JP2021525518A5 - - Google Patents
Info
- Publication number
- JP2021525518A5 JP2021525518A5 JP2020566646A JP2020566646A JP2021525518A5 JP 2021525518 A5 JP2021525518 A5 JP 2021525518A5 JP 2020566646 A JP2020566646 A JP 2020566646A JP 2020566646 A JP2020566646 A JP 2020566646A JP 2021525518 A5 JP2021525518 A5 JP 2021525518A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- population
- genome
- immune effector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862678886P | 2018-05-31 | 2018-05-31 | |
| US62/678,886 | 2018-05-31 | ||
| PCT/US2019/034959 WO2019232409A1 (en) | 2018-05-31 | 2019-05-31 | Methods for genome editing and activation of cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021525518A JP2021525518A (ja) | 2021-09-27 |
| JP2021525518A5 true JP2021525518A5 (enExample) | 2022-06-08 |
Family
ID=68697155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020566646A Pending JP2021525518A (ja) | 2018-05-31 | 2019-05-31 | 細胞をゲノム編集及び活性化するための方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20200109364A1 (enExample) |
| EP (1) | EP3801574A4 (enExample) |
| JP (1) | JP2021525518A (enExample) |
| CN (1) | CN112867498A (enExample) |
| WO (1) | WO2019232409A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12350349B2 (en) | 2016-08-03 | 2025-07-08 | Washington University | Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors |
| CN118853581A (zh) | 2017-06-21 | 2024-10-29 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(CARs)、组合物及其使用方法 |
| IL279063B2 (en) * | 2018-05-31 | 2026-05-01 | Washington University St Louis | Chimeric antigen receptor T cells for cancer treatment |
| EP3824075A4 (en) * | 2018-07-17 | 2022-04-20 | The Regents of The University of California | CHIMERA ANTIGEN RECEPTOR T-CELLS DERIVED FROM IMMUNOMANIPULATED PLURIPOTENTS STEM CELLS |
| US20220213434A1 (en) | 2019-05-10 | 2022-07-07 | The Regents Of The University Of California | Modified pluripotent cells |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| WO2021129927A1 (en) * | 2019-12-23 | 2021-07-01 | Biontech Cell & Gene Therapies Gmbh | Treatment with immune effector cells engineered to express an antigen receptor |
| WO2021223359A1 (en) * | 2020-05-06 | 2021-11-11 | Gracell Biotechnologies (Shanghai) Co., Ltd. | Compositions and methods for t cell engineering |
| CN111849910B (zh) * | 2020-05-27 | 2021-06-15 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
| EP4219707A4 (en) * | 2020-09-24 | 2024-11-13 | Kyoto University | METHOD FOR PRODUCING AN EFFECTOR CELL WITH DESIRED SPECIFICITY |
| IL303269A (en) | 2020-12-03 | 2023-07-01 | Century Therapeutics Inc | Genetically engineered cells and uses thereof |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| CN112980800A (zh) * | 2021-03-08 | 2021-06-18 | 河北森朗生物科技有限公司 | Car-t细胞、其构建方法及其应用 |
| JP2024517641A (ja) * | 2021-04-20 | 2024-04-23 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 免疫細胞の遺伝子改変および治療的使用のための方法および組成物 |
| CN113430202A (zh) * | 2021-08-26 | 2021-09-24 | 山东兴瑞生物科技有限公司 | 一种具有高敲除率的人PD1基因sgRNA及含有该sgRNA的质粒、T细胞 |
| CN113462652A (zh) * | 2021-09-06 | 2021-10-01 | 阿思科力(苏州)生物科技有限公司 | 细胞、免疫治疗产品、基因编辑方法、细胞制备方法及应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015066262A1 (en) * | 2013-11-04 | 2015-05-07 | Trustees Of Dartmouth College | Methods for preventing toxicity of adoptive cell therapy |
| KR102546296B1 (ko) * | 2014-10-31 | 2023-06-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도 |
| WO2016073381A1 (en) * | 2014-11-03 | 2016-05-12 | Cerus Corporation | Compositions and methods for improved car-t cell therapies |
| CA2977106A1 (en) * | 2015-02-27 | 2016-09-01 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof |
| BR112017020750A2 (en) * | 2015-03-27 | 2018-06-26 | President And Fellows Of Harvard College | modified t-cells and methods of producing and using them |
| CN108884460B (zh) * | 2016-03-19 | 2023-04-28 | 埃克苏马生物技术公司 | 淋巴细胞转导及其扩增调节的方法与组合物 |
| AU2017248259A1 (en) * | 2016-04-07 | 2018-10-25 | Bluebird Bio, Inc. | Chimeric antigen receptor T cell compositions |
| EP3452499A2 (en) * | 2016-05-06 | 2019-03-13 | Juno Therapeutics, Inc. | Genetically engineered cells and methods of making the same |
| US12350349B2 (en) * | 2016-08-03 | 2025-07-08 | Washington University | Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors |
| GB201616699D0 (en) * | 2016-09-30 | 2016-11-16 | Mab Designs Ltd | Antibodies |
-
2019
- 2019-05-31 JP JP2020566646A patent/JP2021525518A/ja active Pending
- 2019-05-31 EP EP19812244.2A patent/EP3801574A4/en active Pending
- 2019-05-31 US US16/428,348 patent/US20200109364A1/en not_active Abandoned
- 2019-05-31 WO PCT/US2019/034959 patent/WO2019232409A1/en not_active Ceased
- 2019-05-31 CN CN201980050878.7A patent/CN112867498A/zh active Pending
-
2024
- 2024-05-13 US US18/662,838 patent/US20250043243A1/en active Pending
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