JP2021528206A - 差異性組織工学神経及び応用 - Google Patents
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Abstract
Description
前記類似運動神経は、類似運動神経の神経上管と神経上管内の類似運動神経線維を含み、前記類似運動神経の神経上管の表面又は孔隙内に、運動神経由来のシュワン細胞及び/又は線維芽細胞が含まれており、前記類似運動神経線維の表面又は孔隙内に、経シナプスシグナル分子ニューロリギン(Neuroligin)−1が含まれており、
前記類似感覚神経は、類似感覚神経の神経上管と神経上管内の類似感覚神経線維を含み、前記類似感覚神経の神経上管の表面又は孔隙内に、感覚神経由来のシュワン細胞及び/又は線維芽細胞が含まれており、前記類似感覚神経線維表面又は孔隙内に、経シナプスシグナル分子ニューロリギン(Neuroligin)−2が含まれている。
(1)ニューレキシン−1β(最終濃度200ng/mL)+ニューロリギン−1(最終濃度200ng/mL)、
(2)ニューレキシン−1β(最終濃度1μg/mL)+ニューロリギン−1(最終濃度200ng/mL)、
(3)ニューレキシン−1β(最終濃度1μg/mL)。
感覚ニューロン群:
(4)ニューレキシン−1β(最終濃度200ng/mL)+ニューロリギン−2(最終濃度200ng/mL)、
(5)ニューレキシン−1β(最終濃度1μg/mL)+ニューロリギン−2(最終濃度200ng/mL)、
(6)ニューレキシン−1β(最終濃度1μg/mL)。
カイコ(Bombyx mori)蚕糸を通常に0.05MのNa2CO3水溶液で2回沸騰させ、30分ごとに蚕糸のセリシンを十分に除去し、脱イオン水で十分に洗浄し、室温で乾燥させた後、絹繊維SFが得られ、絹繊維の直径が10〜30μmで、高温高圧滅菌後に予備とした。
Claims (10)
- 差異性組織工学神経において、類似運動神経と類似感覚神経とを含み、
前記類似運動神経は、類似運動神経の神経上管と神経上管内の類似運動神経線維を含み、前記類似運動神経の神経上管の表面又は孔隙内に、運動神経由来のシュワン細胞及び/又は線維芽細胞が含まれており、前記類似運動神経線維の表面又は孔隙内に、経シナプスシグナル分子ニューロリギン−1が含まれており、
前記類似感覚神経は、類似感覚神経の神経上管と神経上管内の類似感覚神経線維を含み、前記類似感覚神経の神経上管の表面又は孔隙内に、感覚神経由来のシュワン細胞及び/又は線維芽細胞が含まれており、前記類似感覚神経線維表面又は孔隙内に、経シナプスシグナル分子ニューロリギン−2が含まれていることを特徴とする、差異性組織工学神経。 - 前記運動神経由来のシュワン細胞及び/又は線維芽細胞と感覚神経由来のシュワン細胞及び/又は線維芽細胞の数との比が1:1〜5であることを特徴とする、請求項1に記載の差異性組織工学神経。
- 前記運動神経由来のシュワン細胞及び/又は線維芽細胞と感覚神経由来のシュワン細胞及び/又は線維芽細胞の数との比が1:3であることを特徴とする、請求項2に記載の差異性組織工学神経。
- ニューロリギン−1とニューロリギン−2との質量比が1:1であることを特徴とする、請求項1に記載の差異性組織工学神経。
- 前記類似運動神経線維及び/又は類似感覚神経線維表面又は孔隙内に、経シナプスシグナル分子ニューレキシン−1βがさらに含まれていることを特徴とする、請求項1に記載の差異性組織工学神経。
- 前記類似運動神経線維におけるニューロリギン−1とニューレキシン−1βとの質量比が1:0.01〜10であり、前記類似感覚神経線維におけるニューロリギン−2とニューレキシン−1βとの質量比が1:0.01〜10であることを特徴とする、請求項5に記載の差異性組織工学神経。
- 前記類似運動神経線維におけるニューロリギン−1とニューレキシン−1βとの質量比が1:5であり、前記類似感覚神経線維におけるニューロリギン−2とニューレキシン−1βとの質量比が1:5であることを特徴とする、請求項6に記載の差異性組織工学神経。
- 前記経シナプスシグナル分子ニューロリギン−1、ニューロリギン−2及びニューレキシン−1βは、微小球内に包埋されていることを特徴とする、請求項5に記載の差異性組織工学神経。
- 前記類似運動神経と類似感覚神経は、平坦状、Y字状、樹木状、櫛歯状のうちの一種又は複数種の形状の多分岐状をなすように配置されていることを特徴とする、請求項1乃至8のいずれか一項に記載の差異性組織工学神経。
- 請求項1乃至9のいずれか一項に記載の組織工学神経の末梢神経欠損修復への使用。
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CN201910640776.2 | 2019-07-16 | ||
CN201910640776.2A CN110227184B (zh) | 2019-07-16 | 2019-07-16 | 差异性组织工程化神经及应用 |
PCT/CN2019/105280 WO2021007941A1 (zh) | 2019-07-16 | 2019-09-11 | 差异性组织工程化神经及应用 |
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AU2019359619B2 (en) | 2020-07-02 |
JP7034523B2 (ja) | 2022-03-14 |
CN110227184B (zh) | 2020-04-24 |
CN110227184A (zh) | 2019-09-13 |
AU2019359619A1 (en) | 2020-06-25 |
WO2021007941A1 (zh) | 2021-01-21 |
EP3785741A1 (en) | 2021-03-03 |
US20210268149A1 (en) | 2021-09-02 |
EP3785741A4 (en) | 2022-05-04 |
EP3785741B1 (en) | 2024-01-17 |
US11110202B1 (en) | 2021-09-07 |
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