JP2021514955A5 - - Google Patents
Info
- Publication number
- JP2021514955A5 JP2021514955A5 JP2020544425A JP2020544425A JP2021514955A5 JP 2021514955 A5 JP2021514955 A5 JP 2021514955A5 JP 2020544425 A JP2020544425 A JP 2020544425A JP 2020544425 A JP2020544425 A JP 2020544425A JP 2021514955 A5 JP2021514955 A5 JP 2021514955A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- nr1c
- nr1r2
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862634632P | 2018-02-23 | 2018-02-23 | |
| US62/634,632 | 2018-02-23 | ||
| PCT/US2019/019162 WO2019165216A1 (en) | 2018-02-23 | 2019-02-22 | Small molecules that block proteasome-associated ubiquitin receptor rpn13 function and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021514955A JP2021514955A (ja) | 2021-06-17 |
| JP2021514955A5 true JP2021514955A5 (https=) | 2023-08-21 |
| JP7389749B2 JP7389749B2 (ja) | 2023-11-30 |
Family
ID=65724533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544425A Active JP7389749B2 (ja) | 2018-02-23 | 2019-02-22 | プロテアソーム関連ユビキチン受容体ｒｐｎ１３機能を阻止する低分子およびその使用法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11702402B2 (https=) |
| EP (1) | EP3755377A1 (https=) |
| JP (1) | JP7389749B2 (https=) |
| AU (1) | AU2019224089B2 (https=) |
| CA (1) | CA3090414A1 (https=) |
| WO (1) | WO2019165216A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3807272A1 (en) | 2018-06-13 | 2021-04-21 | Amphista Therapeutics Ltd | Bifunctional molecules for targeting rpn11 |
| NZ793813A (en) * | 2020-04-29 | 2025-12-19 | Onegene Biotechnology Inc | Novel protein conjugate, and use thereof for preventing or treating nonalcoholic steatohepatitis, obesity and diabetes |
| US20240245787A1 (en) | 2021-04-13 | 2024-07-25 | President And Fellows Of Harvard College | E3 ligase binders and uses thereof |
| CN115260212B (zh) * | 2022-08-01 | 2023-05-23 | 桂林医学院 | 3,5-双(亚苄基)-4-哌啶酮衍生物及其制备方法和应用 |
| US20250137057A1 (en) * | 2023-10-26 | 2025-05-01 | The Chinese University Of Hong Kong | Adrm1/rpn13 spliced variant in the prognosis and treatment of hepatocellular carcinoma |
| WO2025207482A1 (en) * | 2024-03-25 | 2025-10-02 | Augusta University Research Institute, Inc. | Diarylpiperidone hybrid conjugates and methods of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014182744A1 (en) * | 2013-05-08 | 2014-11-13 | The Johns Hopkins University | Novel bis-benzylidine piperidone proteasome inhibitor with anticancer activity |
| RU2738833C9 (ru) * | 2014-04-14 | 2022-02-28 | Арвинас, Оперэйшнз, Инк. | Имидные модуляторы протеолиза и способы их применения |
-
2019
- 2019-02-22 US US16/969,458 patent/US11702402B2/en active Active
- 2019-02-22 AU AU2019224089A patent/AU2019224089B2/en active Active
- 2019-02-22 JP JP2020544425A patent/JP7389749B2/ja active Active
- 2019-02-22 CA CA3090414A patent/CA3090414A1/en active Pending
- 2019-02-22 EP EP19710214.8A patent/EP3755377A1/en active Pending
- 2019-02-22 WO PCT/US2019/019162 patent/WO2019165216A1/en not_active Ceased
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