JP2021534802A5 - - Google Patents

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Publication number
JP2021534802A5
JP2021534802A5 JP2021511646A JP2021511646A JP2021534802A5 JP 2021534802 A5 JP2021534802 A5 JP 2021534802A5 JP 2021511646 A JP2021511646 A JP 2021511646A JP 2021511646 A JP2021511646 A JP 2021511646A JP 2021534802 A5 JP2021534802 A5 JP 2021534802A5
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Japan
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cancer
seq
domain
antigen
cell
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JP2021511646A
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Japanese (ja)
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JP7394840B2 (ja
JP2021534802A (ja
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Priority claimed from PCT/EP2019/073257 external-priority patent/WO2020043899A1/en
Publication of JP2021534802A publication Critical patent/JP2021534802A/ja
Publication of JP2021534802A5 publication Critical patent/JP2021534802A5/ja
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JP2021511646A 2018-08-31 2019-08-30 複数のhla-gアイソフォームに対するキメラ抗原レセプター Active JP7394840B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP18306153 2018-08-31
EP18306153.0 2018-08-31
EP19305809.6 2019-06-21
EP19305809 2019-06-21
PCT/EP2019/073257 WO2020043899A1 (en) 2018-08-31 2019-08-30 Chimeric antigen receptors against multiple hla-g isoforms

Publications (3)

Publication Number Publication Date
JP2021534802A JP2021534802A (ja) 2021-12-16
JP2021534802A5 true JP2021534802A5 (OSRAM) 2022-09-07
JP7394840B2 JP7394840B2 (ja) 2023-12-08

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ID=67766182

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JP2021511646A Active JP7394840B2 (ja) 2018-08-31 2019-08-30 複数のhla-gアイソフォームに対するキメラ抗原レセプター

Country Status (12)

Country Link
US (5) US11117971B2 (OSRAM)
EP (1) EP3843778A1 (OSRAM)
JP (1) JP7394840B2 (OSRAM)
KR (1) KR20210112295A (OSRAM)
CN (1) CN112912105B (OSRAM)
AU (1) AU2019328677A1 (OSRAM)
BR (1) BR112021003757A2 (OSRAM)
IL (1) IL281097A (OSRAM)
MX (1) MX2021002316A (OSRAM)
SG (1) SG11202101849XA (OSRAM)
WO (1) WO2020043899A1 (OSRAM)
ZA (1) ZA202101358B (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201829463A (zh) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 抗hla-g抗體及其用途
AR114789A1 (es) 2018-04-18 2020-10-14 Hoffmann La Roche Anticuerpos anti-hla-g y uso de los mismos
MX2021002316A (es) 2018-08-31 2021-07-15 Invectys SA Receptores de antígeno quimérico frente a múltiples isoformas de hla-g.
CR20210197A (es) 2018-09-27 2021-06-03 Tizona Therapeutics Anticuerpos anti-hla-g, composiciones que comprenden anticuerpos anti-hla-g y métodos de uso de anticuerpos anti-hla-g
CR20230263A (es) 2020-12-17 2023-08-21 Hoffmann La Roche Anticuerpos anti-hla-g y uso de estos
EP4079846A1 (en) * 2021-04-23 2022-10-26 SVAR Life Science AB Novel luciferases with improved properties
CN118234744A (zh) * 2021-05-26 2024-06-21 得克萨斯大学体系董事会 靶向hla-g阳性癌症的嵌合抗原受体
TWI823402B (zh) 2021-07-21 2023-11-21 長聖國際生技股份有限公司 多特異性單域抗體嵌合抗原受體及t細胞銜接體、核酸、其表達細胞、其用途以及治療癌症之醫藥組合物
EP4377336A4 (en) * 2021-07-29 2025-07-16 Nantcell Inc MODIFIED T CELL RECEPTORS FOR THE PREVENTION AND TREATMENT OF VIRAL INFECTIONS AND CANCER
CN116218780A (zh) * 2021-12-03 2023-06-06 洪明奇 外泌体的生产及其用途
CN114605543B (zh) * 2021-12-17 2023-11-07 台州恩泽医疗中心(集团) 一种抗hla-g异构体分子hla-g5及hla-g6的单克隆抗体及其用途
CN114380920B (zh) * 2021-12-17 2024-06-28 广州达安基因股份有限公司 人甲胎蛋白融合蛋白及其制备方法和应用
CN119053618A (zh) 2022-02-04 2024-11-29 恩基尔特医疗有限公司 嵌合ilt受体组合物和方法
EP4501963A4 (en) * 2022-03-25 2026-04-22 Hk Inno N Corp CHIMERIC ANTIGENIC RECEPTOR ANTI-HLA-G AND ITS USE
CN115112900B (zh) * 2022-06-15 2024-08-16 四川大学华西医院 检测脂解激活脂蛋白受体的试剂和/或系统在制备恶性胸腔积液筛查产品中的用途
KR20240002205A (ko) * 2022-06-24 2024-01-04 에이치케이이노엔 주식회사 면역관문 제어 인자를 발현하는 면역세포 및 이의 용도
CN116284387B (zh) * 2022-07-15 2025-10-03 台州恩泽医疗中心(集团) 一种抗hla-g2及hla-g6分子的单克隆抗体及用途
KR20250139268A (ko) * 2022-11-28 2025-09-23 인벡티스, 인크. 인간화 항-hla-g 키메라 항원 수용체 및 이의 용도
CN116535500B (zh) * 2022-11-30 2024-03-22 西南大学 马铃薯x病毒单克隆抗体pvx-6及其应用
CN119569892A (zh) * 2023-09-06 2025-03-07 上海恩凯细胞技术有限公司 特异性靶向肿瘤非经典hla分子的嵌合抗原受体的应用
CN119569893B (zh) * 2023-09-06 2025-10-31 上海恩凯细胞技术有限公司 特异性靶向肿瘤的嵌合抗原受体细胞及其制备方法和应用
CN122055386A (zh) * 2023-10-12 2026-05-15 Im生技股份有限公司 特异性结合hla-g的抗体及其用途
CN118420786B (zh) * 2024-06-12 2025-10-17 浙江大学医学院附属第一医院(浙江省第一医院) 一种靶向her2和hla-g的双特异性嵌合抗原受体及其应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4694778A (en) 1984-05-04 1987-09-22 Anicon, Inc. Chemical vapor deposition wafer boat
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
IN165717B (OSRAM) 1986-08-07 1989-12-23 Battelle Memorial Institute
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
ES2067018T3 (es) 1988-12-28 1995-03-16 Stefan Miltenyi Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos.
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
JP3266311B2 (ja) 1991-05-02 2002-03-18 生化学工業株式会社 新規ポリペプチドおよびこれを用いる抗hiv剤
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
KR100373813B1 (ko) 1994-05-02 2003-10-08 베른트 그로너 이관능성단백질,그의제조및용도
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US5712149A (en) 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
CA2213620A1 (en) 1995-04-07 1996-10-10 The Regents Of The University Of California Antibodies for the detection of hla-g
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6924123B2 (en) 1996-10-29 2005-08-02 Oxford Biomedica (Uk) Limited Lentiviral LTR-deleted vector
AU2472400A (en) 1998-10-20 2000-05-08 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
EP1235842A4 (en) 1999-10-15 2003-04-23 Univ Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
BR0108545A (pt) 2000-02-24 2004-06-29 Xcyte Therapies Inc Estimulação e concentração simultâneas das células
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
AU2001275474A1 (en) 2000-06-12 2001-12-24 Akkadix Corporation Materials and methods for the control of nematodes
US7419829B2 (en) 2000-10-06 2008-09-02 Oxford Biomedica (Uk) Limited Vector system
US7070993B2 (en) 2001-03-13 2006-07-04 Novartis Ag Lentiviral packaging constructs
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US20130266551A1 (en) 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
WO2008045437A2 (en) 2006-10-09 2008-04-17 The General Hospital Corporation Chimeric t-cell receptors and t-cells targeting egfrviii on tumors
CA2682605A1 (en) 2007-04-18 2008-10-30 Zymogenetics, Inc. Single chain fc, methods of making and methods of treatment
ES2640216T3 (es) 2007-12-07 2017-11-02 Miltenyi Biotec Gmbh Sistemas y métodos para procesamiento de células
US20120164718A1 (en) 2008-05-06 2012-06-28 Innovative Micro Technology Removable/disposable apparatus for MEMS particle sorting device
US8822647B2 (en) 2008-08-26 2014-09-02 City Of Hope Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells
PL3824905T3 (pl) 2012-08-20 2025-05-05 Fred Hutchinson Cancer Center Sposób i kompozycje do immunoterapii komórkowej
EP2730588A1 (en) * 2012-11-12 2014-05-14 Intelectys Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof
TWI654206B (zh) 2013-03-16 2019-03-21 諾華公司 使用人類化抗-cd19嵌合抗原受體治療癌症
CN107533051B (zh) * 2015-03-27 2020-11-13 南加利福尼亚大学 Hla-g作为car t细胞免疫疗法的新靶标
AU2016265845B2 (en) * 2015-05-15 2020-10-08 City Of Hope Chimeric antigen receptor compositions
EA201892793A1 (ru) * 2016-06-03 2019-06-28 Инвектис Анти-hla-g специфические антитела
EP3515493A4 (en) 2016-09-23 2020-08-19 University of Southern California CHEMERICAL ANTIGEN RECEPTORS, COORESPONDENT COMPOSITIONS AND METHODS OF USE
TW201829463A (zh) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 抗hla-g抗體及其用途
MX2021002316A (es) 2018-08-31 2021-07-15 Invectys SA Receptores de antígeno quimérico frente a múltiples isoformas de hla-g.
TWI694083B (zh) 2018-09-17 2020-05-21 中國醫藥大學附設醫院 嵌合抗原受體、核酸、嵌合抗原受體表達質體、表達嵌合抗原受體細胞、其用途以及用於治療癌症之醫藥組合物
TWI717880B (zh) 2019-10-24 2021-02-01 中國醫藥大學附設醫院 Hla-g特異性嵌合抗原受體、核酸、hla-g特異性嵌合抗原受體表達質體、表達hla-g特異性嵌合抗原受體細胞、其用途以及用於治療癌症之醫藥組合物

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