JP2021525518A - 細胞をゲノム編集及び活性化するための方法 - Google Patents

細胞をゲノム編集及び活性化するための方法 Download PDF

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JP2021525518A
JP2021525518A JP2020566646A JP2020566646A JP2021525518A JP 2021525518 A JP2021525518 A JP 2021525518A JP 2020566646 A JP2020566646 A JP 2020566646A JP 2020566646 A JP2020566646 A JP 2020566646A JP 2021525518 A JP2021525518 A JP 2021525518A
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cells
cell
car
population
editing
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マシュー・クーパー
ジョン・エフ・ディパージオ
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Washington University in St Louis WUSTL
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JP2020566646A 2018-05-31 2019-05-31 細胞をゲノム編集及び活性化するための方法 Pending JP2021525518A (ja)

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Application Number Priority Date Filing Date Title
US201862678886P 2018-05-31 2018-05-31
US62/678,886 2018-05-31
PCT/US2019/034959 WO2019232409A1 (en) 2018-05-31 2019-05-31 Methods for genome editing and activation of cells

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JP2021525518A true JP2021525518A (ja) 2021-09-27
JP2021525518A5 JP2021525518A5 (https=) 2022-06-08
JPWO2019232409A5 JPWO2019232409A5 (https=) 2022-06-08

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US (2) US20200109364A1 (https=)
EP (1) EP3801574A4 (https=)
JP (1) JP2021525518A (https=)
CN (1) CN112867498A (https=)
WO (1) WO2019232409A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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NZ750256A (en) 2016-08-03 2026-02-27 Dipersio John F Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
CA3287539A1 (en) 2017-06-21 2026-03-02 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF
SG11202011383VA (en) * 2018-05-31 2020-12-30 Univ Washington Chimeric antigen receptor t cells (car-t) for the treatment of cancer
US20210308183A1 (en) * 2018-07-17 2021-10-07 The Regents Of The University Of California Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells
WO2020231882A2 (en) 2019-05-10 2020-11-19 The Regents Of The University Of California Modified pluripotent cells
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
WO2021129927A1 (en) * 2019-12-23 2021-07-01 Biontech Cell & Gene Therapies Gmbh Treatment with immune effector cells engineered to express an antigen receptor
US20230113157A1 (en) * 2020-05-06 2023-04-13 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
CN111849910B (zh) * 2020-05-27 2021-06-15 南京北恒生物科技有限公司 工程化免疫细胞及其用途
CA3193384A1 (en) * 2020-09-24 2022-03-31 Hiroshi Kawamoto Method for preparing effector cells with desired specificity
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
CN112980800A (zh) * 2021-03-08 2021-06-18 河北森朗生物科技有限公司 Car-t细胞、其构建方法及其应用
US20240197782A1 (en) * 2021-04-20 2024-06-20 Board Of Regents, The University Of Texas System Methods and compositions for genetic modification and therapeutic use of immune cells
CN113430202A (zh) * 2021-08-26 2021-09-24 山东兴瑞生物科技有限公司 一种具有高敲除率的人PD1基因sgRNA及含有该sgRNA的质粒、T细胞
CN113462652A (zh) * 2021-09-06 2021-10-01 阿思科力(苏州)生物科技有限公司 细胞、免疫治疗产品、基因编辑方法、细胞制备方法及应用

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WO2017177137A1 (en) * 2016-04-07 2017-10-12 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
WO2017193107A2 (en) * 2016-05-06 2017-11-09 Juno Therapeutics, Inc. Genetically engineered cells and methods of making the same
JP2017535261A (ja) * 2014-10-31 2017-11-30 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｃａｒｔ細胞における遺伝子発現の改変およびその使用
WO2018027036A1 (en) * 2016-08-03 2018-02-08 Dipersio John F Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
JP2018510657A (ja) * 2015-03-27 2018-04-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 改変ｔ細胞ならびにそれを作製および使用する方法

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WO2019232409A1 (en) 2019-12-05
WO2019232409A9 (en) 2020-04-16
EP3801574A1 (en) 2021-04-14
US20250043243A1 (en) 2025-02-06
EP3801574A4 (en) 2022-03-16
US20200109364A1 (en) 2020-04-09
CN112867498A (zh) 2021-05-28

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