JP2021524438A5 - - Google Patents
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- Publication number
- JP2021524438A5 JP2021524438A5 JP2020564425A JP2020564425A JP2021524438A5 JP 2021524438 A5 JP2021524438 A5 JP 2021524438A5 JP 2020564425 A JP2020564425 A JP 2020564425A JP 2020564425 A JP2020564425 A JP 2020564425A JP 2021524438 A5 JP2021524438 A5 JP 2021524438A5
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- oral
- sugar alcohol
- particle population
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 38
- 239000007935 oral tablet Substances 0.000 claims 21
- 229940096978 oral tablet Drugs 0.000 claims 17
- 150000005846 sugar alcohols Chemical class 0.000 claims 15
- 239000003826 tablet Substances 0.000 claims 13
- 239000004480 active ingredient Substances 0.000 claims 4
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 3
- 239000000905 isomalt Substances 0.000 claims 3
- 235000010439 isomalt Nutrition 0.000 claims 3
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000811 xylitol Substances 0.000 claims 3
- 235000010447 xylitol Nutrition 0.000 claims 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 3
- 229960002675 xylitol Drugs 0.000 claims 3
- 239000004386 Erythritol Substances 0.000 claims 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 2
- 230000001055 chewing effect Effects 0.000 claims 2
- 235000019414 erythritol Nutrition 0.000 claims 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 2
- 229940009714 erythritol Drugs 0.000 claims 2
- 239000000845 maltitol Substances 0.000 claims 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 2
- 235000010449 maltitol Nutrition 0.000 claims 2
- 229940035436 maltitol Drugs 0.000 claims 2
- 239000006191 orally-disintegrating tablet Substances 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 208000019505 Deglutition disease Diseases 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000000551 dentifrice Substances 0.000 claims 1
- 206010013781 dry mouth Diseases 0.000 claims 1
- 239000000832 lactitol Substances 0.000 claims 1
- 235000010448 lactitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 1
- 229960003451 lactitol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 239000000606 toothpaste Substances 0.000 claims 1
- 229940034610 toothpaste Drugs 0.000 claims 1
- 239000004034 viscosity adjusting agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/982,758 US11096894B2 (en) | 2018-05-17 | 2018-05-17 | Oral tablet for induced saliva generation |
| US15/982,758 | 2018-05-17 | ||
| PCT/DK2019/050152 WO2019219142A1 (en) | 2018-05-17 | 2019-05-15 | An oral tablet for induced saliva generation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021524438A JP2021524438A (ja) | 2021-09-13 |
| JP2021524438A5 true JP2021524438A5 (https=) | 2021-10-21 |
| JP7403476B2 JP7403476B2 (ja) | 2023-12-22 |
Family
ID=66793731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564425A Active JP7403476B2 (ja) | 2018-05-17 | 2019-05-15 | 誘導唾液生成のための経口錠剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11096894B2 (https=) |
| EP (2) | EP4088716B1 (https=) |
| JP (1) | JP7403476B2 (https=) |
| KR (1) | KR102706980B1 (https=) |
| CN (1) | CN112118834B (https=) |
| AU (1) | AU2019269879B2 (https=) |
| BR (1) | BR112020023173A2 (https=) |
| CA (1) | CA3097055C (https=) |
| DK (1) | DK3773511T3 (https=) |
| ES (1) | ES2926159T3 (https=) |
| MX (1) | MX2020012280A (https=) |
| PL (1) | PL3773511T3 (https=) |
| WO (1) | WO2019219142A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11096896B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Tablet dosage form for buccal absorption of active ingredients |
| DK4146164T3 (da) * | 2020-05-08 | 2025-05-26 | Fertin Pharma As | Flowpack til oral afgivelse af aktive ingredienser |
| WO2023241838A1 (de) * | 2022-06-14 | 2023-12-21 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Kombinationstherapeutikum |
| DK202330231A1 (en) * | 2023-09-27 | 2025-04-10 | Fertin Pharma As | Cannabidiol for alleviating xerostomia |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3070510A (en) | 1959-11-03 | 1962-12-25 | Procter & Gamble | Dentifrice containing resinous cleaning agents |
| US3538230A (en) | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
| US3862307A (en) | 1973-04-09 | 1975-01-21 | Procter & Gamble | Dentifrices containing a cationic therapeutic agent and improved silica abrasive |
| CA1080024A (en) * | 1975-12-24 | 1980-06-24 | Leonard Spooner | Confection containing xylitol |
| US4340583A (en) | 1979-05-23 | 1982-07-20 | J. M. Huber Corporation | High fluoride compatibility dentifrice abrasives and compositions |
| US4627977A (en) | 1985-09-13 | 1986-12-09 | Colgate-Palmolive Company | Anticalculus oral composition |
| US4820506A (en) | 1987-05-01 | 1989-04-11 | Research Foundation, State University Of New York | Salivary stimulant |
| US4997654A (en) | 1989-08-14 | 1991-03-05 | Warner-Lambert Company | Method for increasing salivation for xerostomia patients |
| GB9100009D0 (en) | 1991-01-02 | 1991-02-20 | Cerestar Holding Bv | Erythritol compositions |
| US5576014A (en) | 1994-01-31 | 1996-11-19 | Yamanouchi Pharmaceutical Co., Ltd | Intrabuccally dissolving compressed moldings and production process thereof |
| TW469135B (en) | 1995-10-03 | 2001-12-21 | Chugai Pharmaceutical Co Ltd | Chewable tablet |
| DE69738829D1 (de) | 1996-07-12 | 2008-08-21 | Daiichi Seiyaku Co | Schnell zerfallende, druckgeformte Materialien sowie Prozess zu deren Herstellung |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| GB9716432D0 (en) | 1997-08-05 | 1997-10-08 | Cerestar Holding Bv | Tableting of erythritol |
| US5874068A (en) | 1997-12-08 | 1999-02-23 | Warner-Lambert Company | Stabilized antiplaque and antigingivitis oral compositions containing N.sup.α -alkyl-L-arginine alkyl ester salts |
| CA2315088A1 (en) | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Process for manufacturing bite-dispersion tablets |
| AU1031500A (en) | 1998-11-03 | 2000-05-22 | Dandy A/S | Sucrose fatty acid esters for use as increased release of active ingredients |
| FR2785538B1 (fr) | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Comprime a delitement rapide perfectionne |
| EP1365740A1 (en) | 2001-02-08 | 2003-12-03 | Pharmacia Corporation | Rapid-onset medicament for the treatment of sexual dysfunction |
| KR20030081472A (ko) | 2001-03-06 | 2003-10-17 | 교와 핫꼬 고교 가부시끼가이샤 | 구강내 속붕괴성 제제 |
| SE0102197D0 (sv) | 2001-06-20 | 2001-06-20 | Pharmacia Ab | New product and use and manufacture thereof |
| WO2003080023A2 (en) * | 2002-03-20 | 2003-10-02 | Elan Pharma International Limited | Fast dissolving dosage forms having reduced friability |
| US20060147580A1 (en) | 2003-02-04 | 2006-07-06 | Vibeke Nissen | Compressed chewing gum tablet |
| PL1737302T3 (pl) | 2004-04-20 | 2018-05-30 | Wm. Wrigley Jr. Company | Odświeżające oddech produkty cukiernicze oraz sposoby ich wytwarzania i stosowania |
| WO2006034264A2 (en) | 2004-09-21 | 2006-03-30 | Applera Corporation | Methods of using sulfur nucleophiles as improved alternatives to sodium bisulfite for methylated dna analysis |
| WO2006058250A2 (en) * | 2004-11-24 | 2006-06-01 | Spi Pharma, Inc. | Orally disintegrating compositions |
| WO2006112961A2 (en) | 2005-03-03 | 2006-10-26 | Takasago International Corp. (Usa) | Synergistic salivation components |
| CN1709229A (zh) | 2005-06-10 | 2005-12-21 | 北京阜康仁生物制药科技有限公司 | 盐酸美金刚口腔崩解片及其制备方法 |
| CN1891299B (zh) | 2005-06-28 | 2012-06-27 | 上野制药株式会社 | 用于压片的糖醇组合物 |
| DK2046300T3 (da) | 2006-08-04 | 2010-07-26 | Ethypharm Sa | Oralt desintegrerende multilagstablet |
| WO2009007768A1 (en) | 2007-07-06 | 2009-01-15 | Gumlink A/S | Compressed tablet comprising polyol |
| EP2264042B1 (en) | 2007-07-27 | 2012-07-18 | Cargill, Incorporated | Micronization of polyols |
| WO2009080023A1 (en) | 2007-12-20 | 2009-07-02 | Fertin Pharma A/S | Compressed chewing gum comprising peptide |
| WO2010025796A1 (en) | 2008-09-04 | 2010-03-11 | Cargill Incorporated | Tabletting of ervthritol |
| US8617588B2 (en) | 2009-03-09 | 2013-12-31 | Spi Pharma, Inc. | Highly compactable and durable direct compression excipients and excipient systems |
| US9591852B2 (en) | 2009-11-23 | 2017-03-14 | Mcneil-Ppc, Inc. | Biofilm disruptive compositions |
| US8658139B1 (en) | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
| CN107252419A (zh) | 2010-12-22 | 2017-10-17 | 巴斯夫欧洲公司 | 快速崩解的固体包衣剂型 |
| WO2013091631A1 (en) | 2011-12-22 | 2013-06-27 | Fertin Pharma A/S | Method of releasing nicotine from chewing gum |
| JP6040218B2 (ja) | 2012-02-23 | 2016-12-07 | フロイント産業株式会社 | 口腔内崩壊錠用直打賦形剤及びその製造方法、並びに口腔内崩壊錠 |
| WO2013171164A1 (en) | 2012-05-14 | 2013-11-21 | EJP Pharmaceutical ApS | Compositions and formulations for the treatment of halitosis |
| US20160120793A1 (en) | 2013-05-17 | 2016-05-05 | Alequident Limited | Oral Healthcare Product |
| US10357054B2 (en) | 2013-10-16 | 2019-07-23 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| EP3206671B1 (en) | 2014-10-16 | 2024-06-12 | Cargill, Incorporated | Process for preparing a directly compressible erythritol and uses thereof |
| US9975847B2 (en) | 2014-11-11 | 2018-05-22 | Johnson & Johnson Consumer Inc. | Amino acid derivatives and their uses |
| US11351103B2 (en) | 2016-11-18 | 2022-06-07 | Johnson & Johnson Consumer Inc. | Method of providing oral care benefits |
| US10543205B2 (en) | 2016-11-18 | 2020-01-28 | Fertin Pharma A/S | Oral delivery vehicle containing nicotine |
| US10632076B2 (en) | 2016-11-18 | 2020-04-28 | Fertin Pharma A/S | Tablet comprising separate binder and erythritol |
| ES2870142T3 (es) | 2016-11-18 | 2021-10-26 | Fertin Pharma As | Vehículo de administración oral |
| RU2736072C1 (ru) | 2016-11-18 | 2020-11-11 | Фертин Фарма А/С | Таблетка, содержащая отдельное связывающее вещество и эритрит |
| US11135157B2 (en) | 2018-05-17 | 2021-10-05 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the throat |
| US11096895B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet suitable for active pharmaceutical ingredients |
| US11058641B2 (en) | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Oral tablet for taste masking of active ingredients |
| CA3097953C (en) | 2018-05-17 | 2023-09-12 | Fertin Pharma A/S | A tableted chewing gum suitable for active pharmaceutical ingredients |
| US11052047B2 (en) | 2018-05-17 | 2021-07-06 | Fertin Pharma A/S | Oral tablet suitable for fast release of active pharmaceutical ingredients |
| US11096896B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Tablet dosage form for buccal absorption of active ingredients |
| US20190350858A1 (en) | 2018-05-17 | 2019-11-21 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the gastrointestinal tract |
| ES2966539T3 (es) | 2019-04-17 | 2024-04-22 | Nordiccan As | Comprimido oral de cannabinoides |
-
2018
- 2018-05-17 US US15/982,758 patent/US11096894B2/en active Active
-
2019
- 2019-05-15 JP JP2020564425A patent/JP7403476B2/ja active Active
- 2019-05-15 CN CN201980032458.6A patent/CN112118834B/zh active Active
- 2019-05-15 MX MX2020012280A patent/MX2020012280A/es unknown
- 2019-05-15 CA CA3097055A patent/CA3097055C/en active Active
- 2019-05-15 ES ES19729175T patent/ES2926159T3/es active Active
- 2019-05-15 AU AU2019269879A patent/AU2019269879B2/en active Active
- 2019-05-15 DK DK19729175.0T patent/DK3773511T3/da active
- 2019-05-15 KR KR1020207031849A patent/KR102706980B1/ko active Active
- 2019-05-15 WO PCT/DK2019/050152 patent/WO2019219142A1/en not_active Ceased
- 2019-05-15 PL PL19729175.0T patent/PL3773511T3/pl unknown
- 2019-05-15 EP EP22182854.4A patent/EP4088716B1/en active Active
- 2019-05-15 EP EP19729175.0A patent/EP3773511B1/en active Active
- 2019-05-15 BR BR112020023173-8A patent/BR112020023173A2/pt active Search and Examination
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