JP2021521849A5 - - Google Patents
Info
- Publication number
- JP2021521849A5 JP2021521849A5 JP2020560338A JP2020560338A JP2021521849A5 JP 2021521849 A5 JP2021521849 A5 JP 2021521849A5 JP 2020560338 A JP2020560338 A JP 2020560338A JP 2020560338 A JP2020560338 A JP 2020560338A JP 2021521849 A5 JP2021521849 A5 JP 2021521849A5
- Authority
- JP
- Japan
- Prior art keywords
- foxp3
- sequence
- promoter
- locus
- syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024182444A JP7844581B2 (ja) | 2018-04-27 | 2024-10-18 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
| JP2026059991A JP2026099845A (ja) | 2018-04-27 | 2026-04-01 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862663561P | 2018-04-27 | 2018-04-27 | |
| US62/663,561 | 2018-04-27 | ||
| US201862773414P | 2018-11-30 | 2018-11-30 | |
| US62/773,414 | 2018-11-30 | ||
| PCT/US2019/029159 WO2019210078A1 (en) | 2018-04-27 | 2019-04-25 | Expression of human foxp3 in gene edited t cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024182444A Division JP7844581B2 (ja) | 2018-04-27 | 2024-10-18 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021521849A JP2021521849A (ja) | 2021-08-30 |
| JP2021521849A5 true JP2021521849A5 (enExample) | 2022-11-25 |
| JP7575949B2 JP7575949B2 (ja) | 2024-10-31 |
Family
ID=68295504
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560338A Active JP7575949B2 (ja) | 2018-04-27 | 2019-04-25 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
| JP2024182444A Active JP7844581B2 (ja) | 2018-04-27 | 2024-10-18 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
| JP2026059991A Pending JP2026099845A (ja) | 2018-04-27 | 2026-04-01 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024182444A Active JP7844581B2 (ja) | 2018-04-27 | 2024-10-18 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
| JP2026059991A Pending JP2026099845A (ja) | 2018-04-27 | 2026-04-01 | 遺伝子編集ｔ細胞におけるヒトｆｏｘｐ３の発現 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20210253652A1 (enExample) |
| EP (1) | EP3784689A4 (enExample) |
| JP (3) | JP7575949B2 (enExample) |
| KR (1) | KR102912481B1 (enExample) |
| CN (1) | CN112041334A (enExample) |
| AU (2) | AU2019257708B2 (enExample) |
| CA (1) | CA3091491A1 (enExample) |
| IL (1) | IL277036A (enExample) |
| SG (1) | SG11202007877SA (enExample) |
| WO (1) | WO2019210078A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3042179A1 (en) | 2016-10-31 | 2018-05-03 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Method for treating autoimmune disease using cd4 t-cells with engineered stabilization of expression of endogenous foxp3 gene |
| SG11202007878UA (en) | 2018-04-27 | 2020-09-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Expression of foxp3 in edited cd34+ cells |
| WO2020161122A1 (en) * | 2019-02-05 | 2020-08-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant vectors suitable for the treatment of ipex syndrome |
| JP2022533713A (ja) * | 2019-05-21 | 2022-07-25 | サンガモ セラピューティクス， インコーポレイテッド | 調節性ｔ細胞における制御された導入遺伝子発現 |
| CA3160113A1 (en) * | 2019-11-08 | 2021-05-14 | Sangamo Therapeutics, Inc. | Generation of engineered regulatory t cells |
| EP4103591A4 (en) * | 2020-02-13 | 2024-09-04 | The Board of Trustees of the Leland Stanford Junior University | Crispr-based foxp3 gene engineered t cells and hematopoietic stem cell precursors to treat ipex syndrome patients |
| IL302591A (en) * | 2020-11-09 | 2023-07-01 | Quell Therapeutics Ltd | Method for cryopreservation of transgenic regulatory T cells |
| WO2022266139A2 (en) * | 2021-06-14 | 2022-12-22 | Graphite Bio, Inc. | Methods to genetically engineer hematopoietic stem and progenitor cells for red cell specific expression of therapeutic proteins |
| WO2023122099A2 (en) * | 2021-12-21 | 2023-06-29 | The Board Of Trustees Of The Leland Stanford Junior University | Crispr-based gene editing to preserve splicing and expression of foxp3 isoforms 1 and 2 |
| CN115305237B (zh) * | 2022-07-08 | 2023-07-14 | 中南大学 | 一种优化的调节性t细胞的扩增及规模化生产的方法 |
| WO2024127369A1 (en) * | 2022-12-16 | 2024-06-20 | LifeEDIT Therapeutics, Inc. | Guide rnas that target foxp3 gene and methods of use |
| CN121532517A (zh) * | 2023-06-24 | 2026-02-13 | 索诺玛生物治疗公司 | 用于对细胞进行工程改造的组合物和方法 |
| CN122055438A (zh) * | 2023-09-08 | 2026-05-15 | 索诺玛生物治疗公司 | 异位表达foxp3的细胞 |
| JP7818147B1 (ja) * | 2025-01-23 | 2026-02-20 | 国立研究開発法人国立がん研究センター | エフェクターｔ細胞、およびそれを含む医薬組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110123502A1 (en) | 2007-02-21 | 2011-05-26 | Barry Simon C | Method for obtaining treg-cells |
| JP6608807B2 (ja) * | 2013-05-29 | 2019-11-20 | セレクティス | Ｒｎａガイドｃａｓヌクレアーゼ系を用いることによって免疫療法のためにｔ細胞を操作するための方法 |
| US20190388469A1 (en) | 2015-01-30 | 2019-12-26 | The Regents Of The University Of California | Protein delivery in primary hematopoietic cells |
| EP3294342A4 (en) * | 2015-05-08 | 2018-11-07 | President and Fellows of Harvard College | Universal donor stem cells and related methods |
| EP3500696A4 (en) | 2016-08-16 | 2020-04-08 | Bluebird Bio, Inc. | VARIANTS OF IL-10 ALPHA RECEPTOR HOMING ENDONUCLEASE, COMPOSITIONS AND METHODS OF USE |
| WO2018073391A1 (en) * | 2016-10-19 | 2018-04-26 | Cellectis | Targeted gene insertion for improved immune cells therapy |
| EP3532075A4 (en) * | 2016-10-27 | 2020-07-08 | Intima Bioscience, Inc. | VIRAL METHODS OF MANUFACTURING GENETICALLY MODIFIED CELLS |
| CA3042179A1 (en) | 2016-10-31 | 2018-05-03 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Method for treating autoimmune disease using cd4 t-cells with engineered stabilization of expression of endogenous foxp3 gene |
| CN109790518A (zh) * | 2017-05-08 | 2019-05-21 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| WO2019040655A1 (en) * | 2017-08-22 | 2019-02-28 | The Regents Of The University Of California | LENTIVIRAL VECTORS EXPRESSING FOXP3 IN HEMATOPOIETIC STEM CELLS TO TREAT IMMUNITY DEFICIENCIES AND AUTOIMMUNE DISEASES |
| SG11202007878UA (en) * | 2018-04-27 | 2020-09-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Expression of foxp3 in edited cd34+ cells |
-
2019
- 2019-04-25 JP JP2020560338A patent/JP7575949B2/ja active Active
- 2019-04-25 SG SG11202007877SA patent/SG11202007877SA/en unknown
- 2019-04-25 WO PCT/US2019/029159 patent/WO2019210078A1/en not_active Ceased
- 2019-04-25 US US16/981,213 patent/US20210253652A1/en active Pending
- 2019-04-25 AU AU2019257708A patent/AU2019257708B2/en active Active
- 2019-04-25 EP EP19792759.3A patent/EP3784689A4/en active Pending
- 2019-04-25 KR KR1020207033790A patent/KR102912481B1/ko active Active
- 2019-04-25 CA CA3091491A patent/CA3091491A1/en active Pending
- 2019-04-25 CN CN201980028523.8A patent/CN112041334A/zh active Pending
-
2020
- 2020-08-31 IL IL277036A patent/IL277036A/en unknown
-
2024
- 2024-10-18 JP JP2024182444A patent/JP7844581B2/ja active Active
- 2024-11-22 AU AU2024266825A patent/AU2024266825A1/en active Pending
-
2026
- 2026-04-01 JP JP2026059991A patent/JP2026099845A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021521856A5 (enExample) | ||
| AU2021277627B2 (en) | Anti-CD70-chimeric antigen receptors | |
| KR102859521B1 (ko) | 지속 치료를 위한 나노입자 조성물 | |
| TWI863887B (zh) | 使用具有工程化穩定表現內源性foxp3基因之cd4 t細胞治療自體免疫疾病的方法 | |
| US20190322983A1 (en) | Engineered treg cells | |
| JP2025013879A5 (enExample) | ||
| JP2018512151A5 (enExample) | ||
| Perzova et al. | Constitutive expression of Fas ligand in large granular lymphocyte leukaemia | |
| JP2020528744A5 (enExample) | ||
| JP2020529834A5 (enExample) | ||
| JP2019511236A5 (enExample) | ||
| AU2018336522A1 (en) | A gRNA targeting HPK1 and a method for editing HPK1 gene | |
| WO2023288338A2 (en) | Polycistronic vectors for cell-based therapies | |
| Delhove et al. | Genome-edited T cell therapies | |
| JP2024514355A5 (enExample) | ||
| CA3194577A1 (en) | Methods for triggering safety killing mechanisms using a cd47-sirp.alpha. blockade agent | |
| Lantow et al. | The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus | |
| US20240307444A1 (en) | Methods and compositions for improved immunotherapies | |
| US20240252642A1 (en) | Hypoimmunogenic rhd negative primary t cells | |
| IL315188A (en) | Methods and compositions comprising fusion proteins for improved immunotherapies | |
| JP2023052688A (ja) | 対合が改善されたｔ細胞受容体ｔ細胞 | |
| Tat et al. | Genetically enhanced T lymphocytes and the intensive care unit | |
| US20230272431A1 (en) | Methods and compositions for editing the b2m locus in b cells | |
| Kim et al. | Targeting OCA-B/Pou2af1 blocks type-1 diabetes and reduces infiltration of activated, islet-reactive T cells | |
| EP4384615A2 (en) | Engineering cells for cell-based therapies, and associated compositions and methods |