CN112204046A - 与聚泛素衔接物结合的线性多功能性多聚体生物分子及其用途 - Google Patents

与聚泛素衔接物结合的线性多功能性多聚体生物分子及其用途 Download PDF

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CN112204046A
CN112204046A CN201980036222.XA CN201980036222A CN112204046A CN 112204046 A CN112204046 A CN 112204046A CN 201980036222 A CN201980036222 A CN 201980036222A CN 112204046 A CN112204046 A CN 112204046A
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ubiquitin
biomolecule
multimeric
protein
linear
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朴成真
任大成
崔载永
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Proto Biotechnology Co ltd
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Proto Biotechnology Co ltd
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N9/104—Aminoacyltransferases (2.3.2)
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01307—D-Xylose reductase (1.1.1.307)
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    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
    • C12Y102/03003—Pyruvate oxidase (1.2.3.3)
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02015—Ubiquitin thiolesterase (3.1.2.15)
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    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02021—Ubiquitin--calmodulin ligase (6.3.2.21)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
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    • C07K2319/00—Fusion polypeptide
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    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02019—Ubiquitin-protein ligase (6.3.2.19), i.e. ubiquitin-conjugating enzyme

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CN201980036222.XA 2018-05-28 2019-05-28 与聚泛素衔接物结合的线性多功能性多聚体生物分子及其用途 Pending CN112204046A (zh)

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KR20180060502 2018-05-28
KR10-2018-0060502 2018-05-28
PCT/KR2019/006376 WO2019231208A1 (ko) 2018-05-28 2019-05-28 폴리유비퀴틴 링커에 결합된 선형 다기능성 멀티머 생체분자 및 이의 용도

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EP (1) EP3805256A4 (https=)
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AU (2) AU2019276622A1 (https=)
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Cited By (2)

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CN115678985A (zh) * 2022-10-26 2023-02-03 华南农业大学 March5在鉴别猪对蓝耳病毒易感性及制备药物中的应用
CN119876239A (zh) * 2025-01-27 2025-04-25 吉林大学 拟南芥AtUPL5基因在提高植物抗性方面的应用

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BR112022010445A2 (pt) * 2019-11-27 2022-09-06 Onegene Biotechnology Inc Polímero biomolecular multifuncional, multiespecífico, multimérico , método para preparar um polímero biomolecular multifuncional, multiespecífico, multimérico
EP4144375A4 (en) * 2020-04-29 2024-11-06 Onegene Biotechnology Inc. NOVEL PROTEIN CONJUGATE AND ITS USE FOR PREVENTION OR TREATMENT OF NONALCOHOLIC STEATOHEPATITIS, OBESITY AND DIABETES

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CN119876239A (zh) * 2025-01-27 2025-04-25 吉林大学 拟南芥AtUPL5基因在提高植物抗性方面的应用

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US20210347827A1 (en) 2021-11-11
KR20190139841A (ko) 2019-12-18
JP2021525807A (ja) 2021-09-27
EP3805256A4 (en) 2022-03-23
WO2019231208A1 (ko) 2019-12-05
AU2019276622A1 (en) 2020-12-24
KR20190135393A (ko) 2019-12-06
EP3805256A1 (en) 2021-04-14
JP7402864B2 (ja) 2023-12-21
AU2023204533A1 (en) 2023-08-17
KR102155982B1 (ko) 2020-09-15
CA3101185A1 (en) 2019-12-05

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Application publication date: 20210108