JP2021535489A5 - - Google Patents
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- Publication number
- JP2021535489A5 JP2021535489A5 JP2021510455A JP2021510455A JP2021535489A5 JP 2021535489 A5 JP2021535489 A5 JP 2021535489A5 JP 2021510455 A JP2021510455 A JP 2021510455A JP 2021510455 A JP2021510455 A JP 2021510455A JP 2021535489 A5 JP2021535489 A5 JP 2021535489A5
- Authority
- JP
- Japan
- Prior art keywords
- microsatellite
- sample
- cancer
- loci
- score
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024060146A JP7699261B2 (ja) | 2018-08-31 | 2024-04-03 | 無細胞ｄｎａにおけるマイクロサテライト不安定性の検出 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726182P | 2018-08-31 | 2018-08-31 | |
| US62/726,182 | 2018-08-31 | ||
| US201962823578P | 2019-03-25 | 2019-03-25 | |
| US62/823,578 | 2019-03-25 | ||
| US201962857048P | 2019-06-04 | 2019-06-04 | |
| US62/857,048 | 2019-06-04 | ||
| PCT/US2019/048999 WO2020047378A1 (en) | 2018-08-31 | 2019-08-30 | Microsatellite instability detection in cell-free dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024060146A Division JP7699261B2 (ja) | 2018-08-31 | 2024-04-03 | 無細胞ｄｎａにおけるマイクロサテライト不安定性の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535489A JP2021535489A (ja) | 2021-12-16 |
| JP2021535489A5 true JP2021535489A5 (enExample) | 2022-09-07 |
| JP7539367B2 JP7539367B2 (ja) | 2024-08-23 |
Family
ID=67982149
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510455A Active JP7539367B2 (ja) | 2018-08-31 | 2019-08-30 | 無細胞ｄｎａにおけるマイクロサテライト不安定性の検出 |
| JP2024060146A Active JP7699261B2 (ja) | 2018-08-31 | 2024-04-03 | 無細胞ｄｎａにおけるマイクロサテライト不安定性の検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024060146A Active JP7699261B2 (ja) | 2018-08-31 | 2024-04-03 | 無細胞ｄｎａにおけるマイクロサテライト不安定性の検出 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US11773451B2 (enExample) |
| EP (1) | EP3844761A1 (enExample) |
| JP (2) | JP7539367B2 (enExample) |
| KR (2) | KR20260109960A (enExample) |
| CN (2) | CN112930569B (enExample) |
| AU (2) | AU2019328344B2 (enExample) |
| CA (1) | CA3109539A1 (enExample) |
| SG (1) | SG11202101400UA (enExample) |
| WO (1) | WO2020047378A1 (enExample) |
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|---|---|---|---|---|
| AU2010326672A1 (en) | 2009-07-10 | 2011-08-04 | Syngenta Participations Ag | Novel hydroxyphenylpyruvate dioxygenase polypeptides and methods of use |
| CN105190656B (zh) | 2013-01-17 | 2018-01-16 | 佩索纳里斯公司 | 用于遗传分析的方法和系统 |
| US10125399B2 (en) | 2014-10-30 | 2018-11-13 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
| US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
| JP7470787B2 (ja) | 2019-11-05 | 2024-04-18 | パーソナリス，インコーポレイティド | 単一試料からの腫瘍純度の推定 |
| MX2022011296A (es) | 2020-03-12 | 2023-02-09 | Personal Genome Diagnostics Inc | Distintivos de inestabilidad de microsatélites. |
| CA3170277A1 (en) * | 2020-03-30 | 2021-10-07 | M. Cyrus MAHER | Cancer classification with synthetic training samples |
| KR102717923B1 (ko) * | 2020-12-07 | 2024-10-17 | (주)디엑솜 | 현미부수체 지역의 서열 길이의 변동계수를 이용한 현미부수체 불안정성 진단방법 |
| WO2022124575A1 (ko) * | 2020-12-07 | 2022-06-16 | (주)디엑솜 | 현미부수체 지역의 서열 길이의 변동계수를 이용한 현미부수체 불안정성 진단방법 |
| US20240318256A1 (en) * | 2021-01-29 | 2024-09-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to diagnose msi cancer |
| US20250131981A1 (en) * | 2021-07-14 | 2025-04-24 | Foundation Medicine, Inc. | Methods and systems for determining microsatellite instability |
| CA3264290A1 (en) * | 2021-08-09 | 2023-02-16 | Canexia Health Inc. | METHODS FOR IDENTIFYING HIGH INSTABILITY OF MICROSATELLITES (MSI-H) IN DNA SAMPLES |
| KR102688594B1 (ko) * | 2021-08-10 | 2024-07-24 | (주)디엑솜 | 현미부수체 지역의 서열 길이의 변화율을 이용한 현미부수체 불안정성 진단방법 |
| KR102781271B1 (ko) * | 2021-08-10 | 2025-03-17 | (주)디엑솜 | 현미부수체 지역의 서열 길이의 최대값과 최소값의 차이를 이용한 현미부수체 불안정성 진단방법 |
| CN113744251B (zh) * | 2021-09-07 | 2023-08-29 | 上海桐树生物科技有限公司 | 基于自注意力机制从病理图片预测微卫星不稳定性的方法 |
| WO2023059654A1 (en) | 2021-10-05 | 2023-04-13 | Personalis, Inc. | Customized assays for personalized cancer monitoring |
| CN114972163B (zh) * | 2022-03-15 | 2025-02-18 | 常州桐树生物科技有限公司 | 基于图卷积神经网络识别微卫星不稳定性状态的方法 |
| EP4526465A1 (en) | 2022-05-17 | 2025-03-26 | Guardant Health, Inc. | Methods for identifying druggable targets and treating cancer |
| WO2024103018A2 (en) * | 2022-11-11 | 2024-05-16 | Memorial Sloan-Kettering Cancer Center | Methods for predicting cancer-associated venous thromboembolism using circulating tumor dna |
| CN116543835B (zh) * | 2023-04-21 | 2024-02-06 | 苏州吉因加生物医学工程有限公司 | 一种检测血浆样本微卫星状态的方法和装置 |
| CN116312781B (zh) * | 2023-05-17 | 2023-08-18 | 普瑞基准科技（北京）有限公司 | 一种基于机器学习的基因组不稳定性评估方法及系统 |
| WO2026006629A1 (en) | 2024-06-27 | 2026-01-02 | Personalis, Inc. | System and method for management of compressed sequencing files |
| KR102799531B1 (ko) * | 2024-09-27 | 2025-04-22 | 구본학 | 파이프용 후처리장치 |
Family Cites Families (48)
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| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US20030017081A1 (en) | 1994-02-10 | 2003-01-23 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| ATE226983T1 (de) | 1994-08-19 | 2002-11-15 | Pe Corp Ny | Gekoppeltes ampflikation- und ligationverfahren |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US7501245B2 (en) | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
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| EP2100971A3 (en) | 2000-07-07 | 2009-11-25 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
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| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
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| EP2218794A1 (en) * | 2009-02-13 | 2010-08-18 | Alphagenics International SA | Detection of instability in regions of genomic DNA containing simple tandem repeats |
| US20120135874A1 (en) * | 2009-05-08 | 2012-05-31 | The Johns Hopkins University | Single molecule spectroscopy for analysis of cell-free nucleic acid biomarkers |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US9115402B2 (en) | 2010-05-14 | 2015-08-25 | Dana-Farber Cancer Institute, Inc. | Compositions and methods of identifying tumor specific neoantigens |
| EP3225697A3 (en) | 2010-12-30 | 2017-11-22 | Foundation Medicine, Inc. | Optimization of multigene analysis of tumor samples |
| EP3998347A1 (en) * | 2012-04-10 | 2022-05-18 | Vib Vzw | Novel markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the dna base excision repair pathway |
| PL2893040T3 (pl) | 2012-09-04 | 2019-05-31 | Guardant Health Inc | Sposoby wykrywania rzadkich mutacji i wariantu liczby kopii |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| WO2014099979A2 (en) * | 2012-12-17 | 2014-06-26 | Virginia Tech Intellectual Properties, Inc. | Methods and compositions for identifying global microsatellite instability and for characterizing informative microsatellite loci |
| SG11201605432RA (en) | 2014-01-02 | 2016-07-28 | Sloan Kettering Inst Cancer | Determinants of cancer response to immunotherapy |
| US20150292033A1 (en) | 2014-04-10 | 2015-10-15 | Dana-Farber Cancer Institute, Inc. | Method of determining cancer prognosis |
| KR20170080697A (ko) | 2014-11-13 | 2017-07-10 | 더 존스 홉킨스 유니버시티 | 관문 차단 및 미소부수체 불안정성 |
| MA40737A (fr) | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
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| HK1256412A1 (zh) * | 2016-01-22 | 2019-09-20 | Grail, Inc. | 基於变体的疾病诊断和追踪 |
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| TWI822521B (zh) | 2016-05-13 | 2023-11-11 | 美商再生元醫藥公司 | 藉由投予pd-1抑制劑治療皮膚癌之方法 |
| US10294518B2 (en) | 2016-09-16 | 2019-05-21 | Fluxion Biosciences, Inc. | Methods and systems for ultra-sensitive detection of genomic alterations |
| EP3792922A1 (en) * | 2016-09-30 | 2021-03-17 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
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| US20180203974A1 (en) | 2016-11-07 | 2018-07-19 | Grail, Inc. | Methods of identifying somatic mutational signatures for early cancer detection |
| CN106834479A (zh) * | 2017-02-16 | 2017-06-13 | 凯杰（苏州）转化医学研究有限公司 | 肿瘤免疫治疗中微卫星不稳定状态分析体系 |
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| CN107526944B (zh) * | 2017-09-06 | 2018-08-24 | 南京世和基因生物技术有限公司 | 一种微卫星不稳定性的测序数据分析方法、装置及计算机可读介质 |
| EP4589059A3 (en) | 2017-12-01 | 2025-12-10 | Personal Genome Diagnostics, Inc. | Process for microsatellite instability detection |
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| BR112021004763A2 (pt) | 2018-09-14 | 2021-08-03 | Lexent Bio, Inc. | métodos e sistemas para avaliar a instabilidade de microssatélite |
| ES3070336T3 (es) | 2019-08-01 | 2026-06-15 | Tempus Ai Inc | Métodos y sistemas para detectar la inestabilidad microsatelital de un cáncer en un ensayo de biopsia líquida |
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2019
- 2019-08-30 JP JP2021510455A patent/JP7539367B2/ja active Active
- 2019-08-30 KR KR1020267020143A patent/KR20260109960A/ko active Pending
- 2019-08-30 WO PCT/US2019/048999 patent/WO2020047378A1/en not_active Ceased
- 2019-08-30 CA CA3109539A patent/CA3109539A1/en active Pending
- 2019-08-30 AU AU2019328344A patent/AU2019328344B2/en active Active
- 2019-08-30 SG SG11202101400UA patent/SG11202101400UA/en unknown
- 2019-08-30 KR KR1020217009381A patent/KR102983176B1/ko active Active
- 2019-08-30 EP EP19769633.9A patent/EP3844761A1/en active Pending
- 2019-08-30 CN CN201980071631.3A patent/CN112930569B/zh active Active
- 2019-08-30 CN CN202511402735.1A patent/CN121354685A/zh active Pending
-
2020
- 2020-06-19 US US16/907,034 patent/US11773451B2/en active Active
-
2023
- 2023-08-25 US US18/456,362 patent/US20230416843A1/en active Pending
- 2023-11-02 US US18/500,890 patent/US12344902B2/en active Active
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2024
- 2024-04-03 JP JP2024060146A patent/JP7699261B2/ja active Active
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2025
- 2025-05-27 US US19/219,819 patent/US12692552B2/en active Active
- 2025-08-29 US US19/314,107 patent/US20250388975A1/en active Pending
- 2025-08-29 US US19/314,113 patent/US20260055472A1/en active Pending
- 2025-08-29 US US19/314,101 patent/US20250384954A1/en active Pending
- 2025-09-02 AU AU2025226669A patent/AU2025226669A1/en active Pending
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