JP2021525807A5 - - Google Patents

Info

Publication number
JP2021525807A5
JP2021525807A5 JP2021517169A JP2021517169A JP2021525807A5 JP 2021525807 A5 JP2021525807 A5 JP 2021525807A5 JP 2021517169 A JP2021517169 A JP 2021517169A JP 2021517169 A JP2021517169 A JP 2021517169A JP 2021525807 A5 JP2021525807 A5 JP 2021525807A5
Authority
JP
Japan
Prior art keywords
ubiquitin
factor
biomolecule
protein
terminus
Prior art date
Application number
JP2021517169A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021525807A (ja
JPWO2019231208A5 (https=
JP7402864B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/KR2019/006376 external-priority patent/WO2019231208A1/ko
Publication of JP2021525807A publication Critical patent/JP2021525807A/ja
Publication of JPWO2019231208A5 publication Critical patent/JPWO2019231208A5/ja
Publication of JP2021525807A5 publication Critical patent/JP2021525807A5/ja
Application granted granted Critical
Publication of JP7402864B2 publication Critical patent/JP7402864B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021517169A 2018-05-28 2019-05-28 ポリユビキチンリンカーに結合された線形多機能性マルチマー生体分子及びその用途 Active JP7402864B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20180060502 2018-05-28
KR10-2018-0060502 2018-05-28
PCT/KR2019/006376 WO2019231208A1 (ko) 2018-05-28 2019-05-28 폴리유비퀴틴 링커에 결합된 선형 다기능성 멀티머 생체분자 및 이의 용도

Publications (4)

Publication Number Publication Date
JP2021525807A JP2021525807A (ja) 2021-09-27
JPWO2019231208A5 JPWO2019231208A5 (https=) 2022-09-06
JP2021525807A5 true JP2021525807A5 (https=) 2022-09-06
JP7402864B2 JP7402864B2 (ja) 2023-12-21

Family

ID=68697037

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021517169A Active JP7402864B2 (ja) 2018-05-28 2019-05-28 ポリユビキチンリンカーに結合された線形多機能性マルチマー生体分子及びその用途

Country Status (8)

Country Link
US (1) US20210347827A1 (https=)
EP (1) EP3805256A4 (https=)
JP (1) JP7402864B2 (https=)
KR (2) KR20190135393A (https=)
CN (1) CN112204046A (https=)
AU (2) AU2019276622A1 (https=)
CA (1) CA3101185A1 (https=)
WO (1) WO2019231208A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022010445A2 (pt) * 2019-11-27 2022-09-06 Onegene Biotechnology Inc Polímero biomolecular multifuncional, multiespecífico, multimérico , método para preparar um polímero biomolecular multifuncional, multiespecífico, multimérico
EP4144375A4 (en) * 2020-04-29 2024-11-06 Onegene Biotechnology Inc. NOVEL PROTEIN CONJUGATE AND ITS USE FOR PREVENTION OR TREATMENT OF NONALCOHOLIC STEATOHEPATITIS, OBESITY AND DIABETES
CN115678985B (zh) * 2022-10-26 2025-07-29 华南农业大学 March5在鉴别猪对蓝耳病毒易感性及制备药物中的应用
CN119876239A (zh) * 2025-01-27 2025-04-25 吉林大学 拟南芥AtUPL5基因在提高植物抗性方面的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354722B1 (en) * 1999-06-11 2008-04-08 Signal Pharmaceuticals Modulators of Smurf and BMP/TGFβ signaling pathways
ATE490968T1 (de) * 2001-05-04 2010-12-15 Cornell Res Foundation Inc Schnell spaltbares sumofusionsprotein- expressionssystem für schwer zu exprimierende proteine
DE10324447A1 (de) * 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
AU2004254600A1 (en) * 2003-06-26 2005-01-13 Lifesensors, Inc. Methods and compositions for enhanced protein expression and purification
KR20050050824A (ko) 2003-11-26 2005-06-01 세메스 주식회사 베이크 장치에서의 웨이퍼 안착 상태를 감지하여 인터락을제어하기 위한 시스템 및 그의 제어 방법
DE102004049479A1 (de) * 2004-10-11 2006-04-13 Scil Proteins Gmbh Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
KR100621354B1 (ko) * 2005-06-14 2006-09-08 광주과학기술원 유비퀴틴을 이용한 아밀로이드-베타 펩티드의 제조방법
CA2633887C (en) * 2005-12-15 2015-12-22 Genentech, Inc. Methods and compositions for targeting polyubiquitin
WO2009009773A1 (en) * 2007-07-11 2009-01-15 The Johns Hopkins University Use of otubain enzyme to cleave lysine-48-linked polyubiquitin
AU2010332932B2 (en) * 2009-12-14 2013-01-17 Navigo Proteins Gmbh Modified ubiquitin proteins having a specific binding activity for the extradomain B of fibronectin
US20130065272A1 (en) * 2010-03-24 2013-03-14 Medical Research Council Synthesis of Site Specifically-Linked Ubiquitin
JP6198807B2 (ja) * 2012-03-16 2017-09-20 ジェネンテック, インコーポレイテッド 操作され立体構造的に安定化されたタンパク質
KR101911438B1 (ko) * 2012-10-31 2018-10-24 삼성전자주식회사 이중 특이 항원 결합 단백질 복합체 및 이중 특이 항체의 제조 방법
EP3027745A4 (en) * 2013-08-04 2017-01-25 Yeda Research and Development Co., Ltd. Artificial cellulosomes comprising multiple scaffolds and uses thereof in biomass degradation
TWI569816B (zh) 2014-04-18 2017-02-11 林信湧 一種用於治療痛風之吸入式醫藥組成物及其備製方法
KR20170025040A (ko) * 2015-08-27 2017-03-08 한국기초과학지원연구원 염 용리 가능한 k48 폴리-유비퀴틴 사슬 특이 친화성 컬럼 및 이의 용도

Similar Documents

Publication Publication Date Title
Kontermann Half-life extended biotherapeutics
JP2021525807A5 (https=)
TWI680137B (zh) 免疫球蛋白Fc變體
JP6983202B2 (ja) 変異したヒンジ領域を含むIgG4 Fcフラグメント
KR100725314B1 (ko) 면역글로불린 불변영역의 대량 생산 방법
TWI680768B (zh) 具有降低之受體介導清除之生物活性多肽單體與免疫球蛋白質Fc片段之複合物及其製造方法
EP2536757B1 (en) Fibronectin based scaffold domain proteins that bind il-23
KR20100084996A (ko) 면역글로불린 단편을 이용한 생리활성 단백질 또는 펩타이드의 생산 방법
JP2018172391A5 (https=)
JP2014110816A (ja) 開始メチオニン残基が除去された免疫グロブリンFc領域の大量生産方法
JP7402864B2 (ja) ポリユビキチンリンカーに結合された線形多機能性マルチマー生体分子及びその用途
IL293078A (en) A polymer of multi-functional, multi-specific biomolecules with prolonged in vivo duration
AU2014312456A1 (en) An anti serum albumin Fab-effector moiety fusion construct, and the preparing method thereof
KR101830344B1 (ko) 피브로넥틴 단편 및 면역글로불린 단편의 융합 단백질 및 이의 용도
JPWO2019231208A5 (https=)
KR102334315B1 (ko) 신규 중간체 제조를 통한 지속형 약물 결합체의 제조 방법
RU2805307C1 (ru) Мультифункциональный мультиспецифический мультимерный биомолекулярный полимер, имеющий пролонгированную эффективность in vivo
Wang et al. Molecular engineering approaches to half-life extension of therapeutic biomolecules
RU2008107743A (ru) Химерные терапевтические средства