JP2021519791A5 - - Google Patents
Info
- Publication number
- JP2021519791A5 JP2021519791A5 JP2020553490A JP2020553490A JP2021519791A5 JP 2021519791 A5 JP2021519791 A5 JP 2021519791A5 JP 2020553490 A JP2020553490 A JP 2020553490A JP 2020553490 A JP2020553490 A JP 2020553490A JP 2021519791 A5 JP2021519791 A5 JP 2021519791A5
- Authority
- JP
- Japan
- Prior art keywords
- aav
- mutant
- capsid polypeptide
- aav capsid
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862651010P | 2018-03-30 | 2018-03-30 | |
| US62/651,010 | 2018-03-30 | ||
| US201862745226P | 2018-10-12 | 2018-10-12 | |
| US62/745,226 | 2018-10-12 | ||
| PCT/US2019/025026 WO2019191701A1 (en) | 2018-03-30 | 2019-03-29 | Novel recombinant adeno-associated virus capsids with enhanced human pancreatic tropism |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021519791A JP2021519791A (ja) | 2021-08-12 |
| JP2021519791A5 true JP2021519791A5 (enExample) | 2022-02-21 |
| JP7378417B2 JP7378417B2 (ja) | 2023-11-13 |
Family
ID=66440120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020553490A Active JP7378417B2 (ja) | 2018-03-30 | 2019-03-29 | 増強されたヒト膵臓トロピズムを有する新規な組換えアデノ随伴ウイルスキャプシド |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11608510B2 (enExample) |
| EP (1) | EP3774853A1 (enExample) |
| JP (1) | JP7378417B2 (enExample) |
| CN (1) | CN112004820B (enExample) |
| WO (1) | WO2019191701A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3774853A1 (en) * | 2018-03-30 | 2021-02-17 | The Board of Trustees of the Leland Stanford Junior University | Novel recombinant adeno-associated virus capsids with enhanced human pancreatic tropism |
| CN113966399A (zh) | 2018-09-26 | 2022-01-21 | 加州理工学院 | 用于靶向基因疗法的腺相关病毒组合物 |
| WO2021154414A2 (en) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides |
| BR112022016965A2 (pt) * | 2020-02-25 | 2022-12-06 | Childrens Medical Res Institute | Polipeptídeos e vetores de capsídeo do vírus adenoassociado |
| US20230235353A1 (en) * | 2020-03-19 | 2023-07-27 | Ultragenyx Pharmaceutical Inc. | Compositions and methods for reducing reverse packaging of cap and rep sequences in recombinant aav |
| US20250188126A1 (en) * | 2021-04-26 | 2025-06-12 | Alexion Pharma International Operations Limited | Adeno-associated viral vector capsids with improved tissue tropism |
| WO2022232267A1 (en) * | 2021-04-27 | 2022-11-03 | The Trustees Of The University Of Pennsylvania | Porcine-derived adeno-associated virus capsids and uses thereof |
| US20240374755A1 (en) * | 2021-06-02 | 2024-11-14 | Uniqure Biopharma B.V. | Adeno-associated virus vectors modified to bind High-Density Lipoprotein |
| JP2024522230A (ja) * | 2021-06-18 | 2024-06-11 | ダイノ セラピューティクス インコーポレイテッド | カプシドバリアント及びそれを使用する方法 |
| EP4355889A4 (en) * | 2021-06-18 | 2025-07-09 | Dyno Therapeutics Inc | CAPSID VARIANTS AND METHODS OF USE |
| WO2023034996A1 (en) * | 2021-09-03 | 2023-03-09 | Biomarin Pharmaceutical Inc. | Aav capsid compositions and methods for delivery |
| WO2023034980A1 (en) * | 2021-09-03 | 2023-03-09 | Bomarin Pharmaceutical Inc. | Aav capsid compositions and methods for delivery |
| WO2023034990A1 (en) * | 2021-09-03 | 2023-03-09 | Biomarin Pharmaceutical Inc. | Aav capsid compositions and methods for delivery |
| JP2024533174A (ja) * | 2021-09-03 | 2024-09-12 | ビオマリン プハルマセウトイカル インコーポレイテッド | Ａａｖカプシド組成物及び送達方法 |
| JP2024534888A (ja) * | 2021-09-03 | 2024-09-26 | ビオマリン プハルマセウトイカル インコーポレイテッド | Ａａｖカプシド組成物及び送達方法 |
| KR20240095539A (ko) | 2021-10-08 | 2024-06-25 | 디노 테라퓨틱스, 인코포레이티드 | 캡시드 변이체 및 이의 사용 방법 |
| CN114107231B (zh) * | 2021-12-13 | 2023-08-18 | 重庆大学 | 实现全脑突触后神经元胞体标记的重组腺相关病毒及其应用 |
| AU2022414072A1 (en) * | 2021-12-15 | 2024-07-04 | Fractyl Health, Inc. | Gene therapies for metabolic disorders |
| CN116686050B (zh) * | 2021-12-30 | 2026-01-23 | 京东方科技集团股份有限公司 | 预测大分子间相互作用的负样本集的生成方法、预测大分子间相互作用的方法、模型的训练方法 |
| CN114561337B (zh) * | 2022-03-09 | 2023-10-03 | 广州源井生物科技有限公司 | 一种提高HepG2细胞克隆形成率的单克隆增强培养基和方法 |
| GB202304767D0 (en) * | 2023-03-30 | 2023-05-17 | Ucl Business Ltd | Synthetic AAV Capsid |
| CN121013858A (zh) * | 2023-04-27 | 2025-11-25 | 俄勒冈健康与科学大学 | 靶向肾脏的aav衣壳及其使用方法 |
| WO2024233135A1 (en) * | 2023-05-05 | 2024-11-14 | The Regents Of The University Of California | Long-read sequencing of diverse dna libraries through barcode-labeled short reads |
| WO2025019295A2 (en) * | 2023-07-17 | 2025-01-23 | Oregon Health & Science University | Renal pelvic injection for drug delivery to the kidney |
| GB202407863D0 (en) | 2024-06-03 | 2024-07-17 | Purespring Therapeutics Ltd | Methods |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| AU8200191A (en) | 1990-07-09 | 1992-02-04 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| DE69233013T2 (de) | 1991-08-20 | 2004-03-04 | The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer | Adenovirus vermittelter gentransfer in den gastrointestinaltrakt |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| EP0931158A1 (en) | 1996-09-06 | 1999-07-28 | The Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| WO1998011244A2 (en) | 1996-09-11 | 1998-03-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Aav4 vector and uses thereof |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
| AU780231B2 (en) | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| WO2003042361A2 (en) | 2001-11-09 | 2003-05-22 | Government Of The United States Of America, Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| PT1453547T (pt) | 2001-12-17 | 2016-12-28 | Univ Pennsylvania | Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas |
| SI1633772T1 (sl) * | 2003-06-19 | 2016-06-30 | Genzyme Corporation | AAV virioni z zmanjšano imunoreaktivnostjo in uporaba za ta namen |
| US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US8106180B2 (en) | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US20050142581A1 (en) | 2003-09-04 | 2005-06-30 | Griffey Richard H. | Microrna as ligands and target molecules |
| WO2005056761A2 (en) | 2003-12-05 | 2005-06-23 | Massachusetts Institute Of Technology | REAGENTS AND METHODS FOR IDENTIFICATION OF RNAi PATHWAY GENES AND CHEMICAL MODULATORS OF RNAi |
| KR100614827B1 (ko) | 2004-05-06 | 2006-08-25 | 재단법인서울대학교산학협력재단 | 양방향 은닉 마코프 모델을 이용한 완숙한마이크로알엔에이 위치예측방법 및 이를 구현하기 위한컴퓨터 프로그램을 기록한 저장매체 |
| WO2008024998A2 (en) | 2006-08-24 | 2008-02-28 | Virovek, Inc. | Expression in insect cells of genes with overlapping open reading frames, methods and compositions therefor |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| ES2857773T5 (es) * | 2011-08-24 | 2024-06-04 | Univ Leland Stanford Junior | Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos |
| WO2013170078A1 (en) | 2012-05-09 | 2013-11-14 | Oregon Health & Science University | Adeno associated virus plasmids and vectors |
| EP3003391B1 (en) * | 2013-05-31 | 2021-09-22 | The Regents of The University of California | Adeno-associated virus variants and methods of use thereof |
| IL297919A (en) | 2013-07-22 | 2023-01-01 | Childrens Hospital Philadelphia | Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues |
| EP3200830B1 (en) | 2014-10-03 | 2020-09-09 | University of Massachusetts | High efficiency library-identified aav vectors |
| CN107073051B (zh) | 2014-10-21 | 2021-08-24 | 马萨诸塞大学 | 重组aav变体及其用途 |
| GB201508026D0 (en) * | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| KR102423442B1 (ko) | 2015-12-11 | 2022-07-20 | 캘리포니아 인스티튜트 오브 테크놀로지 | 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드 |
| JP6947739B2 (ja) * | 2016-02-16 | 2021-10-13 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 既存のヒト中和抗体に対して耐性である新規組換えアデノ随伴ウイルスカプシド |
| EP3774853A1 (en) * | 2018-03-30 | 2021-02-17 | The Board of Trustees of the Leland Stanford Junior University | Novel recombinant adeno-associated virus capsids with enhanced human pancreatic tropism |
-
2019
- 2019-03-29 EP EP19722733.3A patent/EP3774853A1/en active Pending
- 2019-03-29 JP JP2020553490A patent/JP7378417B2/ja active Active
- 2019-03-29 CN CN201980024467.0A patent/CN112004820B/zh active Active
- 2019-03-29 US US16/370,735 patent/US11608510B2/en active Active
- 2019-03-29 WO PCT/US2019/025026 patent/WO2019191701A1/en not_active Ceased
-
2022
- 2022-12-06 US US18/062,333 patent/US12467065B2/en active Active