JP2021523108A5 - - Google Patents
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- Publication number
- JP2021523108A5 JP2021523108A5 JP2020561053A JP2020561053A JP2021523108A5 JP 2021523108 A5 JP2021523108 A5 JP 2021523108A5 JP 2020561053 A JP2020561053 A JP 2020561053A JP 2020561053 A JP2020561053 A JP 2020561053A JP 2021523108 A5 JP2021523108 A5 JP 2021523108A5
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862664891P | 2018-04-30 | 2018-04-30 | |
| US201862664850P | 2018-04-30 | 2018-04-30 | |
| US201862664860P | 2018-04-30 | 2018-04-30 | |
| US201862664863P | 2018-04-30 | 2018-04-30 | |
| US62/664,860 | 2018-04-30 | ||
| US62/664,863 | 2018-04-30 | ||
| US62/664,850 | 2018-04-30 | ||
| US62/664,891 | 2018-04-30 | ||
| PCT/US2019/030039 WO2019213160A1 (en) | 2018-04-30 | 2019-04-30 | Acyl phosphonamidates and acyl benzylamines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021523108A JP2021523108A (ja) | 2021-09-02 |
| JP2021523108A5 true JP2021523108A5 (https=) | 2022-04-20 |
| JPWO2019213160A5 JPWO2019213160A5 (https=) | 2022-04-20 |
| JP7204780B2 JP7204780B2 (ja) | 2023-01-16 |
Family
ID=66530472
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560258A Active JP7080346B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホノアミダート |
| JP2020561053A Active JP7204780B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるアシルホスホノアミダートおよびアシルベンジルアミン |
| JP2020561057A Expired - Fee Related JP7089062B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホリジン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560258A Active JP7080346B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホノアミダート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020561057A Expired - Fee Related JP7089062B2 (ja) | 2018-04-30 | 2019-04-30 | 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホリジン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10703745B2 (https=) |
| EP (3) | EP3787626B1 (https=) |
| JP (3) | JP7080346B2 (https=) |
| CN (4) | CN112513057B (https=) |
| WO (3) | WO2019213160A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020140005A2 (en) | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| EP3906235B1 (en) | 2019-01-04 | 2023-03-15 | Ascentage Pharma (Suzhou) Co., Ltd. | Method for preparing sulfonamides drugs |
| CN113248415B (zh) * | 2021-05-26 | 2022-08-09 | 苏州正永生物医药有限公司 | 一种abt-737关键中间体的制备方法以及abt-737的制备方法 |
| CN118717761A (zh) * | 2024-05-27 | 2024-10-01 | 复旦大学 | 瑞美吉泮在制备治疗/预防阿尔茨海默病药物中的应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807846A (en) | 1996-11-14 | 1998-09-15 | Warner-Lambert Company | Phosphonamide ACAT inhibitors |
| HUP0200260A3 (en) * | 1999-03-05 | 2002-11-28 | Metabasis Therapeutics Inc San | Novel phosphorus-containing prodrugs, their preparation and their use |
| WO2003000188A2 (en) | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel quinazolines and uses thereof |
| EP1575591A4 (en) | 2002-12-23 | 2007-09-12 | Ariad Pharma Inc | HETEROCYCLES AND ITS USE |
| AU2006223257A1 (en) * | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Michigan | Chromen-4-one inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof |
| US7834023B2 (en) * | 2006-09-20 | 2010-11-16 | Portola Pharmaceuticals, Inc. | Substituted dihydroquinazolines as platelet ADP receptor inhibitors |
| WO2008100423A1 (en) * | 2007-02-09 | 2008-08-21 | Sirtris Pharmaceuticals, Inc. | Gut microsomal triglyceride transport protein inhibitors |
| US8124605B2 (en) * | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| CA2822039C (en) | 2010-12-16 | 2019-05-28 | Allergan, Inc. | Sulfur derivatives as chemokine receptor modulators |
| SG192126A1 (en) | 2011-01-25 | 2013-09-30 | Univ Michigan | Bcl-2/bcl-xl inhibitors and therapeutic methods using the same |
| US20140189897A1 (en) | 2011-06-21 | 2014-07-03 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
| WO2013052943A2 (en) * | 2011-10-06 | 2013-04-11 | The Regents Of The University Of Michgian | Small molecule inhibitors of mcl-1 and uses thereof |
| US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
| EP2922544B1 (en) | 2012-11-21 | 2018-08-01 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| KR102318204B1 (ko) | 2013-01-16 | 2021-10-26 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Bcl-2bcl-xl 억제제 및 그를 사용하는 치료 방법 |
| CN105377289A (zh) | 2013-04-21 | 2016-03-02 | 耶达研究及发展有限公司 | 用于下调Bcl-xL和/或Bcl-w的活性和/或量的试剂 |
| US10328058B2 (en) * | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| AU2015211021B2 (en) | 2014-01-28 | 2020-07-02 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| EP3125943B1 (en) | 2014-04-04 | 2026-04-22 | Merck Sharp & Dohme LLC | Phosphate based linkers for intracellular delivery of drug conjugates |
| EP3139942B1 (en) | 2014-05-05 | 2019-12-18 | Bioventures, Llc | COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS |
| US20180000816A1 (en) * | 2015-02-06 | 2018-01-04 | Unity Biotechnology, Inc. | Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions |
| CA2981753A1 (en) * | 2015-02-06 | 2016-08-11 | Unity Biotechnology, Inc. | Compounds and uses in treatment of senescence-associated conditions |
| US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
| CN107846899A (zh) | 2015-07-15 | 2018-03-27 | 拜耳农作物科学股份公司 | 取代的氧代四氢喹啉基次膦酰胺和‑膦酰胺或其盐及其提高植物中的胁迫耐受性的用途 |
| CN105646587B (zh) * | 2016-03-02 | 2018-03-23 | 云南中医学院 | 1,3,2‑氧氮磷杂环戊烷类化合物、制备方法及应用 |
| WO2019001171A1 (zh) | 2017-06-27 | 2019-01-03 | 维眸生物科技上海有限公司 | 一种含磷化合物及其制备和应用 |
| WO2019033122A1 (en) | 2017-08-11 | 2019-02-14 | Unity Biotechnology, Inc. | TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS |
| EP3441069B1 (en) | 2017-08-11 | 2023-04-05 | Unity Biotechnology, Inc. | Treatment of diabetic retinopathy using pharmaceutical agents that eliminate senescent cells |
-
2019
- 2019-04-30 JP JP2020560258A patent/JP7080346B2/ja active Active
- 2019-04-30 JP JP2020561053A patent/JP7204780B2/ja active Active
- 2019-04-30 EP EP19797087.4A patent/EP3787626B1/en active Active
- 2019-04-30 CN CN201980034704.1A patent/CN112513057B/zh active Active
- 2019-04-30 WO PCT/US2019/030039 patent/WO2019213160A1/en not_active Ceased
- 2019-04-30 CN CN202410023605.6A patent/CN117866015A/zh active Pending
- 2019-04-30 EP EP19723963.5A patent/EP3788054B1/en active Active
- 2019-04-30 EP EP19796304.4A patent/EP3788052A4/en not_active Withdrawn
- 2019-04-30 CN CN201980034780.2A patent/CN112469411B/zh active Active
- 2019-04-30 JP JP2020561057A patent/JP7089062B2/ja not_active Expired - Fee Related
- 2019-04-30 CN CN201980002328.8A patent/CN110662752B/zh active Active
- 2019-04-30 WO PCT/US2019/030023 patent/WO2019213151A1/en not_active Ceased
- 2019-04-30 WO PCT/US2019/030028 patent/WO2019213153A1/en not_active Ceased
- 2019-05-29 US US16/425,665 patent/US10703745B2/en active Active
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