JP2021526123A - オートタキシン阻害剤とその使用 - Google Patents

オートタキシン阻害剤とその使用 Download PDF

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Publication number
JP2021526123A
JP2021526123A JP2020540731A JP2020540731A JP2021526123A JP 2021526123 A JP2021526123 A JP 2021526123A JP 2020540731 A JP2020540731 A JP 2020540731A JP 2020540731 A JP2020540731 A JP 2020540731A JP 2021526123 A JP2021526123 A JP 2021526123A
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JP
Japan
Prior art keywords
alkyl
heterocycloalkyl
cycloalkyl
pharmaceutically acceptable
solvate
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Pending
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JP2020540731A
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English (en)
Japanese (ja)
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JP2021526123A5 (https=
JPWO2019228403A5 (https=
Inventor
ジン，ボハン
ドン，シン
ハン，ジーン
リー，ヤオ
Original Assignee
シーチュアン ハイスコ ファーマシューティカル シーオー．，エルティーディー．
シーチュアン ハイスコ ファーマシューティカル シーオー．，エルティーディー．
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Application filed by シーチュアン ハイスコ ファーマシューティカル シーオー．，エルティーディー．, シーチュアン ハイスコ ファーマシューティカル シーオー．，エルティーディー． filed Critical シーチュアン ハイスコ ファーマシューティカル シーオー．，エルティーディー．
Publication of JP2021526123A publication Critical patent/JP2021526123A/ja
Publication of JP2021526123A5 publication Critical patent/JP2021526123A5/ja
Publication of JPWO2019228403A5 publication Critical patent/JPWO2019228403A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020540731A 2018-05-29 2019-05-29 オートタキシン阻害剤とその使用 Pending JP2021526123A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862677459P 2018-05-29 2018-05-29
US62/677,459 2018-05-29
US201862731003P 2018-09-13 2018-09-13
US62/731,003 2018-09-13
PCT/CN2019/089025 WO2019228403A1 (en) 2018-05-29 2019-05-29 Autotaxin inhibitors and uses thereof

Publications (3)

Publication Number Publication Date
JP2021526123A true JP2021526123A (ja) 2021-09-30
JP2021526123A5 JP2021526123A5 (https=) 2022-05-27
JPWO2019228403A5 JPWO2019228403A5 (https=) 2022-05-27

Family

ID=68697812

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020540731A Pending JP2021526123A (ja) 2018-05-29 2019-05-29 オートタキシン阻害剤とその使用

Country Status (5)

Country Link
EP (1) EP3728257A4 (https=)
JP (1) JP2021526123A (https=)
CN (1) CN111801328B (https=)
CA (1) CA3089527A1 (https=)
WO (1) WO2019228403A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021513551A (ja) * 2018-02-14 2021-05-27 スーチョウ、シノベント、ファーマスーティカルズ、カンパニー、リミテッドＳｕｚｈｏｕ Ｓｉｎｏｖｅｎｔ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． 複素環式化合物、その応用及びそれを含有する医薬組成物

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113912600A (zh) * 2020-07-09 2022-01-11 苏州爱科百发生物医药技术有限公司 一种atx抑制剂及其制备方法和应用
CN115916777B (zh) * 2020-07-09 2024-07-12 苏州爱科百发生物医药技术有限公司 一种atx抑制剂及其制备方法和应用
JP2023536159A (ja) * 2020-07-31 2023-08-23 ジェネンテック， インコーポレイテッド 炎症性呼吸器疾患の増悪を治療するための方法
CN114315825A (zh) * 2020-09-30 2022-04-12 江西济民可信集团有限公司 吡啶并咪唑衍生物及其制备方法和应用
EP4225756A2 (en) 2020-10-06 2023-08-16 Ildong Pharmaceutical Co., Ltd. Autotaxin inhibitor compounds
US20240317736A1 (en) * 2020-11-04 2024-09-26 Xizang Haisco Pharmaceutical Co., Ltd. Deuterated derivative as atx inhibitor, and application thereof
CN112675308B (zh) * 2020-12-09 2023-05-05 中国人民解放军军事科学院军事医学研究院 抑制enpp2基因和/或蛋白表达的物质在制备治疗多发性骨髓瘤的药物中的应用
US20240327407A1 (en) 2021-01-05 2024-10-03 Cadila Heal Thcare Limited Novel inhibitors of autotaxin
EP4323356A1 (en) 2021-04-13 2024-02-21 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
TW202342138A (zh) * 2022-03-31 2023-11-01 大陸商蘇州愛科百發生物醫藥技術有限公司 Ａｔｘ抑制劑或其鹽的結晶形式及其制備方法與應用
JP2025525350A (ja) * 2022-06-24 2025-08-05 エフ． ホフマン－ラ ロシュ アーゲー Ｍａｇｌ阻害剤としての新規複素環－カルボニル－環式化合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014139882A1 (en) * 2013-03-14 2014-09-18 Galapagos Nv Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2014202458A1 (en) * 2013-06-19 2014-12-24 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2019158107A1 (zh) * 2018-02-14 2019-08-22 苏州信诺维医药科技有限公司 一种杂环化合物、其应用及含其的药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201908293A (zh) * 2017-07-12 2019-03-01 美商必治妥美雅史谷比公司 作為rock抑制劑之5員及雙環雜環醯胺

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014139882A1 (en) * 2013-03-14 2014-09-18 Galapagos Nv Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2014202458A1 (en) * 2013-06-19 2014-12-24 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2019158107A1 (zh) * 2018-02-14 2019-08-22 苏州信诺维医药科技有限公司 一种杂环化合物、其应用及含其的药物组合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, JPN6023025388, 1 May 2017 (2017-05-01), pages 3580 - 3590, ISSN: 0005086903 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, JPN6023025389, 18 August 2017 (2017-08-18), pages 7371 - 7392, ISSN: 0005086902 *
野崎 正勝 他, 創薬化学, vol. 第1版, JPN7023001664, 1995, JP, pages 98 - 99, ISSN: 0005086904 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021513551A (ja) * 2018-02-14 2021-05-27 スーチョウ、シノベント、ファーマスーティカルズ、カンパニー、リミテッドＳｕｚｈｏｕ Ｓｉｎｏｖｅｎｔ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． 複素環式化合物、その応用及びそれを含有する医薬組成物

Also Published As

Publication number Publication date
EP3728257A4 (en) 2021-06-23
CA3089527A1 (en) 2019-12-05
CN111801328B (zh) 2023-06-02
CN111801328A (zh) 2020-10-20
WO2019228403A1 (en) 2019-12-05
EP3728257A1 (en) 2020-10-28

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