JP2021519343A - ポリビニルアルコール及びポリ酸を含む、口腔疾患治療用の殺菌性及び/又は抗炎症性ゲル - Google Patents
ポリビニルアルコール及びポリ酸を含む、口腔疾患治療用の殺菌性及び/又は抗炎症性ゲル Download PDFInfo
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Abstract
Description
以下に、本発明の製剤の調剤、その特徴、及び使用に関する実施例を提示するが、これらは、あくまでも例示を目的とするものであり、添付の請求項によって規定される本発明の権利範囲を何ら限定するものではない。
ポリビニルアルコールを、分子量が90,000、濃度が2重量%になるように水に溶解させて、ゲル化用溶液を得た。この水溶液を攪拌して均一溶液とした後に、分子量が400,000で濃度が0.5重量%のポリアクリル酸、及び濃度1.5重量%のアルギン酸ナトリウムを追加した。また、混合物全体に対して、濃度2重量%のクロルヘキシジングルコン酸塩と、濃度10重量%のアセチルサリチル酸を最後に追加した。
実施例1にしたがって調剤された、クロルヘキシジングルコン酸塩を含有するゲル化用溶液を、針先が斜めにカットされた注射器を使って、歯間空隙に注入(又は人工歯根の周辺に投与)した。前記ゲルは、その部位で局所的に固化して、歯間又は人工歯根の周辺に食物残渣が入り込むことを防止する。このような治療は、歯根清掃、歯根の研磨、歯周ポケットの掻爬、歯周ポケットの殺菌、及び/又はスケーリング及びルートプレイニングの後に行うことが推奨され、これにより、同じ症状が頻繁に再発することを予防できる。
実施例2に説明した手順で得られるゴム状フィルムは、弾性を備え、また、含有するクロルヘキシジングルコン酸塩を放出する機能を備えることを特徴とする。ゲルのサンプルを用いて測定したところ、100%を超える破断時の弾性伸びを示す結果が得られた。また、クロルヘキシジングルコン酸塩の放出の持続期間は、7日間超であった。
実施例1の製剤について行われた臨床前研究(preliminary clinical studies)によって、スケーリング及びルートプレイニング、歯根清掃、歯根の研磨、歯周ポケットの掻爬、歯周ポケットの殺菌を行った後に、最適な口内環境が従来よりも長く維持されることが明らかにされた。したがって、同じ治療を短期間のうちに繰り返し行う必要がなくなる。加えて、前記製剤は、歯瘻、嚢胞、或いは、抜歯又は主要な歯科治療の後の歯牙感染、固定又は可動性の歯科補綴物の支台を介した感染の治療又は予防に有用であることが明らかにされた。
ポリビニルアルコールを、分子量が90,000、濃度が2重量%になるように水に溶解させて、ゲル化用溶液を得た。この水溶液を攪拌して均一溶液とした後に、濃度0.2重量%のヒアルロン酸、濃度5重量%のフルルビプロフェン、及び比粘度が4,000cPで濃度が2重量%のアルギン酸ナトリウムを追加した。また、混合物全体に対して、濃度2重量%のクロルヘキシジングルコン酸塩と、濃度3重量%のクロルヘキシジン二塩酸塩を最後に追加した。
Claims (17)
- ポリビニルアルコール水溶液に、1種以上のポリ酸又はその塩、1種以上の殺菌剤及び/又は抗炎症剤を混合した混合物を含むことを特徴とする、口腔又は歯牙の衛生、審美、治療用製剤。
- ポリビニルアルコールは、分子量が10から1,000,000の間、好ましくは、10,000超であり、濃度が0.0001重量%から30重量%の間、好ましくは4重量%未満である、請求項1に記載の製剤。
- 前記ポリ酸及びその塩は、ポリアクリル酸及びその一価の塩からなる群から選択されるとともに、10から5,000,000の間の分子量、及び0.0001重量%から30重量%の間の濃度を有する、請求項1又は2に記載の製剤。
- 前記ポリ酸及びその塩は、アルギン酸及びそのアルギン酸一価塩からなる群から選択されるとともに、0.0001重量%から30重量%の間の濃度を有する、請求項1〜3のいずれか1つに記載の製剤。
- 前記ポリ酸塩は、1.5重量%の溶液中における温度20℃時の粘度が40センチポアズ超であるとともに、濃度が0.0001重量%から5重量%の間である高分子アルギン酸ナトリウムである、請求項1〜4のいずれか1つに記載の製剤。
- 前記殺菌剤は、クロルヘキシジングルコン酸塩、クロルヘキシジン二塩酸塩、ヨウ素、銀イオン、及びそれらの任意の組み合わせからなる群から選択される、請求項1〜5のいずれか1つに記載の製剤。
- 前記抗炎症剤は、アセチルサリチル酸、フルルビプロフェン、及びそれらの任意の組み合わせからなる群から選択される抗炎症剤である、請求項1〜6のいずれか1つに記載の製剤。
- パーフォレーション、食物片の侵入、及び引張に対する耐性を有するゴム状弾性固体に変化する粘性流体状のゲル化用溶液の形態である、請求項1〜7のいずれか1つに記載の製剤。
- 前記ゲル化用溶液を、無菌状態の維持と細菌感染又は食物片の侵入に対する保護とを必要とする患者の口腔内、或いは歯牙又は人工歯根の周辺領域に塗布して、その場に、前記薬剤、殺菌剤、及び抗炎症剤の生物学的利用能を促進する粘着性の保護バリアを形成する、請求項8に記載の使用。
- 前記ゲル化用溶液は、組織再生刺激成分を含有する、請求項8又は9に記載の製剤。
- 前記組織再生刺激成分は、ヒアルロン酸である、請求項10に記載の製剤。
- 前記ゲル化用溶液は、審美治療に使用される、請求項8〜11のいずれか1つに記載の製剤。
- 過酸化物、過酸化水素水、過酸化カルバミド、及びそれらの任意の組み合わせをベースとする歯面漂白剤の形態である、請求項12に記載の製剤。
- 前記ゲル化用溶液は、当該製剤の経時的な安定性を維持するための防腐剤を含有する、請求項8〜13のいずれか1つに記載の製剤。
- 前記防腐剤は、パラオキシ安息香酸プロピル、パラオキシ安息香酸メチル、及びその任意の組み合わせと同じく、パラベン類に属する、請求項14に記載の製剤。
- 医療行為者が前記構成成分のすべて又は一部を混合することで調剤されることを特徴とする、請求項1〜15のいずれか1つに記載の製剤。
- 前記構成成分を二液型の形態、即ち、ゲル化用溶液と架橋溶液の形態で用いることにより調剤されることを特徴とする、請求項1〜16のいずれか1つに記載の製剤。
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IT102018000003872A IT201800003872A1 (it) | 2018-03-22 | 2018-03-22 | Prodotto per il trattamento terapeutico per la prevenzione e cura di patologie del cavo orale, dei denti e degli impianti dentali |
IT102018000003872 | 2018-03-22 | ||
PCT/IB2019/051880 WO2019180530A1 (en) | 2018-03-22 | 2019-03-08 | Antiseptic and/or anti-inflammatory gel for treatment of oral cavity diseases comprising polyvinyl alcohol and polyacids |
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US5876744A (en) * | 1994-08-01 | 1999-03-02 | Lifegroup S.P.A. | Highly bioadhesive and mucoadhesive compositions containing polyvinyl alcohol, polycarbophil and biopolymer for the treatment of skin conditions and as vehicles for active ingredients |
JP2003010308A (ja) * | 2001-06-28 | 2003-01-14 | Denki Kagaku Kogyo Kk | 細胞組織再生用基材 |
US20060110447A1 (en) * | 2002-11-05 | 2006-05-25 | Piero Chiarelli | Controlled and continued delivery of rifaximin and/or other substances |
WO2014181299A1 (en) * | 2013-05-10 | 2014-11-13 | Benzi Marco | A product for use in the therapeutic treatment of periodontitis and peri- implantitis |
WO2017123020A2 (ko) * | 2016-01-13 | 2017-07-20 | 주식회사 엘지생활건강 | 구강용 제제 |
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JP3526887B2 (ja) * | 1993-04-23 | 2004-05-17 | 帝國製薬株式会社 | 消炎鎮痛外用貼付剤 |
US6365131B1 (en) | 1997-10-31 | 2002-04-02 | J. B. Chemicals & Pharmaceuticals Ltd. | Pharmaceutical dental formulation for topical application of metronidazole benzoate, chlorhexidine gluconate and local anesthetic |
US20040185009A1 (en) * | 2003-03-19 | 2004-09-23 | Dexcel Pharma Technologies Ltd. | Composition and device for treating periodontal diseases |
WO2005074883A1 (en) * | 2004-01-29 | 2005-08-18 | Sinclair Pharmaceuticals Limited | Aqueous compositions containing mixtures of synthetic polymers and biopolymers, useful in the treatment of skin and mucosal tissues dryness, and suitable as vehicles of active ingredients |
JP4592326B2 (ja) * | 2004-04-28 | 2010-12-01 | 久光製薬株式会社 | 貼付剤 |
US20090148486A1 (en) | 2005-04-28 | 2009-06-11 | Helen Lu | Compositions and methods for treating pulp inflammations caused by infection or trauma |
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2018
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- 2019-03-08 JP JP2021500363A patent/JP2021519343A/ja active Pending
- 2019-03-08 EP EP19714246.6A patent/EP3768224A1/en not_active Withdrawn
- 2019-03-08 US US16/982,949 patent/US20210007983A1/en not_active Abandoned
- 2019-03-08 WO PCT/IB2019/051880 patent/WO2019180530A1/en active Application Filing
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Publication number | Priority date | Publication date | Assignee | Title |
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US5876744A (en) * | 1994-08-01 | 1999-03-02 | Lifegroup S.P.A. | Highly bioadhesive and mucoadhesive compositions containing polyvinyl alcohol, polycarbophil and biopolymer for the treatment of skin conditions and as vehicles for active ingredients |
JP2003010308A (ja) * | 2001-06-28 | 2003-01-14 | Denki Kagaku Kogyo Kk | 細胞組織再生用基材 |
US20060110447A1 (en) * | 2002-11-05 | 2006-05-25 | Piero Chiarelli | Controlled and continued delivery of rifaximin and/or other substances |
WO2014181299A1 (en) * | 2013-05-10 | 2014-11-13 | Benzi Marco | A product for use in the therapeutic treatment of periodontitis and peri- implantitis |
WO2017123020A2 (ko) * | 2016-01-13 | 2017-07-20 | 주식회사 엘지생활건강 | 구강용 제제 |
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