JP2021523108A5 - - Google Patents
Info
- Publication number
- JP2021523108A5 JP2021523108A5 JP2020561053A JP2020561053A JP2021523108A5 JP 2021523108 A5 JP2021523108 A5 JP 2021523108A5 JP 2020561053 A JP2020561053 A JP 2020561053A JP 2020561053 A JP2020561053 A JP 2020561053A JP 2021523108 A5 JP2021523108 A5 JP 2021523108A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- independently
- alkoxy
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862664891P | 2018-04-30 | 2018-04-30 | |
| US201862664863P | 2018-04-30 | 2018-04-30 | |
| US201862664860P | 2018-04-30 | 2018-04-30 | |
| US201862664850P | 2018-04-30 | 2018-04-30 | |
| US62/664,850 | 2018-04-30 | ||
| US62/664,860 | 2018-04-30 | ||
| US62/664,891 | 2018-04-30 | ||
| US62/664,863 | 2018-04-30 | ||
| PCT/US2019/030039 WO2019213160A1 (en) | 2018-04-30 | 2019-04-30 | Acyl phosphonamidates and acyl benzylamines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523108A JP2021523108A (ja) | 2021-09-02 |
| JP2021523108A5 true JP2021523108A5 (https=) | 2022-04-20 |
| JP7204780B2 JP7204780B2 (ja) | 2023-01-16 |
Family
ID=66530472
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560258A Active JP7080346B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホノアミダート |
| JP2020561053A Active JP7204780B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるアシルホスホノアミダートおよびアシルベンジルアミン |
| JP2020561057A Expired - Fee Related JP7089062B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホリジン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560258A Active JP7080346B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホノアミダート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020561057A Expired - Fee Related JP7089062B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホリジン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10703745B2 (https=) |
| EP (3) | EP3788052A4 (https=) |
| JP (3) | JP7080346B2 (https=) |
| CN (4) | CN117866015A (https=) |
| WO (3) | WO2019213160A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020140005A2 (en) | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| EP3906235B1 (en) | 2019-01-04 | 2023-03-15 | Ascentage Pharma (Suzhou) Co., Ltd. | Method for preparing sulfonamides drugs |
| CN113248415B (zh) * | 2021-05-26 | 2022-08-09 | 苏州正永生物医药有限公司 | 一种abt-737关键中间体的制备方法以及abt-737的制备方法 |
| CN118717761A (zh) * | 2024-05-27 | 2024-10-01 | 复旦大学 | 瑞美吉泮在制备治疗/预防阿尔茨海默病药物中的应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807846A (en) | 1996-11-14 | 1998-09-15 | Warner-Lambert Company | Phosphonamide ACAT inhibitors |
| MXPA01008937A (es) * | 1999-03-05 | 2004-04-05 | Metabasis Therapeutics Inc | Nuevos profarmacos que contienen fosforo. |
| US7132427B2 (en) | 2001-06-21 | 2006-11-07 | Ariad Pharmaceuticals, Inc. | Quinazolines and uses thereof |
| US7238679B2 (en) | 2002-12-23 | 2007-07-03 | Ariad Pharmaceuticals, Inc. | Heterocycles and uses thereof |
| CA2600797A1 (en) * | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Michigan | Chromen-4-one inhibitors of anti-apoptotic bcl-2 family members and the uses thereof |
| US7834023B2 (en) * | 2006-09-20 | 2010-11-16 | Portola Pharmaceuticals, Inc. | Substituted dihydroquinazolines as platelet ADP receptor inhibitors |
| US20080249130A1 (en) * | 2007-02-09 | 2008-10-09 | Sirtris Pharmaceuticals, Inc. | Gut microsomal triglyceride transport protein inhibitors |
| US8124605B2 (en) * | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| CN103370326B (zh) | 2010-12-16 | 2016-05-11 | 阿勒根公司 | 作为趋化因子受体调节剂的磷衍生物 |
| EP2668180B1 (en) * | 2011-01-25 | 2018-08-01 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors for use in the treatment of cancer |
| WO2012177927A1 (en) | 2011-06-21 | 2012-12-27 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
| WO2013052943A2 (en) * | 2011-10-06 | 2013-04-11 | The Regents Of The University Of Michgian | Small molecule inhibitors of mcl-1 and uses thereof |
| US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
| US20160038503A1 (en) | 2012-11-21 | 2016-02-11 | David Richard | Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives |
| EP3689886A1 (en) * | 2013-01-16 | 2020-08-05 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors and their use in the treatment of cancer |
| RU2015149680A (ru) | 2013-04-21 | 2017-05-24 | Йеда Ресеарч Энд Девелопмент Ко. Лтд. | Агенты для подавления активности и/или снижения количества bcl-xl и/или bcl-w |
| US10328058B2 (en) * | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| IL286427B2 (en) | 2014-01-28 | 2024-08-01 | Mayo Found Medical Education & Res | Inhibitors bcl-2 anti-apoptotic protein family members for treatment of non cancer pulmonary disease or an opthalmic disease |
| US10550190B2 (en) | 2014-04-04 | 2020-02-04 | Merck Sharp & Dohme Corp. | Phosphate based linkers for intracellular delivery of drug conjugates |
| EP3139942B1 (en) | 2014-05-05 | 2019-12-18 | Bioventures, Llc | COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS |
| US20180000816A1 (en) * | 2015-02-06 | 2018-01-04 | Unity Biotechnology, Inc. | Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions |
| WO2016127135A1 (en) * | 2015-02-06 | 2016-08-11 | Unity Biotechnology, Inc. | Compounds and uses in treatment of senescence-associated conditons |
| US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
| US20180199575A1 (en) | 2015-07-15 | 2018-07-19 | Bayer Cropscience Aktiengesellschaft | Substituted oxotetrahydroquinolinylphosphinic acid and phosphinic acid amides or salts thereof and use thereof to increase stress tolerance in plants |
| CN105646587B (zh) * | 2016-03-02 | 2018-03-23 | 云南中医学院 | 1,3,2‑氧氮磷杂环戊烷类化合物、制备方法及应用 |
| WO2019001171A1 (zh) | 2017-06-27 | 2019-01-03 | 维眸生物科技上海有限公司 | 一种含磷化合物及其制备和应用 |
| WO2019033122A1 (en) | 2017-08-11 | 2019-02-14 | Unity Biotechnology, Inc. | TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS |
| WO2019033119A1 (en) | 2017-08-11 | 2019-02-14 | Unity Biotechnology, Inc. | TREATMENT OF OPHTHALMIC CONDITIONS SUCH AS MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS |
-
2019
- 2019-04-30 CN CN202410023605.6A patent/CN117866015A/zh active Pending
- 2019-04-30 WO PCT/US2019/030039 patent/WO2019213160A1/en not_active Ceased
- 2019-04-30 JP JP2020560258A patent/JP7080346B2/ja active Active
- 2019-04-30 EP EP19796304.4A patent/EP3788052A4/en not_active Withdrawn
- 2019-04-30 EP EP19797087.4A patent/EP3787626B1/en active Active
- 2019-04-30 WO PCT/US2019/030028 patent/WO2019213153A1/en not_active Ceased
- 2019-04-30 EP EP19723963.5A patent/EP3788054B1/en active Active
- 2019-04-30 WO PCT/US2019/030023 patent/WO2019213151A1/en not_active Ceased
- 2019-04-30 JP JP2020561053A patent/JP7204780B2/ja active Active
- 2019-04-30 CN CN201980034780.2A patent/CN112469411B/zh active Active
- 2019-04-30 CN CN201980034704.1A patent/CN112513057B/zh active Active
- 2019-04-30 JP JP2020561057A patent/JP7089062B2/ja not_active Expired - Fee Related
- 2019-04-30 CN CN201980002328.8A patent/CN110662752B/zh active Active
- 2019-05-29 US US16/425,665 patent/US10703745B2/en active Active
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