JP2013505296A5 - - Google Patents
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- JP2013505296A5 JP2013505296A5 JP2012530955A JP2012530955A JP2013505296A5 JP 2013505296 A5 JP2013505296 A5 JP 2013505296A5 JP 2012530955 A JP2012530955 A JP 2012530955A JP 2012530955 A JP2012530955 A JP 2012530955A JP 2013505296 A5 JP2013505296 A5 JP 2013505296A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- activated
- lymphocytes
- cells
- antigenic peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000001744 T-lymphocyte Anatomy 0.000 claims description 76
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 33
- 210000004027 cell Anatomy 0.000 claims description 31
- 230000000890 antigenic effect Effects 0.000 claims description 20
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 claims description 19
- 108010002350 Interleukin-2 Proteins 0.000 claims description 13
- 239000000427 antigen Substances 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 108010002586 Interleukin-7 Proteins 0.000 claims description 12
- 102000000704 Interleukin-7 Human genes 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 102000004127 Cytokines Human genes 0.000 claims description 10
- 108090000695 Cytokines Proteins 0.000 claims description 10
- 208000034578 Multiple myelomas Diseases 0.000 claims description 10
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 10
- 230000004069 differentiation Effects 0.000 claims description 9
- 102000003812 Interleukin-15 Human genes 0.000 claims description 8
- 108090000172 Interleukin-15 Proteins 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 230000001464 adherent effect Effects 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 7
- 108010074108 interleukin-21 Proteins 0.000 claims description 7
- 230000035755 proliferation Effects 0.000 claims description 7
- 231100000433 cytotoxic Toxicity 0.000 claims description 6
- 230000001472 cytotoxic effect Effects 0.000 claims description 6
- 230000001737 promoting effect Effects 0.000 claims description 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 4
- 102000013462 Interleukin-12 Human genes 0.000 claims description 4
- 108010065805 Interleukin-12 Proteins 0.000 claims description 4
- 108090000978 Interleukin-4 Proteins 0.000 claims description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 4
- -1 IFN-g Proteins 0.000 claims description 3
- 102000013691 Interleukin-17 Human genes 0.000 claims description 3
- 108050003558 Interleukin-17 Proteins 0.000 claims description 3
- 108010071384 Peptide T Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000014314 Dynamin-1-like proteins Human genes 0.000 description 4
- 108050003303 Dynamin-1-like proteins Proteins 0.000 description 4
- 230000003321 amplification Effects 0.000 description 4
- 239000013592 cell lysate Substances 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 238000001262 western blot Methods 0.000 description 4
- 230000010261 cell growth Effects 0.000 description 3
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 238000002659 cell therapy Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 101710102907 Interferon-induced GTP-binding protein Mx Proteins 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102100030703 Interleukin-22 Human genes 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 206010042618 Surgical procedure repeated Diseases 0.000 description 1
- 210000000447 Th1 cell Anatomy 0.000 description 1
- 210000004241 Th2 cell Anatomy 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000003071 memory t lymphocyte Anatomy 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/564,501 | 2009-09-22 | ||
| US12/564,501 US8075895B2 (en) | 2009-09-22 | 2009-09-22 | Identification of antigenic peptides from multiple myeloma cells |
| PCT/US2010/049466 WO2011037859A2 (en) | 2009-09-22 | 2010-09-20 | Identification of antigenic peptides from multiple myeloma cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505296A JP2013505296A (ja) | 2013-02-14 |
| JP2013505296A5 true JP2013505296A5 (enExample) | 2015-07-30 |
| JP5916613B2 JP5916613B2 (ja) | 2016-05-11 |
Family
ID=43756801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012530955A Expired - Fee Related JP5916613B2 (ja) | 2009-09-22 | 2010-09-20 | 多発性骨髄腫細胞からの抗原ペプチドの同定 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8075895B2 (enExample) |
| EP (1) | EP2480562B1 (enExample) |
| JP (1) | JP5916613B2 (enExample) |
| AU (1) | AU2010298519B2 (enExample) |
| CA (1) | CA2774946A1 (enExample) |
| IL (1) | IL218720A0 (enExample) |
| NZ (1) | NZ598932A (enExample) |
| WO (1) | WO2011037859A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201808811QA (en) | 2014-04-10 | 2018-11-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Method and compositions for cellular immunotherapy |
| MX2018001568A (es) | 2015-08-07 | 2019-04-25 | Seattle Children´S Hospital Dba Seattle Children´S Res Institute | Celulas t biespecificas de receptor quimerico de antigeno (car) para focalizacion a tumores solidos. |
| US11116784B2 (en) | 2016-02-26 | 2021-09-14 | Beth Israel Deaconess Medical Center, Inc. | Niacinamide (NAM) in ischemic tissue injury |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| WO2018111763A1 (en) | 2016-12-12 | 2018-06-21 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
| EP3572502B1 (en) | 2017-01-20 | 2023-01-11 | Kyoto University | Method for producing cd8alpha +beta + cytotoxic t cells |
| PT3515465T (pt) | 2017-08-18 | 2024-03-04 | Regeneron Pharma | Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r |
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| JP7863702B2 (ja) * | 2018-11-08 | 2026-05-22 | セルキュア インコーポレイテッド | 表現型特性が向上したｔ細胞組成物 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766920A (en) * | 1982-08-11 | 1998-06-16 | Cellcor, Inc. | Ex vivo activation of immune cells |
| US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| WO1988000970A2 (en) * | 1986-08-08 | 1988-02-11 | Regents Of The University Of Minnesota | Method of culturing leukocytes |
| US4844893A (en) * | 1986-10-07 | 1989-07-04 | Scripps Clinic And Research Foundation | EX vivo effector cell activation for target cell killing |
| US5126132A (en) * | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
| US5728388A (en) * | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
| EP0726941B1 (en) * | 1993-08-06 | 2002-04-03 | Epimmune Inc. | Methods for (ex vivo) therapy using peptide-loaded antigen presenting cells for the activation of ctl |
| IL109540A0 (en) * | 1994-05-03 | 1994-08-26 | Yeda Res & Dev | Synthetic peptides and their use in tumor diagnosis and therapy |
| US5827642A (en) * | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| AU712441B2 (en) * | 1994-12-14 | 1999-11-04 | Scripps Research Institute, The | In vivo activation of tumor-specific cytotoxic T cells |
| WO1996027392A1 (en) * | 1995-03-08 | 1996-09-12 | The Scripps Research Institute | Antigen presenting system and methods for activation of t-cells |
| IL126843A (en) * | 1996-05-23 | 2007-06-17 | Scripps Research Inst | Mhc class ii antigen-presenting systems and methods for activating cd4+t cells in vitro |
| CA2278847A1 (en) * | 1997-01-31 | 1998-08-06 | Hemosol Inc. | Method for the production of selected lymphocytes |
| US6790662B1 (en) * | 1999-03-12 | 2004-09-14 | Ortho-Mcneil Pharmaceutical, Inc. | Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides |
| EP1290217A2 (en) * | 2000-02-04 | 2003-03-12 | Aeomica, Inc. | Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence |
| US20020048763A1 (en) * | 2000-02-04 | 2002-04-25 | Penn Sharron Gaynor | Human genome-derived single exon nucleic acid probes useful for gene expression analysis |
| EP1326961B1 (en) | 2000-09-15 | 2007-08-22 | Ortho-McNeil Pharmaceutical, Inc. | Compositions and methods for inducing specific cytolytic t cell responses |
| US20090062512A1 (en) * | 2000-10-10 | 2009-03-05 | Hildebrand William H | Comparative ligand mapping from MHC class I positive cells |
| US7919467B2 (en) * | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| US20040071671A1 (en) * | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
| ATE438710T1 (de) * | 2001-05-15 | 2009-08-15 | Ortho Mcneil Janssen Pharm | Ex-vivo-priming zur erzeugung cd40-ligand spezifischer zytotoxischer t-lymphozyten zur behandlung von autoimmun- und allergischen erkrankungen |
| US20050053918A1 (en) * | 2001-05-16 | 2005-03-10 | Technion Research & Development Foundation Ltd. | Method of identifying peptides capable of binding to MHC molecules, peptides identified thereby and their uses |
| EP1409650B1 (en) * | 2001-05-30 | 2006-04-12 | Fondazione Telethon | Ex-vivo isolated cd25+cd4+ t cells with immunosuppressive activity and uses thereof |
| DE10148236A1 (de) * | 2001-09-29 | 2003-04-24 | Immugenics Ag | Tumor-Peptidantigene aus humanem PRDI-BF1-Protein |
| WO2003033667A2 (en) * | 2001-10-18 | 2003-04-24 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of mx gtpases in the prognosis and treatment of cancer |
| US7371736B2 (en) * | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
| DE10225144A1 (de) * | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| US8222033B2 (en) * | 2002-08-12 | 2012-07-17 | Argos Therapeutics, Inc. | CD4+CD25− T cells and Tr1-like regulatory T cells |
| DE102004026135A1 (de) * | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| CA2598889A1 (en) * | 2005-02-24 | 2006-08-31 | Cemines, Inc. | Compositions and methods for classifying biological samples |
| WO2007035717A2 (en) * | 2005-09-19 | 2007-03-29 | The Rockefeller University | Glycolipids and analogues thereof as antigents for nk t cells |
| WO2007071390A1 (en) * | 2005-12-21 | 2007-06-28 | Sentoclone Ab | Method for treating malignant melanoma |
| CA2643337C (en) | 2006-03-01 | 2016-01-12 | Janssen Pharmaceutica N.V. | Cancer treatment combining lymphodepleting agent with ctls and cytokines |
| CN101548008B (zh) * | 2006-10-04 | 2013-04-17 | 詹森药业有限公司 | 失活的人工抗原提呈细胞的制备及其在细胞疗法中的用途 |
| US20090028847A1 (en) * | 2007-04-12 | 2009-01-29 | Trustees Of Boston University | Multiple myeloma and al amyloid immunotherapy targeting immunoglobulin light chains and uses thereof |
-
2009
- 2009-09-22 US US12/564,501 patent/US8075895B2/en not_active Expired - Fee Related
-
2010
- 2010-09-20 JP JP2012530955A patent/JP5916613B2/ja not_active Expired - Fee Related
- 2010-09-20 WO PCT/US2010/049466 patent/WO2011037859A2/en not_active Ceased
- 2010-09-20 NZ NZ598932A patent/NZ598932A/en not_active IP Right Cessation
- 2010-09-20 AU AU2010298519A patent/AU2010298519B2/en not_active Ceased
- 2010-09-20 CA CA2774946A patent/CA2774946A1/en not_active Abandoned
- 2010-09-20 EP EP10819298.0A patent/EP2480562B1/en active Active
-
2011
- 2011-10-31 US US13/285,517 patent/US8323655B2/en not_active Expired - Fee Related
- 2011-10-31 US US13/285,459 patent/US8232101B2/en not_active Expired - Fee Related
- 2011-10-31 US US13/285,491 patent/US8323965B2/en not_active Expired - Fee Related
-
2012
- 2012-03-19 IL IL218720A patent/IL218720A0/en not_active IP Right Cessation
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