JP2021525530A - キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制 - Google Patents

キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制 Download PDF

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JP2021525530A
JP2021525530A JP2020567078A JP2020567078A JP2021525530A JP 2021525530 A JP2021525530 A JP 2021525530A JP 2020567078 A JP2020567078 A JP 2020567078A JP 2020567078 A JP2020567078 A JP 2020567078A JP 2021525530 A JP2021525530 A JP 2021525530A
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car
cell
cells
gene
cytokine
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JP2021525530A5 (https=
JPWO2019232425A5 (https=
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アルン・カーター
マシュー・クーパー
ジョン・エフ・ディパージオ
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Washington University in St Louis WUSTL
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JP2020567078A 2018-06-01 2019-05-31 キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制 Pending JP2021525530A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862679597P 2018-06-01 2018-06-01
US62/679,597 2018-06-01
PCT/US2019/034981 WO2019232425A1 (en) 2018-06-01 2019-05-31 Suppression of cytokine release syndrome in chimeric antigen receptor cell therapy

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JP2021525530A true JP2021525530A (ja) 2021-09-27
JP2021525530A5 JP2021525530A5 (https=) 2022-06-30
JPWO2019232425A5 JPWO2019232425A5 (https=) 2022-06-30

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US (3) US20200054675A1 (https=)
EP (1) EP3802578A4 (https=)
JP (1) JP2021525530A (https=)
CN (1) CN112533942A (https=)
WO (1) WO2019232425A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025535446A (ja) * 2022-10-20 2025-10-24 マイクロ クリスパー プライベート リミテッド 免疫療法におけるサイトカイン放出症候群の軽減
JP2025535448A (ja) * 2022-10-20 2025-10-24 マイクロ クリスパー プライベート リミテッド 免疫療法におけるサイトカイン放出症候群の軽減
JP2025535441A (ja) * 2022-10-20 2025-10-24 マイクロ クリスパー プライベート リミテッド 免疫療法におけるサイトカイン放出症候群の軽減

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NZ750256A (en) 2016-08-03 2026-02-27 Dipersio John F Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
AU2018316166A1 (en) 2017-08-07 2020-02-06 The Regents Of The University Of California Platform for generating safe cell therapeutics
SG11202011383VA (en) * 2018-05-31 2020-12-30 Univ Washington Chimeric antigen receptor t cells (car-t) for the treatment of cancer
JP2022516389A (ja) * 2018-05-31 2022-02-28 ワシントン・ユニバーシティ 血液悪性腫瘍を治療するためのゲノム編集インバリアントナチュラルキラーＴ（ｉＮＫＴ）細胞
JP2021525530A (ja) 2018-06-01 2021-09-27 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制
CN109735558B (zh) * 2018-12-12 2022-04-15 中南大学 一种重组car19-il24基因、慢病毒载体、car19-il24-t细胞及应用
EP3931208A1 (en) 2019-03-01 2022-01-05 Allogene Therapeutics, Inc. Chimeric cytokine receptors bearing a pd-1 ectodomain
WO2021041806A1 (en) 2019-08-30 2021-03-04 Allogene Therapeutics, Inc. Chimeric cytokine receptors comprising tgf beta binding domains
AU2020405049A1 (en) * 2019-12-17 2022-06-23 The General Hospital Corporation Engineered immune cells with reduced toxicity and uses thereof
EP3845646A1 (en) * 2019-12-30 2021-07-07 Secarna Pharmaceuticals GmbH & Co. KG Modified antisense oligonucleotide for inhibition of foxp3 expression
JP2023514407A (ja) * 2020-02-24 2023-04-05 アロジーン セラピューティクス，インコーポレイテッド 増強された活性を有するｂｃｍａ ｃａｒ－ｔ細胞
JP2023521519A (ja) * 2020-04-06 2023-05-24 セレディット エルエルシー キメラ抗原受容体を発現し低減した炎症性サイトカインシグナル伝達を有する遺伝子改変された免疫細胞
CN111548420B (zh) * 2020-05-14 2021-10-15 深圳普瑞金生物药业有限公司 一种抗间皮素嵌合抗原受体、表达基因、表达载体、t细胞及其用途
WO2022098756A1 (en) * 2020-11-03 2022-05-12 WUGEN, Inc. Chimeric antigen receptor cell therapy
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
IL304904A (en) * 2021-02-01 2023-10-01 St Phi Therapeutics Co Ltd Target protein degradation system and its use
CN112876535B (zh) * 2021-02-08 2023-06-30 浙江华缔药业集团医药开发有限公司 生物活性多肽及其应用
AU2022311936A1 (en) * 2021-07-16 2024-02-29 George GENTSCH Gene editing to improve joint function
CN118056012B (zh) * 2021-08-24 2025-05-30 赛斯尔擎生物技术（上海）有限公司 一种修饰细胞的方法
CN114410686B (zh) * 2021-12-24 2023-10-03 武汉大学 一种工程化外泌体原位纳米疫苗及其制备方法和应用
EP4504221A4 (en) * 2022-03-22 2026-02-25 Celyntra Therapeutics Sa Compositions and methods for generating cells with reduced immunogenicity
US20250302918A1 (en) * 2022-05-20 2025-10-02 President And Fellows Of Harvard College Methods and compositions relating to treatment of cns diseases
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