JP7018210B2 - ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 - Google Patents

ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 Download PDF

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JP7018210B2
JP7018210B2 JP2019512761A JP2019512761A JP7018210B2 JP 7018210 B2 JP7018210 B2 JP 7018210B2 JP 2019512761 A JP2019512761 A JP 2019512761A JP 2019512761 A JP2019512761 A JP 2019512761A JP 7018210 B2 JP7018210 B2 JP 7018210B2
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JP2019532040A (ja
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レベッカ ジェイ． アベルジェル，
テイラー エー． チョイ，
ケネス エヌ． レイモンド，
デイビッド ケー． シュー，
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019512761A 2016-09-06 2017-09-05 ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤 Active JP7018210B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022008581A JP7391403B2 (ja) 2016-09-06 2022-01-24 ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤
JP2023194144A JP7712699B2 (ja) 2016-09-06 2023-11-15 ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤

Applications Claiming Priority (3)

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US201662384087P 2016-09-06 2016-09-06
US62/384,087 2016-09-06
PCT/US2017/050121 WO2018048812A1 (en) 2016-09-06 2017-09-05 Formulations of hydroxypyridonate actinide/lanthanide decorporation agents

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JP2019532040A JP2019532040A (ja) 2019-11-07
JP7018210B2 true JP7018210B2 (ja) 2022-02-10

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JP2022008581A Active JP7391403B2 (ja) 2016-09-06 2022-01-24 ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤
JP2023194144A Active JP7712699B2 (ja) 2016-09-06 2023-11-15 ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤

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JP2023194144A Active JP7712699B2 (ja) 2016-09-06 2023-11-15 ヒドロキシピリドネートアクチニド／ランタニド体外除去剤の製剤

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US (2) US11684614B2 (enExample)
EP (1) EP3509595B1 (enExample)
JP (3) JP7018210B2 (enExample)
CA (1) CA3035966A1 (enExample)
DK (1) DK3509595T3 (enExample)
FI (1) FI3509595T3 (enExample)
WO (1) WO2018048812A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12268678B2 (en) 2016-09-06 2025-04-08 The Regents Of The University Of California Formulations of hydroxypyridonate actinide/lanthanide decorporation agents
US12479792B2 (en) 2016-09-29 2025-11-25 The Regents Of The University Of California Compositions of chelating molecules

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10982136B2 (en) 2016-02-26 2021-04-20 The Regents Of The University Of California Ligand-sensitized lanthanide nanocrystals as ultraviolet downconverters
US11235076B2 (en) 2016-08-29 2022-02-01 Fred Hutchinson Cancer Research Center Chelating platform for delivery of radionuclides
WO2018097871A2 (en) 2016-09-29 2018-05-31 The Regents Of The University Of California Separation of metal ions by liquid-liquid extraction

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120214843A1 (en) 2009-05-08 2012-08-23 The Regents Of The University Of California Combination Treatment of Hydroxpyridonate Actinide/Lanthanide Decorporation Agents
CN104825389A (zh) 2015-04-10 2015-08-12 广东药学院 一种口服生物利用度好的盐酸小檗碱自微乳制剂及其制备方法
CN104998251A (zh) 2015-07-08 2015-10-28 哈尔滨吉象隆生物技术有限公司 用于口服肠溶制剂制备的具有促肠吸收作用的利拉鲁肽盐

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3323857A (en) 1965-12-16 1967-06-06 Donald J Bauer Selective extraction and separation of lanthanides with a quaternary ammonium compound
US3634113A (en) 1968-10-30 1972-01-11 Larry L Fehrenbacher Stabilized zirconium dioxide and hafnium dioxide compositions
US4025602A (en) 1976-05-25 1977-05-24 The United States Of America As Represented By The United States Energy Research And Development Administration Recovery of transplutonium elements from nuclear reactor waste
US4278559A (en) 1978-02-16 1981-07-14 Electric Power Research Institute Method for processing spent nuclear reactor fuel
US4698431A (en) 1985-11-12 1987-10-06 The United States Of America As Represented By The United States Department Of Energy Hydroxypyridonate chelating agents
GB8602304D0 (en) 1986-01-30 1986-03-05 Dakubu S Dihydropyridine condensation products
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
FI941572A7 (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
ATE503496T1 (de) 1992-02-06 2011-04-15 Novartis Vaccines & Diagnostic Biosynthetisches bindeprotein für tumormarker
FR2694451B1 (fr) 1992-07-29 1994-09-30 Asulab Sa Cellule photovoltaïque.
US5634901A (en) 1992-11-02 1997-06-03 Localmed, Inc. Method of using a catheter sleeve
JPH07104096A (ja) 1993-10-05 1995-04-21 Japan Atom Energy Res Inst 酸性溶液中のランタニド元素と超プルトニウム元素の溶媒抽出による相互分離法
US5624901A (en) 1994-04-15 1997-04-29 The Regents Of The University Of California 3-hydroxy-2(1H)-pyridinone chelating agents
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
FR2748951B1 (fr) 1996-05-24 1998-07-03 Commissariat Energie Atomique Procede de separation selective des actinides (iii) et lanthanides (iii)
US20020122752A1 (en) 1998-11-05 2002-09-05 Taylor Charles E. Electro-kinetic air transporter-conditioner devices with interstitial electrode
FR2794032B1 (fr) 1999-05-27 2002-06-14 Univ Claude Bernard Lyon Procede pour separer en milieu aqueux des lanthanides et/ou des actinides par complexation-nanofiltration, et nouveaux complexants mis en oeuvre dans ce procede
US6221476B1 (en) 1999-06-11 2001-04-24 Ibc Advanced Technologies, Inc. Polymeric membranes functionalized with polyhydroxypyridinone ligands
US6846915B2 (en) 2001-08-13 2005-01-25 The Regents Of The University Of California Hydroxypyridonate and hydroxypyrimidinone chelating agents
EP1755586A2 (en) 2004-04-29 2007-02-28 The Regents of the University of California Hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone metalloprotein inhibitors
DK1791865T3 (da) 2004-06-29 2010-11-01 Immunocore Ltd Celler der udtrykker en modificeret T-cellerecptor
FR2880180B1 (fr) 2004-12-29 2007-03-02 Cogema Perfectionnement du procede purex et ses utilisations
EP1752471B9 (en) 2005-01-05 2009-04-15 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
PL3190106T3 (pl) * 2005-04-04 2019-10-31 Univ Florida Polieterowe analogi desferitiocyny
EP1829895A1 (en) 2006-03-03 2007-09-05 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
FR2900159B1 (fr) 2006-04-19 2008-06-13 Commissariat Energie Atomique Separation groupee des actinides a partir d'une phase aqueuse fortement acide
AU2007272604B2 (en) 2006-07-10 2013-08-01 The Regents Of The University Of California Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
JP4911538B2 (ja) 2006-12-26 2012-04-04 独立行政法人日本原子力研究開発機構 酸素及び窒素原子が活性な官能基を持つハイブリットドナー型抽出剤による３価及び４価アクチノイドの３価ランタノイドからの選択的分離法
WO2008100907A2 (en) 2007-02-13 2008-08-21 Board Of Supervisors Of Louisiana State University And Argricultural And Mechanical College Fluoride-releasing compositions
TW200836315A (en) * 2007-02-16 2008-09-01 Richtek Techohnology Corp Electronic package structure and method thereof
WO2009018332A1 (en) 2007-08-01 2009-02-05 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand
US8475747B1 (en) 2008-06-13 2013-07-02 U.S. Department Of Energy Processing fissile material mixtures containing zirconium and/or carbon
US20100317117A1 (en) 2009-06-16 2010-12-16 Los Alamos National Security, Llc Selective membrane extraction of radioactive analytes
US8933526B2 (en) 2009-07-15 2015-01-13 First Solar, Inc. Nanostructured functional coatings and devices
US20120132277A1 (en) 2010-11-30 2012-05-31 General Electric Company Photovoltaic device and method for making
FR2988222B1 (fr) 2012-03-13 2016-06-24 Commissariat Energie Atomique Module photovoltaique comprenant des elements de conversion spectrale localises et procede de realisation
US9472694B2 (en) 2012-04-23 2016-10-18 The Board Of Trustees Of The Leland Stanford Junior University Composition and method for upconversion of light and devices incorporating same
US10010535B2 (en) 2013-11-22 2018-07-03 University Of Florida Research Foundation, Incorporated Desferrithiocin analogs and uses thereof
AU2015369722A1 (en) 2014-12-22 2017-08-03 Lumiphore, Inc. Functionalized linear ligands and complexes thereof
WO2017105565A2 (en) 2015-09-10 2017-06-22 Memorial Sloan Kettering Cancer Center Compositions for therapeutics, targeted pet imaging and methods of their use
US10982136B2 (en) 2016-02-26 2021-04-20 The Regents Of The University Of California Ligand-sensitized lanthanide nanocrystals as ultraviolet downconverters
EP3452040B1 (en) 2016-05-03 2024-04-03 The Regents of The University of California Formulations and treatments employing hydroxypyridonate actinide/lanthanide decorporation agents
DK3509595T3 (da) 2016-09-06 2023-01-23 Univ California Formuleringer af hydroxypyridonat-actinid/lanthanid-dekorporeringsmidler
WO2018097871A2 (en) 2016-09-29 2018-05-31 The Regents Of The University Of California Separation of metal ions by liquid-liquid extraction
EP3519034A4 (en) 2016-09-29 2021-02-17 The Regents of The University of California CHELATING MOLECULES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120214843A1 (en) 2009-05-08 2012-08-23 The Regents Of The University Of California Combination Treatment of Hydroxpyridonate Actinide/Lanthanide Decorporation Agents
CN104825389A (zh) 2015-04-10 2015-08-12 广东药学院 一种口服生物利用度好的盐酸小檗碱自微乳制剂及其制备方法
CN104998251A (zh) 2015-07-08 2015-10-28 哈尔滨吉象隆生物技术有限公司 用于口服肠溶制剂制备的具有促肠吸收作用的利拉鲁肽盐

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Pharmacy and Pharmacology，1995年，Vol.47 No.6，pp.469-473
薬剤学, 1997年, ，1997年，Vol.57 No.Suppl，pp.62-63

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12268678B2 (en) 2016-09-06 2025-04-08 The Regents Of The University Of California Formulations of hydroxypyridonate actinide/lanthanide decorporation agents
US12479792B2 (en) 2016-09-29 2025-11-25 The Regents Of The University Of California Compositions of chelating molecules

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US20220152003A1 (en) 2022-05-19
JP7712699B2 (ja) 2025-07-24
US12268678B2 (en) 2025-04-08
WO2018048812A1 (en) 2018-03-15
US20210283115A1 (en) 2021-09-16
DK3509595T3 (da) 2023-01-23
JP2024012598A (ja) 2024-01-30
EP3509595B1 (en) 2022-11-02
US11684614B2 (en) 2023-06-27
EP3509595A4 (en) 2020-04-22
JP2019532040A (ja) 2019-11-07
CA3035966A1 (en) 2018-03-15
JP2022044699A (ja) 2022-03-17
EP3509595A1 (en) 2019-07-17
FI3509595T3 (fi) 2023-03-01
JP7391403B2 (ja) 2023-12-05

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