JP2021534785A5 - - Google Patents

Info

Publication number
JP2021534785A5
JP2021534785A5 JP2021510707A JP2021510707A JP2021534785A5 JP 2021534785 A5 JP2021534785 A5 JP 2021534785A5 JP 2021510707 A JP2021510707 A JP 2021510707A JP 2021510707 A JP2021510707 A JP 2021510707A JP 2021534785 A5 JP2021534785 A5 JP 2021534785A5
Authority
JP
Japan
Prior art keywords
cells
exposure process
approximately
days
notch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021510707A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021534785A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/048574 external-priority patent/WO2020047099A1/en
Publication of JP2021534785A publication Critical patent/JP2021534785A/ja
Publication of JP2021534785A5 publication Critical patent/JP2021534785A5/ja
Pending legal-status Critical Current

Links

JP2021510707A 2018-08-28 2019-08-28 誘導ノッチシグナル伝達を用いた養子t細胞療法の方法及び組成物 Pending JP2021534785A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862723936P 2018-08-28 2018-08-28
US62/723,936 2018-08-28
PCT/US2019/048574 WO2020047099A1 (en) 2018-08-28 2019-08-28 Methods and compositions for adoptive t cell therapy incorporating induced notch signaling

Publications (2)

Publication Number Publication Date
JP2021534785A JP2021534785A (ja) 2021-12-16
JP2021534785A5 true JP2021534785A5 (enExample) 2022-06-03

Family

ID=67982131

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021510707A Pending JP2021534785A (ja) 2018-08-28 2019-08-28 誘導ノッチシグナル伝達を用いた養子t細胞療法の方法及び組成物

Country Status (9)

Country Link
US (1) US20210292711A1 (enExample)
EP (1) EP3844266A1 (enExample)
JP (1) JP2021534785A (enExample)
CN (1) CN112930393A (enExample)
AU (1) AU2019329984A1 (enExample)
BR (1) BR112021003830A2 (enExample)
CA (1) CA3110089A1 (enExample)
SG (1) SG11202101455TA (enExample)
WO (1) WO2020047099A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12624072B2 (en) 2019-05-01 2026-05-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Engineering broadly reactive human notch ligands as novel tools for biomedical applications
EP3996725A4 (en) * 2019-07-11 2023-06-28 H. Lee Moffitt Cancer Center & Research Institute, Inc. Engineering notch ligands to enhance the anti-tumor activity of adoptively transferred t cells
US12365871B2 (en) 2020-04-28 2025-07-22 Lyell Immunopharma, Inc. Methods for culturing cells
WO2022165367A1 (en) * 2021-01-29 2022-08-04 Fred Hutchinson Cancer Research Center Methods and compositions for enhancing cd4+ phenotype for adoptive t cell therapy
CN113832102B (zh) * 2021-09-27 2024-03-12 苏州东岭生物技术有限公司 Cd3/cd28/dll4磁珠及其制备方法和应用
CN116716349B (zh) * 2023-08-01 2023-10-31 江苏集萃药康生物科技股份有限公司 一种dll4人源化小鼠模型的构建方法及其应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA136551A (en) 1911-08-03 1911-10-31 Hedwig Heeron Rolling mill
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
IE20030749A1 (en) 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
US5420032A (en) 1991-12-23 1995-05-30 Universitge Laval Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence
US5792632A (en) 1992-05-05 1998-08-11 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
WO1997034634A1 (en) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Single chain fv constructs of anti-ganglioside gd2 antibodies
EP0942998B1 (en) * 1996-11-07 2005-07-06 Lorantis Limited Notch
WO2000014257A1 (en) 1998-09-04 2000-03-16 Sloan-Kettering Institute For Cancer Research Fusion receptors specific for prostate-specific membrane antigen and uses thereof
CA2410510A1 (en) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US6689744B2 (en) 2000-09-22 2004-02-10 Genentech, Inc. Notch receptor agonists and uses
US20030119771A1 (en) 2001-08-22 2003-06-26 Rompaey Luc Van Modulators of bone homeostasis identified in a high-throughput screen
JP2003093048A (ja) * 2001-09-26 2003-04-02 Asahi Kasei Corp 新規細胞製剤製造用培養媒体
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
AU2003215869B2 (en) 2002-03-15 2008-04-24 Cellectis Hybrid and single chain meganucleases and use thereof
EP1492816A2 (en) * 2002-04-05 2005-01-05 Lorantis Limited Modulators of the notch signalling pathway and uses thereof in medical treatment
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
AU2003269268A1 (en) * 2002-10-09 2004-05-04 Lorantis Limited Modulation of immune function
WO2004064863A1 (en) * 2003-01-23 2004-08-05 Lorantis Limited Treatment of autoimmune diseases using an activator for the notch signaling pathway
AU2004208031B2 (en) 2003-01-28 2009-10-08 Cellectis Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof.
CA2589279A1 (en) * 2004-11-24 2006-06-01 Val-Chum, S.E.C. Methods to identify, prepare, and use naive t cell recent thymic emigrants
WO2007027226A2 (en) * 2005-04-28 2007-03-08 Board Of Regents, The University Of Texas System Systems and methods for the production of differentiated cells
EP2650366B1 (en) 2005-10-18 2017-03-22 Precision Biosciences Rationally designed meganucleases with altered sequence specificity and DNA-binding affinity
CL2007002987A1 (es) 2006-10-19 2008-06-06 Genentech Inc Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para tratar enfermedades relacionadas con notch3.
UA102061C2 (ru) 2006-10-19 2013-06-10 Дженентек, Інк. Агонистическое антитело к notch3 и его применение для лечения notch3- ассоциированных заболеваний
WO2008092445A2 (de) * 2007-01-30 2008-08-07 Deutsches Rheuma-Forschungszentrum Berlin Verfahren zur modulation der immunantwort durch aktivierung oder inaktivierung des notch und/oder stat4 signalweges
PL2856876T3 (pl) 2007-03-30 2018-06-29 Memorial Sloan-Kettering Cancer Center Konstytutywna ekspresja ligandów kostymulujących na limfocytach T poddanych transferowi adoptywnemu
WO2010054007A1 (en) 2008-11-07 2010-05-14 Fabrus Llc Combinatorial antibody libraries and uses thereof
WO2010059543A1 (en) 2008-11-20 2010-05-27 Merck Sharp & Dohme Corp. Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use
WO2010141249A2 (en) 2009-06-02 2010-12-09 Merck Sharp & Dohme Corp. Generation, characterization and uses thereof of anti-notch3 antibodies
EP3156062A1 (en) 2010-05-17 2017-04-19 Sangamo BioSciences, Inc. Novel dna-binding proteins and uses thereof
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
LT3401400T (lt) 2012-05-25 2019-06-10 The Regents Of The University Of California Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui
WO2014039044A1 (en) * 2012-09-06 2014-03-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing t memory stem cell populations
EP2896697B1 (en) 2012-12-12 2015-09-02 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions for sequence manipulation
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US10696946B2 (en) * 2013-02-22 2020-06-30 The Board Of Trustees Of The University Of Illinois T-REG cell expansion
US9683039B2 (en) 2013-03-14 2017-06-20 New York University Notch agonists for the treatment of cancer
CA2930877A1 (en) 2013-11-18 2015-05-21 Crispr Therapeutics Ag Crispr-cas system materials and methods
CA2948871A1 (en) 2014-05-22 2015-11-26 Fred Hutchinson Cancer Research Center Lilrb2 and notch-mediated expansion of hematopoietic precursor cells
JP6641299B2 (ja) 2014-06-04 2020-02-05 フレッド ハッチンソン キャンサー リサーチ センター Notch 1および/またはNotch 2アゴニストを用いた幹細胞の増殖および生着
MX389823B (es) * 2014-10-27 2025-03-20 Fred Hutchinson Cancer Center Composiciones y metodos para reforzar la eficacia de inmunoterapia celular adoptiva.
ES2862676T3 (es) * 2015-10-20 2021-10-07 Fujifilm Cellular Dynamics Inc Producción de células precursoras hematopoyéticas multilinaje mediante programación genética
US11466253B2 (en) * 2015-10-22 2022-10-11 Juno Therapeutics Gmbh Methods for culturing cells and kits and apparatus for same
MX2018005274A (es) * 2015-10-30 2019-09-19 The Regents Of The Universtiy Of California Metodos para la generacion de celulas-t a partir de celulas madre y metodos inmunoterapeuticos que utilizan las celulas-t.
US12076342B2 (en) * 2016-04-08 2024-09-03 The Governing Council Of The University Of Toronto Method for generating progenitor t cells from stem and/or progenitor cells and use of same
US11261250B2 (en) 2016-07-22 2022-03-01 Fred Hutchinson Cancer Research Center Bi-specific molecule for cell-specific Notch inhibition and related methods and compositions

Similar Documents

Publication Publication Date Title
JP2024041873A5 (enExample)
JP7698672B2 (ja) ガンマデルタt細胞の増幅、組成物およびその使用
McGeachy et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo
Karpus et al. CD4+ suppressor cells of autoimmune encephalomyelitis respond to T cell receptor‐associated determinants on effector cells by interleukin‐4 secretion
Linterman et al. Signals that influence T follicular helper cell differentiation and function
Berger et al. The growth of cutaneous T-cell lymphoma is stimulated by immature dendritic cells
Ko et al. GM-CSF–responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis
CA2446981C (fr) Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene
Sredni et al. Antigen-specific human T-cell clones: development of clones requiring HLA-DR-compatible presenting cells for stimulation in presence of antigen.
JP2021502414A5 (enExample)
JP2021501596A5 (enExample)
CA2133409A1 (en) Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens
JP2018531035A5 (enExample)
Lee et al. Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis
RU2016151694A (ru) Экспансия лимфоцитов с использованием композиции цитокинов для активной клеточной иммунотерапии
JP2000509604A (ja) サプレッサー細胞集団を生成するためのインターロイキン―10の使用
EP0768890B1 (en) Methods for modulating t cell responses by manipulating a common cytokine receptor gamma chain
JP2023539056A5 (enExample)
JP2013505296A5 (enExample)
WO2001038494A1 (en) Method of proliferating natural killer cells
Rohrer et al. Human breast carcinoma patients develop clonable oncofetal antigen-specific effector and regulatory T lymphocytes
CN107206258A (zh) 衣原体激活的b细胞平台及其方法
JP2005185275A (ja) T細胞活性化
US10647961B2 (en) Methods and materials for expanding antigen-specific T cells in culture
JP2022510387A5 (enExample)