KR20260109960A - 무세포 dna에서의 미세부수체 불안정성 검출 - Google Patents

무세포 dna에서의 미세부수체 불안정성 검출

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Publication number
KR20260109960A
KR20260109960A KR1020267020143A KR20267020143A KR20260109960A KR 20260109960 A KR20260109960 A KR 20260109960A KR 1020267020143 A KR1020267020143 A KR 1020267020143A KR 20267020143 A KR20267020143 A KR 20267020143A KR 20260109960 A KR20260109960 A KR 20260109960A
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KR
South Korea
Prior art keywords
sample
nucleic acid
msi
microsatellite
sequencing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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KR1020267020143A
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English (en)
Korean (ko)
Inventor
앨리아크산드르 아트시오멘카
마신 시코라
카탈린 바바시오루
다르야 추도바
마티나 아이. 레프터로바
Original Assignee
가던트 헬쓰, 인크.
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Application filed by 가던트 헬쓰, 인크. filed Critical 가던트 헬쓰, 인크.
Publication of KR20260109960A publication Critical patent/KR20260109960A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020267020143A 2018-08-31 2019-08-30 무세포 dna에서의 미세부수체 불안정성 검출 Pending KR20260109960A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201862726182P 2018-08-31 2018-08-31
US62/726,182 2018-08-31
US201962823578P 2019-03-25 2019-03-25
US62/823,578 2019-03-25
US201962857048P 2019-06-04 2019-06-04
US62/857,048 2019-06-04
PCT/US2019/048999 WO2020047378A1 (en) 2018-08-31 2019-08-30 Microsatellite instability detection in cell-free dna
KR1020217009381A KR102983176B1 (ko) 2018-08-31 2019-08-30 무세포 dna에서의 미세부수체 불안정성 검출

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Publications (1)

Publication Number Publication Date
KR20260109960A true KR20260109960A (ko) 2026-07-13

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KR1020217009381A Active KR102983176B1 (ko) 2018-08-31 2019-08-30 무세포 dna에서의 미세부수체 불안정성 검출

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Country Status (9)

Country Link
US (7) US11773451B2 (enExample)
EP (1) EP3844761A1 (enExample)
JP (2) JP7539367B2 (enExample)
KR (2) KR20260109960A (enExample)
CN (2) CN112930569B (enExample)
AU (2) AU2019328344B2 (enExample)
CA (1) CA3109539A1 (enExample)
SG (1) SG11202101400UA (enExample)
WO (1) WO2020047378A1 (enExample)

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Also Published As

Publication number Publication date
KR102983176B1 (ko) 2026-06-29
US12692552B2 (en) 2026-07-28
KR20210052511A (ko) 2021-05-10
US20230416843A1 (en) 2023-12-28
JP7699261B2 (ja) 2025-06-26
JP7539367B2 (ja) 2024-08-23
CN112930569B (zh) 2025-10-03
EP3844761A1 (en) 2021-07-07
JP2024084802A (ja) 2024-06-25
US20250388975A1 (en) 2025-12-25
WO2020047378A1 (en) 2020-03-05
AU2019328344B2 (en) 2025-06-12
US20260055472A1 (en) 2026-02-26
US12344902B2 (en) 2025-07-01
JP2021535489A (ja) 2021-12-16
US20240247319A1 (en) 2024-07-25
SG11202101400UA (en) 2021-03-30
US20250384954A1 (en) 2025-12-18
US11773451B2 (en) 2023-10-03
US20250283181A1 (en) 2025-09-11
CN112930569A (zh) 2021-06-08
US20210363586A1 (en) 2021-11-25
AU2019328344A1 (en) 2021-04-08
CA3109539A1 (en) 2020-03-05
AU2025226669A1 (en) 2025-09-18
CN121354685A (zh) 2026-01-16

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