JP2021530478A5 - - Google Patents
Info
- Publication number
- JP2021530478A5 JP2021530478A5 JP2021500411A JP2021500411A JP2021530478A5 JP 2021530478 A5 JP2021530478 A5 JP 2021530478A5 JP 2021500411 A JP2021500411 A JP 2021500411A JP 2021500411 A JP2021500411 A JP 2021500411A JP 2021530478 A5 JP2021530478 A5 JP 2021530478A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridine
- trifluoromethyl
- carboxamide
- alkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024111875A JP2024153683A (ja) | 2018-07-09 | 2024-07-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
| JP2025150845A JP2026009899A (ja) | 2018-07-09 | 2025-09-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862695571P | 2018-07-09 | 2018-07-09 | |
| US62/695,571 | 2018-07-09 | ||
| PCT/US2019/041029 WO2020014246A1 (en) | 2018-07-09 | 2019-07-09 | Pyridine carboxamide compounds for inhibiting nav1.8 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024111875A Division JP2024153683A (ja) | 2018-07-09 | 2024-07-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021530478A JP2021530478A (ja) | 2021-11-11 |
| JP2021530478A5 true JP2021530478A5 (enExample) | 2022-04-12 |
Family
ID=69141639
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021500411A Pending JP2021530478A (ja) | 2018-07-09 | 2019-07-09 | ＮａＶ１．８を阻害するためのピリジンカルボキシアミド化合物 |
| JP2024111875A Pending JP2024153683A (ja) | 2018-07-09 | 2024-07-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
| JP2025150845A Pending JP2026009899A (ja) | 2018-07-09 | 2025-09-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024111875A Pending JP2024153683A (ja) | 2018-07-09 | 2024-07-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
| JP2025150845A Pending JP2026009899A (ja) | 2018-07-09 | 2025-09-11 | ＮａＶ１．８を阻害するピリジンカルボキサミド化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12234221B2 (enExample) |
| EP (1) | EP3820866A4 (enExample) |
| JP (3) | JP2021530478A (enExample) |
| KR (1) | KR20210019581A (enExample) |
| CN (1) | CN112689633B (enExample) |
| AU (2) | AU2019301628C1 (enExample) |
| CA (1) | CA3105657A1 (enExample) |
| SG (1) | SG11202100130QA (enExample) |
| WO (1) | WO2020014246A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3105657A1 (en) * | 2018-07-09 | 2020-01-16 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting nav1.8 |
| WO2020176763A1 (en) | 2019-02-27 | 2020-09-03 | Vertex Pharmaceuticals Incorporated | Dosage form comprising prodrug of na 1.8 sodium channel inhibitor |
| WO2020219867A1 (en) | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Pyridone amide co-crystal compositions for the treatment of pain |
| CN112390745B (zh) * | 2019-08-19 | 2022-10-21 | 江苏恒瑞医药股份有限公司 | 吡啶烟酰胺类衍生物、其制备方法及其在医药上的应用 |
| BR112022004495A8 (pt) * | 2019-09-12 | 2023-04-18 | Jiangxi Jemincare Group Co Ltd | Compostos oxinitreto de piridina, composição farmacêutica compreendendo os mesmos e usos dos mesmos |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| CN114591293A (zh) * | 2020-12-07 | 2022-06-07 | 成都康弘药业集团股份有限公司 | 作为Nav1.8抑制剂的并环化合物及其用途 |
| MX2023010638A (es) | 2021-03-11 | 2023-11-28 | Latigo Biotherapeutics Inc | Compuestos de piridina y piridazina metil-sustituidos, derivados de los mismos y métodos de su uso. |
| CN116829539B (zh) * | 2021-03-11 | 2025-11-25 | 上海济煜医药科技股份有限公司 | 吡啶氮氧化合物晶型及其应用 |
| US20240400544A1 (en) | 2021-06-04 | 2024-12-05 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| CA3221938A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
| WO2022256842A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| AU2022283934A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| HRP20260068T1 (hr) | 2021-06-04 | 2026-02-27 | Vertex Pharmaceuticals Incorporated | Čvrsti farmaceutski oblici i režimi doziranja koji obuhvaćaju (2r,3s,4s,5r)-4-[[3-(3,4-difluor-2-metoksifenil)-4,5-dimetil-5-(trifluormetil)tetrahidrofuran-2-karbonil]amino]piridin-2-karboksamid |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| US20250154109A1 (en) * | 2022-02-04 | 2025-05-15 | Latigo Biotherapeutics, Inc | Sodium channel blocking compounds, derivatives thereof, and methods of their use |
| CN116655497B (zh) * | 2022-02-25 | 2025-06-03 | 中国科学院上海药物研究所 | 脒类衍生化合物及其制备方法和用途 |
| CN116891432A (zh) * | 2022-04-02 | 2023-10-17 | 武汉人福创新药物研发中心有限公司 | Nav1.8抑制剂及其用途 |
| CA3256248A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | HETEROARYL COMPOUNDS FOR PAIN RELIEF |
| US20230382910A1 (en) | 2022-04-22 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2023205463A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| CA3257285A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | HETEROARYL COMPOUNDS FOR PAIN RELIEF |
| JP2025516005A (ja) | 2022-04-25 | 2025-05-23 | サイトワン セラピューティクス インコーポレイテッド | 疼痛の処置のためのｎａｖ１．８の二環式複素環アミド阻害剤 |
| TW202400560A (zh) * | 2022-04-28 | 2024-01-01 | 南韓商愛思開生物製藥股份有限公司 | Ｎ－氧化物化合物及其用途 |
| WO2024123815A1 (en) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
| WO2025090511A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Methods of preparing modulators of sodium channels and solid forms of the same for treating pain |
| WO2025090480A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090465A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090516A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Methods of preparing compounds for treating pain and solid forms thereof |
| US20250186419A1 (en) | 2023-12-07 | 2025-06-12 | Vertex Pharmaceuticals Incorporated | Dosing regimens for treating pain |
| WO2025160286A1 (en) | 2024-01-24 | 2025-07-31 | Siteone Therapeutics, Inc. | 2-aryl cycloalkyl and heterocycloalkyl inhibitors of nav1.8 for the treatment of pain |
| US20260001877A1 (en) | 2024-06-28 | 2026-01-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2026013449A2 (en) | 2024-07-11 | 2026-01-15 | Sea4Us - Biotecnologia E Recursos Marinhos, Sa | Oxazolidone-derived compounds and their use in the treatment of chronic and acute pain |
| WO2026030525A1 (en) | 2024-07-31 | 2026-02-05 | Vertex Pharmaceuticals Incorporated | Zilvetrigine dosage forms and dosing regimens for treating pain |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL64220A (en) * | 1980-11-21 | 1985-06-30 | May & Baker Ltd | Nicotinamide derivatives,their preparation and their use as herbicides |
| ES2114654T3 (es) | 1993-06-08 | 1998-06-01 | Vertex Pharma | Piridazinas como inhibidores de la enzima de conversion de la interleuquina-1beta. |
| DE19946852A1 (de) | 1999-09-30 | 2001-04-05 | Bayer Ag | Substituierte N-Phenyl-phenoxynicotinsäure-(thio)amide |
| MXPA04007737A (es) | 2002-02-11 | 2004-10-15 | Pfizer | Derivados de nicotinamida utiles como inhibidores de fosfodesterasas 4. |
| JP2004238361A (ja) * | 2003-02-07 | 2004-08-26 | Tosoh Corp | ピリミジン−５−カルボキサミド誘導体、その中間体及びそれらの製造方法 |
| US7504396B2 (en) * | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| EP1673357A2 (en) | 2003-08-08 | 2006-06-28 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
| CN1863785A (zh) * | 2003-08-08 | 2006-11-15 | 沃泰克斯药物股份有限公司 | 在疼痛的治疗中用作钠或钙通道阻断剂的杂芳基氨基磺酰基苯基衍生物 |
| AU2004285053B2 (en) | 2003-10-28 | 2010-10-21 | Vertex Pharmaceuticals, Incorporated | Benzimidazoles useful as modulators of ion channels |
| DE602004007284T2 (de) * | 2003-10-31 | 2008-02-28 | Warner-Lambert Company Llc | PYRIMIDINE ALS INHIBITOREN VON PHOSPHOINOSITID-3-KINASEN (PI3Ks) |
| CA2608599A1 (en) | 2005-05-16 | 2006-11-23 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
| MX2007015726A (es) | 2005-06-09 | 2008-03-04 | Vertex Pharma | Derivados de indano como moduladores de canales ionicos. |
| MX2008003337A (es) | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| EP1934191B1 (en) | 2005-10-12 | 2012-03-28 | Vertex Pharmaceuticals, Inc. | Biphenyl derivatives as modulators of voltage gated ion channels |
| WO2008060789A2 (en) | 2006-10-12 | 2008-05-22 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| KR20100075631A (ko) * | 2007-10-11 | 2010-07-02 | 버텍스 파마슈티칼스 인코포레이티드 | 전압개폐 나트륨 채널의 억제제로서 유용한 아릴 아미드 |
| WO2009049181A1 (en) | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Amides useful as inhibitors of voltage-gated sodium channels |
| AU2008310660A1 (en) * | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Heteroaryl amides useful as inhibitors of voltage-gated sodium channels |
| BRPI0919648A2 (pt) * | 2008-10-29 | 2015-12-08 | Hoffmann La Roche | novos derivados de fenil amida ou piridil amida e seu uso como agonistas de gpbar1 |
| AU2009308982A1 (en) | 2008-10-30 | 2010-05-06 | Merck Sharp & Dohme Corp. | Pyridazine carboxamide orexin receptor antagonists |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| WO2011026240A1 (en) | 2009-09-04 | 2011-03-10 | Zalicus Pharmaceuticals Ltd. | Oxopiperazine derivatives for the treatment of pain and epilepsy |
| US8598164B2 (en) | 2010-05-06 | 2013-12-03 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| KR101923367B1 (ko) | 2011-02-02 | 2018-12-04 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드 |
| MX2013009393A (es) | 2011-02-18 | 2013-08-29 | Vertex Pharma | Piperidinamidas cromano-espirociclicas como moduladores de canales de iones. |
| CA2828456C (en) | 2011-03-03 | 2021-05-04 | Zalicus Pharmaceuticals Ltd. | N-benzl-amino-carboxamide inhibitors of the sodium channel |
| CN103517910B (zh) | 2011-03-14 | 2016-12-14 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的吗啉-螺环哌啶酰胺 |
| CN102850321A (zh) | 2011-06-28 | 2013-01-02 | 中国科学院上海药物研究所 | 芳香氧基嘧啶甲酰胺或芳香氧基吡啶甲酰胺类化合物及其制备方法、药物组合物和用途 |
| NZ627259A (en) | 2012-01-16 | 2016-12-23 | Vertex Pharma | Pyran-spirocyclic piperidine amides as modulators of ion channels |
| RU2683788C2 (ru) | 2013-01-31 | 2019-04-02 | Вертекс Фармасьютикалз Инкорпорейтед | Амиды хинолина и хиназолина, полезные в качестве модуляторов натриевых каналов |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| CA2939549C (en) | 2013-03-15 | 2020-08-18 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| UA119147C2 (uk) * | 2013-07-19 | 2019-05-10 | Вертекс Фармасьютікалз Інкорпорейтед | Сульфонаміди як модулятори натрієвих каналів |
| CA2931550C (en) | 2013-12-13 | 2023-09-26 | Vertex Pharmaceuticals Incorporated | Prodrugs of pyridone amides useful as modulators of sodium channels |
| US9452986B2 (en) | 2014-02-06 | 2016-09-27 | Abbvie Inc. | 6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use |
| CN106715418A (zh) | 2014-07-07 | 2017-05-24 | 基因泰克公司 | 治疗化合物及其使用方法 |
| EP3580220B1 (en) | 2017-02-13 | 2021-11-17 | Bristol-Myers Squibb Company | Aminotriazolopyridines as kinase inhibitors |
| AU2018300150A1 (en) | 2017-07-11 | 2020-01-30 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| CA3105657A1 (en) * | 2018-07-09 | 2020-01-16 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting nav1.8 |
-
2019
- 2019-07-09 CA CA3105657A patent/CA3105657A1/en active Pending
- 2019-07-09 CN CN201980058952.XA patent/CN112689633B/zh active Active
- 2019-07-09 US US17/256,781 patent/US12234221B2/en active Active
- 2019-07-09 EP EP19833816.2A patent/EP3820866A4/en active Pending
- 2019-07-09 KR KR1020217004054A patent/KR20210019581A/ko active Pending
- 2019-07-09 SG SG11202100130QA patent/SG11202100130QA/en unknown
- 2019-07-09 JP JP2021500411A patent/JP2021530478A/ja active Pending
- 2019-07-09 AU AU2019301628A patent/AU2019301628C1/en active Active
- 2019-07-09 WO PCT/US2019/041029 patent/WO2020014246A1/en not_active Ceased
-
2024
- 2024-07-11 JP JP2024111875A patent/JP2024153683A/ja active Pending
-
2025
- 2025-01-13 US US19/018,680 patent/US20260001861A1/en active Pending
- 2025-01-29 AU AU2025200580A patent/AU2025200580A1/en active Pending
- 2025-09-11 JP JP2025150845A patent/JP2026009899A/ja active Pending
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