JP2022044699A5 - - Google Patents
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- Publication number
- JP2022044699A5 JP2022044699A5 JP2022008581A JP2022008581A JP2022044699A5 JP 2022044699 A5 JP2022044699 A5 JP 2022044699A5 JP 2022008581 A JP2022008581 A JP 2022008581A JP 2022008581 A JP2022008581 A JP 2022008581A JP 2022044699 A5 JP2022044699 A5 JP 2022044699A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- hopo
- microcrystalline cellulose
- sodium
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 20
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 claims 16
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 15
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 15
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 15
- 229960001681 croscarmellose sodium Drugs 0.000 claims 15
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 15
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 15
- 239000008108 microcrystalline cellulose Substances 0.000 claims 15
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 12
- 235000019359 magnesium stearate Nutrition 0.000 claims 10
- 229920002907 Guar gum Polymers 0.000 claims 9
- 235000010417 guar gum Nutrition 0.000 claims 9
- 239000000665 guar gum Substances 0.000 claims 9
- 229960002154 guar gum Drugs 0.000 claims 9
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 8
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 8
- 239000004615 ingredient Substances 0.000 claims 8
- 229960001021 lactose monohydrate Drugs 0.000 claims 8
- KUWKQASGHNTJAT-UHFFFAOYSA-N 1-hydroxy-n-[3-[(1-hydroxy-6-oxopyridine-2-carbonyl)-[4-[(1-hydroxy-6-oxopyridine-2-carbonyl)-[3-[(1-hydroxy-6-oxopyridine-2-carbonyl)amino]propyl]amino]butyl]amino]propyl]-6-oxopyridine-2-carboxamide Chemical compound C1=CC(=O)N(O)C(C(=O)NCCCN(CCCCN(CCCNC(=O)C=2N(C(=O)C=CC=2)O)C(=O)C=2N(C(=O)C=CC=2)O)C(=O)C=2N(C(=O)C=CC=2)O)=C1 KUWKQASGHNTJAT-UHFFFAOYSA-N 0.000 claims 7
- 239000002738 chelating agent Substances 0.000 claims 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 5
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 5
- 229960003943 hypromellose Drugs 0.000 claims 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 4
- 229930195725 Mannitol Natural products 0.000 claims 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 4
- 229960000913 crospovidone Drugs 0.000 claims 4
- 239000000594 mannitol Substances 0.000 claims 4
- 235000010355 mannitol Nutrition 0.000 claims 4
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 4
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 229940069328 povidone Drugs 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 3
- 229940057948 magnesium stearate Drugs 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229920000881 Modified starch Polymers 0.000 claims 1
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 claims 1
- 229940068682 chewable tablet Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- 239000013081 microcrystal Substances 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 239000007916 tablet composition Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023194144A JP7712699B2 (ja) | 2016-09-06 | 2023-11-15 | ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662384087P | 2016-09-06 | 2016-09-06 | |
| US62/384,087 | 2016-09-06 | ||
| JP2019512761A JP7018210B2 (ja) | 2016-09-06 | 2017-09-05 | ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 |
| PCT/US2017/050121 WO2018048812A1 (en) | 2016-09-06 | 2017-09-05 | Formulations of hydroxypyridonate actinide/lanthanide decorporation agents |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512761A Division JP7018210B2 (ja) | 2016-09-06 | 2017-09-05 | ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023194144A Division JP7712699B2 (ja) | 2016-09-06 | 2023-11-15 | ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022044699A JP2022044699A (ja) | 2022-03-17 |
| JP2022044699A5 true JP2022044699A5 (enExample) | 2022-12-07 |
| JP7391403B2 JP7391403B2 (ja) | 2023-12-05 |
Family
ID=61562894
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512761A Active JP7018210B2 (ja) | 2016-09-06 | 2017-09-05 | ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 |
| JP2022008581A Active JP7391403B2 (ja) | 2016-09-06 | 2022-01-24 | ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 |
| JP2023194144A Active JP7712699B2 (ja) | 2016-09-06 | 2023-11-15 | ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512761A Active JP7018210B2 (ja) | 2016-09-06 | 2017-09-05 | ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023194144A Active JP7712699B2 (ja) | 2016-09-06 | 2023-11-15 | ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11684614B2 (enExample) |
| EP (1) | EP3509595B1 (enExample) |
| JP (3) | JP7018210B2 (enExample) |
| CA (1) | CA3035966A1 (enExample) |
| DK (1) | DK3509595T3 (enExample) |
| FI (1) | FI3509595T3 (enExample) |
| WO (1) | WO2018048812A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10982136B2 (en) | 2016-02-26 | 2021-04-20 | The Regents Of The University Of California | Ligand-sensitized lanthanide nanocrystals as ultraviolet downconverters |
| US11235076B2 (en) | 2016-08-29 | 2022-02-01 | Fred Hutchinson Cancer Research Center | Chelating platform for delivery of radionuclides |
| DK3509595T3 (da) | 2016-09-06 | 2023-01-23 | Univ California | Formuleringer af hydroxypyridonat-actinid/lanthanid-dekorporeringsmidler |
| EP3519034A4 (en) | 2016-09-29 | 2021-02-17 | The Regents of The University of California | CHELATING MOLECULES |
| WO2018097871A2 (en) | 2016-09-29 | 2018-05-31 | The Regents Of The University Of California | Separation of metal ions by liquid-liquid extraction |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3323857A (en) | 1965-12-16 | 1967-06-06 | Donald J Bauer | Selective extraction and separation of lanthanides with a quaternary ammonium compound |
| US3634113A (en) | 1968-10-30 | 1972-01-11 | Larry L Fehrenbacher | Stabilized zirconium dioxide and hafnium dioxide compositions |
| US4025602A (en) | 1976-05-25 | 1977-05-24 | The United States Of America As Represented By The United States Energy Research And Development Administration | Recovery of transplutonium elements from nuclear reactor waste |
| US4278559A (en) | 1978-02-16 | 1981-07-14 | Electric Power Research Institute | Method for processing spent nuclear reactor fuel |
| US4698431A (en) | 1985-11-12 | 1987-10-06 | The United States Of America As Represented By The United States Department Of Energy | Hydroxypyridonate chelating agents |
| GB8602304D0 (en) | 1986-01-30 | 1986-03-05 | Dakubu S | Dihydropyridine condensation products |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| ATE503496T1 (de) | 1992-02-06 | 2011-04-15 | Novartis Vaccines & Diagnostic | Biosynthetisches bindeprotein für tumormarker |
| FR2694451B1 (fr) | 1992-07-29 | 1994-09-30 | Asulab Sa | Cellule photovoltaïque. |
| US5634901A (en) | 1992-11-02 | 1997-06-03 | Localmed, Inc. | Method of using a catheter sleeve |
| JPH07104096A (ja) | 1993-10-05 | 1995-04-21 | Japan Atom Energy Res Inst | 酸性溶液中のランタニド元素と超プルトニウム元素の溶媒抽出による相互分離法 |
| US5624901A (en) | 1994-04-15 | 1997-04-29 | The Regents Of The University Of California | 3-hydroxy-2(1H)-pyridinone chelating agents |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| FR2748951B1 (fr) | 1996-05-24 | 1998-07-03 | Commissariat Energie Atomique | Procede de separation selective des actinides (iii) et lanthanides (iii) |
| US20020122752A1 (en) | 1998-11-05 | 2002-09-05 | Taylor Charles E. | Electro-kinetic air transporter-conditioner devices with interstitial electrode |
| FR2794032B1 (fr) | 1999-05-27 | 2002-06-14 | Univ Claude Bernard Lyon | Procede pour separer en milieu aqueux des lanthanides et/ou des actinides par complexation-nanofiltration, et nouveaux complexants mis en oeuvre dans ce procede |
| US6221476B1 (en) | 1999-06-11 | 2001-04-24 | Ibc Advanced Technologies, Inc. | Polymeric membranes functionalized with polyhydroxypyridinone ligands |
| US6846915B2 (en) | 2001-08-13 | 2005-01-25 | The Regents Of The University Of California | Hydroxypyridonate and hydroxypyrimidinone chelating agents |
| EP1755586A2 (en) | 2004-04-29 | 2007-02-28 | The Regents of the University of California | Hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone metalloprotein inhibitors |
| DK1791865T3 (da) | 2004-06-29 | 2010-11-01 | Immunocore Ltd | Celler der udtrykker en modificeret T-cellerecptor |
| FR2880180B1 (fr) | 2004-12-29 | 2007-03-02 | Cogema | Perfectionnement du procede purex et ses utilisations |
| EP1752471B9 (en) | 2005-01-05 | 2009-04-15 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| PL3190106T3 (pl) * | 2005-04-04 | 2019-10-31 | Univ Florida | Polieterowe analogi desferitiocyny |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| FR2900159B1 (fr) | 2006-04-19 | 2008-06-13 | Commissariat Energie Atomique | Separation groupee des actinides a partir d'une phase aqueuse fortement acide |
| AU2007272604B2 (en) | 2006-07-10 | 2013-08-01 | The Regents Of The University Of California | Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides |
| JP4911538B2 (ja) | 2006-12-26 | 2012-04-04 | 独立行政法人日本原子力研究開発機構 | 酸素及び窒素原子が活性な官能基を持つハイブリットドナー型抽出剤による３価及び４価アクチノイドの３価ランタノイドからの選択的分離法 |
| WO2008100907A2 (en) | 2007-02-13 | 2008-08-21 | Board Of Supervisors Of Louisiana State University And Argricultural And Mechanical College | Fluoride-releasing compositions |
| TW200836315A (en) * | 2007-02-16 | 2008-09-01 | Richtek Techohnology Corp | Electronic package structure and method thereof |
| WO2009018332A1 (en) | 2007-08-01 | 2009-02-05 | Alnylam Pharmaceuticals, Inc. | Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand |
| US8475747B1 (en) | 2008-06-13 | 2013-07-02 | U.S. Department Of Energy | Processing fissile material mixtures containing zirconium and/or carbon |
| WO2010129962A2 (en) | 2009-05-08 | 2010-11-11 | The Regents Of The University Of California | Combination treatment of hydroxypyridonate actinide/lanthanide decorporation agents |
| US20100317117A1 (en) | 2009-06-16 | 2010-12-16 | Los Alamos National Security, Llc | Selective membrane extraction of radioactive analytes |
| US8933526B2 (en) | 2009-07-15 | 2015-01-13 | First Solar, Inc. | Nanostructured functional coatings and devices |
| US20120132277A1 (en) | 2010-11-30 | 2012-05-31 | General Electric Company | Photovoltaic device and method for making |
| FR2988222B1 (fr) | 2012-03-13 | 2016-06-24 | Commissariat Energie Atomique | Module photovoltaique comprenant des elements de conversion spectrale localises et procede de realisation |
| US9472694B2 (en) | 2012-04-23 | 2016-10-18 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method for upconversion of light and devices incorporating same |
| US10010535B2 (en) | 2013-11-22 | 2018-07-03 | University Of Florida Research Foundation, Incorporated | Desferrithiocin analogs and uses thereof |
| AU2015369722A1 (en) | 2014-12-22 | 2017-08-03 | Lumiphore, Inc. | Functionalized linear ligands and complexes thereof |
| CN104825389B (zh) | 2015-04-10 | 2018-03-16 | 广东药学院 | 一种盐酸小檗碱自微乳制剂及其制备方法 |
| CN104998251A (zh) | 2015-07-08 | 2015-10-28 | 哈尔滨吉象隆生物技术有限公司 | 用于口服肠溶制剂制备的具有促肠吸收作用的利拉鲁肽盐 |
| WO2017105565A2 (en) | 2015-09-10 | 2017-06-22 | Memorial Sloan Kettering Cancer Center | Compositions for therapeutics, targeted pet imaging and methods of their use |
| US10982136B2 (en) | 2016-02-26 | 2021-04-20 | The Regents Of The University Of California | Ligand-sensitized lanthanide nanocrystals as ultraviolet downconverters |
| EP3452040B1 (en) | 2016-05-03 | 2024-04-03 | The Regents of The University of California | Formulations and treatments employing hydroxypyridonate actinide/lanthanide decorporation agents |
| DK3509595T3 (da) | 2016-09-06 | 2023-01-23 | Univ California | Formuleringer af hydroxypyridonat-actinid/lanthanid-dekorporeringsmidler |
| WO2018097871A2 (en) | 2016-09-29 | 2018-05-31 | The Regents Of The University Of California | Separation of metal ions by liquid-liquid extraction |
| EP3519034A4 (en) | 2016-09-29 | 2021-02-17 | The Regents of The University of California | CHELATING MOLECULES |
-
2017
- 2017-09-05 DK DK17849400.1T patent/DK3509595T3/da active
- 2017-09-05 WO PCT/US2017/050121 patent/WO2018048812A1/en not_active Ceased
- 2017-09-05 US US16/330,601 patent/US11684614B2/en active Active
- 2017-09-05 JP JP2019512761A patent/JP7018210B2/ja active Active
- 2017-09-05 CA CA3035966A patent/CA3035966A1/en active Pending
- 2017-09-05 EP EP17849400.1A patent/EP3509595B1/en active Active
- 2017-09-05 FI FIEP17849400.1T patent/FI3509595T3/fi active
-
2022
- 2022-01-24 JP JP2022008581A patent/JP7391403B2/ja active Active
- 2022-02-04 US US17/665,135 patent/US12268678B2/en active Active
-
2023
- 2023-11-15 JP JP2023194144A patent/JP7712699B2/ja active Active
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