CA3109539A1 - Microsatellite instability detection in cell-free dna - Google Patents

Microsatellite instability detection in cell-free dna Download PDF

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Publication number
CA3109539A1
CA3109539A1 CA3109539A CA3109539A CA3109539A1 CA 3109539 A1 CA3109539 A1 CA 3109539A1 CA 3109539 A CA3109539 A CA 3109539A CA 3109539 A CA3109539 A CA 3109539A CA 3109539 A1 CA3109539 A1 CA 3109539A1
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CA
Canada
Prior art keywords
microsatellite
sample
loci
nucleic acid
score
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Pending
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CA3109539A
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English (en)
French (fr)
Inventor
Aliaksandr ARTSIOMENKA
Marcin Sikora
Catalin Barbacioru
Darya CHUDOVA
Martina I. LEFTEROVA
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Guardant Health Inc
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Guardant Health Inc
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Publication of CA3109539A1 publication Critical patent/CA3109539A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3109539A 2018-08-31 2019-08-30 Microsatellite instability detection in cell-free dna Pending CA3109539A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862726182P 2018-08-31 2018-08-31
US62/726,182 2018-08-31
US201962823578P 2019-03-25 2019-03-25
US62/823,578 2019-03-25
US201962857048P 2019-06-04 2019-06-04
US62/857,048 2019-06-04
PCT/US2019/048999 WO2020047378A1 (en) 2018-08-31 2019-08-30 Microsatellite instability detection in cell-free dna

Publications (1)

Publication Number Publication Date
CA3109539A1 true CA3109539A1 (en) 2020-03-05

Family

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Application Number Title Priority Date Filing Date
CA3109539A Pending CA3109539A1 (en) 2018-08-31 2019-08-30 Microsatellite instability detection in cell-free dna

Country Status (9)

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US (7) US11773451B2 (enExample)
EP (1) EP3844761A1 (enExample)
JP (2) JP7539367B2 (enExample)
KR (2) KR20260109960A (enExample)
CN (2) CN112930569B (enExample)
AU (2) AU2019328344B2 (enExample)
CA (1) CA3109539A1 (enExample)
SG (1) SG11202101400UA (enExample)
WO (1) WO2020047378A1 (enExample)

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Also Published As

Publication number Publication date
KR102983176B1 (ko) 2026-06-29
US12692552B2 (en) 2026-07-28
KR20210052511A (ko) 2021-05-10
US20230416843A1 (en) 2023-12-28
JP7699261B2 (ja) 2025-06-26
JP7539367B2 (ja) 2024-08-23
CN112930569B (zh) 2025-10-03
EP3844761A1 (en) 2021-07-07
JP2024084802A (ja) 2024-06-25
US20250388975A1 (en) 2025-12-25
WO2020047378A1 (en) 2020-03-05
AU2019328344B2 (en) 2025-06-12
US20260055472A1 (en) 2026-02-26
US12344902B2 (en) 2025-07-01
JP2021535489A (ja) 2021-12-16
US20240247319A1 (en) 2024-07-25
SG11202101400UA (en) 2021-03-30
KR20260109960A (ko) 2026-07-13
US20250384954A1 (en) 2025-12-18
US11773451B2 (en) 2023-10-03
US20250283181A1 (en) 2025-09-11
CN112930569A (zh) 2021-06-08
US20210363586A1 (en) 2021-11-25
AU2019328344A1 (en) 2021-04-08
AU2025226669A1 (en) 2025-09-18
CN121354685A (zh) 2026-01-16

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