JP2021525807A5 - - Google Patents
Info
- Publication number
- JP2021525807A5 JP2021525807A5 JP2021517169A JP2021517169A JP2021525807A5 JP 2021525807 A5 JP2021525807 A5 JP 2021525807A5 JP 2021517169 A JP2021517169 A JP 2021517169A JP 2021517169 A JP2021517169 A JP 2021517169A JP 2021525807 A5 JP2021525807 A5 JP 2021525807A5
- Authority
- JP
- Japan
- Prior art keywords
- ubiquitin
- factor
- biomolecule
- protein
- terminus
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20180060502 | 2018-05-28 | ||
| KR10-2018-0060502 | 2018-05-28 | ||
| PCT/KR2019/006376 WO2019231208A1 (ko) | 2018-05-28 | 2019-05-28 | 폴리유비퀴틴 링커에 결합된 선형 다기능성 멀티머 생체분자 및 이의 용도 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021525807A JP2021525807A (ja) | 2021-09-27 |
| JPWO2019231208A5 JPWO2019231208A5 (https=) | 2022-09-06 |
| JP2021525807A5 true JP2021525807A5 (https=) | 2022-09-06 |
| JP7402864B2 JP7402864B2 (ja) | 2023-12-21 |
Family
ID=68697037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517169A Active JP7402864B2 (ja) | 2018-05-28 | 2019-05-28 | ポリユビキチンリンカーに結合された線形多機能性マルチマー生体分子及びその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210347827A1 (https=) |
| EP (1) | EP3805256A4 (https=) |
| JP (1) | JP7402864B2 (https=) |
| KR (2) | KR20190135393A (https=) |
| CN (1) | CN112204046A (https=) |
| AU (2) | AU2019276622A1 (https=) |
| CA (1) | CA3101185A1 (https=) |
| WO (1) | WO2019231208A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112022010445A2 (pt) * | 2019-11-27 | 2022-09-06 | Onegene Biotechnology Inc | Polímero biomolecular multifuncional, multiespecífico, multimérico , método para preparar um polímero biomolecular multifuncional, multiespecífico, multimérico |
| EP4144375A4 (en) * | 2020-04-29 | 2024-11-06 | Onegene Biotechnology Inc. | NOVEL PROTEIN CONJUGATE AND ITS USE FOR PREVENTION OR TREATMENT OF NONALCOHOLIC STEATOHEPATITIS, OBESITY AND DIABETES |
| CN115678985B (zh) * | 2022-10-26 | 2025-07-29 | 华南农业大学 | March5在鉴别猪对蓝耳病毒易感性及制备药物中的应用 |
| CN119876239A (zh) * | 2025-01-27 | 2025-04-25 | 吉林大学 | 拟南芥AtUPL5基因在提高植物抗性方面的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7354722B1 (en) * | 1999-06-11 | 2008-04-08 | Signal Pharmaceuticals | Modulators of Smurf and BMP/TGFβ signaling pathways |
| ATE490968T1 (de) * | 2001-05-04 | 2010-12-15 | Cornell Res Foundation Inc | Schnell spaltbares sumofusionsprotein- expressionssystem für schwer zu exprimierende proteine |
| DE10324447A1 (de) * | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| AU2004254600A1 (en) * | 2003-06-26 | 2005-01-13 | Lifesensors, Inc. | Methods and compositions for enhanced protein expression and purification |
| KR20050050824A (ko) | 2003-11-26 | 2005-06-01 | 세메스 주식회사 | 베이크 장치에서의 웨이퍼 안착 상태를 감지하여 인터락을제어하기 위한 시스템 및 그의 제어 방법 |
| DE102004049479A1 (de) * | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
| KR100621354B1 (ko) * | 2005-06-14 | 2006-09-08 | 광주과학기술원 | 유비퀴틴을 이용한 아밀로이드-베타 펩티드의 제조방법 |
| CA2633887C (en) * | 2005-12-15 | 2015-12-22 | Genentech, Inc. | Methods and compositions for targeting polyubiquitin |
| WO2009009773A1 (en) * | 2007-07-11 | 2009-01-15 | The Johns Hopkins University | Use of otubain enzyme to cleave lysine-48-linked polyubiquitin |
| AU2010332932B2 (en) * | 2009-12-14 | 2013-01-17 | Navigo Proteins Gmbh | Modified ubiquitin proteins having a specific binding activity for the extradomain B of fibronectin |
| US20130065272A1 (en) * | 2010-03-24 | 2013-03-14 | Medical Research Council | Synthesis of Site Specifically-Linked Ubiquitin |
| JP6198807B2 (ja) * | 2012-03-16 | 2017-09-20 | ジェネンテック, インコーポレイテッド | 操作され立体構造的に安定化されたタンパク質 |
| KR101911438B1 (ko) * | 2012-10-31 | 2018-10-24 | 삼성전자주식회사 | 이중 특이 항원 결합 단백질 복합체 및 이중 특이 항체의 제조 방법 |
| EP3027745A4 (en) * | 2013-08-04 | 2017-01-25 | Yeda Research and Development Co., Ltd. | Artificial cellulosomes comprising multiple scaffolds and uses thereof in biomass degradation |
| TWI569816B (zh) | 2014-04-18 | 2017-02-11 | 林信湧 | 一種用於治療痛風之吸入式醫藥組成物及其備製方法 |
| KR20170025040A (ko) * | 2015-08-27 | 2017-03-08 | 한국기초과학지원연구원 | 염 용리 가능한 k48 폴리-유비퀴틴 사슬 특이 친화성 컬럼 및 이의 용도 |
-
2018
- 2018-11-14 KR KR1020180140340A patent/KR20190135393A/ko not_active Ceased
-
2019
- 2019-05-28 CA CA3101185A patent/CA3101185A1/en active Pending
- 2019-05-28 JP JP2021517169A patent/JP7402864B2/ja active Active
- 2019-05-28 WO PCT/KR2019/006376 patent/WO2019231208A1/ko not_active Ceased
- 2019-05-28 AU AU2019276622A patent/AU2019276622A1/en not_active Abandoned
- 2019-05-28 US US15/733,814 patent/US20210347827A1/en not_active Abandoned
- 2019-05-28 EP EP19810034.9A patent/EP3805256A4/en not_active Withdrawn
- 2019-05-28 KR KR1020197026895A patent/KR102155982B1/ko active Active
- 2019-05-28 CN CN201980036222.XA patent/CN112204046A/zh active Pending
-
2023
- 2023-07-10 AU AU2023204533A patent/AU2023204533A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kontermann | Half-life extended biotherapeutics | |
| JP2021525807A5 (https=) | ||
| TWI680137B (zh) | 免疫球蛋白Fc變體 | |
| JP6983202B2 (ja) | 変異したヒンジ領域を含むIgG4 Fcフラグメント | |
| KR100725314B1 (ko) | 면역글로불린 불변영역의 대량 생산 방법 | |
| TWI680768B (zh) | 具有降低之受體介導清除之生物活性多肽單體與免疫球蛋白質Fc片段之複合物及其製造方法 | |
| EP2536757B1 (en) | Fibronectin based scaffold domain proteins that bind il-23 | |
| KR20100084996A (ko) | 면역글로불린 단편을 이용한 생리활성 단백질 또는 펩타이드의 생산 방법 | |
| JP2018172391A5 (https=) | ||
| JP2014110816A (ja) | 開始メチオニン残基が除去された免疫グロブリンFc領域の大量生産方法 | |
| JP7402864B2 (ja) | ポリユビキチンリンカーに結合された線形多機能性マルチマー生体分子及びその用途 | |
| IL293078A (en) | A polymer of multi-functional, multi-specific biomolecules with prolonged in vivo duration | |
| AU2014312456A1 (en) | An anti serum albumin Fab-effector moiety fusion construct, and the preparing method thereof | |
| KR101830344B1 (ko) | 피브로넥틴 단편 및 면역글로불린 단편의 융합 단백질 및 이의 용도 | |
| JPWO2019231208A5 (https=) | ||
| KR102334315B1 (ko) | 신규 중간체 제조를 통한 지속형 약물 결합체의 제조 방법 | |
| RU2805307C1 (ru) | Мультифункциональный мультиспецифический мультимерный биомолекулярный полимер, имеющий пролонгированную эффективность in vivo | |
| Wang et al. | Molecular engineering approaches to half-life extension of therapeutic biomolecules | |
| RU2008107743A (ru) | Химерные терапевтические средства |