JP2021518340A5 - - Google Patents
Info
- Publication number
- JP2021518340A5 JP2021518340A5 JP2020548963A JP2020548963A JP2021518340A5 JP 2021518340 A5 JP2021518340 A5 JP 2021518340A5 JP 2020548963 A JP2020548963 A JP 2020548963A JP 2020548963 A JP2020548963 A JP 2020548963A JP 2021518340 A5 JP2021518340 A5 JP 2021518340A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- alkyl
- halo
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642932P | 2018-03-14 | 2018-03-14 | |
| US62/642,932 | 2018-03-14 | ||
| US201862690536P | 2018-06-27 | 2018-06-27 | |
| US62/690,536 | 2018-06-27 | ||
| US201862699443P | 2018-07-17 | 2018-07-17 | |
| US62/699,443 | 2018-07-17 | ||
| PCT/US2019/021995 WO2019178191A1 (en) | 2018-03-14 | 2019-03-13 | O-glycoprotein-2-acetamido-2-deoxy-3-d-glycopyranosidase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021518340A JP2021518340A (ja) | 2021-08-02 |
| JP2021518340A5 true JP2021518340A5 (enExample) | 2022-03-22 |
| JP7453916B2 JP7453916B2 (ja) | 2024-03-21 |
Family
ID=65952097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020548963A Active JP7453916B2 (ja) | 2018-03-14 | 2019-03-13 | Ｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グリコピラノシダーゼ阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230117898A1 (enExample) |
| EP (2) | EP3765458B1 (enExample) |
| JP (1) | JP7453916B2 (enExample) |
| CN (2) | CN112218863B (enExample) |
| AU (1) | AU2019234759C1 (enExample) |
| CA (1) | CA3093315A1 (enExample) |
| ES (1) | ES2942211T3 (enExample) |
| MA (1) | MA52004A (enExample) |
| MX (1) | MX2020009530A (enExample) |
| WO (1) | WO2019178191A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018154133A1 (en) * | 2017-02-27 | 2018-08-30 | Janssen Pharmaceutica Nv | [1,2,4]-triazolo [1,5-a]-pyrimidinyl derivatives substituted with piperidine, morpholine or piperazine as oga inhibitors |
| US12180205B2 (en) * | 2018-09-19 | 2024-12-31 | Biogen Ma Inc. | O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors |
| WO2021094312A1 (en) | 2019-11-11 | 2021-05-20 | Janssen Pharmaceutica Nv | Pyrrolidine and bicycloheteroaryl containing oga inhibitor compounds |
| WO2021110656A1 (en) | 2019-12-02 | 2021-06-10 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
| US20230058733A1 (en) | 2019-12-18 | 2023-02-23 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
| CN114867725A (zh) | 2019-12-18 | 2022-08-05 | 詹森药业有限公司 | Oga抑制剂化合物 |
| WO2021123291A1 (en) | 2019-12-18 | 2021-06-24 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
| KR102533471B1 (ko) * | 2020-11-23 | 2023-05-19 | (주) 메디프론디비티 | O-GlcNAcase 저해 활성을 갖는 화합물 및 이의 용도 |
| CN114213315A (zh) * | 2021-12-31 | 2022-03-22 | 上海陶术生物科技有限公司 | 含氮杂环类化合物及其中间体的合成方法 |
| CN114560805B (zh) * | 2022-01-20 | 2024-11-29 | 上海陶术生物科技有限公司 | 含氮杂环化合物及其中间体的合成方法 |
| WO2026021588A1 (zh) * | 2024-07-26 | 2026-01-29 | 浙江同源康医药股份有限公司 | Oga抑制剂及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| EP2780014A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| US9051269B2 (en) | 2011-11-18 | 2015-06-09 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2013078320A1 (en) | 2011-11-21 | 2013-05-30 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP5989805B2 (ja) | 2012-02-10 | 2016-09-07 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | メチル基変更酵素の調節物質、組成物及びその使用 |
| MA38341B1 (fr) | 2013-02-11 | 2018-11-30 | Constellation Pharmaceuticals Inc | Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées |
| PT2970272T (pt) * | 2013-03-14 | 2019-06-05 | Merck Patent Gmbh | Inibidores de glicosidase |
| US9745305B2 (en) | 2013-03-15 | 2017-08-29 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| EP3389658B1 (en) * | 2015-12-18 | 2020-11-25 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
| EP3555087A1 (en) * | 2016-12-16 | 2019-10-23 | Janssen Pharmaceutica NV | Monocyclic oga inhibitor compounds |
| US20190359609A1 (en) | 2016-12-16 | 2019-11-28 | Janssen Pharmaceutica Nv | Bicyclic oga inhibitor compounds |
| WO2018154133A1 (en) * | 2017-02-27 | 2018-08-30 | Janssen Pharmaceutica Nv | [1,2,4]-triazolo [1,5-a]-pyrimidinyl derivatives substituted with piperidine, morpholine or piperazine as oga inhibitors |
-
2019
- 2019-03-13 JP JP2020548963A patent/JP7453916B2/ja active Active
- 2019-03-13 MX MX2020009530A patent/MX2020009530A/es unknown
- 2019-03-13 WO PCT/US2019/021995 patent/WO2019178191A1/en not_active Ceased
- 2019-03-13 EP EP19713945.4A patent/EP3765458B1/en active Active
- 2019-03-13 CA CA3093315A patent/CA3093315A1/en active Pending
- 2019-03-13 ES ES19713945T patent/ES2942211T3/es active Active
- 2019-03-13 CN CN201980019170.5A patent/CN112218863B/zh active Active
- 2019-03-13 AU AU2019234759A patent/AU2019234759C1/en active Active
- 2019-03-13 CN CN202410813893.5A patent/CN118955490A/zh active Pending
- 2019-03-13 EP EP23151036.3A patent/EP4186899A1/en active Pending
- 2019-03-13 MA MA052004A patent/MA52004A/fr unknown
-
2022
- 2022-08-24 US US17/894,461 patent/US20230117898A1/en active Pending
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