JP2021514373A5 - - Google Patents
Info
- Publication number
- JP2021514373A5 JP2021514373A5 JP2020544238A JP2020544238A JP2021514373A5 JP 2021514373 A5 JP2021514373 A5 JP 2021514373A5 JP 2020544238 A JP2020544238 A JP 2020544238A JP 2020544238 A JP2020544238 A JP 2020544238A JP 2021514373 A5 JP2021514373 A5 JP 2021514373A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- group
- substituted
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18157881 | 2018-02-21 | ||
| EP18157881.6 | 2018-02-21 | ||
| PCT/EP2019/054208 WO2019162323A1 (en) | 2018-02-21 | 2019-02-20 | New benzimidazole compounds and derivatives as egfr inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021514373A JP2021514373A (ja) | 2021-06-10 |
| JP2021514373A5 true JP2021514373A5 (https=) | 2022-03-03 |
| JP7313364B2 JP7313364B2 (ja) | 2023-07-24 |
Family
ID=61256692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544238A Active JP7313364B2 (ja) | 2018-02-21 | 2019-02-20 | Ｅｇｆｒ阻害剤としての新たなベンズイミダゾール化合物および誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11174245B2 (https=) |
| EP (1) | EP3755694B1 (https=) |
| JP (1) | JP7313364B2 (https=) |
| CN (1) | CN111741954B (https=) |
| WO (1) | WO2019162323A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102267662B1 (ko) * | 2019-11-19 | 2021-06-22 | 한국화학연구원 | 벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| EP4079735B1 (en) * | 2019-12-16 | 2025-08-06 | Beijing Tide Pharmaceutical Co., Ltd. | Macrocyclic compounds for inhibiting and inducing degradation of egfr kinase in the treatment of cancer |
| CN113880804A (zh) * | 2020-07-01 | 2022-01-04 | 微境生物医药科技(上海)有限公司 | 新型苯并咪唑化合物 |
| CN114057770B (zh) * | 2020-08-06 | 2023-05-02 | 成都先导药物开发股份有限公司 | 靶向egfr蛋白降解的双功能化合物 |
| CA3194824A1 (en) * | 2020-10-07 | 2022-04-14 | Dana Farber Cancer Institute, Inc. | Covalent egfr inhibitors and methods of use thereof |
| US12064421B2 (en) * | 2020-11-02 | 2024-08-20 | Boehringer Ingelheim International Gmbh | Substituted 1H-pyrazolo[4,3-c]pyridines and derivatives as EGFR inhibitors |
| CN116761603A (zh) * | 2021-02-06 | 2023-09-15 | 正大天晴药业集团股份有限公司 | 含有苯并杂环的作为egfr激酶抑制剂的大环化合物、其药物组合物和用途 |
| TW202309022A (zh) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | 用於治療具egfr突變之癌症之胺基取代雜環 |
| WO2023001069A1 (zh) * | 2021-07-23 | 2023-01-26 | 南京明德新药研发有限公司 | 大环酰胺类化合物及其应用 |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
| TW202409023A (zh) | 2022-07-14 | 2024-03-01 | 美商富曼西公司 | 除草苯并𠯤 |
| TW202428267A (zh) * | 2022-11-10 | 2024-07-16 | 英屬開曼群島商百濟神州有限公司 | 用於降解ｅｇｆｒ激酶之化合物 |
| WO2025111184A1 (en) | 2023-11-21 | 2025-05-30 | Fmc Corporation | Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides |
| CN119019366A (zh) * | 2024-08-19 | 2024-11-26 | 广州医科大学附属第五医院(广州再生医学与健康广东省实验室附属医院) | 一种肺癌细胞靶向治疗药物及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7132438B2 (en) | 2001-10-09 | 2006-11-07 | Amgen Inc. | Benzimidazole derivatives |
| JP2005509003A (ja) | 2001-11-09 | 2005-04-07 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼインヒビターとして有用なベンゾイミダゾール化合物 |
| EP1388341A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
| AU2003257094A1 (en) | 2002-08-08 | 2004-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted benzimidazole compounds |
| WO2005070420A1 (en) | 2004-01-14 | 2005-08-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1h-benzimidazol-2-yl-benzamide derivatives and related compounds as itk inhibitors (interleukin-2-inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders |
| WO2005079791A1 (en) * | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders |
| US20060223849A1 (en) * | 2005-03-14 | 2006-10-05 | Mjalli Adnan M | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors |
| WO2007133983A2 (en) | 2006-05-08 | 2007-11-22 | Pharmacopeia, Inc. | 2-aminobenzimidazoles for treating neurodegenerative diseases |
| SG10201505997TA (en) | 2010-08-05 | 2015-09-29 | Amgen Inc | Benzimidazole And Azabenzimidazole Compounds That Inhibit Anaplastic Lymphoma Kinase |
| JO3300B1 (ar) * | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
| US20150152083A1 (en) * | 2012-06-06 | 2015-06-04 | Irm Llc, A Delaware Limited Liability Company | Compounds and Compositions for Modulating EGFR Activity |
| US9573958B2 (en) | 2012-08-31 | 2017-02-21 | Principia Biopharma, Inc. | Benzimidazole derivatives as ITK inhibitors |
| WO2014081718A1 (en) | 2012-11-20 | 2014-05-30 | Genentech, Inc. | Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants |
| WO2014210354A1 (en) | 2013-06-28 | 2014-12-31 | Genentech, Inc. | Azaindazole compounds as inhibitors of t790m containing egfr mutants |
| CA2943220C (en) * | 2014-03-20 | 2024-01-16 | Capella Therapeutics, Inc. | Benzimidazole derivatives as erbb tyrosine kinase inhibitors for the treatment of cancer |
| JP6568926B2 (ja) * | 2014-03-20 | 2019-08-28 | カペラ セラピューティクス，インコーポレーテッド | 癌の治療のためのｅｒｂｂチロシンキナーゼ阻害剤としてのベンゾイミダゾール誘導体 |
| WO2016176473A1 (en) | 2015-04-28 | 2016-11-03 | Sanford-Burnham Medical Researc Institute | Apelin receptor agonists and methods of use thereof |
| CN108012529A (zh) | 2015-05-15 | 2018-05-08 | 诺华股份有限公司 | 治疗egfr突变的癌症的方法 |
| JP6845165B2 (ja) | 2015-06-30 | 2021-03-17 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｅｇｆｒ阻害剤およびその使用方法 |
| EP3328418A1 (en) | 2015-07-29 | 2018-06-06 | Novartis AG | Combination therapies comprising antibody molecules to pd-1 |
| BR112018003812B1 (pt) | 2015-09-18 | 2024-04-30 | Merck Patent Gmbh | Compostos de heteroarila como inibidores de irak, seu uso, composição farmacêutica, e kit |
| CN108602776B (zh) | 2015-09-18 | 2021-12-03 | 默克专利有限公司 | 用作irak抑制剂的杂芳基化合物及其用途 |
-
2019
- 2019-02-20 JP JP2020544238A patent/JP7313364B2/ja active Active
- 2019-02-20 CN CN201980014281.7A patent/CN111741954B/zh active Active
- 2019-02-20 WO PCT/EP2019/054208 patent/WO2019162323A1/en not_active Ceased
- 2019-02-20 EP EP19708792.7A patent/EP3755694B1/en active Active
- 2019-02-20 US US16/970,705 patent/US11174245B2/en active Active
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