg], C = 300 [mgI / mL], and T = 25 [sec], the injection amount of the contrast medium L = 100 from the formula (1). It is calculated as [mL], and the injection rate of the contrast medium S = 4.0 [mL / sec] is calculated from the formula (2).

Then, by multiplying each of the obtained injection amount and injection rate by the miscibility ratio, the injection amount and injection rate of the contrast medium and the physiological saline in the first phase are obtained. That is, the injection amount of the contrast medium in the first phase is 100 [mL] × 0.7 = 70 [mL], and the injection rate is 100 [mL] × (1-0.7) = 30 [mL]. Desired.

Next, in the second phase, the injection rate is the same as that in the first phase, so that it is determined to be 4.0 [mL / sec], and since the injection amount is 20 [mL], the injection time is 20 [mL]. It is calculated as 5 [sec].

In the above formula (1), the injection amount L of the contrast medium is calculated using the iodine amount I required per subject's body weight, but in the vascular system, per unit body weight and unit injection time of the subject. It is common to calculate the injection volume using the required reference iodine volume I'[mgI / kg / sec]. The following equation (1') can be used to calculate the injection amount in this case.

As described above, if the injection amount of the contrast medium is too small or the injection speed of the contrast medium is too low, the contrast medium may diffuse into the blood or surround the area until the contrast medium reaches the target site. The phenomenon of being absorbed by the tissue of the patient may occur. Therefore, the lower limit values of the injection amount and the injection rate of the contrast medium are set in advance in the injection control unit 150, and the injection control unit 150 compares these values with the calculated injection amount and the injection rate and calculates the values. A warning may be issued if at least one of the injection volume and the injection rate is less than a preset value. The lower limit of the injection amount of the contrast medium set in the injection control unit 150 can be preferably 30 [mL], more preferably 50 [mL]. The lower limit of the injection rate of the contrast medium set in the injection control unit 150 can be preferably 3 [mL / sec], more preferably 5 [mL / sec]. These lower limit values may be set for each imaging site, or may be arbitrarily changed by the operator. Further, the warning may be displayed on the display unit 154 (at least one of these when the second display unit is provided as described later) with characters, graphics, or the like, or a sounding device such as a buzzer or a speaker. May be provided and a warning may be given by voice from this sounding device.

The injection protocol obtained as described above is displayed in the main display area 355 of the protocol setting screen 350 as a preview screen having the same configuration as the protocol screen 310 shown in FIG. 10, so that the operator can confirm it. Can be. At the same time as the preview screen, the "Save" icon (when newly registering) or "Overwrite" icon (when editing the registered injection conditions) is displayed in the menu display area or main display area, and the operator can display it. By tapping the "save" icon or the "overwrite" icon, it is registered in the memory of the injection control unit 150 as a parameter used to set one of the injection protocols at the specific site or the like.

When calling the injection condition described above, the calculation of the injection protocol described above (a series of calculations for obtaining the injection protocol) is performed after the target site is determined and before the display of the protocol screen 310 shown in FIG. It is performed by the injection control unit 150 using the parameters registered in advance. At this stage, the result calculated using the parameters registered in advance is displayed on the injection graph thumbnail 311 of the protocol screen 310. Further, the calculation of the injection protocol using the parameters registered in advance may be performed at an arbitrary timing.

Referring again to FIG. 10, the infusion protocol and parameters displayed on the protocol screen 310 are displayed on the volume value and actual iodine volume icon 320 displayed on the syringe capacity icon 316, as described above. Except for the iodine amount value, it can be changed arbitrarily by the operator according to the actual conditions or automatically according to the data read from the RFID tag 802. For example, the body weight of a subject varies from subject to subject, and the reference iodine amount and reference iodine concentration vary depending on the type of contrast medium used.

Therefore, when the parameters displayed on the protocol screen 310 are changed according to the actual weight of the subject, the type of contrast medium actually used, and the like, the injection control unit 150 performs the injection protocol according to the changed parameters. The set and newly set injection protocol is displayed on the protocol screen 310.

Below, as an example, in the registered injection protocol, as shown in FIG. 11B, the injection amount and the injection rate are obtained with the reference iodine concentration of the contrast medium as 300 [mgI / mL]. As shown in the actual iodine concentration icon 317 of 10, the calculation when a contrast medium having an iodine concentration of 350 [mgI / mL] is used will be described. In this example, the contrast medium is injected only in the first phase, so the following description is for the first phase.

First, the injection control unit 150 obtains the actual iodine amount In, which _is the iodine amount of the contrast medium injected by this injection protocol, from the reference iodine amount _{In_base} and the reference miscibility ratio R _base by the following formula (2).
In = _{In_base} × R _base・ ・ ・ Equation (2)
The reference iodine amount is the amount of iodine used to calculate the registered infusion protocol, and the reference admixture ratio is the admixture ratio used to calculate the registered infusion protocol. In this example, the reference iodine amount _{In_base} = 500 [mgI / mL] and the reference miscibility ratio R _base = 0.7.
Actual iodine amount In = 500 [ _mgI / mL] x 0.7 = 350 [mgI / mL]
Is required. That is, with the registered injection protocol, an iodine amount of 350 [mgI / mL] will be injected.

Next, the injection control unit 150 sets the reference injection amount V _total , which is the injection amount when the contrast medium is not diluted with physiological saline, from the reference iodine amount _{In_base} , the reference iodine concentration I _{c_base} , and the body weight W of the subject. It is obtained by the formula (3) of.

基準ヨード濃度とは、登録された注入プロトコルを計算するのに用いたヨード濃度であり、また、ここでは、被験者の体重は、登録された注入プロトコルを計算するのに用いた体重と同じであるとする。すなわち、被験者の体重Ｗ＝６０［ｋｇ］、基準ヨード濃度Ｉ_{ｃ＿ｂａｓｅ}＝３００［ｍｇＩ／ｍＬ］であるので、式（３）より、
Ｖ_{ｔｏｔａｌ}＝１００［ｍＬ］
と、求められる。

The reference iodine concentration is the iodine concentration used to calculate the registered infusion protocol, and here the body weight of the subject is the same as the body weight used to calculate the registered infusion protocol. And. That is, since the subject's body weight W = 60 [kg] and the reference iodine concentration I _{c_base} = 300 [mgI / mL], from the formula (3),
V _total = 100 [mL]
Is required.

Further, the injection control unit 150 sets the actual iodine concentration, which is the iodine concentration of the contrast medium used in this examination, as _Ic , and the miscibility ratio when injecting with the changed parameter (iodine concentration in this example). The actual miscibility ratio R is calculated by the following formula (4). As a result, even when the iodine concentration is changed to a different contrast medium, the mixing ratio in which the contrast medium is injected with the same iodine amount as the iodine amount injected by the registered injection protocol can be obtained.

本例では、実ヨード濃度Ｉｃ＝３５０［ｍｇＩ／ｍＬ］であるから、式（４）より、
Ｒ＝０．６
と、求められる。その結果、混和比率は、０．７から０．６に変更される。変更された実混和比率は、１０に示すプロトコル画面３１０の注入グラフサムネイル３１１の経時グラフの横に、造影剤の割合６０％および生理食塩水の割合４０％として表示されている。

In this example, since the actual iodine concentration Ic = 350 [mgI / mL], from the formula (4),
R = 0.6
Is required. As a result, the miscibility is changed from 0.7 to 0.6. The modified actual miscibility ratio is displayed as a contrast agent ratio of 60% and a saline ratio of 40% next to the time-lapse graph of the injection graph thumbnail 311 of the protocol screen 310 shown in 10.

If the value of the obtained actual miscibility ratio R is larger than 1, the actual miscibility ratio R = 1 and the injection protocol is such that only the contrast medium is injected. On the other hand, when the actual miscibility ratio R = 0, it means that the contrast medium is not injected, so that one of the parameters that can be changed is changed until the actual miscibility ratio R larger than 0 is obtained. You will not be able to proceed to the next step.

In this way, by automatically changing the mixing ratio according to the iodine concentration of the contrast medium used for the actual injection, the amount of iodine to be injected even if the contrast medium is changed. Does not change, and as a result, good contrast effects can be obtained with various contrast media having different iodine concentrations. In addition, as a formula for calculating the actual admixture ratio, it is appropriate to multiply the pre-given reference admixture ratio by using the ratio between the pre-given reference iodine concentration and the actual iodine concentration of the contrast agent actually used as a coefficient. It is possible to give a different mixing ratio.

When the actual miscibility ratio R is obtained as described above, the injection control unit 150 determines the injection amount _VA [mL] of the contrast medium and the physiological saline solution from the obtained actual miscibility ratio R and the reference injection amount V _total . Obtain the injection volume V _B [mL]. These are given by the following equations (5) and (6).
V _A [mL] = V _total [mL] × R ・ ・ ・ Equation (5)
V _B [mL] = V _total [mL] × (1-R) ・ ・ ・ Equation (6)

From the reference injection amount V _total [mL] and the injection time t [sec], the reference injection rate F _total [mL / sec], which is the injection rate when the contrast medium is not diluted with physiological saline, is
F _total = V _total [mL] / t [sec] ・ ・ ・ Equation (7)
From the formula (7), the injection rate FA [mL / sec] of the contrast medium and the injection rate _{FB [} mL / sec] of the physiological saline can be obtained. These are given by the following equations (8) and (9).
FA [mL / sec] = _{F total} [mL / sec] × R ・ ・ ・ Equation (8)
FB [mL / sec] = _{F total} [mL / sec] × (1-R) ・ ・ ・ Equation (9)

The injection control unit 150 applies the parameters obtained as described above to the injection protocol, and displays the changed injection protocol on the protocol screen 310. After that, the injection operation is executed by a series of procedures as described above. Note that the changes made here are changes on the called injection protocol, and the registered injection protocol itself is not changed. The injection protocol can be created and edited only from the protocol setting screen 350 called from the home screen.

As described above, in the present embodiment, the injection control unit 150 obtains the miscibility ratio so that the amount of iodine used does not change when the iodine concentration is changed, and the value of the miscibility ratio is the value of the obtained miscibility ratio. And apply the changed miscibility to the injection protocol. However, the value of the miscibility to be changed may be a value different from the obtained value within a range that does not affect the contrast effect. For example, if it is determined that the miscibility when the iodine concentration is changed is 0.57 (contrast medium amount: physiological saline amount = 57:43), the second decimal place is rounded off and the miscibility ratio = 0. Injection at 6 does not have a significant effect on the contrast effect. In this sense, the same result can be obtained even if the miscibility ratio when the iodine concentration is changed is estimated by, for example, the value up to the first decimal place, and the value of the miscibility ratio is changed to the estimated miscibility ratio value. Can be done.

Therefore, it can be said that the injection control unit 150 is configured to change the miscibility ratio according to the changed iodine concentration and apply the changed miscibility ratio to the injection protocol when the iodine concentration is changed. .. Here, the miscibility ratio is preferably changed within a range that does not affect the contrast effect, and more preferably changed so that the amount of iodine used does not change.

In the above, the case where the miscibility in the injection protocol is changed by changing the iodine concentration has been described as an example. However, the injection protocol can also be changed by changing other parameters. For example, if the reference iodine amount is changed, the actual iodine amount, injection rate and injection amount are changed in the injection protocol, and if the mixing ratio is changed, the actual iodine amount is changed in the injection protocol. If the body weight of the iodine is changed, the infusion rate and infusion volume are changed in the infusion protocol. When the injection time is changed, the injection amount is changed if the imaging target is a vascular system, and the injection speed is changed if the imaging target is a substantial system.

Further, in the above description, the case where the injection protocol is set for each imaging site has been described. However, in addition, the injection protocol may be registered for each manufacturer and / or specification of the fluoroscopic imager. The fluoroscopic imager generally performs image processing by the successive approximation method or image processing using the successive approximation method when reconstructing an image. This image processing differs depending on the manufacturer of the fluoroscopic image pickup device, and even if it is the same manufacturer, it may differ depending on the specifications of the fluoroscopic image pickup device. The image quality of the image obtained when the chemical solution is injected under the same injection conditions differs depending on what kind of image processing is performed. Therefore, an injection protocol corresponding to not only the imaging site but also the fluoroscopic imaging device to be used may be registered.

When a contrast medium is injected as a drug solution, the contrast effect of the contrast medium varies from subject to individual. In order to grasp the degree of individual difference in the contrast effect, a test injection is performed in which the drug solution is injected with an injection amount smaller than the injection amount for the imaging prior to the injection for imaging the tomographic image by the fluoroscopic imaging device 200. And determine the imaging timing based on the result.

In such a case, the injection operation of the chemical solution after the test injection can be started by the injection control unit 150 receiving the command transmitted from the fluoroscopic image pickup device 200 from the image pickup control unit 152. The fluoroscopic image pickup device 200, for example, captures a tomographic image displayed on the monitor of the fluoroscopic image pickup device 200 with a CCD camera (not shown), monitors the brightness (whiteness) of the tomographic image in ROI, and determines the brightness. Is above a predetermined threshold, or when the signal strength from the cable connected to the monitor is measured and the measurement result is above a predetermined threshold, the injection operation is started. Command can be transmitted to the injection control unit 150. In addition, when performing a test injection prior to the injection for imaging a tomographic image (main injection), the CT value and TDC (Time Density Curve) at the time of the test injection are monitored, and the injection protocol is determined according to the result. Then, the optimum imaging start suitable for that may be transmitted from the chemical injection device 100 to the fluoroscopic imaging device 200.

The above-described embodiment has been described by exemplifying a case where the fluoroscopic image pickup device 200 is an X-ray CT device. However, in the present invention, the fluoroscopic image pickup device 200 includes an angio device and an MRI in addition to the X-ray CT device. It may be any fluoroscopic imaging device that utilizes the irradiation of electromagnetic waves to acquire an image, such as an apparatus, an MRA apparatus, a PET apparatus, and an ultrasonic diagnostic imaging apparatus. When the fluoroscopic image pickup device 200 is a device other than the X-ray CT device, the configuration, screen display, operation procedure, operation, and the like of the chemical solution injection device 100 may be appropriately changed accordingly.

For example, when the fluoroscopic imaging device 200 is an MRI device, the MRI device has a high-frequency pulse transmitter that irradiates a high-frequency pulse as an electromagnetic wave irradiator, and the high-frequency pulse transmitter changes the irradiation intensity of the high-frequency pulse depending on the setting. can do. Normally, the stronger the irradiation intensity of the high-frequency pulse, the higher the contrast effect of the contrast medium. Therefore, the injection control unit 150 determines that the irradiation intensity of the high-frequency pulse set in the electromagnetic wave irradiator is higher than the specific irradiation intensity. In addition, a treatment is performed such that the contrast medium is diluted with physiological saline. The specific procedure of this process can be the same as the above-mentioned procedure except that the relationship of the intensity of the irradiation intensity of the electromagnetic wave set in the electromagnetic wave irradiator is opposite to that of the X-ray CT device.

Further, in the above-described embodiment, the image pickup control unit 152 is incorporated in the image pickup control unit, and the injection control unit 150 is described as being incorporated in the console 101 of the chemical solution injection device 100. However, both the image pickup control unit 152 and the injection control unit 150 may be incorporated in the image pickup control unit, the image pickup control unit 152 and the injection control unit 150 may both be incorporated in the console 101, or the image pickup may be performed. Both the control unit 152 and the injection control unit 150 may be incorporated in a programmable computer device (not shown) separate from the image pickup control unit and the console 101. By doing so, the console 101 of the chemical injection device 100 or the console of the fluoroscopic imaging device 200 becomes unnecessary, and the entire system can be simplified.

Furthermore, a particular function of the injection control unit 150 can be incorporated into a unit separate from the rest of the other functions. For example, the determination (calculation) function of the injection protocol can be incorporated into the imaging control unit of the fluoroscopic imaging device 200, and the remaining other functions can be incorporated into the console 101 of the chemical solution injection device 100. In this case, it is not necessary to input the data common to the setting of the imaging condition and the setting of the injection condition to the fluoroscopic imaging device 200 and the chemical solution injection device 100 in duplicate. Data that is insufficient when setting the injection conditions may be input from the image pickup control unit, or may be transmitted from the console 101 of the chemical solution injection device 100 to the image pickup control unit.

The functions of the image pickup control unit 152 and the functions of the injection control unit 150 can be realized by using various hardware as necessary, but the main body thereof is realized by the function of the CPU corresponding to the computer program.

The computer program is at least part of the procedure described above, eg,
When the concentration of the contrast enhancer of the contrast agent is changed among the plurality of parameters used to set the registered injection protocol, the step of changing the miscibility ratio according to the changed concentration and the step. ,
The step of applying the modified miscibility to the injection protocol, and
Can be implemented as a computer program for causing a fluoroscopic image pickup device 200, a chemical solution injection device 100, or a fluoroscopic image pickup system including these fluoroscopic image pickup device 200 and a chemical solution injection device 100.

Further, from a structural point of view, the injection head 110 and the console 101 can be integrally configured. When the console 101 and the injection head 110 are integrally configured, the console 101 is also arranged in the examination room. Therefore, a remote controller 170 (see FIG. 1) can be used to start and stop the injection operation. By using the remote controller 170, the operator can control the start and stop of the injection operation in the operation room.

Specifically, the syringe may be one as shown in FIGS. 12 (a) and 12 (b). This syringe can be for, for example, 100 ml. This syringe includes a cylinder member 501 and a piston member 502, and the cylinder flange 501a formed at the end of the cylinder member 501 has an I-cut contour shape, and two notches are formed on the outer peripheral portion of the flange 501a. A portion 505 (showing only one) is formed. The conduit portion 501b at the tip of the cylinder member 501 may be for a luer lock connection having two coaxially arranged inner and outer tubular portions. As shown in FIG. 12B, a ring-shaped protrusion 501c may be formed on the rear surface of the cylinder flange 501a.

As another example of the syringe, it may be a syringe as shown in FIGS. 12 (a) and 12 (b), and this syringe can be for, for example, 200 ml. Like the syringe, this syringe also includes a cylinder member 501 and a piston member 502, and the cylinder flange 501a formed at the end of the cylinder member 501 may have an I-cut contour shape. Two notches 505 (showing only one) are formed on the outer peripheral portion of the cylinder flange 501a. The conduit portion 501b at the tip of the cylinder member 501 may be for a luer lock connection having two coaxially arranged inner and outer tubular portions. As shown in FIG. 12B, a ring-shaped protrusion 501c and a plurality of ribs 501d extending outward from the protrusion 501c may be formed on the rear surface of the cylinder flange 501a.

In addition, although FIG. 13 shows a cylinder flange 501a in which both a notch portion 505 and a rib 501d are formed, a cylinder flange 501a in which only one of them is formed (for example, the notch portion 505 is formed). It may not be). Further, the rib 501d may have a shape in which only the upper and lower ribs of the plurality of ribs arranged in the vertical direction in the drawing are left and the other ribs are omitted. Such a rib group may be a syringe formed on only one of the left and right sides of the flange portion.

As shown in FIGS. 12 and 13, an adapter in which a syringe having a notch 505 is attached to the cylinder flange 501a has a groove in which the cylinder flange 501a is inserted from above in the illustrated posture, and the cylinder flange 501a is inserted. Further, it is preferable to have a protrusion that engages with the notch 505 in a state of being rotated 90 degrees around the axis. This makes the cylinder more secure. Therefore, even if a problem occurs in the injection pressure control during the injection operation and an excessive pressure acts on the syringe, the syringe is firmly held, so that the cylinder flange 501a is less likely to be damaged. In addition, an unbalanced load due to the syringe being mounted at an angle is unlikely to occur, and liquid leakage due to a gap between the piston and the cylinder can be prevented.

The syringes shown in FIGS. 12 and 13 may also have an RFID tag on the outer peripheral surface of the cylinder, similar to the syringe 800 described above.

(Other configurations that the chemical injection device can have)
The drug solution injection device may further have a load cell for detecting the injection pressure. The load cell can be provided, for example, in the presser 112. When having a plurality of pressers 112 as shown in FIG. 3, at least one of them may have a load cell. The injection pressure can also be detected by measuring the motor current. When the load acting on the presser 112 becomes large, the motor current which is the drive source of the piston drive mechanism 140 becomes large according to the magnitude of the load. This is used to detect the injection pressure using the motor current. The injection pressure may be detected only by using a load cell or by using a motor current, or both may be used in combination. When both are used in combination, the injection pressure is usually detected by the load cell, and the injection pressure can be measured by using the measurement result of the motor current only when the load cell fails.

(Other forms of extension tube)
The extension tube is preferably equipped with a mixing device that allows the contrast agent and saline to be mixed well. An example of an extension tube with a mixing device will be described with reference to FIGS. 14A, 14B and 14C.

This extension tube includes a first tube 231a for connecting a syringe filled with a contrast medium and a mixing device 241 and a second tube 231b for connecting a syringe filled with physiological saline and a mixing device 241. It has a third tube 231c that is connected to the liquid outlet of the mixing device 241 (details below) and extends towards the patient. Although not particularly limited, the first and second tubes 231a and 231b may be connected to the conduit portion of the syringe via the connection connectors 239a and 239b, respectively. Similarly, the third tube 231c may also be connected to a catheter or the like via the connector 239c.

Before injecting the chemical solution by the chemical solution injection device, priming is performed for the purpose of bleeding air. There are several methods for this priming, and the extension tube is filled with a saline solution or a contrast medium. Specific examples include:
(A) First, the contrast medium is extruded from the contrast medium syringe, and the first tube to the mixing device is filled with the contrast medium. Then, the saline solution is extruded from the saline solution syringe, and the second tube, the mixing device, the third tube, and even the catheter are filled with the saline solution. As a result, the entire circuit is filled with the chemical solution and the air is evacuated. Other,
(B) First, the contrast medium is extruded from the contrast medium syringe, then the physiological saline solution is extruded from the physiological saline solution syringe, and then the drug solution is extruded from both syringes at the same time.
(C) There is also a method of first extruding the physiological saline solution from the physiological saline solution syringe and then extruding the contrast medium from the contrast agent syringe to fill the entire circuit of the drug solution with the drug solution.

The chemical injection device may be provided with a function for automatically performing the priming operation as described above, and the trigger for starting the priming operation may be, for example, an input operation by an operator.

Subsequently, the mixing device 241 will be described in detail. As shown in FIGS. 14A and 14B, the mixing device 241 has a first chamber which is a swirling flow generation chamber 242a for generating a swirling flow and a second chamber which is a constriction chamber 242b for concentrating the swirling flow in the axial direction. The main body portion 242 is provided. In this example, the swirl flow generation chamber 242a has a columnar internal space, and the constriction chamber 242b has a conical internal space coaxial with the swirl flow generation chamber 242a. As the cross-sectional shape of the swirling flow generation chamber in the lateral direction, various shapes formed from a circle, an ellipse, or another curve can be considered. Further, the swirling flow generation chamber can be configured to have a stenotic shape in which the tip narrows as it approaches the stenotic chamber.

A conduit portion 243a to which the first tube 231a is connected is provided on the upstream side of the flow of the main body portion 242 of the mixing device 241, and a conduit portion 243c to which the third tube 231c is connected is provided on the downstream side. .. The conduit portion 243b to which the second tube 231b is connected is arranged at a position upstream from the center of the swirl flow generation chamber 242a (details below).

In this example, the contrast medium flows in from the conduit portion 243a and the physiological saline solution flows in from the conduit portion 243b, and both chemicals are mixed in the mixing device. After that, the mixed drug solution of the contrast medium and the physiological saline flows out from the conduit portion 243c as the liquid outlet.

The conduit portion 243a into which the chemical liquid having a large specific density flows is provided in the central portion of the upstream side wall surface of the swirling flow generation chamber 242a on the upstream side in the flow direction. The conduit portion 243c, which is a liquid outlet, is provided so that the center line of the conduit portion 243c and the center line of the conduit portion 243a coincide with each other, that is, both of them are coaxial. By arranging each part so as to have a co-axis, the isotropic property of the vortex generated in the mixing device can be enhanced. That is, the vortex can be generated uniformly in the space without stagnation, and the mixing efficiency can be improved.

On the other hand, the conduit portion 243b into which the chemical solution having a small specific gravity flows is arranged on the side surface of the swirl flow generation chamber 242a and extends in the tangential direction of the circumference of the swirl flow generation chamber 242a having a circular cross section. In other words, the conduit portion 243b is provided at a position shifted to the peripheral edge side from the central axis of the columnar space of the swirl flow generation chamber 242a, whereby the chemical liquid having a small specific gravity flowing from the conduit portion 243b is provided. The swirling flow of is to be generated. More specifically, as shown in FIG. 14C, the flow path 241fb is configured to extend in the circumferential tangential direction of the curved inner surface of the swirl flow generation chamber 242a, thereby flowing in from this flow path. The chemical solution becomes a swirling flow. Further, as is clear from the drawing, the constriction chamber 242b has an inclined inner surface that narrows toward the downstream side in the flow direction, so that the generated swirling flow is concentrated in the central axis direction of the vortex. Become.

Further, the conduit portion 243a into which the contrast medium flows communicates with the swirling flow generation chamber 242a via the flow path 241fa. As a result, the chemical solution having a large specific gravity can be introduced into the swirling flow generation chamber in a direction parallel to the central axis of the swirling flow of the chemical solution having a small specific gravity. That is, the chemical solution having a large specific gravity is introduced in the direction parallel to the central axis of the columnar space of the swirling flow generation chamber. Further, the conduit portion into which the physiological saline solution flows is communicated with the swirling flow generation chamber via the flow path 241fb. As an example, the inner diameter of the flow path 241fb may be formed smaller than the inner diameter of the flow path 241fa into which the contrast medium flows. According to such a configuration, when the chemical solution is injected at a predetermined pressure, the flow velocity of the chemical solution having a small specific gravity flowing in from the flow path 241fb having a relatively small cross section becomes faster than the flow velocity of the chemical solution having a large specific gravity. Therefore, it is possible to avoid a decrease in the mixing efficiency between the chemicals due to the attenuation of the inertial force of the swirling flow and the accompanying lack of the swirling strength, which may occur when the flow velocity of the chemicals having a small specific gravity is slow.

In the mixing device 241 configured as described above, for example, when the contrast medium and the physiological saline flow into the device, the contrast medium flowing into the swirling flow generation chamber from the flow path 241fa flows toward the downstream side in the axial direction. Become. On the other hand, the physiological saline solution that has flowed into the swirling flow generation chamber from the flow path 241fb becomes a swirling flow that swirls along the curved inner surface of the chamber, and the swirling flow of the physiological saline solution is guided to the constriction chamber and swirls. Concentrate in the direction of the central axis of the flow. Such a vortex is known as a Rankine vortex, and the inertial force of the swirling flow can be concentrated in the vicinity of the rotation axis of the vortex.

When two chemical solutions are simultaneously injected with an extension tube having such a mixing device 241, both chemical solutions are well mixed. That is, in this example, a diluted contrast medium in which the contrast medium and the physiological saline are well mixed can be obtained, and as a result, unevenness in the concentration of the contrast medium is eliminated, so that the case is compared with the case of a general branch tube. Therefore, an excellent contrast effect can be expected.

(Second display unit)
The fluoroscopic imaging system can include a second display unit A151 as shown in FIGS. 15A and 15B, in addition to the display unit 154 (touch panel 103 provided on the console 101) described above. Usually, the injection head 110 is arranged in the examination room together with the fluoroscopic imaging device 200, and the console 101 is often arranged in the operation room adjacent to the examination room. Various settings related to the injection of the drug solution are made by the operator appropriately operating the console 101 arranged in the operation room, but in the preparation stage for injection, the subject is punctured with an injection needle or a catheter is inserted, and the inside of the tube is inserted. The operator performs various operations in the inspection room to bleed air and check the operation of the injection head 110. In this preparatory stage, the second display unit A151 is preferably arranged in the examination chamber so that the operator can confirm the injection conditions and the like without moving to the operation chamber.

The second display unit A151 displays various data related to the injection of the drug solution, for example, the image target site, the body weight of the subject, the injection rate of the drug solution, the injection amount of the drug solution, the type of the drug solution to be injected, the injection protocol of the drug solution, and the like. can do. These display formats may be arbitrary, and may be displayed on the same screen as the touch panel 103 provided on the console 101, or may be displayed on a different screen. It is also possible to display the injection condition calling screen (FIG. 9, FIG. 9A) 300 and the protocol screen 310 (FIG. 10) described above. At the same time, when the operation of the piston pressing portion is stopped in the preparatory operation and the injection operation, a message or an icon to that effect can be displayed.

The second display unit A151 is preferably a touch panel. The second display unit A151 is used as a touch panel, and data input for setting injection conditions and the like, and operations for starting and stopping the operation of the injection head 110 can be performed from the second display unit A151 as well. When the injection conditions are changed or the injection is stopped in the initial stage of the stage and the injection, the operator can change the injection conditions on the spot without returning to the operation room. When changing the injection conditions or stopping the injection, for example, when the subject is not in good physical condition and it is judged that it is better to relax the injection conditions than the regular injection conditions, or when the drug solution from the blood vessel is used. For example, when a leak occurs. Even if the second display unit A151 is not a touch panel, if the second display unit A151 is configured to include an appropriate operation switch, the injection conditions can be set and / or changed by operating the operation switch. be able to.

The second display unit A151 is preferably arranged in the vicinity of the injection head 110 particularly in the inspection room, and can be provided integrally with the injection head 110 or a member supporting the injection head, for example. Referring to FIG. 15A, an example of a second display unit A151 integrally provided with the injection head 110 is shown. On the other hand, in the example shown in FIG. 15B, the injection head 110 and the second display unit A151 are supported by the head support structure A158. The head support structure A158 may be part of a known movable stand or part of an articulated support arm assembly secured to the ceiling. As shown in FIG. 15B, the support arm assembly 160 may have, for example, a base portion 161 fixed to the ceiling and an articulated arm portion 163 extending from the base portion 161. In the example shown in FIG. 15B, the second display unit A151 is attached to the middle portion of the arm portion 163, which extends vertically and the injection head 110 is attached to the lower end portion.

The second display unit A151 is connected to the head support structure A158 via the connecting mechanism A155. Although not particularly limited, the second display unit A151 may be located above the injection head 110 at a distance from the injection head 110. The coupling mechanism A155 may, for example, hold the injection head 110 so that the injection head 110 can rotate around the vertical axis and / or around the horizontal axis. The connection between the second display unit A151 and the injection head 110 and / or the console 101 may be a wired connection via a cable or a wireless connection.

According to the configuration as described above, the orientation of the second display unit A151 can be adjusted in a wide range in the vertical direction and the horizontal direction regardless of the orientation of the injection head 110, so that the operator can adjust the orientation of the second display unit A151 in a wide range. Will be easier to see. Further, by arranging the second display unit A151 at a distance from the injection head 110, the second display unit A151 is arranged at an optimum position where the injection head 110 and other devices are less likely to be affected by noise. Can be done. Further, by connecting the second display unit A151 wirelessly, it is possible to prevent the propagation of noise via the cable.

(Other forms of fluoroscopic imaging systems)
As shown in FIG. 16, the fluoroscopic imaging system includes a chemical injection device 100 and a fluoroscopic imaging device 200, as well as a warmer 900 that heats a syringe 800 before use to a predetermined temperature, and a used and discarded device. It may further include a disposal box 910 that houses the power syringe 800. The warmer 900 and the disposal box 910 may be devices independent of the chemical injection device 100 and the fluoroscopic image pickup device 200, or may be connected to at least one of them so as to be capable of data communication via a network. .. The warmer 900 and the disposal box 910 may be independent of each other or may be connected to each other via a network so that data communication is possible. The warmer 900 and the disposal box 910 can be provided with readers / writers 902 and 912 for reading the information recorded on the RFID tag 802 and writing the information to the RFID tag 802, respectively. Information indicating that the syringe 800 has been heated by the reader / writer 902 to the RFID tag 802 of the syringe 800 by being heated by the warmer 900 is recorded in the syringe 800. Further, when the used syringe 800 is stored in the disposal box 910, the information that the used syringe 800 is the discarded syringe 800 is recorded on the RFID tag 802 by the 912.

The fluoroscopic imaging system may further include a chemical filling device 920. The chemical solution filling device 920 is a device on which an empty syringe not filled with the chemical solution is mounted and the empty syringe can be filled with the chemical solution. The chemical filling device 920 may also be a device independent of the chemical filling device 100, the fluoroscopic imaging device 200, the warmer 900, and the disposal box 910, or may be connected to at least one of these so as to be capable of data communication via a network. It may have been done. With the piston in the most advanced position, the empty syringe is connected to the drug solution container 930 of any form such as a bag or a bottle containing the drug solution so as to communicate the fluid by a tube or the like. After connecting the empty syringe and the chemical solution container 930, the empty syringe can be filled with the chemical solution by retracting the piston by the chemical solution filling device 920. It is preferable that the empty syringe is equipped with an RFID tag which is a data carrier. In the following description, the empty syringe will be described as the syringe 800 before being filled with the drug solution to which the RFID tag 802 is attached.

The RFID tag 932, which is a data carrier, is also attached to the chemical solution container 930. The RFID tag 932 relates to the chemical solution, for example, the type of the chemical solution contained, the content, the pharmaceutical manufacturer, the product number, the viscosity, the expiration date, and if the chemical solution is a contrast medium, the iodine content per unit contrast medium amount. Information is recorded as data. The chemical filling device 920 includes a reader 922a capable of reading data from the RFID tag 932 and a writer 922b capable of writing data to the RFID tag 802 attached to the syringe 800.

In the above configuration, when the syringe 800 is filled with the chemical solution from the chemical solution container 930 using the chemical solution filling device 920, the data recorded on the RFID tag 932 attached to the chemical solution container 930 is read out by the reader 922a. The chemical solution filling device 920 includes a storage device such as a memory, and the read data is temporarily stored in this storage device. Next, the operator sets the filling amount in the chemical solution filling device 920 and operates the chemical solution filling device 920.

As a result, the set amount of the chemical solution is filled in the syringe 800. The filling amount can be set according to a predetermined operating procedure of the chemical solution filling device 920. After filling the chemical solution, the writer 922b writes the filling amount of the chemical solution and the filling date and time on the RFID tag 802 of the syringe 800 together with the data temporarily stored in the storage device. As described above, the syringe 800 is filled with the chemical solution, and the data regarding the filled chemical solution is recorded on the RFID tag 802.

The RFID tag 802 may be pre-recorded with data related to the syringe as described above. Further, the reader 922a that reads data from the RFID tag 932 of the chemical solution container 930 can be used as a reader / writer that can also write data. In this case, the current internal volume (remaining amount) obtained by subtracting the filling amount from the content before filling contained in the chemical solution container 930 may be written on the RFID tag 932. The remaining amount can be calculated by the CPU included in the chemical filling device 920.

As described above, the injection control unit 150 has a time measuring function of the current time. Utilizing this, the filling date and time recorded on the RFID tag 802 is read out by the RFID module 166 (see FIG. 6), and the current date and time measured by the timekeeping function and the read filling date and time are set by the injection control unit 150 (see FIG. 6). As a result of comparison in FIG. 6), if the current date and time is after a predetermined period has elapsed from the filling date and time, that is, if the expiration date has been exceeded, the injection control unit 150 should perform a process for preventing the injection of this chemical solution. Can be. The processing for preventing the injection of the chemical solution is, for example, disabling the operation of the piston drive mechanism 140 (see FIG. 6), and the expiration date of the chemical solution has expired on the display unit 154 (see FIG. 6). Is displayed, and a sound or voice warning is issued from a sounding unit (not shown) such as a buzzer. The expiration date of the chemical solution is set in advance in the injection control unit 150, but the set expiration date can be arbitrarily changed by the operator. By controlling the filling date and time of the chemical solution in this way, the safety of the injected contrast medium can be ensured.

Each medical device constituting the fluoroscopic imaging system, such as a chemical injection device 100, a fluoroscopic image pickup device 200, a warmer 900, a disposal box 910, and a chemical solution filling device 920, may be connected to a medical network. This makes it possible to easily store and track the history of treatment for the subject, the history of drug solution use, the history of syringe use, and the like.

Further, at least the chemical injection device 100 and the fluoroscopic imaging device 200 may be connected to the medical network. As a result, the injection result including the injection speed, injection time, injection amount, and injection graph of the chemical solution injected by the chemical solution injection device 100, and the imaging conditions by the fluoroscopic imaging device 200 (imaging time, when the imaging device is a CT device). (Including tube voltage, etc.) can be stored as injection data in a fluoroscopic imager, RIS (radiology information system), PACS (medical image storage management system), HIS (hospital information system), etc. through a medical network. As a result, the stored injection data is used for managing the injection history. In particular, the injection amount and the like can be recorded in the medical record information as a used chemical solution and used for accounting processing. It is also possible to acquire physical information such as the body weight of the subject, ID, name, examination site, and examination method from RIS, PACS, HIS, etc., display them on the drug solution injection device, and perform injection according to the acquisition. This information and the data acquired from the RFID tag 802 by the RFID module 166 may be transmitted from the drug solution injection device 100 to the RIS, PACS, HIS, etc. via the fluoroscopic image pickup device 200, or from the drug solution injection device 100. It may be transmitted directly to RIS, PACS, HIS, or the like.

Further, the filling amount of the chemical solution by the chemical solution filling device 920 can be the injection amount of the chemical solution into the subject. By doing so, the filled chemical solution can be used without waste. The injection amount can be calculated by using a calculation formula considering factors such as physical characteristics such as the body weight of the subject, the imaging site and the imaging time, or the value can be directly determined by a doctor or the like. The above factors used to calculate the injection amount, or the value of the injection amount determined by a doctor or the like can be input by the operator, or RIS, HIS, PACS, or an external server connected via a network or a direct line. It can also be obtained from an external database such as the cloud. By obtaining the factor used for calculating the injection amount from an external database, it is possible to prevent input errors by the operator.

The calculation of the injection amount using the calculation formula is executed by the injection control unit 150. The function of the injection control unit 150 may be possessed by any computer device such as a chemical solution injection device, a fluoroscopic image pickup device, and various control circuits included in the chemical solution filling device. That is, the injection amount of the chemical solution can be configured to be calculated by any other computer device instead of the chemical solution injection device. In addition, by having the function of the console control circuit not only in the drug solution injection device but in any other computer device, the injection protocol with parameters such as the injection rate and the injection time as well as the injection amount of the drug solution can be used in the arbitrary computer. Can be created on the device.

The filling of the chemical solution into the empty syringe can be replaced by the chemical solution injection device 100. This makes it possible to eliminate the need for a chemical filling device. When filling an empty syringe with a drug solution using the drug solution injection device 100, the presser 112 has a claw or a hook for detachably holding a flange formed at the piston end of the empty syringe attached to the injection head 110. It has a flange holding structure such as. By retracting the presser 112 in a state where the flange of the piston is held by this flange holding structure and the syringe is connected to the chemical liquid container 930, the chemical liquid in the chemical liquid container 930 can be filled in the syringe.

(Container and drive mechanism)
In the above-described embodiment, the case where the container filled with the chemical solution is a syringe has been described as an example. However, in the present invention, the container is not limited to the syringe, and may be a chemical solution bottle, a chemical solution bag, or the like. In that case, as the drive mechanism for injecting the chemical solution in the container, a tube pump type drive mechanism can be used, and a drive mechanism according to the form of the container can be used. Further, for example, in the form shown in FIG. 16, the chemical solution container 930 is a first container filled with a contrast medium and a second container filled with physiological saline, and the chemical solution injection device 100 is a first and first container thereof. It has first and second holding mechanisms and first and second drive mechanisms corresponding to the two containers, respectively, which directly holds the first and second containers and the first and second containers. It is also possible to inject the drug solution filled in the container directly without going through a syringe. In this case, the chemical filling device 920 is unnecessary.

(Additional note)
This application discloses the following inventions.

[1] A chemical injection device that injects a contrast medium and a physiological saline into the subject as a chemical solution prior to imaging the medical image when the medical image of the subject is captured by using a fluoroscopic imager equipped with an electromagnetic wave irradiator. hand,
A first driving mechanism that operates to drain the contrast medium from the first container filled with the contrast medium, and a second driving mechanism filled with the saline solution to drain the saline solution. With a second drive mechanism that operates in, and an injection head,
At least one data entry interface that accepts data entry,
The injection protocol of the contrast medium and the saline solution is set using the data input via the data input interface, and the operation of the first drive mechanism and the second drive mechanism according to the set injection protocol. With an injection control unit configured to control
Have,
A plurality of parameters including mixed injection in which a contrast medium and physiological saline are injected at a predetermined mixing ratio, which is the basis for setting the injection protocol, are registered in the injection control unit.
When the concentration of the contrast enhancer of the contrast medium is changed among the plurality of registered parameters, the injection control unit changes the miscibility ratio according to the changed concentration, and the change is made. A drug solution infusion device configured to apply the miscibility to the infusion protocol.

[2] The injection control unit obtains a reference injection amount, which is an injection amount when only the contrast medium is injected, and also has a reference mixture ratio, which is a preset mixing ratio, and a contrast enhancement agent for the contrast medium. The actual mixing ratio, which is the actual mixing ratio, is obtained from the concentration of the above, and the injection amount of the contrast medium and the injection amount of the physiological saline are obtained using the obtained reference injection amount and the actual mixing ratio. The drug solution injection device according to [1], which is configured.

[3] The actual miscibility ratio is R, the reference miscibility ratio is R _base , the preset concentration of the contrast enhancer is I _{c_base} , and the concentration of the contrast enhancer actually used is I _c . When
The injection control unit has the following formula R = (I _{c_base} / I _c ) × R _base .
The chemical solution injection device according to [2], wherein the actual miscibility ratio is obtained by the method.

[4] Further having a display unit
The injection control unit is configured to display the protocol screen representing the injection protocol and the protocol setting screen used for registering the parameters on the display unit by menus independent of each other [1] to [. 3] The chemical injection device according to any one of.

[5] The first container has an RFID tag on which data including the concentration of the contrast enhancer of the contrast agent is recorded.
The drug solution injection device according to any one of [1] to [4], which has an RFID reader that acquires data from the RFID tag as one of the input interfaces.

[6] A fluoroscopic imager having an electromagnetic wave irradiator,
A plurality of containers including a first container for contrast medium and a second container for saline solution.
Injection including a first driving mechanism that operates to discharge the contrast medium from the first container and a second driving mechanism that operates to discharge the physiological saline solution from the second container. With the head
At least one data entry interface that accepts data entry,
The injection protocol of the contrast medium and the saline solution is set using the data input via the data input interface, and the operation of the first drive mechanism and the second drive mechanism according to the set injection protocol. With an injection control unit configured to control
Have,
A plurality of parameters including mixed injection in which a contrast medium and physiological saline are injected at a predetermined mixing ratio, which is the basis for setting the injection protocol, are registered in the injection control unit.
When the concentration of the contrast enhancer of the contrast medium is changed among the plurality of registered parameters, the injection control unit changes the miscibility ratio according to the changed concentration, and the change is made. A fluoroscopic imaging system configured to apply the miscibility to the injection protocol.

[7] The injection control unit obtains a reference injection amount, which is an injection amount when only the contrast medium is injected, and also has a reference mixture ratio, which is a preset mixing ratio, and a contrast enhancement agent for the contrast medium. The actual mixing ratio, which is the actual mixing ratio, is obtained from the concentration of the above, and the injection amount of the contrast medium and the injection amount of the physiological saline are obtained using the obtained reference injection amount and the actual mixing ratio. The fluoroscopic imaging system according to [6].

[8] The actual miscibility ratio is R, the reference miscibility ratio is R _base , the preset concentration of the contrast enhancer is I _{c_base} , and the concentration of the contrast enhancer actually used is I _c . When
The injection control unit has the following formula R = (I _{c_base} / I _c ) × R _base .
The fluoroscopic imaging system according to [7], wherein the actual miscibility ratio is obtained.

[9] Further having a display unit
The injection control unit is configured to display the protocol screen representing the injection protocol and the protocol setting screen used for registering the parameters on the display unit by menus independent of each other [6] to [. 8] The fluoroscopic imaging system according to any one of the items.

[10] The first container has an RFID tag on which data including the concentration of the contrast enhancer of the contrast agent is recorded.
The fluoroscopic imaging system according to any one of [6] to [9], which has an RFID reader that acquires data from the RFID tag as one of the input interfaces.

[11] A first driving mechanism that operates to allow the contrast medium to flow out of the first container filled with the contrast medium, and the physiological saline solution from the second container filled with the physiological saline solution. A second drive mechanism that operates to drain the contrast medium and the saline solution injection protocol is set, and the operation of the first drive mechanism and the second drive mechanism is performed according to the set injection protocol. The injection control unit is provided with a plurality of parameters including an injection control unit for controlling and an admixture injection for injecting the contrast medium and the saline solution at a predetermined mixing ratio, which is the basis for setting the injection protocol. It is a control method of the registered drug solution injection device.
When the concentration of the contrast enhancing agent of the contrast medium is changed among the plurality of registered parameters, the injection control unit changes the mixing ratio according to the changed concentration.
A step in which the injection control unit applies the modified miscibility to the injection protocol.
A method for controlling a chemical injection device.

[12] In the step of changing the miscibility, the injection control unit obtains a reference injection amount, which is the injection amount when only the contrast medium is injected, and the reference miscibility, which is the preset mixing ratio. Including obtaining the actual miscibility ratio, which is the actual miscibility ratio, from the ratio and the concentration of the contrast enhancer of the contrast agent.
The drug solution injection device according to [11], wherein the injection control unit further includes a step of obtaining an injection amount of the contrast medium and an injection amount of the physiological saline using the obtained reference injection amount and the actual miscibility ratio. Control method.

[13] In the step of changing the miscibility, the actual miscibility ratio is R, the reference miscibility ratio is R _base , the preset concentration of the contrast enhancement agent is I _{c_base} , and the contrast medium actually used. When the concentration of the contrast enhancer is _Ic ,
The injection control unit uses the following formula R = (I _{c_base} / I _c ) × R _base .
The control method of the chemical solution injection device according to [12], which comprises obtaining the actual miscibility ratio.

[14] A method for calculating an injection protocol including mixed injection in which a contrast medium and physiological saline are injected at a predetermined mixing ratio in a drug solution injection device having an injection control unit.
A step of obtaining a reference injection amount, which is an injection amount when the injection control unit injects only the contrast medium in the mixed injection, and a step.
A step in which the injection control unit obtains an actual miscibility ratio, which is an actual miscibility ratio, from a reference miscibility ratio, which is a preset miscibility ratio, and a concentration of a contrast enhancer of the contrast medium.
A step in which the injection control unit obtains the injection amount of the contrast medium and the injection amount of the physiological saline using the obtained reference injection amount and the actual miscibility ratio.
How to calculate the injection protocol with.

100 Chemical injection device 101 Console 103 Touch panel 112 Presser 110 Injection head 121 Stand 140 Piston drive mechanism 150 Injection control unit 152 Imaging control unit 153 Electromagnetic wave irradiator 154 Display unit 156 Input unit 164 RFID control circuit 165 Antenna 166 RFID module 200 Perspective imaging device 300 Injection condition call screen 310 Protocol screen 350 Protocol setting screen 600 Adapter 800 Syringe 802 RFID tag

Claims (14)

A drug solution injection device that injects a contrast medium and a physiological saline solution into the subject as a drug solution prior to imaging the medical image when the subject's medical image is imaged using a fluoroscopic imager equipped with an electromagnetic wave irradiator.
A first driving mechanism that operates to drain the contrast medium from the first container filled with the contrast medium, and a second driving mechanism filled with the saline solution to drain the saline solution. With a second drive mechanism that operates in, and an injection head,
At least one data entry interface that accepts data entry,
The injection protocol of the contrast medium and the saline solution is set using the data input via the data input interface, and the operation of the first drive mechanism and the second drive mechanism according to the set injection protocol. With an injection control unit configured to control
Have,
A plurality of parameters including mixed injection in which a contrast medium and physiological saline are injected at a predetermined mixing ratio, which is the basis for setting the injection protocol, are registered in the injection control unit.
When the concentration of the contrast enhancer of the contrast medium is changed among the plurality of registered parameters, the injection control unit changes the miscibility ratio according to the changed concentration, and the change is made. A drug solution infusion device configured to apply the miscibility to the infusion protocol. The injection control unit obtains a reference injection amount, which is an injection amount when only the contrast medium is injected, and also obtains a reference mixture ratio, which is a preset mixing ratio, and a concentration of the contrast enhancement agent of the contrast medium. , The actual mixing ratio, which is the actual mixing ratio, is obtained, and the injection amount of the contrast medium and the injection amount of the physiological saline are obtained using the obtained reference injection amount and the actual mixing ratio. The drug solution injection device according to claim 1. When the actual miscibility ratio is R, the reference miscibility ratio is R _base , the preset concentration of the contrast enhancer is I _{c_base} , and the concentration of the contrast enhancer actually used is I _c . ,
The injection control unit has the following formula R = (I _{c_base} / I _c ) × R _base .
The chemical injection device according to claim 2, wherein the actual miscibility ratio is obtained. Has more display units,
The injection control unit is configured to display the protocol screen representing the injection protocol and the protocol setting screen used for registering the parameters on the display unit by menus independent of each other. The drug solution injection device according to any one of the above. The first container has an RFID tag on which data including the concentration of the contrast enhancer of the contrast agent is recorded.
The drug solution injection device according to any one of claims 1 to 4, which has an RFID reader that acquires data from the RFID tag as one of the input interfaces. A fluoroscopic imager with an electromagnetic wave irradiator and
A plurality of containers including a first container for contrast medium and a second container for saline solution.
Injection including a first driving mechanism that operates to discharge the contrast medium from the first container and a second driving mechanism that operates to discharge the physiological saline solution from the second container. With the head
At least one data entry interface that accepts data entry,
The injection protocol of the contrast medium and the saline solution is set using the data input via the data input interface, and the operation of the first drive mechanism and the second drive mechanism according to the set injection protocol. With an injection control unit configured to control
Have,
A plurality of parameters including mixed injection in which a contrast medium and physiological saline are injected at a predetermined mixing ratio, which is the basis for setting the injection protocol, are registered in the injection control unit.
When the concentration of the contrast enhancer of the contrast medium is changed among the plurality of registered parameters, the injection control unit changes the miscibility ratio according to the changed concentration, and the change is made. A fluoroscopic imaging system configured to apply the miscibility to the injection protocol. The injection control unit obtains a reference injection amount, which is an injection amount when only the contrast medium is injected, and also obtains a reference mixture ratio, which is a preset mixing ratio, and a concentration of the contrast enhancement agent of the contrast medium. , The actual mixing ratio, which is the actual mixing ratio, is obtained, and the injection amount of the contrast medium and the injection amount of the physiological saline are obtained using the obtained reference injection amount and the actual mixing ratio. The fluoroscopic imaging system according to claim 6. When the actual miscibility ratio is R, the reference miscibility ratio is R _base , the preset concentration of the contrast enhancer is I _{c_base} , and the concentration of the contrast enhancer actually used is I _c . ,
The injection control unit has the following formula R = (I _{c_base} / I _c ) × R _base .
The fluoroscopic imaging system according to claim 7, wherein the actual miscibility ratio is obtained. Has more display units,
The injection control unit is configured to display the protocol screen representing the injection protocol and the protocol setting screen used for registering the parameters on the display unit by menus independent of each other. The fluoroscopic imaging system according to any one of the above. The first container has an RFID tag on which data including the concentration of the contrast enhancer of the contrast agent is recorded.
The fluoroscopic imaging system according to any one of claims 6 to 9, further comprising an RFID reader that acquires data from the RFID tag as one of the input interfaces. A first driving mechanism that operates to drain the contrast medium from the first container filled with the contrast medium, and a second driving mechanism filled with the saline solution to drain the saline solution. The injection that controls the operation of the first drive mechanism and the second drive mechanism according to the set injection protocol by setting the injection protocol of the contrast medium and the saline solution with the second drive mechanism that operates in A plurality of parameters including a control unit and a mixed injection in which the contrast medium and the physiological saline are injected at a predetermined mixing ratio, which has a control unit and is the basis for setting the injection protocol, are registered in the injection control unit. It is a control method for the chemical injection device.
When the concentration of the contrast enhancing agent of the contrast medium is changed among the plurality of registered parameters, the injection control unit changes the mixing ratio according to the changed concentration.
A step in which the injection control unit applies the modified miscibility to the injection protocol.
A method for controlling a chemical injection device. In the step of changing the miscibility, the injection control unit obtains a reference injection amount, which is the injection amount when only the contrast medium is injected, and the reference miscibility ratio, which is the preset mixing ratio, and the above. Including obtaining the actual miscibility ratio, which is the actual miscibility ratio, from the concentration of the contrast enhancer of the contrast medium.
The drug solution injection device according to claim 11, wherein the injection control unit further includes a step of obtaining an injection amount of the contrast medium and an injection amount of the physiological saline using the obtained reference injection amount and the actual mixing ratio. Control method. In the step of changing the miscibility, the actual miscibility ratio is R, the reference miscibility ratio is R _base , the preset concentration of the contrast enhancement agent is I _{c_base} , and the contrast enhancement of the contrast medium actually used is the contrast enhancement. When the concentration of the agent is _Ic ,
The injection control unit uses the following formula R = (I _{c_base} / I _c ) × R _base .
The control method of the chemical solution injection device according to claim 12, which comprises obtaining the actual miscibility ratio. A calculation method for an injection protocol including mixed injection in which a contrast medium and physiological saline are injected at a predetermined mixing ratio in a drug solution injection device having an injection control unit.
A step of obtaining a reference injection amount, which is an injection amount when the injection control unit injects only the contrast medium in the mixed injection, and a step.
A step in which the injection control unit obtains an actual miscibility ratio, which is an actual miscibility ratio, from a reference miscibility ratio, which is a preset miscibility ratio, and a concentration of a contrast enhancer of the contrast medium.
A step in which the injection control unit obtains the injection amount of the contrast medium and the injection amount of the physiological saline using the obtained reference injection amount and the actual miscibility ratio.
How to calculate the injection protocol with.

Images