JP2022062172A5 - - Google Patents
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- Publication number
- JP2022062172A5 JP2022062172A5 JP2022015508A JP2022015508A JP2022062172A5 JP 2022062172 A5 JP2022062172 A5 JP 2022062172A5 JP 2022015508 A JP2022015508 A JP 2022015508A JP 2022015508 A JP2022015508 A JP 2022015508A JP 2022062172 A5 JP2022062172 A5 JP 2022062172A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- fluticasone propionate
- nanocrystals
- phase
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 18
- 239000002159 nanocrystal Substances 0.000 claims 18
- 210000000744 eyelid Anatomy 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- 229960000289 fluticasone propionate Drugs 0.000 claims 13
- 239000006070 nanosuspension Substances 0.000 claims 13
- 239000000725 suspension Substances 0.000 claims 10
- 208000010217 blepharitis Diseases 0.000 claims 8
- 239000000243 solution Substances 0.000 claims 8
- 210000000720 eyelash Anatomy 0.000 claims 7
- 235000011187 glycerol Nutrition 0.000 claims 7
- 238000002156 mixing Methods 0.000 claims 6
- 230000000699 topical effect Effects 0.000 claims 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 5
- 239000004327 boric acid Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 4
- 206010065062 Meibomian gland dysfunction Diseases 0.000 claims 4
- 239000007853 buffer solution Substances 0.000 claims 4
- 239000002055 nanoplate Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 4
- 229920000053 polysorbate 80 Polymers 0.000 claims 4
- 229920012266 Poly(ether sulfone) PES Polymers 0.000 claims 3
- 239000008135 aqueous vehicle Substances 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 claims 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 229920001451 polypropylene glycol Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 238000000527 sonication Methods 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 1
- 238000000137 annealing Methods 0.000 claims 1
- 239000007979 citrate buffer Substances 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- KDQPSPMLNJTZAL-UHFFFAOYSA-L disodium hydrogenphosphate dihydrate Chemical compound O.O.[Na+].[Na+].OP([O-])([O-])=O KDQPSPMLNJTZAL-UHFFFAOYSA-L 0.000 claims 1
- 229940102213 injectable suspension Drugs 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- NJTGANWAUPEOAX-UHFFFAOYSA-N molport-023-220-454 Chemical compound OCC(O)CO.OCC(O)CO NJTGANWAUPEOAX-UHFFFAOYSA-N 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims 1
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 239000008215 water for injection Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962877599P | 2019-07-23 | 2019-07-23 | |
| US62/877,599 | 2019-07-23 | ||
| US201962942551P | 2019-12-02 | 2019-12-02 | |
| US62/942,551 | 2019-12-02 | ||
| JP2020124238A JP7021301B2 (ja) | 2019-07-23 | 2020-07-21 | 無菌眼用水性プロピオン酸フルチカゾンａ型ナノ結晶懸濁液の調製方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020124238A Division JP7021301B2 (ja) | 2019-07-23 | 2020-07-21 | 無菌眼用水性プロピオン酸フルチカゾンａ型ナノ結晶懸濁液の調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022062172A JP2022062172A (ja) | 2022-04-19 |
| JP2022062172A5 true JP2022062172A5 (enExample) | 2022-08-05 |
| JP7494230B2 JP7494230B2 (ja) | 2024-06-03 |
Family
ID=71738074
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020124238A Active JP7021301B2 (ja) | 2019-07-23 | 2020-07-21 | 無菌眼用水性プロピオン酸フルチカゾンａ型ナノ結晶懸濁液の調製方法 |
| JP2022015508A Active JP7494230B2 (ja) | 2019-07-23 | 2022-02-03 | 無菌眼用水性プロピオン酸フルチカゾンａ型ナノ結晶懸濁液の調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020124238A Active JP7021301B2 (ja) | 2019-07-23 | 2020-07-21 | 無菌眼用水性プロピオン酸フルチカゾンａ型ナノ結晶懸濁液の調製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US11406596B2 (enExample) |
| EP (1) | EP3769753B1 (enExample) |
| JP (2) | JP7021301B2 (enExample) |
| KR (1) | KR20220038443A (enExample) |
| CN (2) | CN115120557B (enExample) |
| AU (1) | AU2020317084A1 (enExample) |
| CA (1) | CA3145055A1 (enExample) |
| CY (1) | CY1124930T1 (enExample) |
| DK (1) | DK3769753T3 (enExample) |
| ES (1) | ES2905793T3 (enExample) |
| HR (1) | HRP20220165T1 (enExample) |
| HU (1) | HUE057416T2 (enExample) |
| LT (1) | LT3769753T (enExample) |
| MD (1) | MD3769753T2 (enExample) |
| MX (1) | MX420447B (enExample) |
| PH (1) | PH12022550003A1 (enExample) |
| PL (1) | PL3769753T3 (enExample) |
| PT (1) | PT3769753T (enExample) |
| RS (1) | RS62932B1 (enExample) |
| SI (1) | SI3769753T1 (enExample) |
| SM (1) | SMT202200082T1 (enExample) |
| TW (1) | TWI864053B (enExample) |
| WO (1) | WO2021014348A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020317084A1 (en) * | 2019-07-23 | 2022-03-03 | Nicox Ophthalmics, Inc. | Process for the preparation of sterile ophthalmic aqueous fluticasone propionate form a nanocrystals suspensions |
| CN115887372A (zh) * | 2022-10-25 | 2023-04-04 | 苏州欧康维视生物科技有限公司 | 丙酸氟替卡松混悬液及其制备方法 |
| CN115554238A (zh) * | 2022-10-25 | 2023-01-03 | 苏州欧康维视生物科技有限公司 | 眼用混悬液及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0639070T4 (da) | 1992-05-06 | 2010-12-13 | Alcon Lab Inc | Anvendelse af borat-polyolkomplekser til ophtalmiske præparater |
| JP3450805B2 (ja) * | 2000-08-08 | 2003-09-29 | わかもと製薬株式会社 | 水性医薬組成物 |
| US6900184B2 (en) * | 2003-04-14 | 2005-05-31 | Wyeth Holdings Corporation | Compositions containing pipercillin and tazobactam useful for injection |
| US20060229219A1 (en) | 2005-04-11 | 2006-10-12 | Advanced Medical Optics, Inc. | Borate-polyol mixtures as a buffering system |
| US8010032B2 (en) * | 2005-05-23 | 2011-08-30 | Xerox Corporation | Fuser member comprising deflocculated material |
| WO2010141834A1 (en) | 2009-06-05 | 2010-12-09 | Aciex Therapeutics, Inc. | Ophthalmic formulations of fluticasone and methods of use |
| TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
| US20130065888A1 (en) | 2011-08-15 | 2013-03-14 | Biserka Cetina-Cizmek | Ophthalmic formulations and processes for their preparation |
| DK3517541T3 (da) | 2012-05-08 | 2020-09-07 | Nicox Ophthalmics Inc | Polymorf form af fluticasonpropionat |
| CA2893654A1 (en) * | 2012-12-17 | 2014-06-26 | Glaxo Group Limited | Combination of levocabastine and fluticasone furoate for the treatment of inflammatory and/or allergic conditions |
| TWI773641B (zh) | 2015-05-08 | 2022-08-11 | 日商活效製藥股份有限公司 | 含有糖皮質類固醇（ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ）之奈米微粒子之水性懸浮液劑 |
| AU2020317084A1 (en) * | 2019-07-23 | 2022-03-03 | Nicox Ophthalmics, Inc. | Process for the preparation of sterile ophthalmic aqueous fluticasone propionate form a nanocrystals suspensions |
-
2020
- 2020-07-21 AU AU2020317084A patent/AU2020317084A1/en not_active Abandoned
- 2020-07-21 US US16/934,807 patent/US11406596B2/en active Active
- 2020-07-21 LT LTEP20186965.8T patent/LT3769753T/lt unknown
- 2020-07-21 PH PH1/2022/550003A patent/PH12022550003A1/en unknown
- 2020-07-21 TW TW109124497A patent/TWI864053B/zh active
- 2020-07-21 HR HRP20220165TT patent/HRP20220165T1/hr unknown
- 2020-07-21 KR KR1020227006020A patent/KR20220038443A/ko active Pending
- 2020-07-21 CN CN202210807241.1A patent/CN115120557B/zh active Active
- 2020-07-21 SM SM20220082T patent/SMT202200082T1/it unknown
- 2020-07-21 MD MDE20210297T patent/MD3769753T2/ro unknown
- 2020-07-21 DK DK20186965.8T patent/DK3769753T3/da active
- 2020-07-21 US US17/629,267 patent/US20220241296A1/en not_active Abandoned
- 2020-07-21 EP EP20186965.8A patent/EP3769753B1/en active Active
- 2020-07-21 JP JP2020124238A patent/JP7021301B2/ja active Active
- 2020-07-21 RS RS20220142A patent/RS62932B1/sr unknown
- 2020-07-21 CN CN202010707466.0A patent/CN111821261B/zh active Active
- 2020-07-21 HU HUE20186965A patent/HUE057416T2/hu unknown
- 2020-07-21 PT PT201869658T patent/PT3769753T/pt unknown
- 2020-07-21 SI SI202030032T patent/SI3769753T1/sl unknown
- 2020-07-21 ES ES20186965T patent/ES2905793T3/es active Active
- 2020-07-21 CA CA3145055A patent/CA3145055A1/en active Pending
- 2020-07-21 WO PCT/IB2020/056832 patent/WO2021014348A1/en not_active Ceased
- 2020-07-21 PL PL20186965T patent/PL3769753T3/pl unknown
- 2020-07-21 MX MX2022000928A patent/MX420447B/es unknown
-
2022
- 2022-01-27 CY CY20221100069T patent/CY1124930T1/el unknown
- 2022-02-03 JP JP2022015508A patent/JP7494230B2/ja active Active
- 2022-06-27 US US17/850,515 patent/US20220323352A1/en active Pending
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