JP2018502141A5 - - Google Patents
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- JP2018502141A5 JP2018502141A5 JP2017537966A JP2017537966A JP2018502141A5 JP 2018502141 A5 JP2018502141 A5 JP 2018502141A5 JP 2017537966 A JP2017537966 A JP 2017537966A JP 2017537966 A JP2017537966 A JP 2017537966A JP 2018502141 A5 JP2018502141 A5 JP 2018502141A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- branched
- linear
- occurrence
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000001931 aliphatic group Chemical group 0.000 claims description 241
- 229910052760 oxygen Inorganic materials 0.000 claims description 125
- 229910052739 hydrogen Inorganic materials 0.000 claims description 110
- 229910052717 sulfur Inorganic materials 0.000 claims description 110
- 229910052757 nitrogen Inorganic materials 0.000 claims description 91
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 91
- 239000001257 hydrogen Substances 0.000 claims description 88
- 125000005842 heteroatom Chemical group 0.000 claims description 71
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 69
- 239000001301 oxygen Chemical group 0.000 claims description 69
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 65
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 65
- 239000011593 sulfur Chemical group 0.000 claims description 58
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 53
- 229910052736 halogen Inorganic materials 0.000 claims description 48
- 150000002367 halogens Chemical group 0.000 claims description 48
- 150000001875 compounds Chemical class 0.000 claims description 45
- 150000003839 salts Chemical class 0.000 claims description 39
- 125000003118 aryl group Chemical group 0.000 claims description 36
- 125000000623 heterocyclic group Chemical group 0.000 claims description 35
- 125000004429 atom Chemical group 0.000 claims description 29
- 125000002947 alkylene group Chemical group 0.000 claims description 26
- 150000002431 hydrogen Chemical class 0.000 claims description 22
- 125000001072 heteroaryl group Chemical group 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 14
- 229920006395 saturated elastomer Polymers 0.000 claims description 14
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 13
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 12
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 12
- 229910052731 fluorine Inorganic materials 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 11
- 102000015532 Nicotinamide phosphoribosyltransferase Human genes 0.000 claims description 8
- 108010064862 Nicotinamide phosphoribosyltransferase Proteins 0.000 claims description 8
- -1 cycloaliphatic Chemical group 0.000 claims description 8
- 230000001404 mediated effect Effects 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 125000002950 monocyclic group Chemical group 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 2
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 150000001412 amines Chemical group 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000010261 cell growth Effects 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000011737 fluorine Substances 0.000 claims description 2
- 230000003463 hyperproliferative effect Effects 0.000 claims description 2
- 230000004968 inflammatory condition Effects 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 9
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003464 sulfur compounds Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105387P | 2015-01-20 | 2015-01-20 | |
| US62/105,387 | 2015-01-20 | ||
| PCT/US2016/014026 WO2016118565A1 (en) | 2015-01-20 | 2016-01-20 | Quinazoline and quinoline compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502141A JP2018502141A (ja) | 2018-01-25 |
| JP2018502141A5 true JP2018502141A5 (https=) | 2019-02-28 |
Family
ID=56417670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017537966A Pending JP2018502141A (ja) | 2015-01-20 | 2016-01-20 | キナゾリン及びキノリン化合物、ならびにその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10323018B2 (https=) |
| EP (1) | EP3247705B1 (https=) |
| JP (1) | JP2018502141A (https=) |
| CN (1) | CN107438598A (https=) |
| CA (1) | CA2974078A1 (https=) |
| WO (1) | WO2016118565A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI835714B (zh) | 2016-10-18 | 2024-03-21 | 美商思進公司 | 菸鹼醯胺腺嘌呤二核苷酸補救合成(salvage pathway)抑制劑之靶向投遞 |
| CN106632087B (zh) * | 2016-12-30 | 2019-03-08 | 江西师范大学 | 4-芳基-2-(2-(硫三氟甲基)芳基)喹唑啉的制备方法 |
| WO2018201087A1 (en) | 2017-04-27 | 2018-11-01 | Seattle Genetics, Inc. | Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates |
| CN108929267B (zh) * | 2018-07-09 | 2021-07-02 | 中南大学 | 一种喹诺酮骨架及其合成方法 |
| CA3118752A1 (en) | 2018-11-09 | 2020-05-14 | Vivace Therapeutics, Inc. | Bicyclic compounds |
| HUE070525T2 (hu) | 2019-04-16 | 2025-06-28 | Vivace Therapeutics Inc | Biciklusos vegyületek |
| US20230098872A1 (en) * | 2021-03-26 | 2023-03-30 | Cedilla Therapeutics, Inc. | Tead inhibitors and uses thereof |
| TW202509018A (zh) * | 2023-05-09 | 2025-03-01 | 美商安進公司 | 用作１５－前列腺素脫氫酶調節劑的６，６－稠合雙環醯胺和組成物 |
| WO2025168575A1 (en) | 2024-02-05 | 2025-08-14 | Institut National de la Santé et de la Recherche Médicale | Inhibitors of nad biosynthesis for the treatment of dengue virus infections |
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|---|---|---|---|---|
| WO1999042461A1 (en) * | 1998-02-23 | 1999-08-26 | Warner-Lambert Company | Substituted quinoxaline derivatives as interleukin-8 receptor antagonists |
| AR043059A1 (es) | 2002-11-12 | 2005-07-13 | Bayer Pharmaceuticals Corp | Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos |
| CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| JP2006522750A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法 |
| US7189724B2 (en) * | 2003-04-15 | 2007-03-13 | Valeant Research And Development | Quinoxaline derivatives having antiviral activity |
| WO2005007099A2 (en) | 2003-07-10 | 2005-01-27 | Imclone Systems Incorporated | Pkb inhibitors as anti-tumor agents |
| JP2007099641A (ja) | 2005-09-30 | 2007-04-19 | Tsumura & Co | インドールキノキサリン類化合物、その製造方法およびそれを用いた医薬組成物 |
| US8119656B2 (en) | 2007-12-07 | 2012-02-21 | The Board Of Regents Of The University Of Texas System | Inhibitors of the influenza virus non-structural 1 protein |
| CA2729757A1 (en) * | 2008-07-01 | 2010-01-07 | The Johns Hopkins University | Methods for treating neoplasia by inhibiting lactate dehydrogenase and/or nicotinamide phosphoribosyltransferase |
| JP5688367B2 (ja) | 2008-08-29 | 2015-03-25 | トポターゲット・アクティーゼルスカブＴｏｐｏＴａｒｇｅｔ Ａ／Ｓ | 新規なウレアおよびチオウレア誘導体 |
| EP2440527A1 (en) | 2009-06-09 | 2012-04-18 | Topo Target A/S | Pyridinyl derivatives as inhibitors of enzyme nicotinamide phosphoribosyltransferase |
| PH12012500382A1 (en) | 2009-09-03 | 2012-10-22 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
| AU2011223790A1 (en) | 2010-03-01 | 2012-08-30 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
| US20130317027A1 (en) | 2010-03-01 | 2013-11-28 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
| WO2011121055A1 (en) | 2010-03-31 | 2011-10-06 | Topotarget A/S | Pyridinyl derivatives comprising a cyanoguanidine or squaric acid moiety |
| EP2552444B1 (en) | 2010-04-01 | 2018-10-10 | Council of Scientific & Industrial Research | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NMPRTase) INHIBITOR FOR GLIOMA THERAPY |
| TWI516264B (zh) * | 2010-05-06 | 2016-01-11 | 臺北醫學大學 | 芳香醯喹啉化合物 |
| CN106243023A (zh) | 2010-09-03 | 2016-12-21 | 福马Tm有限责任公司 | 用于抑制nampt的胍化合物和组合物 |
| PE20140011A1 (es) | 2010-09-03 | 2014-01-31 | Forma Tm Llc | Compuestos y composiciones novedosos para la inhibicion de nampt |
| JP6038792B2 (ja) | 2010-09-03 | 2016-12-07 | フォーマ ティーエム， エルエルシー． | 癌などの疾患の治療のためのｎａｍｐｔ阻害剤としての４−｛［（ピリジン−３−イル−メチル）アミノカルボニル］アミノ｝ベンゼン−スルホン誘導体 |
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| BR112013022147A2 (pt) | 2011-03-02 | 2017-04-25 | Bioenergenix | composto, composição farmacêutica, método de inibição da pask, método de tratamento de uma doença, método para alcançar um efeito em um paciente e método de tratamento de uma doença mediada pela pask |
| US20120225846A1 (en) | 2011-03-02 | 2012-09-06 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
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| RU2017112522A (ru) | 2011-05-04 | 2019-01-24 | ФОРМА ТиЭм, ЭлЭлСИ | Новые соединения и композиции для ингибирования nampt |
| WO2012154194A1 (en) * | 2011-05-09 | 2012-11-15 | Forma Tm, Llc | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (nampt) |
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-
2016
- 2016-01-20 EP EP16740634.7A patent/EP3247705B1/en active Active
- 2016-01-20 US US15/544,192 patent/US10323018B2/en not_active Expired - Fee Related
- 2016-01-20 CA CA2974078A patent/CA2974078A1/en not_active Abandoned
- 2016-01-20 WO PCT/US2016/014026 patent/WO2016118565A1/en not_active Ceased
- 2016-01-20 CN CN201680013053.4A patent/CN107438598A/zh active Pending
- 2016-01-20 JP JP2017537966A patent/JP2018502141A/ja active Pending