JP2021534815A - Ｔｎｆｒ２ドメインを含む新規ｃａｒ構築物 - Google Patents

Ｔｎｆｒ２ドメインを含む新規ｃａｒ構築物 Download PDF

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JP2021534815A
JP2021534815A JP2021531201A JP2021531201A JP2021534815A JP 2021534815 A JP2021534815 A JP 2021534815A JP 2021531201 A JP2021531201 A JP 2021531201A JP 2021531201 A JP2021531201 A JP 2021531201A JP 2021534815 A JP2021534815 A JP 2021534815A
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cells
fragment
variant
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JP2021534815A5 (enExample
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アベル，トビアス
フェナード，デイビッド
ガートナー−ダーデン，ジュリー
メイヤー，フランソワ
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サンガモ セラピューティクス フランス
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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JP2021531201A 2018-08-10 2019-08-09 Ｔｎｆｒ２ドメインを含む新規ｃａｒ構築物 Pending JP2021534815A (ja)

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JP2024099001A JP2024123133A (ja) 2018-08-10 2024-06-19 Ｔｎｆｒ２ドメインを含む新規ｃａｒ構築物

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US201862717234P 2018-08-10 2018-08-10
US62/717,234 2018-08-10
PCT/IB2019/000907 WO2020030979A2 (en) 2018-08-10 2019-08-09 New car constructs comprising tnfr2 domains

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JP2024099001A Pending JP2024123133A (ja) 2018-08-10 2024-06-19 Ｔｎｆｒ２ドメインを含む新規ｃａｒ構築物

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US (1) US20210292389A1 (enExample)
EP (1) EP3833446A2 (enExample)
JP (2) JP2021534815A (enExample)
KR (1) KR20210046006A (enExample)
CN (1) CN112888481A (enExample)
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BR (1) BR112021002579A2 (enExample)
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KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
EP3808766A1 (en) * 2019-10-15 2021-04-21 Sangamo Therapeutics France Chimeric antigen receptor specific for interleukin-23 receptor
US20230121433A1 (en) * 2020-03-11 2023-04-20 Poseida Therapeutics, Inc. Chimeric stimulatory receptors and methods of use in t cell activation and differentiation
CN113528449A (zh) * 2020-04-20 2021-10-22 浙江瑞加美生物科技有限公司 一种制备通用型人源化car19-dnt细胞的技术及其应用
BR112023014615A2 (pt) * 2021-01-20 2023-10-03 Seoul Nat Univ Hospital Células t reguladoras de receptor de antígeno quimérico anti-c4d e usos das mesmas.
JP2024526201A (ja) * 2021-06-25 2024-07-17 サンガモ セラピューティクス，インコーポレイテッド Ｉｌ－２３ｒに特異的な抗原結合体及びその使用
WO2023010122A2 (en) * 2021-07-29 2023-02-02 Sonoma Biotherapeutics, Inc. Synovial extracellular matrix-specific chimeric antigen receptor for targeting regulatory t cells to treat autoimmune diseases
WO2023076912A2 (en) * 2021-10-26 2023-05-04 ImmPACT Bio USA Inc. Cd4+ and/or cd8+ cell populations comprising icars for use in treatment therapies
CN114262689A (zh) * 2021-12-17 2022-04-01 上海纳米技术及应用国家工程研究中心有限公司 一种快速检测cd19/cd20-car-t细胞活性的方法
WO2023156587A1 (en) * 2022-02-18 2023-08-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance
WO2025006795A1 (en) * 2023-06-30 2025-01-02 Board Of Regents, The University Of Texas System Tsyn-seq: a t cell synapse-based tumor antigen identification platform
WO2025170881A1 (en) * 2024-02-06 2025-08-14 The Board Of Trustees Of The University Of Illinois Methods and kits for reducing the risk of allograft rejection
WO2025250847A1 (en) * 2024-05-29 2025-12-04 The Texas A&M University System Compositions containing hsp60-specific regulatory t cells and methods of treatment using the same

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JP2017502690A (ja) * 2013-12-20 2017-01-26 ノバルティス アーゲー 調節可能キメラ抗原受容体
WO2017025038A1 (en) * 2015-08-11 2017-02-16 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors based on single-domain antibodies and methods of use thereof
JP2017524367A (ja) * 2014-08-14 2017-08-31 ノバルティス アーゲー ＧＦＲα−４キメラ抗原受容体を用いる癌の治療
WO2018106993A1 (en) * 2016-12-09 2018-06-14 H. Lee Moffitt Cancer Center And Research Institute Inc. Tlr9-binding chimeric antigen receptors

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